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metabolic-syndrome
304 studies tagged metabolic-syndrome, dated 1984-04-01 to 2026-10-26. Bibliography: BibTeX (.bib) · RIS (.ris)
Newest in this topic
- Interventions for Cognitive Impairment in Type 2 Diabetes Mellitus: An Umbrella Review of Pharmacological and Lifestyle Strategies, Mechanisms, and Clinical Implications 2026-10-26
- Visit-to-Visit Blood Pressure Variability, Glycemic Status and the Risk of Dementia, Stroke, and All-Cause Mortality: A UK Biobank Cohort Study 2026-10-13
- Plasma metabolomic profiling of frailty in older adults at risk of dementia 2026-10-08
Studies
304 studies carry this tag.
Date range
1984 to 2026
Top journals
- Journal of Alzheimer's disease : JAD 21
- medRxiv 16
- Alzheimer's & dementia : the journal of the Alzheimer's Association 14
- Neurology 10
- Nutrients 10
164 journals in all.
Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.
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SGLT2 inhibitors and GLP-1 receptor agonists have the greatest effect on cognition in T2DM, and the multi-component exercise as the most effective lifestyle component.
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Absolute BPV was associated with mortality, and DBP and MAP variability with overall stroke, after accounting for glycemic status and mean blood pressure.
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Frailty index was associated with carboxylic acids and derivatives, fatty acyls and organooxygen compounds across multiple clusters, and a large number of lipids were linked to frailty score, potentially implicating dysregulation of energy metabolism in the pathophysiology of frailty and forming a panel of predictive biomarkers of at risk patients.
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Educational attainment and physical activity PRSs were associated with AD in both sexes.
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Vascular dementia (VaD) is a leading cause of cognitive decline with no disease-modifying therapies.
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Hypertension is associated with lower risk of dementia-related outcomes in aECAD patients.
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Of total 8,321 participants, 24.88% (2,070) developed cognitive impairment during a 10-year follow-up.
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This study reports the prevalence of CF among elderly hypertensive residents of a community in Inner Mongolia.
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The 2,885 participants had a mean age of 69.5 years.
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The association declines monotonically as control over ascertainment improves.
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In this nationwide cohort, probucol use was associated with substantially lower dementia risk than statins, supporting evaluation of probucol for repurposing in dementia prevention.
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53.0% of the participants were in the group of possible mild cognitive impairment (MCI).
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HbA1c levels had warning value for cognitive impairment in non diabetes patients with WMH, and a nonlinear correlation exists between HbA1c and WMH-related cognitive impairment.
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Insulin resistance is increasingly recognized as a metabolic factor associated with Alzheimer’s disease (AD); however, its relevance to hippocampal structural changes—a key pathological feature of AD—across disease stages is not fully understood.
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16/100
Long-term metformin treatment is associated with a reduced risk of dementia and better memory performance among persons with pre-diabetes or T2D. Longer follow-up with more dementia cases is needed to confirm our findings.
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Specific disease clusters involving diabetes, oral disease, sensory impairment, and osteoporosis were associated with suspected dementia and neuropsychiatric heterogeneity, supporting integrated multimorbidity-oriented screening and care.
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We investigated brain, inflammation, cardiometabolic, and gut health changes associated with a six-month multidomain lifestyle intervention in Dutch older adults at risk for cognitive decline and dementia.
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AD prevention must transcend the "geriatric disease" mindset.
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Electronic health records linked documented glucosamine use to faster progression from mild cognitive impairment (MCI) to Alzheimer’s disease (AD) and poorer survival after dementia.
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From 12,770 records, 3,636 duplicates were removed and 9,134 titles and abstracts were screened.
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Dysregulated insulin signaling in brain has been linked to cognitive impairment and dementia.
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INTRODUCTIONLittle is understood about the extent to which lifestyle factors can advance or delay the risk of developing dementia, and whether that is dependent on non-modifiable factors, e.g. sex and genetic susceptibility.METHODSAmong 224,516 UK Biobank participants aged ≥50 years at baseline, Cox regression examined the relations of apolipoprotein E gene (APOE) genotypes, and lifestyle with incident dementia.
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This study demonstrated MMSE scores can be systematically extracted and curated from the VA EHR.
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Dementia is a progressive condition that impairs cognitive processes such as memory, decision-making, and the ability to manage daily activities.
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Multidomain interventions have small but consistent beneficial effects on cognitive measures, suggesting the potential to reduce cognitive impairment and dementia risk.
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In SPRINT, intensive vs standard SBP control yielded a significantly larger 4-year absolute risk reduction in dementia among APOE ε4 carriers (−1.7%) than non-carriers (0.2%; P-interaction = .045); the relative-scale interactions were directionally consistent but not significant.
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42 participants completed the study (NR = 22, placebo = 20).
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Eligible studies reported MACE or dementia outcomes in adults ≥ 50 years for at least one of three intervention classes (RZV, SGLT2i, GLP-1 RA) versus placebo or active comparator, with follow-up ≥ 6 months.
