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48/100

✓ Peer-reviewed alzhub usefulness score 48 out of 100. Tau biomarkers

Topic: Amyloid, tau and blood-test diagnosis

Background The aim of this study was to explore the relationship between cerebrospinal fluid Alzheimer's disease (AD) markers and depression in elderly people. Method We included subjects with AD as well as persons with subjective cognitive impairment and normal cognition. Depression was assessed with the Cornell Scale for Depression in Dementia, and a cut-off score of >6 was used to define depression.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Kramberger, M. G., Jelic, V., Kåreholt, I., Enache, D., Eriksdotter Jönhagen, M., Winblad, B., et al. (2012). Cerebrospinal Fluid Alzheimer Markers in Depressed Elderly Subjects with and without Alzheimer's Disease. Dementia and geriatric cognitive disorders extra. https://doi.org/10.1159/000334644

Vancouver

Kramberger MG, Jelic V, Kåreholt I, Enache D, Eriksdotter Jönhagen M, Winblad B, et al. Cerebrospinal Fluid Alzheimer Markers in Depressed Elderly Subjects with and without Alzheimer's Disease. Dementia and geriatric cognitive disorders extra. 2012. doi:10.1159/000334644. PMID: 22649429.

BibTeX

@article{kramberger2012-22649429,
  author  = {Kramberger, M. G. and Jelic, V. and Kåreholt, I. and Enache, D. and Eriksdotter Jönhagen, M. and Winblad, B. and Aarsland, D.},
  title   = {{Cerebrospinal Fluid Alzheimer Markers in Depressed Elderly Subjects with and without Alzheimer's Disease}},
  journal = {Dementia and geriatric cognitive disorders extra},
  year    = {2012},
  doi     = {10.1159/000334644},
  pmid    = {22649429},
  url     = {https://doi.org/10.1159/000334644}
}

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 7 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.

Key findings

Method We included subjects with AD as well as persons with subjective cognitive impairment and normal cognition.
Depression was assessed with the Cornell Scale for Depression in Dementia, and a cut-off score of >6 was used to define depression.
Cerebrospinal fluid was analyzed using commercially available assays for β-amyloid 1-42, total tau, and phosphorylated tau 181.
Results A total of 183 participants (66.7% female) were included (92 with AD and 91 with subjective cognitive impairment), with a mean age (±SD) of 67.6 ± 7.4 years, a Mini-Mental State Examination score of 26.0 ± 4.0, and a median Cornell Scale for Depression in Dementia score of 5 (range 0-19).

Why it matters

This study explored the relationship between cerebrospinal fluid Alzheimer's markers and depression in 183 elderly participants with Alzheimer's disease or subjective cognitive impairment. It is an observational study of depression and markers, not a treatment, cure, or prevention for Alzheimer's disease.

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Study details

Participants183
Effect size66.7%
Evidence strengthLow

How this study scored 48/100

Published in a peer-reviewed journal. Scored zero for study design and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Dementia and geriatric cognitive disorders extra)
Journal's citation record	0 / 4	Dementia and Geriatric Cognitive Disorders Extra: journal h-index 52 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	1 / 5	2012 — within 20 year(s) of the newest study here
Sample size	2 / 4	183 participants
Effect reported	2 / 3	Effect reported as a number, without an interval or test
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	4 / 7	Cited 46 times (OpenAlex, 2026-10-10)
Citations per year	1 / 5	2.9 citations a year over 16 year(s) since 2012
Impact for its field and year	3 / 6	Cited 3.7× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	2 / 6	Cited by 4 other studies in this library
Still being cited	1 / 4	Cited 3 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	4 / 4	Last-listed author Dag Aarsland: h-index 141 (OpenAlex, whole career)
Institution's track record	1 / 3	Karolinska Institutet: institution h-index 1,477 (OpenAlex)
Multi-centre collaboration	2 / 3	OpenAlex lists 4 institution(s) in 2 countries
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 22649429)
Free to read	2 / 2	Free to read
Total	48 / 100	—

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