Home › Research › Tau biomarkers
Regional cortical thinning predicts worsening apathy and hallucinations across the Alzheimer disease spectrum
Donovan NJ, Wadsworth LP, Lorius N, Locascio JJ, Rentz DM, Johnson KA, Sperling RA, Marshall GA et al.. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2013-07-24
Topic: Amyloid, tau and blood-test diagnosis
Objectives To examine regions of cortical thinning and cerebrospinal fluid (CSF) Alzheimer disease (AD) biomarkers associated with apathy and hallucinations in a continuum of individuals including clinically normal elderly, mild cognitive impairment, and mild AD dementia. Design Cross-sectional and longitudinal studies. Setting Fifty-seven research sites across North America.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Donovan, N. J., Wadsworth, L. P., Lorius, N., Locascio, J. J., Rentz, D. M., Johnson, K. A., et al. (2014). Regional cortical thinning predicts worsening apathy and hallucinations across the Alzheimer disease spectrum. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. https://doi.org/10.1016/j.jagp.2013.03.006
Vancouver
Donovan NJ, Wadsworth LP, Lorius N, Locascio JJ, Rentz DM, Johnson KA, et al. Regional cortical thinning predicts worsening apathy and hallucinations across the Alzheimer disease spectrum. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. 2014. doi:10.1016/j.jagp.2013.03.006. PMID: 23890751.
BibTeX
@article{donovan2014-23890751,
author = {Donovan, N. J. and Wadsworth, L. P. and Lorius, N. and Locascio, J. J. and Rentz, D. M. and Johnson, K. A. and Sperling, R. A. and Marshall, G. A. and others},
title = {{Regional cortical thinning predicts worsening apathy and hallucinations across the Alzheimer disease spectrum}},
journal = {The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry},
year = {2014},
doi = {10.1016/j.jagp.2013.03.006},
pmid = {23890751},
url = {https://doi.org/10.1016/j.jagp.2013.03.006}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
Key findings
- Design Cross-sectional and longitudinal studies.
- Setting Fifty-seven research sites across North America.
- Participants Eight-hundred twelve community-dwelling volunteers; 413 participants in the CSF sub-study.
- Measurements Structural magnetic resonance imaging data and CSF concentrations of amyloid-β 1-42, total tau, and phosphorylated tau derived from the Alzheimer Disease Neuroimaging Initiative database were analyzed.
Why it matters
This study examined whether regional cortical thinning and CSF Alzheimer's biomarkers were associated with apathy and hallucinations across the Alzheimer's disease spectrum. It is an observational study of symptoms and brain measures, not a test of any treatment, cure, or prevention.
New to this subject? Start with our plain-English guide: Blood tests & biomarkers →
Study details
- Study designcross-sectional
- Participants413
- Evidence strengthModerate
How this study scored 56/100
Published in a peer-reviewed journal, and it is a snapshot of people at one point in time. Scored zero for effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry) |
| Journal's citation record | 2 / 4 | American Journal of Geriatric Psychiatry: journal h-index 178 (OpenAlex, 2026-10-29) |
| Study design | 4 / 12 | A snapshot of people at one point in time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2014 — within 20 year(s) of the newest study here |
| Sample size | 2 / 4 | 413 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 106 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 7.6 citations a year over 14 year(s) since 2014 |
| Impact for its field and year | 3 / 6 | Cited 4.9× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 4 other studies in this library |
| Still being cited | 2 / 4 | Cited 21 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Gad A. Marshall: h-index 75 (OpenAlex, whole career) |
| Institution's track record | 3 / 3 | Harvard University: institution h-index 3,235 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | PubMed indexes it as a multicentre study |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 23890751) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 56 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Studies this one cites
Referenced by this study and also in the alzhub library, so you can read them here.
Later studies that cite this one
4 studies in the alzhub library list this one in their references.
Related studies in Tau biomarkers
Also tagged “machine”
835 studies in the library carry the topic tag “machine”; these are this study's neighbours in a fixed, alphabetical-by-hash tour of them, not the closest in content. All 835 tagged studies.