27,380 Alzheimer's and dementia studies in plain English, each scored out of 100.
Homozygous loss-of-function mutations in TREM2, encoding the triggering receptor expressed on myeloid cells 2 protein, have previously been associated with an autosomal recessive form of early-onset dementia. 4 key findings →
Design: meta-analysis Participants: 1,092 Evidence: high
Full summary, score breakdown and related studies → Original source Free full text
AF is independently associated with increased risk of dementia. 5 key findings →
Design: meta-analysis Participants: 77,668 Evidence: high
Full summary, score breakdown and related studies → Original source
More than 25% of the U.S. population aged ≥ 65 years has diabetes mellitus (hereafter referred to as diabetes),1 and the aging of the overall population is a significant driver of the diabetes epidemic. 5 key findings →
Design: meta-analysis Participants: 1,000 Evidence: high
Full summary, score breakdown and related studies → Original source
Concentrations of amyloid-beta (Aβ)(42) in the CSF appeared to decline 25 years before expected symptom onset. 5 key findings →
Design: cross-sectional Participants: 128 Evidence: moderate
Full summary, score breakdown and related studies → Original source Free full text
Identifying genetic variants influencing human brain structures may reveal new biological mechanisms underlying cognition and neuropsychiatric illness. 2 key findings →
Design: meta-analysis Participants: 21,151 Evidence: high
Full summary, score breakdown and related studies → Original source
Task-free functional magnetic resonance imaging (TF-fMRI) has great potential for advancing the understanding and treatment of neurologic illness. 1 key finding →
Design: meta-analysis Participants: 892 Evidence: high
Full summary, score breakdown and related studies → Original source
Antibody administration was well tolerated with doses up to 400 mg weekly. 2 key findings →
Design: clinical trial Participants: 52 Evidence: high
Full summary, score breakdown and related studies → Original source
Patients with CKD could have an elevated dementia risk. 4 key findings →
Design: cohort study Participants: 37,049 Evidence: moderate
Full summary, score breakdown and related studies → Original source
Prevalence and incidence estimates associated with MCI vary greatly both between definitions and within a definition across the 42 publications. 4 key findings →
Design: systematic review Participants: 3,705 Evidence: high
Full summary, score breakdown and related studies → Original source Full text may need a subscription
RO emphasised the engagement of nursing assistants in a hopeful, therapeutic process but became associated with a rigid, confrontational approach to people with dementia, leading to its use becoming less and less common. 3 key findings →
Design: systematic review Participants: 718 Evidence: high
Full summary, score breakdown and related studies → Original source Free full text
This study examined the association of diabetes with the onset of dementia (including Alzheimer's disease (AD), vascular dementia (VD) and any dementia) and mild cognitive impairment (MCI) by using a quantitative meta-analysis of longitudinal studies. 2 key findings →
Design: meta-analysis Participants: 6,184 Evidence: high
Full summary, score breakdown and related studies → Original source Free full text
Avagacestat dosed at 25 and 50 mg daily was relatively well tolerated and had low discontinuation rates. 2 key findings →
Design: clinical trial Participants: 209 Evidence: high
Full summary, score breakdown and related studies → Original source Full text may need a subscription
Sequence variants, including the ε4 allele of apolipoprotein E, have been associated with the risk of the common late-onset form of Alzheimer's disease. 4 key findings →
Design: case-control study Evidence: moderate
Full summary, score breakdown and related studies → Original source Free full text
Previous Cochrane reviews have considered the use of cholinesterase inhibitors in both Parkinson's disease with dementia (PDD) and dementia with Lewy bodies (DLB). 4 key findings →
Participants: 1,236 Evidence: high
Full summary, score breakdown and related studies → Original source Free full text
Cognitive training was effective in enhancing the overall cognitive functioning of less educated older adults with subjective memory complaints. 2 key findings →
Participants: 111 Evidence: high
Full summary, score breakdown and related studies → Original source
The meta-analysis suggests a consistent moderate association between ADL and EF, supporting the growing evidence for a link between ADL and executive dysfunction in early dementia. 3 key findings →
Design: meta-analysis Participants: 3,663 Evidence: high
Full summary, score breakdown and related studies → Original source
The evidence base on tools for detection of delirium superimposed on dementia is limited, although some existing tools show promise. 1 key finding →
Design: systematic review Participants: 1,569 Evidence: high
Full summary, score breakdown and related studies → Original source
The beneficial effect of DBS on motor function was stable and comparable by target over 36 months. 3 key findings →
Design: randomized controlled trial Participants: 89 Evidence: high
