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Beyond the neuron-cellular interactions early in Alzheimer disease pathogenesis
Henstridge CM, Hyman BT, Spires-Jones TL.. Nature reviews. Neuroscience, 2019-02-01
Topic: Amyloid, tau and blood-test diagnosis
The symptoms of Alzheimer disease reflect a loss of neural circuit integrity in the brain, but neurons do not work in isolation. Emerging evidence suggests that the intricate balance of interactions between neurons, astrocytes, microglia and vascular cells required for healthy brain function becomes perturbed during the disease, with early changes likely protecting neural circuits from damage, followed later by harmful effects when the balance cannot be restored. Moving beyond a neuronal focus to understand the complex cellular interactions in Alzheimer disease and how these change throughout the course of the disease may provide important insight into developing effective therapeutics.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Henstridge, C. M., Hyman, B. T., & Spires-Jones, T. L. (2019). Beyond the neuron-cellular interactions early in Alzheimer disease pathogenesis. Nature reviews. Neuroscience. https://doi.org/10.1038/s41583-018-0113-1
Vancouver
Henstridge CM, Hyman BT, Spires-Jones TL. Beyond the neuron-cellular interactions early in Alzheimer disease pathogenesis. Nature reviews. Neuroscience. 2019. doi:10.1038/s41583-018-0113-1. PMID: 30643230.
BibTeX
@article{henstridge2019-30643230,
author = {Henstridge, C. M. and Hyman, B. T. and Spires-Jones, T. L.},
title = {{Beyond the neuron-cellular interactions early in Alzheimer disease pathogenesis}},
journal = {Nature reviews. Neuroscience},
year = {2019},
doi = {10.1038/s41583-018-0113-1},
pmid = {30643230},
url = {https://doi.org/10.1038/s41583-018-0113-1}
}
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Key findings
- Emerging evidence suggests that the intricate balance of interactions between neurons, astrocytes, microglia and vascular cells required for healthy brain function becomes perturbed during the disease, with early changes likely protecting neural circuits from damage, followed later by harmful effects when the balance cannot be restored.
- Moving beyond a neuronal focus to understand the complex cellular interactions in Alzheimer disease and how these change throughout the course of the disease may provide important insight into developing effective therapeutics.
Why it matters
This review proposes that the balance of interactions among neurons, astrocytes, microglia and vascular cells becomes perturbed in Alzheimer's disease, with early changes possibly protective and later changes harmful. It is a conceptual review and reports no treatment or patient outcome.
Study details
- Evidence strengthLow
How this study scored 52/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Nature reviews. Neuroscience) |
| Journal's citation record | 4 / 4 | Nature reviews. Neuroscience: journal h-index 572 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2019 — within 10 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 6 / 7 | Cited 346 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 38.4 citations a year over 9 year(s) since 2019 |
| Impact for its field and year | 3 / 6 | Cited 7.4× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 6 other studies in this library |
| Still being cited | 3 / 4 | Cited 117 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Tara L. Spires‐Jones: h-index 78 (OpenAlex, whole career) |
| Institution's track record | 3 / 3 | Harvard University: institution h-index 3,235 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 4 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 30643230) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 52 / 100 | — |
What each of these 20 components measures, and what this score is not →
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