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The Middle East and North Africa (MENA) region represents the area of greatest projected growth in instances of Alzheimer’s disease and related dementias (ADRDs) globally, yet, it remains virtually uncharacterized in health studies of aging and ADRDs.
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Greater multimorbidity burden was associated with worse cognition and biomarkers of AD (PET amyloid standardized uptake value ratios and positivity, p-tau181, and p-tau217), neurodegeneration (neurofilament light, total tau, cortical thickness, and hippocampal volume), and SVD (white matter hyperintensity volume and presence of lacune and cerebral microbleeds).
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The prevalence of dementia and Parkinson’s disease in Russia varies widely depending on diagnostic method, age group, and study design.
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Findingss: upport multidomain prevention strategies targeting clustered modifiable risks.
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Four distinct subtypes were identified: I low-risk healthy aging, II behavioral/social vulnerability, III cardiometabolic–depressive multimorbidity, and IV mixed social-medical vulnerability profiles.
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16/100
Our findings demonstrate differential effects of nicotine on AD risk and smoking intensity on white matter integrity, requiring triangulation with complementary methodological approaches to better inform potential long-term risks of nicotine intake on neurocognitive outcomes.
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To effectively combat dementia onset and progression, lifestyle-based interventions targeting multiple risk factors and disease mechanisms through a multidomain approach - tailored and implemented early in the disease process - have emerged as promising.
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Significant interaction effects were observed: MoCA (β = -1.86×10-4, P = 0.006) and PACC (β = -4.0×10-5, P = 0.004), indicating HDL moderates the negative association between NfL and cognition.
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Forty-five studies involving over 730 000 participants were included.
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The total effect of cholesterol on risk of AD was significant and heterogeneous.
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MIND diet scores from the screener showed strong positive correlation (r = 0.71, ρ = 0.70, p < 0.001) and comparable ranking ability (63% correctly classified, 1% grossly misclassified, kw = 0.67) compared to those from the FFQ, as well as significant associations with nutrient profiles.
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To better characterize the potential biological mechanisms underlying insulin resistance (IR) and dementia, we derive cross-population and population specific polygenic scores [PSs] for fasting insulin and IR-related partitioned PSs [pPSs].
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Clusters with diffuse or frontal-predominant cortical thinning, but with more favourable vascular profiles, characterized by lower blood pressure and reduced obesity, showed significantly less cortical thinning (mean thickness, AD-signature, and resilience-signature regions; all p < 0.05) following the intervention.
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43/100
Epidemiological studies consistently show an elevated intake of fish and long-chain omega-3 polyunsaturated fatty acids (PUFAs), such as docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), reduces the risk of developing neurodegenerative diseases, particularly dementia and Alzheimer's disease.
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Metformin is the most widely used oral insulin-sensitizing agent.
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The search over five databases identified 898 articles, with 26 meeting the inclusion criteria.
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We respond to the commentary by Ballenger et al. While appreciating "our provocative article", they called for "a more rigorous historical approach…".
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Our search yielded 182 meta-analyses meeting the inclusion criteria, of which 59 were selected to calculate DALY-weighted risk factors for a composite outcome.
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Hypertension or diabetes before age 62 exerted greater AD risk than APOEε4 alone.
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Our two-sample MR analysis indicated that T2D is not associated with the risk of AD (OR: 1.03, CI: 0.99-1.08, P = 0.128).
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55/100
A total of 260 AD deaths occurred during a median follow-up of 9.8 years.
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The cohort study revealed that persistent HI significantly increased the risk of heart disease (P < 0.001, HR 1.63, 95% CI 1.31-2.03), stroke (P 0.004, HR 1.59, 95% CI 1.16-2.18), chronic lung disease (P 0.002, HR 1.53, 95% CI 1.17-1.99), and emotional, nervous, or psychiatric problems (P 0.016, HR 2.03, 95% CI 1.14-3.60).
From across this tag
9 of the 304 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 9. The same 9 appear here every time.
- Design and rationale of the EBBINGHAUS trial: A phase 3, double-blind, placebo-controlled, multicenter study to assess the effect of evolocumab on cognitive function in patients with clinically evident cardiovascular disease and receiving statin background lipid-lowering therapy-A cognitive study of patients enrolled in the FOURIER trial
- Association Between Hormone-Modulating Breast Cancer Therapies and Incidence of Neurodegenerative Outcomes for Women With Breast Cancer
- Associations between multimorbidity burden and Alzheimer's pathology in older adults without dementia: the CABLE study
- Ubiquitin Is Not a Blood Biomarker of an Early Cognitive Decline in the Polish Elderly
- Is there a relationship between blood pressure values and dementia?
- Estrogen replacement therapy in older women. Comparisons between Alzheimer's disease cases and nondemented control subjects
- Mediterranean Diet and Lifestyle in Persons with Mild to Moderate Alzheimer's Disease
- Association between features of the insulin resistance syndrome and alzheimer's disease independently of apolipoprotein e4 phenotype: cross sectional population based study
- Metabolic syndrome, hypertension, and nervous system injury: Epidemiological correlates