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Cerebrospinal Fluid Biomarkers Profiling in Cerebral Amyloid Angiopathy and Relationship With Disease Phenotypes
Losa M, Ramusino MC, Cama I, Gualco L, Gandoglia I, Massa F, Donniaquio A, Mortola P et al.. Journal of the American Heart Association, 2025-10-14
Topic: Amyloid, tau and blood-test diagnosis
Background Cerebral amyloid angiopathy (CAA) is a heterogeneous small vessel disease that can occur independently or alongside Alzheimer disease (AD). CAA is diagnosed using the Boston Criteria 2.0, integrating clinical and neuroimaging features, whereas the Cerebrospinal Fluid (CSF) role in clinical practice remains under investigation. This study explores whether CSF biomarkers can identify distinct disease phenotypes, supporting hemorrhagic risk stratification.
Key findings
- CAA is diagnosed using the Boston Criteria 2.0, integrating clinical and neuroimaging features, whereas the Cerebrospinal Fluid (CSF) role in clinical practice remains under investigation.
- This study explores whether CSF biomarkers can identify distinct disease phenotypes, supporting hemorrhagic risk stratification.
- Methods We enrolled probable patients with CAA retrospectively (Boston Criteria 2.0) from 2 institutions, collecting clinical, neuroimaging, and follow-up data alongside core CSF biomarkers (Aβ40 [amyloid β 1-40], Aβ42 [amyloid β 1-42], p-Tau181 [phosphorylated Tau], total-Tau).
- Patients with CAA were stratified applying the Amyloid Tau Neurodegeneration (ATN) research framework, according to the presence of CSF amyloidosis (A + CAA versus A - CAA) and tauopathy (A + T + CAA versus A + T - CAA), and using unsupervised clustering, which defined CAA subgroups based on CSF biomarker levels only.
Why it matters
This study asked whether spinal fluid biomarkers can distinguish different patterns of cerebral amyloid angiopathy and help assess bleeding risk. It is about diagnosis and risk classification, not about treating or preventing Alzheimer's disease.
New to this subject? Start with our plain-English guide: Blood tests & biomarkers →
Study details
- Evidence strengthLow
How this study scored 44/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of the American Heart Association) |
| Journal's citation record | 2 / 4 | Journal of the American Heart Association: journal h-index 200 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 2 / 7 | Cited 10 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 3.3 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 3 / 6 | Cited 5.6× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 1 / 4 | Cited 10 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Matteo Pardini: h-index 43 (OpenAlex, whole career) |
| Institution's track record | 3 / 3 | Harvard University: institution h-index 3,235 (OpenAlex) |
| Multi-centre collaboration | 3 / 3 | OpenAlex lists 13 institution(s) in 3 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 41085178) |
| Free to read | 2 / 2 | Free to read |
| Total | 44 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1161/jaha.125.044784
- PubMed: 41085178
- Original source →
- Free full text: Journal of the American Heart Association →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Losa, M., Ramusino, M. C., Cama, I., Gualco, L., Gandoglia, I., Massa, F., et al. (2025). Cerebrospinal Fluid Biomarkers Profiling in Cerebral Amyloid Angiopathy and Relationship With Disease Phenotypes. Journal of the American Heart Association. https://doi.org/10.1161/jaha.125.044784
Vancouver
Losa M, Ramusino MC, Cama I, Gualco L, Gandoglia I, Massa F, et al. Cerebrospinal Fluid Biomarkers Profiling in Cerebral Amyloid Angiopathy and Relationship With Disease Phenotypes. Journal of the American Heart Association. 2025. doi:10.1161/jaha.125.044784. PMID: 41085178.
BibTeX
@article{losa2025-41085178,
author = {Losa, M. and Ramusino, M. C. and Cama, I. and Gualco, L. and Gandoglia, I. and Massa, F. and Donniaquio, A. and Mortola, P. and others},
title = {{Cerebrospinal Fluid Biomarkers Profiling in Cerebral Amyloid Angiopathy and Relationship With Disease Phenotypes}},
journal = {Journal of the American Heart Association},
year = {2025},
doi = {10.1161/jaha.125.044784},
pmid = {41085178},
url = {https://doi.org/10.1161/jaha.125.044784}
}
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