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Human brain connectivity: Clinical applications for clinical neurophysiology
Hallett M, de Haan W, Deco G, Dengler R, Di Iorio R, Gallea C, Gerloff C, Grefkes C et al.. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2020-04-21
Topic: Brain proteins, microglia and lab models
This manuscript is the second part of a two-part description of the current status of understanding of the network function of the brain in health and disease. We start with the concept that brain function can be understood only by understanding its networks, how and why information flows in the brain. The first manuscript dealt with methods for network analysis, and the current manuscript focuses on the use of these methods to understand a wide variety of neurological and psychiatric disorders. Disorders considered are neurodegenerative disorders, such as Alzheimer disease and amyotrophic lateral sclerosis, stroke, movement disorders, including essential tremor, Parkinson disease, dystonia and apraxia, epilepsy, psychiatric disorders such as schizophrenia, and phantom limb pain. This state-of-the-art review makes clear the value of networks and brain models for understanding symptoms and signs of disease and can serve as a foundation for further work.
Key findings
- This manuscript is the second part of a two-part description of the current status of understanding of the network function of the brain in health and disease.
- We start with the concept that brain function can be understood only by understanding its networks, how and why information flows in the brain.
- The first manuscript dealt with methods for network analysis, and the current manuscript focuses on the use of these methods to understand a wide variety of neurological and psychiatric disorders.
- Disorders considered are neurodegenerative disorders, such as Alzheimer disease and amyotrophic lateral sclerosis, stroke, movement disorders, including essential tremor, Parkinson disease, dystonia and apraxia, epilepsy, psychiatric disorders such as schizophrenia, and phantom limb pain.
- This state-of-the-art review makes clear the value of networks and brain models for understanding symptoms and signs of disease and can serve as a foundation for further work.
Why it matters
This review discusses how brain network analysis methods can be applied to understand various neurological and psychiatric disorders, including Alzheimer's disease. It is a general overview of methods and does not test any specific treatment, cure, or prevention.
New to this subject? Start with our plain-English guide: Brain scans & tests →
Study details
- Evidence strengthLow
How this study scored 48/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology) |
| Journal's citation record | 2 / 4 | Clinical Neurophysiology: journal h-index 247 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2020 — within 10 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 119 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 14.9 citations a year over 8 year(s) since 2020 |
| Impact for its field and year | 3 / 6 | Cited 7.8× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 3 / 4 | Cited 56 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Paolo Maria Rossini: h-index 121 (OpenAlex, whole career) |
| Institution's track record | 3 / 3 | National Institutes of Health: institution h-index 2,723 (OpenAlex) |
| Multi-centre collaboration | 3 / 3 | OpenAlex lists 34 institution(s) in 12 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 32417703) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 48 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
May need a subscription OpenAlex found no free copy of the full text (checked 6 Feb 1020), so the publisher may charge for it. The PubMed abstract is free.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Hallett, M., de Haan, W., Deco, G., Dengler, R., Di Iorio, R., Gallea, C., et al. (2020). Human brain connectivity: Clinical applications for clinical neurophysiology. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. https://doi.org/10.1016/j.clinph.2020.03.031
Vancouver
Hallett M, de Haan W, Deco G, Dengler R, Di Iorio R, Gallea C, et al. Human brain connectivity: Clinical applications for clinical neurophysiology. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. 2020. doi:10.1016/j.clinph.2020.03.031. PMID: 32417703.
BibTeX
@article{hallett2020-32417703,
author = {Hallett, M. and de Haan, W. and Deco, G. and Dengler, R. and Di Iorio, R. and Gallea, C. and Gerloff, C. and Grefkes, C. and others},
title = {{Human brain connectivity: Clinical applications for clinical neurophysiology}},
journal = {Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology},
year = {2020},
doi = {10.1016/j.clinph.2020.03.031},
pmid = {32417703},
url = {https://doi.org/10.1016/j.clinph.2020.03.031}
}
Studies this one cites
Referenced by this study and also in the alzhub library, so you can read them here.