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54/100

✓ Peer-reviewed alzhub usefulness score 54 out of 100. Inflammation and the immune system

Topic: Amyloid, tau and blood-test diagnosis

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that is characterized by cognitive decline and the presence of two core pathologies, amyloid β plaques and neurofibrillary tangles. Over the last decade, the presence of a sustained immune response in the brain has emerged as a third core pathology in AD. The sustained activation of the brain's resident macrophages (microglia) and other immune cells has been demonstrated to exacerbate both amyloid and tau pathology and may serve as a link in the pathogenesis of the disorder. In the following review, we provide an overview of inflammation in AD and a detailed coverage of a number of microglia-related signaling mechanisms that have been implicated in AD. Additional information on microglia signaling and a number of cytokines in AD are also reviewed. We also review the potential connection of risk factors for AD and how they may be related to inflammatory mechanisms.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Kinney, J. W., Bemiller, S. M., Murtishaw, A. S., Leisgang, A. M., Salazar, A., & Lamb, B. T. (2018). Inflammation as a central mechanism in Alzheimer's disease. Alzheimer s & Dementia Translational Research & Clinical Interventions. https://doi.org/10.1016/j.trci.2018.06.014

Vancouver

Kinney JW, Bemiller SM, Murtishaw AS, Leisgang AM, Salazar A, Lamb BT. Inflammation as a central mechanism in Alzheimer's disease. Alzheimer s & Dementia Translational Research & Clinical Interventions. 2018. doi:10.1016/j.trci.2018.06.014. PMID: 30406177.

BibTeX

@article{kinney2018-30406177,
  author  = {Kinney, Jefferson W. and Bemiller, Shane M. and Murtishaw, Andrew S. and Leisgang, Amanda M. and Salazar, Arnold and Lamb, Bruce T.},
  title   = {{Inflammation as a central mechanism in Alzheimer's disease}},
  journal = {Alzheimer s \& Dementia Translational Research \& Clinical Interventions},
  year    = {2018},
  doi     = {10.1016/j.trci.2018.06.014},
  pmid    = {30406177},
  url     = {https://doi.org/10.1016/j.trci.2018.06.014}
}

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.

Why it matters

Reviews evidence that a sustained immune response in the brain, involving microglia and other immune cells, has emerged as a third core feature of Alzheimer's alongside amyloid plaques and tangles. It also covers how risk factors for Alzheimer's may relate to inflammation.

How this study scored 54/100

Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it. We have no data on strength of evidence, so that was left out: it earned 51 of the 95 points we could judge it on, which is 54 out of 100.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Alzheimer s & Dementia Translational Research & Clinical Interventions)
Journal's citation record	1 / 4	Alzheimer s & Dementia Translational Research & Clinical Interventions: journal h-index 84 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	— / 5	No evidence rating recorded — left out of this score
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	2 / 5	2018 — within 10 year(s) of the newest study here
Sample size	0 / 4	Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	0 / 3	Not stated whether this was studied in people — scores zero (not stated in the record — scored 0)
Randomized / blinded	0 / 2	No randomization or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	7 / 7	Cited 2,247 times (OpenAlex, 2026-10-10)
Citations per year	5 / 5	224.7 citations a year over 10 year(s) since 2018
Impact for its field and year	6 / 6	Cited 54.3× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	4 / 4	Cited 971 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	3 / 4	Last-listed author Bruce T. Lamb: h-index 63 (OpenAlex, whole career)
Institution's track record	1 / 3	Indiana University School of Medicine: institution h-index 784 (OpenAlex)
Multicenter collaboration	1 / 3	OpenAlex lists 3 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 30406177)
Free to read	2 / 2	Free to read
Points	51 / 95	Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 51 of the 95 points we could judge it on is 54 out of 100.
Total	54 / 100	—

What each of these 20 components measures, and what this score is not →

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