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65/100

✓ Peer-reviewed alzhub usefulness score 65 out of 100. Disparities

Topic: Brain proteins, microglia and lab models

The objective is to identify risk factors associated with PASC/long-COVID diagnosis. Results Among 8,325 individuals with PASC, the majority were > 50 years of age (56.6%), female (62.8%), and non-Hispanic White (68.6%). In logistic regression, middle-age categories (40 to 69 years; OR ranging from 2.32 to 2.58), female sex (OR 1.4, 95% CI 1.33-1.48), hospitalization associated with COVID-19 (OR 3.8, 95% CI 3.05-4.73), long (8-30 days, OR 1.69, 95% CI 1.31-2.17) or extended hospital stay (30 + days, OR 3.38, 95% CI 2.45-4.67), receipt of mechanical ventilation (OR 1.44, 95% CI 1.18-1.74), and several comorbidities including depression (OR 1.50, 95% CI 1.40-1.60), chronic lung disease (OR 1.63, 95% CI 1.53-1.74), and obesity (OR 1.23, 95% CI 1.16-1.3) were associated with increased likelihood of PASC diagnosis or care at a long-COVID clinic. Characteristics associated with a lower likelihood of PASC diagnosis or care at a long-COVID clinic included younger age (18 to 29 years), male sex, non-Hispanic Black race, and comorbidities such as substance abuse, cardiomyopathy, psychosis, and dementia. More doctors per capita in the county of residence was associated with an increased likelihood of PASC diagnosis or care at a long-COVID clinic. Our findings were consistent in sensitivity analyses using a variety of analytic techniques and approaches to select controls.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Hill, E. L., Mehta, H. B., Sharma, S., Mane, K., Singh, S. K., Xie, C., et al. (2023). Risk factors associated with post-acute sequelae of SARS-CoV-2: an N3C and NIH RECOVER study. BMC public health. https://doi.org/10.1186/s12889-023-16916-w

Vancouver

Hill EL, Mehta HB, Sharma S, Mane K, Singh SK, Xie C, et al. Risk factors associated with post-acute sequelae of SARS-CoV-2: an N3C and NIH RECOVER study. BMC public health. 2023. doi:10.1186/s12889-023-16916-w. PMID: 37880596.

BibTeX

@article{hill2023-37880596,
  author  = {Hill, E. L. and Mehta, H. B. and Sharma, S. and Mane, K. and Singh, S. K. and Xie, C. and Cathey, E. and Loomba, J. and others},
  title   = {{Risk factors associated with post-acute sequelae of SARS-CoV-2: an N3C and NIH RECOVER study}},
  journal = {BMC public health},
  year    = {2023},
  doi     = {10.1186/s12889-023-16916-w},
  pmid    = {37880596},
  url     = {https://doi.org/10.1186/s12889-023-16916-w}
}

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Key findings

The objective is to identify risk factors associated with PASC/long-COVID diagnosis.
Results Among 8,325 individuals with PASC, the majority were > 50 years of age (56.6%), female (62.8%), and non-Hispanic White (68.6%).
In logistic regression, middle-age categories (40 to 69 years; OR ranging from 2.32 to 2.58), female sex (OR 1.4, 95% CI 1.33-1.48), hospitalization associated with COVID-19 (OR 3.8, 95% CI 3.05-4.73), long (8-30 days, OR 1.69, 95% CI 1.31-2.17) or extended hospital stay (30 + days, OR 3.38, 95% CI 2.45-4.67), receipt of mechanical ventilation (OR 1.44, 95% CI 1.18-1.74), and several comorbidities including depression (OR 1.50, 95% CI 1.40-1.60), chronic lung disease (OR 1.63, 95% CI 1.53-1.74), and obesity (OR 1.23, 95% CI 1.16-1.3) were associated with increased likelihood of PASC diagnosis or care at a long-COVID clinic.
Characteristics associated with a lower likelihood of PASC diagnosis or care at a long-COVID clinic included younger age (18 to 29 years), male sex, non-Hispanic Black race, and comorbidities such as substance abuse, cardiomyopathy, psychosis, and dementia.
More doctors per capita in the county of residence was associated with an increased likelihood of PASC diagnosis or care at a long-COVID clinic.

Why it matters

This study identified risk factors associated with post-acute sequelae of SARS-CoV-2, finding that dementia was among the characteristics associated with a lower likelihood of PASC diagnosis or care at a long-COVID clinic. It concerns long-COVID risk factors, not the treatment, cure, or prevention of Alzheimer's disease.

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Study details

Study designcase-control study
Participants8,325
Effect size56.6%; 62.8%; 68.6%
Evidence strengthModerate

How this study scored 65/100

Published in a peer-reviewed journal, and it is a case-control study. Scored zero for randomized / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (BMC public health)
Journal's citation record	3 / 4	BMC Public Health: journal h-index 289 (OpenAlex, 2026-10-29)
Study design	6 / 12	A case-control study
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	3 / 5	2023 — within 6 year(s) of the newest study here
Sample size	3 / 4	8,325 participants
Effect reported	2 / 3	Effect reported as a number, without an interval or test
Studied in people	3 / 3	Studied in people (participant count stated)
Randomized / blinded	0 / 2	No randomization or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	4 / 7	Cited 62 times (OpenAlex, 2026-10-10)
Citations per year	3 / 5	12.4 citations a year over 5 year(s) since 2023
Impact for its field and year	4 / 6	Cited 9.1× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	3 / 4	Cited 61 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	2 / 4	Last-listed author Tellen D. Bennett: h-index 43 (OpenAlex, whole career)
Institution's track record	2 / 3	Johns Hopkins University: institution h-index 2,306 (OpenAlex)
Multicenter collaboration	3 / 3	OpenAlex lists 10 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 37880596)
Free to read	2 / 2	Free to read
Total	65 / 100	—

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Read the original

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