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Lack of association between acute stroke, post-stroke dementia, race, and β-amyloid status
Lauren N Koenig, Lena M McCue, Elizabeth Grant, Parinaz Massoumzadeh, Catherine M Roe, Chengjie Xiong, Krista L Moulder, Liang Wang et al.. NeuroImage. Clinical, 2021-01-05
Topic: Plasma and spinal-fluid biomarkers
A total of 243 participants were enrolled, 81 of which had a recent ischemic stroke. Participants had a mean age of 75, 57% were women, and 52% were African American. Cortical amyloid did not differ significantly by race, stroke status, or CDR post-stroke. There were racial differences in MMSE scores at baseline (mean 26.8 for African Americans, 27.9 for non-Hispanic whites, p = 0.03), but not longitudinally. African Americans were more likely to have microbleeds (32.8% vs 22.6%, p = 0.04), and within the acute stroke group, African Americans were more likely to have small infarcts (75.6% vs 56.8%, p = 0.049). Preclinical Alzheimer disease did not show evidence of being a risk factor for stroke nor predictive of post-stroke dementia. We did not observe racial differences in β-amyloid levels. However, even after controlling for several vascular risk factors, African Americans with clinical stroke presentations had greater levels of vascular pathology on MRI.
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APA 7th
Koenig, L. N., McCue, L. M., Grant, E., Massoumzadeh, P., Roe, C. M., Xiong, C., et al. (2021). Lack of association between acute stroke, post-stroke dementia, race, and β-amyloid status. NeuroImage. Clinical. https://doi.org/10.1016/j.nicl.2020.102553
Vancouver
Koenig LN, McCue LM, Grant E, Massoumzadeh P, Roe CM, Xiong C, et al. Lack of association between acute stroke, post-stroke dementia, race, and β-amyloid status. NeuroImage. Clinical. 2021. doi:10.1016/j.nicl.2020.102553. PMID: 33524806.
BibTeX
@article{koenig2021-33524806,
author = {Koenig, Lauren N and McCue, Lena M and Grant, Elizabeth and Massoumzadeh, Parinaz and Roe, Catherine M and Xiong, Chengjie and Moulder, Krista L and Wang, Liang and others},
title = {{Lack of association between acute stroke, post-stroke dementia, race, and β-amyloid status}},
journal = {NeuroImage. Clinical},
year = {2021},
doi = {10.1016/j.nicl.2020.102553},
pmid = {33524806},
url = {https://doi.org/10.1016/j.nicl.2020.102553}
}
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Key findings
- A total of 243 participants were enrolled, 81 of which had a recent ischemic stroke.
- Participants had a mean age of 75, 57% were women, and 52% were African American.
- Cortical amyloid did not differ significantly by race, stroke status, or CDR post-stroke.
- There were racial differences in MMSE scores at baseline (mean 26.8 for African Americans, 27.9 for non-Hispanic whites, p = 0.03), but not longitudinally.
- African Americans were more likely to have microbleeds (32.8% vs 22.6%, p = 0.04), and within the acute stroke group, African Americans were more likely to have small infarcts (75.6% vs 56.8%, p = 0.049).
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Study details
- Study designcase-control study
- Participants243
- Effect size32.8%; 22.6%; 75.6%
- Evidence strengthModerate
How this study scored 68/100
Published in a peer-reviewed journal, and it is a case-control study. Scored zero for randomized / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multicenter collaboration and free to read, so those were left out: it earned 38 of the 56 points we could judge it on, which is 68 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (NeuroImage. Clinical) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 6 / 12 | A case-control study |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2021 — within 6 year(s) of the newest study here |
| Sample size | 2 / 4 | 243 participants |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multicenter collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 33524806) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 38 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 38 of the 56 points we could judge it on is 68 out of 100. |
| Total | 68 / 100 | — |
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