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Altered concentrations of amyloid precursor protein metabolites in the cerebrospinal fluid of patients with bipolar disorder
Jakobsson J, Zetterberg H, Blennow K, Johan Ekman C, Johansson AG, Landén M.. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2012-11-06
Topic: Brain proteins, microglia and lab models
Bipolar disorder is a psychiatric disorder characterized by recurrent episodes of mania/hypomania and depression. Progressive cognitive dysfunction such as impairments in executive function and verbal memory is common in euthymic bipolar patients. The cerebrospinal fluid has previously been used to study neurodegenerative processes in Alzheimer's disease, from which changes in three core biomarkers have emerged as indicative of degeneration: amyloid β, total tau, and hyperphosphorylated tau.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Jakobsson, J., Zetterberg, H., Blennow, K., Johan Ekman, C., Johansson, A. G., & Landén, M. (2013). Altered concentrations of amyloid precursor protein metabolites in the cerebrospinal fluid of patients with bipolar disorder. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. https://doi.org/10.1038/npp.2012.231
Vancouver
Jakobsson J, Zetterberg H, Blennow K, Johan Ekman C, Johansson AG, Landén M. Altered concentrations of amyloid precursor protein metabolites in the cerebrospinal fluid of patients with bipolar disorder. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2013. doi:10.1038/npp.2012.231. PMID: 23212456.
BibTeX
@article{jakobsson2013-23212456,
author = {Jakobsson, J. and Zetterberg, H. and Blennow, K. and Johan Ekman, C. and Johansson, A. G. and Landén, M.},
title = {{Altered concentrations of amyloid precursor protein metabolites in the cerebrospinal fluid of patients with bipolar disorder}},
journal = {Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology},
year = {2013},
doi = {10.1038/npp.2012.231},
pmid = {23212456},
url = {https://doi.org/10.1038/npp.2012.231}
}
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Key findings
- Progressive cognitive dysfunction such as impairments in executive function and verbal memory is common in euthymic bipolar patients.
- The cerebrospinal fluid has previously been used to study neurodegenerative processes in Alzheimer's disease, from which changes in three core biomarkers have emerged as indicative of degeneration: amyloid β, total tau, and hyperphosphorylated tau.
- Here, neurodegeneration in bipolar disorder was investigated by assessing the association between bipolar disorder and cerebrospinal fluid biomarkers for neurodegenerative processes.
- Cerebrospinal fluid was obtained from 139 bipolar disorder patients and 71 healthy controls.
Why it matters
This study assessed amyloid precursor protein metabolites in the CSF of patients with bipolar disorder, drawing on biomarkers previously used to study neurodegeneration in Alzheimer's disease. It concerns bipolar disorder and does not test any treatment, cure, or prevention for Alzheimer's disease.
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Study details
- Evidence strengthLow
How this study scored 56/100
Published in a peer-reviewed journal, and it is a randomised controlled trial. Scored zero for sample size and effect reported because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology) |
| Journal's citation record | 3 / 4 | Neuropsychopharmacology: journal h-index 306 (OpenAlex, 2026-10-29) |
| Study design | 11 / 12 | A randomised controlled trial (from PubMed type “Randomized Controlled Trial”) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2013 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (pubmed indexes it as a clinical or observational study) |
| Randomised / blinded | 1 / 2 | Randomised (as stated in the record) |
| Times cited | 4 / 7 | Cited 81 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 5.4 citations a year over 15 year(s) since 2013 |
| Impact for its field and year | 3 / 6 | Cited 3.9× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 1 other studies in this library |
| Still being cited | 2 / 4 | Cited 16 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Mikael Landén: h-index 98 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Karolinska Institutet: institution h-index 1,477 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 23212456) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 56 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1038/npp.2012.231
- PubMed: 23212456
- Original source →
- Free full text: Neuropsychopharmacology →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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