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A feasibility randomized controlled trial of a community-level physical activity strategy for older adults with motoric cognitive risk syndrome
Hernon SM, Singh Y, Ward N, Kramer AF, Travison TG, Verghese J, Fielding RA, Kowaleski C et al.. Frontiers in aging, 2024-08-08
Topic: Risk, prevention and care in population studies
The motoric cognitive risk syndrome (MCR) is a syndrome characterized by subjective memory complaints and slow walking speeds that can identify older adults at increased risk for developing Alzheimer's disease or a related dementia (ADRD). To date, the feasibility of community-based physical activity (PA) programs for improving outcomes in MCR have yet to be examined. To address this knowledge gap, we conducted a translational randomized controlled trial (RCT) comparing 24-weeks of PA to a healthy aging education (HE) control intervention delivered within the infrastructure of an urban senior center in Greater Boston (clincaltrials.gov identifier: NCT03750682). An existing senior center employee was trained to administer the multimodal group-based PA program that included moderate-intensity aerobic walking, strength, flexibility and balance training. A total of 79 older adults attended the senior center for a screening visit, of whom 29 met the MCR criteria and 25 were randomized to PA or HE (mean age: 74.4 ± 7 years; BMI: 32.4 ± 7 kg/m 2 ; 85% female; 3MSE score: 92.4 ± 7; gait speed: 0.52 ± 0.1 m/s; SPPB score 4.8 ± 1.9). Due to the Covid-19 pandemic the study was stopped prematurely. Participants could successfully adhere to the study interventions (overall attendance rate: PA: 69% vs. HE:70% at study termination). Participants also successfully completed baseline and follow-up study assessments that included a computerized cognitive testing battery and objective tests of physical performance and functional exercise capacity. No study-related adverse events occurred. Notable trends for improved cognitive performance, gait speed and 6-min walk distance were exhibited in PA compared to HE. Our study provides important preliminary information to aid the design of larger-scale RCTs of PA that may help to preserve the independence of vulnerable older adults at high risk for ADRD in community-based settings.
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APA 7th
Hernon, S. M., Singh, Y., Ward, N., Kramer, A. F., Travison, T. G., Verghese, J., et al. (2024). A feasibility randomized controlled trial of a community-level physical activity strategy for older adults with motoric cognitive risk syndrome. Frontiers in aging. https://doi.org/10.3389/fragi.2024.1329177
Vancouver
Hernon SM, Singh Y, Ward N, Kramer AF, Travison TG, Verghese J, et al. A feasibility randomized controlled trial of a community-level physical activity strategy for older adults with motoric cognitive risk syndrome. Frontiers in aging. 2024. doi:10.3389/fragi.2024.1329177. PMID: 39175624.
BibTeX
@article{hernon2024-39175624,
author = {Hernon, S. M. and Singh, Y. and Ward, N. and Kramer, A. F. and Travison, T. G. and Verghese, J. and Fielding, R. A. and Kowaleski, C. and others},
title = {{A feasibility randomized controlled trial of a community-level physical activity strategy for older adults with motoric cognitive risk syndrome}},
journal = {Frontiers in aging},
year = {2024},
doi = {10.3389/fragi.2024.1329177},
pmid = {39175624},
url = {https://doi.org/10.3389/fragi.2024.1329177}
}
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Key findings
- The motoric cognitive risk syndrome (MCR) is a syndrome characterized by subjective memory complaints and slow walking speeds that can identify older adults at increased risk for developing Alzheimer's disease or a related dementia (ADRD).
- Participants could successfully adhere to the study interventions (overall attendance rate: PA: 69% vs.
- Notable trends for improved cognitive performance, gait speed and 6-min walk distance were exhibited in PA compared to HE.
Study details
- Study designrandomized controlled trial
- Participants79
- Evidence strengthHigh
How this study scored 79/100
Published in a peer-reviewed journal, and it is a randomised controlled trial. Scored zero for effect reported because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 46 of the 58 points we could judge it on, which is 79 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Frontiers in aging) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 11 / 12 | A randomised controlled trial |
| Strength of evidence | 5 / 5 | Rated “high” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2024 — within 3 year(s) of the newest study here |
| Sample size | 1 / 4 | 79 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 1 / 2 | Randomised (as stated in the record) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 39175624) |
| Free to read | 2 / 2 | Free to read |
| Points | 46 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 46 of the 58 points we could judge it on is 79 out of 100. |
| Total | 79 / 100 | — |
What each of these 20 components measures, and what this score is not →
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