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Inflammation context in Alzheimer's disease, a relationship intricate to define
Novoa C, Salazar P, Cisternas P, Gherardelli C, Vera-Salazar R, Zolezzi JM, Inestrosa NC.. Biological research, 2022-12-23
Topic: Amyloid, tau and blood-test diagnosis
Alzheimer's disease (AD), the most common form of dementia, is characterized by the accumulation of amyloid β (Aβ) and hyperphosphorylated tau protein aggregates. Importantly, Aβ and tau species are able to activate astrocytes and microglia, which release several proinflammatory cytokines, such as tumor necrosis factor α (TNF-α) and interleukin 1β (IL-1β), together with reactive oxygen (ROS) and nitrogen species (RNS), triggering neuroinflammation. However, this inflammatory response has a dual function: it can play a protective role by increasing Aβ degradation and clearance, but it can also contribute to Aβ and tau overproduction and induce neurodegeneration and synaptic loss.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Novoa, C., Salazar, P., Cisternas, P., Gherardelli, C., Vera-Salazar, R., Zolezzi, J. M., et al. (2022). Inflammation context in Alzheimer's disease, a relationship intricate to define. Biological research. https://doi.org/10.1186/s40659-022-00404-3
Vancouver
Novoa C, Salazar P, Cisternas P, Gherardelli C, Vera-Salazar R, Zolezzi JM, et al. Inflammation context in Alzheimer's disease, a relationship intricate to define. Biological research. 2022. doi:10.1186/s40659-022-00404-3. PMID: 36550479.
BibTeX
@article{novoa2022-36550479,
author = {Novoa, C. and Salazar, P. and Cisternas, P. and Gherardelli, C. and Vera-Salazar, R. and Zolezzi, J. M. and Inestrosa, N. C.},
title = {{Inflammation context in Alzheimer's disease, a relationship intricate to define}},
journal = {Biological research},
year = {2022},
doi = {10.1186/s40659-022-00404-3},
pmid = {36550479},
url = {https://doi.org/10.1186/s40659-022-00404-3}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 7 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
Key findings
- Importantly, Aβ and tau species are able to activate astrocytes and microglia, which release several proinflammatory cytokines, such as tumor necrosis factor α (TNF-α) and interleukin 1β (IL-1β), together with reactive oxygen (ROS) and nitrogen species (RNS), triggering neuroinflammation.
- However, this inflammatory response has a dual function: it can play a protective role by increasing Aβ degradation and clearance, but it can also contribute to Aβ and tau overproduction and induce neurodegeneration and synaptic loss.
- Due to the significant role of inflammation in the pathogenesis of AD, several inflammatory mediators have been proposed as AD markers, such as TNF-α, IL-1β, Iba-1, GFAP, NF-κB, TLR2, and MHCII.
- Importantly, the use of anti-inflammatory drugs such as NSAIDs has emerged as a potential treatment against AD.
Why it matters
This review describes the inflammatory response in Alzheimer's disease as having a dual function, potentially protective by increasing amyloid-beta clearance but also contributing to amyloid-beta and tau overproduction and neurodegeneration. It reports no treatment, cure, or prevention.
Study details
- Evidence strengthLow
How this study scored 49/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Biological research) |
| Journal's citation record | 1 / 4 | Biological Research: journal h-index 89 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2022 — within 6 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 200 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 33.3 citations a year over 6 year(s) since 2022 |
| Impact for its field and year | 4 / 6 | Cited 10.9× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 4 other studies in this library |
| Still being cited | 3 / 4 | Cited 177 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Nibaldo C. Inestrosa: h-index 85 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | Pontificia Universidad Católica de Chile: institution h-index 508 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 4 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 36550479) |
| Free to read | 2 / 2 | Free to read |
| Total | 49 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1186/s40659-022-00404-3
- PubMed: 36550479
- Original source →
- Free full text: Biological Research →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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