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Web-Based Assessment of Cognition and Dementia Risk Factors in Over 3000 Norwegian Adults Aged 50 Years and Older: Cross-Sectional PROTECT Norge Study
Testad I, Aakre JA, Gjestsen MT, Ballard C, Corbett A, Aarsland D, Pickering E, Ushakova A.. JMIR aging, 2025-08-25
Topic: Risk, prevention and care in population studies
Background With the growing number of older adults in the Norwegian population and the associated rapid rise in dementia and cognitive impairment, novel and more efficient methodologies are needed to facilitate research, improve diagnostic triage, and deliver effective brain health interventions in the community. Platform for Research Online to Investigate Genetics and Cognition in Ageing Norge (PROTECT Norge) is a web-based, remote research platform on the aging brain, culturally adapted from the UK PROTECT study, incorporating a Norwegian cohort of adults aged 50 years and older, where participants complete study activities via a dedicated website. Data were collected through study activities, which included self-reported questionnaires and a computerized neuropsychological test battery. Objective The study aimed to assess associations between dementia risk factors, including obesity, hypertension, smoking, and hearing loss, and cognition using baseline data from the PROTECT Norge study. Methods Data from the PROTECT Norge study were used to assess associations between dementia risk factors and cognition. These associations were assessed using independent-sample t tests for each of the cognitive tests, which included paired associate learning, self-ordered search, digit span, and verbal reasoning tasks. Results During the first 2 years of data collection, records from 3214 participants were obtained. Associations between established risk factors and cognitive performance were found, with significant detriments to cognitive performance on the computerized neuropsychological test battery. In the PROTECT Norge cohort, consisting of 74.5% females, the mean age was 64.1 (SD 7.7), and 94% of participants provided consent for contact regarding future research. Conclusions These data show the associations between dementia risk factors and cognition and attest to the excellent feasibility of the PROTECT Norge cohort, with over 3000 participants included over a period of 2 years and accessibility for people with early cognitive impairment. This, combined with the cohort's willingness to participate in future studies (94%), positions PROTECT Norge as a tremendous opportunity for cost-efficient, large-scale brain health research and potentially for clinical digital cognitive health programs.
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APA 7th
Testad, I., Aakre, J. A., Gjestsen, M. T., Ballard, C., Corbett, A., Aarsland, D., et al. (2025). Web-Based Assessment of Cognition and Dementia Risk Factors in Over 3000 Norwegian Adults Aged 50 Years and Older: Cross-Sectional PROTECT Norge Study. JMIR aging. https://doi.org/10.2196/69867
Vancouver
Testad I, Aakre JA, Gjestsen MT, Ballard C, Corbett A, Aarsland D, et al. Web-Based Assessment of Cognition and Dementia Risk Factors in Over 3000 Norwegian Adults Aged 50 Years and Older: Cross-Sectional PROTECT Norge Study. JMIR aging. 2025. doi:10.2196/69867. PMID: 40854096.
BibTeX
@article{testad2025-40854096,
author = {Testad, I. and Aakre, J. A. and Gjestsen, M. T. and Ballard, C. and Corbett, A. and Aarsland, D. and Pickering, E. and Ushakova, A.},
title = {{Web-Based Assessment of Cognition and Dementia Risk Factors in Over 3000 Norwegian Adults Aged 50 Years and Older: Cross-Sectional PROTECT Norge Study}},
journal = {JMIR aging},
year = {2025},
doi = {10.2196/69867},
pmid = {40854096},
url = {https://doi.org/10.2196/69867}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 8 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
Key findings
- Results During the first 2 years of data collection, records from 3214 participants were obtained.
- Associations between established risk factors and cognitive performance were found, with significant detriments to cognitive performance on the computerized neuropsychological test battery.
Study details
- Participants3,214
- Effect size74.5%
- Evidence strengthModerate
How this study scored 62/100
Published in a peer-reviewed journal. Scored zero for study design and randomized / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multicenter collaboration, so those were left out: it earned 36 of the 58 points we could judge it on, which is 62 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (JMIR aging) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 3 / 4 | 3,214 participants |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multicenter collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 40854096) |
| Free to read | 2 / 2 | Free to read |
| Points | 36 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 36 of the 58 points we could judge it on is 62 out of 100. |
| Total | 62 / 100 | — |
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