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Herpes simplex virus 1 and the risk of dementia: a population-based study
Murphy MJ, Fani L, Ikram MK, Ghanbari M, Ikram MA.. Scientific reports, 2021-04-22
Topic: Risk, prevention and care in population studies
Herpes simplex virus 1 (HSV1) is a neuroinvasive virus capable of entering the brain which makes it a candidate pathogen for increasing risk of dementia. Previous studies are inconsistent in their findings regarding the link between HSV1 and dementia, therefore, we investigated how HSV1 relates to cognitive decline and dementia risk using data from a population-based study. We measured HSV1 immunoglobulin (IgG) antibodies in serum collected between 2002 and 2005 from participants of the Rotterdam Study.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Murphy, M. J., Fani, L., Ikram, M. K., Ghanbari, M., & Ikram, M. A. (2021). Herpes simplex virus 1 and the risk of dementia: a population-based study. Scientific reports. https://doi.org/10.1038/s41598-021-87963-9
Vancouver
Murphy MJ, Fani L, Ikram MK, Ghanbari M, Ikram MA. Herpes simplex virus 1 and the risk of dementia: a population-based study. Scientific reports. 2021. doi:10.1038/s41598-021-87963-9. PMID: 33888766.
BibTeX
@article{murphy2021-33888766,
author = {Murphy, M. J. and Fani, L. and Ikram, M. K. and Ghanbari, M. and Ikram, M. A.},
title = {{Herpes simplex virus 1 and the risk of dementia: a population-based study}},
journal = {Scientific reports},
year = {2021},
doi = {10.1038/s41598-021-87963-9},
pmid = {33888766},
url = {https://doi.org/10.1038/s41598-021-87963-9}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- Previous studies are inconsistent in their findings regarding the link between HSV1 and dementia, therefore, we investigated how HSV1 relates to cognitive decline and dementia risk using data from a population-based study.
- We measured HSV1 immunoglobulin (IgG) antibodies in serum collected between 2002 and 2005 from participants of the Rotterdam Study.
- We used linear regression to determine HSV1 in relation to change in cognitive performance during 2 consecutive examination rounds on average 6.5 years apart.
- Next, we determined the association of HSV1 with risk of dementia (until 2016) using a Cox regression model.
Why it matters
This study investigated whether infection with herpes simplex virus 1 is related to cognitive decline and dementia risk in a population-based group. Previous findings on this link have been inconsistent, so this study aimed to clarify the relationship.
Study details
- Participants244
- Effect size56.7%
- Evidence strengthLow
How this study scored 52/100
Published in a peer-reviewed journal. Scored zero for study design and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Scientific reports) |
| Journal's citation record | 3 / 4 | Scientific Reports: journal h-index 463 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2021 — within 6 year(s) of the newest study here |
| Sample size | 2 / 4 | 244 participants |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 4 / 7 | Cited 47 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 6.7 citations a year over 7 year(s) since 2021 |
| Impact for its field and year | 3 / 6 | Cited 5.4× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 1 other studies in this library |
| Still being cited | 2 / 4 | Cited 25 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author M. Arfan Ikram: h-index 167 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Erasmus MC: institution h-index 1,321 (OpenAlex) |
| Multicenter collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 33888766) |
| Free to read | 2 / 2 | Free to read |
| Total | 52 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1038/s41598-021-87963-9
- PubMed: 33888766
- Original source →
- Free full text: Scientific Reports →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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