Risk factors for dementia with Lewy bodies: a case-control study
Boot BP, Orr CF, Ahlskog JE, Ferman TJ, Roberts R, Pankratz VS, Dickson DW, Parisi J et al.. Neurology, 2013-07-26
Topic: Risk, prevention and care in population studies
Objective To determine the risk factors associated with dementia with Lewy bodies (DLB). Methods We identified 147 subjects with DLB and sampled 2 sex- and age-matched cognitively normal control subjects for each case. We also identified an unmatched comparison group of 236 subjects with Alzheimer disease (AD). We evaluated 19 candidate risk factors in the study cohort. Results Compared with controls, subjects with DLB were more likely to have a history of anxiety (odds ratio; 95% confidence interval) (7.4; 3.5-16; p Conclusion DLB risk factors are an amalgam of those for AD and PD. Smoking and education, which have opposing risk effects on AD and PD, are not risk factors for DLB; however, depression and low caffeine intake, both risk factors for AD and PD, increase risk of DLB more strongly than in either.
Key findings
- Objective To determine the risk factors associated with dementia with Lewy bodies (DLB).
- Results Compared with controls, subjects with DLB were more likely to have a history of anxiety (odds ratio; 95% confidence interval) (7.4; 3.5-16; p Conclusion DLB risk factors are an amalgam of those for AD and PD.
Why it matters
In this case-control study, people with dementia with Lewy bodies were more likely to have a history of anxiety, and the authors concluded that DLB risk factors are an amalgam of those for Alzheimer's disease and Parkinson's disease. This concerns risk factors for dementia with Lewy bodies and does not test any treatment, cure, or prevention for Alzheimer's disease.
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Study details
- Participants147
- Evidence strengthModerate
How this study scored 58/100
Published in a leading specialty journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Neurology) |
| Journal's citation record | 4 / 4 | Neurology: journal h-index 525 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2013 — within 20 year(s) of the newest study here |
| Sample size | 2 / 4 | 147 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 173 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 11.5 citations a year over 15 year(s) since 2013 |
| Impact for its field and year | 4 / 6 | Cited 8.7× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 3 / 6 | Cited by 10 other studies in this library |
| Still being cited | 2 / 4 | Cited 34 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Bradley F. Boeve: h-index 173 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | Mayo Clinic: institution h-index 1,606 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 23892702) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 58 / 100 | — |
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Read the original
- DOI: 10.1212/wnl.0b013e3182a2cbd1
- PubMed: 23892702
- Original source →
- Free full text: PubMed Central →
Full text: free to read — PubMed Central lists this copy as free to read: the link above (checked 10 Oct 2026).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Boot, B. P., Orr, C. F., Ahlskog, J. E., Ferman, T. J., Roberts, R., Pankratz, V. S., et al. (2013). Risk factors for dementia with Lewy bodies: a case-control study. Neurology. https://doi.org/10.1212/wnl.0b013e3182a2cbd1
Vancouver
Boot BP, Orr CF, Ahlskog JE, Ferman TJ, Roberts R, Pankratz VS, et al. Risk factors for dementia with Lewy bodies: a case-control study. Neurology. 2013. doi:10.1212/wnl.0b013e3182a2cbd1. PMID: 23892702.
BibTeX
@article{boot2013-23892702,
author = {Boot, B. P. and Orr, C. F. and Ahlskog, J. E. and Ferman, T. J. and Roberts, R. and Pankratz, V. S. and Dickson, D. W. and Parisi, J. and others},
title = {{Risk factors for dementia with Lewy bodies: a case-control study}},
journal = {Neurology},
year = {2013},
doi = {10.1212/wnl.0b013e3182a2cbd1},
pmid = {23892702},
url = {https://doi.org/10.1212/wnl.0b013e3182a2cbd1}
}
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