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Neuropathologic features of amnestic mild cognitive impairment
Petersen RC, Parisi JE, Dickson DW, Johnson KA, Knopman DS, Boeve BF, Jicha GA, Ivnik RJ et al.. Archives of neurology, 2006-05-01
Topic: Risk, prevention and care in population studies
Background The neuropathologic substrate of amnestic mild cognitive impairment (aMCI) is not known. Objective To determine the neuropathologic features of patients who died while their clinical classification was aMCI. Participants Sixty-six individuals, including 15 who had memory impairment beyond that allowed for aging but who were not demented, were studied along with 28 clinically healthy individuals and 23 patients with probable Alzheimer disease (AD) for comparison.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Petersen, R. C., Parisi, J. E., Dickson, D. W., Johnson, K. A., Knopman, D. S., Boeve, B. F., et al. (2006). Neuropathologic features of amnestic mild cognitive impairment. Archives of neurology. https://doi.org/10.1001/archneur.63.5.665
Vancouver
Petersen RC, Parisi JE, Dickson DW, Johnson KA, Knopman DS, Boeve BF, et al. Neuropathologic features of amnestic mild cognitive impairment. Archives of neurology. 2006. doi:10.1001/archneur.63.5.665. PMID: 16682536.
BibTeX
@article{petersen2006-16682536,
author = {Petersen, R. C. and Parisi, J. E. and Dickson, D. W. and Johnson, K. A. and Knopman, D. S. and Boeve, B. F. and Jicha, G. A. and Ivnik, R. J. and others},
title = {{Neuropathologic features of amnestic mild cognitive impairment}},
journal = {Archives of neurology},
year = {2006},
doi = {10.1001/archneur.63.5.665},
pmid = {16682536},
url = {https://doi.org/10.1001/archneur.63.5.665}
}
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Key findings
- Objective To determine the neuropathologic features of patients who died while their clinical classification was aMCI.
- Participants Sixty-six individuals, including 15 who had memory impairment beyond that allowed for aging but who were not demented, were studied along with 28 clinically healthy individuals and 23 patients with probable Alzheimer disease (AD) for comparison.
- Main outcome measures Standard neuropathologic techniques and classification according to Khachaturian, Consortium to Establish a Registry for Alzheimer Disease, and National Institute on Aging-Reagan criteria were used to analyze autopsy tissue from 15 individuals who died while their clinical diagnosis was aMCI.
- For comparison, autopsy data on age-matched groups of clinically healthy individuals and patients with probable AD were analyzed.
Why it matters
When this study was published, the authors wrote that the brain changes underlying amnestic mild cognitive impairment — memory problems beyond normal ageing but short of dementia — were 'not known'. They examined brain tissue at autopsy from 15 people who died while diagnosed with amnestic MCI, scored it against three standard Alzheimer's pathology criteria (Khachaturian, CERAD and NIA-Reagan), and compared it with 28 clinically healthy people and 23 people with probable Alzheimer's disease. The results are not included in our record, so this page cannot say what was found; see the original paper.
Study details
- Study designcohort study
- Participants23
- Evidence strengthModerate
How this study scored 63/100
Published in a peer-reviewed journal, and it is a cohort study following people over time. Scored zero for effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Archives of neurology) |
| Journal's citation record | 3 / 4 | Archives of Neurology: journal h-index 353 (OpenAlex, 2026-10-29) |
| Study design | 7 / 12 | A cohort study following people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2006 — older than 20 years, still counted |
| Sample size | 1 / 4 | 23 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 6 / 7 | Cited 619 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 28.1 citations a year over 22 year(s) since 2006 |
| Impact for its field and year | 5 / 6 | Cited 31.2× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 4 / 6 | Cited by 60 other studies in this library |
| Still being cited | 2 / 4 | Cited 38 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Emre Kokmen: h-index 48 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | Mayo Clinic: institution h-index 1,606 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 16682536) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 63 / 100 | — |
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