Full summary, score breakdown and related studies → Original source
This systematic review and meta-analyses covering a wide range of observational studies and diverse settings provides robust support for the CR hypothesis. 5 key findings →
Design: systematic review Participants: 437,477 Evidence: high
Full summary, score breakdown and related studies → Original source Free full text
Antioxidants did not influence CSF biomarkers related to amyloid or tau pathology. 1 key finding →
Evidence: high
Full summary, score breakdown and related studies → Original source Free full text
Donepezil is safe and well tolerated. 1 key finding →
Design: clinical trial Participants: 35 Evidence: high
Full summary, score breakdown and related studies → Original source Free full text
12,887 participants were interviewed at baseline. 11,718 were free of dementia, of whom 8137 (69%) were reinterviewed, contributing 34,718 person-years of follow-up. 3 key findings →
Design: cohort study Participants: 12,887 Evidence: moderate
Full summary, score breakdown and related studies → Original source Free full text
Main results Nine studies (from eight published reports) of 5149 individuals with mild cognitive impairment (however defined) were included in the review. 5 key findings →
Design: meta-analysis Participants: 5,149 Evidence: high
Full summary, score breakdown and related studies → Original source Free full text
Recently, several genome-wide association studies (GWASs) have led to the discovery of nine new loci of genetic susceptibility in Alzheimer's disease (AD). 2 key findings →
Design: case-control study Participants: 2,025 Evidence: moderate
Full summary, score breakdown and related studies → Original source
Four hundred ninety-four individuals eventually developed dementia and 427 (86%) of these persons were admitted at least once; 2525 remained free of dementia and 1478 (59%) of those were admitted at least once. 4 key findings →
Design: cohort study Participants: 3,019 Evidence: moderate
Full summary, score breakdown and related studies → Original source Free full text
Free full text links and the Full text may need a subscription label come from Unpaywall, Europe PMC and OpenAlex records of free copies, checked 10 Oct 2026. A study with neither is unknown, not paywalled. Show only studies that are free to read
This is alzhub's own score. It is not an official metric, not an impact factor, and no journal, publisher or ranking body endorses it. We built it so that a reader who is not a scientist can tell a landmark trial from a conference abstract without having to already know the difference. Every point comes from one of 20 components, all of them printed on the study itself, so you can disagree with our arithmetic rather than having to trust the total.
Journals are placed in ordered tiers, never given a numeric impact factor — we could not verify current impact factors from a source we control, and an invented one would be worse than none. Tier 1 is the top-tier general journals (NEJM, The Lancet, JAMA, Nature, Science, Nature Medicine); tier 2 is the leading specialty journals; tier 3 is every other peer-reviewed journal. A separate part scores how much the journal's own papers are cited, which tells the tier-3 journals apart.
Two rules we don't bend. First, we never fill in a missing value: if a record does not state a sample size or a design, that component scores zero, and if we simply have no data for a part, such as a citation count, that part is left out and the study is scored on the parts we could check. The study card says which. Second, anything that is not a peer-reviewed article is capped at 16/100 and carries a warning chip — so a conference abstract or a company press release can never outrank a peer-reviewed paper, no matter how good it looks.
We rank a rigorous null result — a good trial showing that something does not work — above an early positive finding. Someone deciding whether to buy a supplement is served by that, and the rigour is already counted by the design and journal components.
The score is computed from the published data alone and is reproducible: the same file always yields the same numbers.
See the whole rubric drawn out → — four charts covering all 27,380 studies: how the scores are spread and where the cap bites, which of the 20 components the library is strong and weak on, which subjects rest on stronger evidence, and what kinds of study each subject is actually built from.
This is a large sample of the Alzheimer's literature, not an exhaustive index of it. It holds 27,380 records, built mostly from automated pulls of Europe PMC (60.6% of the library) and OpenAlex (18.6%), plus smaller pulls from PubMed, Crossref and medRxiv. If a study, a drug, or a finding isn't here, that is not evidence it doesn't exist in the literature — it may simply not have been pulled in yet.
1,032 records (3.8% of the library) are not peer-reviewed — 962 of those are preprints posted before any journal review, and the rest are conference abstracts, regulatory notices and reports. Every study card on this page states its status plainly, and the score above is capped for anything that isn't a peer-reviewed article.
See the full, machine-readable breakdown of this library's coverage →