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Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein
George G. Glenner, Caine W. Wong. Biochemical and Biophysical Research Communications, 1984-05-01
Topic: Amyloid, tau and blood-test diagnosis
Researchers isolated and purified a protein derived from twisted beta-pleated sheet fibrils in cerebrovascular amyloidosis associated with Alzheimer's disease using specific column chromatography and high performance liquid chromatography methods. Amino acid sequence analysis and a computer search showed that this protein has no homology with any previously sequenced protein. The authors suggest this protein could originate from a unique serum precursor, potentially offering a diagnostic test for Alzheimer's disease and a way to understand its pathogenesis.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Glenner, G. G., & Wong, C. W. (1984). Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochemical and Biophysical Research Communications. https://doi.org/10.1016/s0006-291x(84)80190-4
Vancouver
Glenner GG, Wong CW. Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochemical and Biophysical Research Communications. 1984. doi:10.1016/s0006-291x(84)80190-4. PMID: 6375662.
BibTeX
@article{glenner1984-6375662,
author = {Glenner, George G. and Wong, Caine W.},
title = {{Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein}},
journal = {Biochemical and Biophysical Research Communications},
year = {1984},
doi = {10.1016/s0006-291x(84)80190-4},
pmid = {6375662},
url = {https://doi.org/10.1016/s0006-291x(84)80190-4}
}
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Key findings
- A purified protein derived from the twisted beta-pleated sheet fibrils in cerebrovascular amyloidosis associated with Alzheimer's disease has been isolated by Sephadex G-100 column chromatography with 5 M guanidine-HC1 in 1 N acetic acid and by high performance liquid chromatography.
- Amino acid sequence analysis and a computer search reveals this protein to have no homology with any protein sequenced thus far.
- This protein may be derived from a unique serum precursor which may provide a diagnostic test for Alzheimer's disease and a means to understand its pathogenesis.
Why it matters
An initial report on purifying and characterising a cerebrovascular amyloid protein in Alzheimer's disease. Isolating and describing a protein is early laboratory groundwork that may open lines of research, not a treatment.
Study details
- Evidence strengthLow
How this study scored 54/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Biochemical and Biophysical Research Communications) |
| Journal's citation record | 3 / 4 | Biochemical and Biophysical Research Communications: journal h-index 393 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 1984 — older than 20 years, still counted |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 7 / 7 | Cited 5,407 times (OpenAlex, 2026-10-10) |
| Citations per year | 5 / 5 | 122.9 citations a year over 44 year(s) since 1984 |
| Impact for its field and year | 6 / 6 | Cited 40.4× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 5 / 6 | Cited by 161 other studies in this library |
| Still being cited | 4 / 4 | Cited 388 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 1 / 4 | Last-listed author Caine W. Wong: h-index 8 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University of California San Diego: institution h-index 1,852 (OpenAlex) |
| Multicenter collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 6375662) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 54 / 100 | — |
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