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Mild cognitive impairment: Can FDG-PET predict who is to rapidly convert to Alzheimer's disease?
Gaël Chételat, Béatrice Desgranges, Vincent de La Sayette, Fausto Viader, Francis Eustache, Jean‐Claude Baron. Neurology, 2003-04-22
Topic: Amyloid, tau and blood-test diagnosis
Patients with mild cognitive impairment (MCI) were assessed, and a metabolic profile associated with conversion to AD at 18-month follow-up was sought. As compared with nonconverters (n = 10), converters (n = 7) had lower fluorodeoxyglucose uptake in the right temporoparietal cortex (p = 0.02, corrected for cluster size), without individual overlap. Awaiting replication in an independent sample, these findings suggest that among patients with MCI, fluorodeoxyglucose PET may accurately identify rapid converters.
Why it matters
Among patients with mild cognitive impairment, 7 who converted to Alzheimer's disease within 18 months had lower FDG PET glucose uptake in the right temporoparietal cortex than 10 who did not. The authors say FDG PET may identify rapid converters, pending replication.
How this study scored 54/100
Published in a leading specialty journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on strength of evidence, so that was left out: it earned 51 of the 95 points we could judge it on, which is 54 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Neurology) |
| Journal's citation record | 4 / 4 | Neurology: journal h-index 525 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | — / 5 | No evidence rating recorded — left out of this score |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2003 — older than 20 years, still counted |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 6 / 7 | Cited 604 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 24.2 citations a year over 25 year(s) since 2003 |
| Impact for its field and year | 4 / 6 | Cited 18.0× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 2 / 4 | Cited 19 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Jean‐Claude Baron: h-index 117 (OpenAlex, whole career) |
| Institution's track record | 3 / 3 | Centre National de la Recherche Scientifique: institution h-index 2,511 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 7 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 12707450) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 51 / 95 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 51 of the 95 points we could judge it on is 54 out of 100. |
| Total | 54 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Chételat, G., Desgranges, B., de La Sayette, V., Viader, F., Eustache, F., & Baron, J. (2003). Mild cognitive impairment: Can FDG-PET predict who is to rapidly convert to Alzheimer's disease? Neurology. https://doi.org/10.1212/01.wnl.0000055847.17752.e6
Vancouver
Chételat G, Desgranges B, de La Sayette V, Viader F, Eustache F, Baron J. Mild cognitive impairment: Can FDG-PET predict who is to rapidly convert to Alzheimer's disease? Neurology. 2003. doi:10.1212/01.wnl.0000055847.17752.e6. PMID: 12707450.
BibTeX
@article{chetelat2003-12707450,
author = {Chételat, Gaël and Desgranges, Béatrice and de La Sayette, Vincent and Viader, Fausto and Eustache, Francis and Baron, Jean‐Claude},
title = {{Mild cognitive impairment: Can FDG-PET predict who is to rapidly convert to Alzheimer's disease?}},
journal = {Neurology},
year = {2003},
doi = {10.1212/01.wnl.0000055847.17752.e6},
pmid = {12707450},
url = {https://doi.org/10.1212/01.wnl.0000055847.17752.e6}
}
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