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Home › Research › Topics › trem2

trem2

363 studies tagged trem2, dated 2000-05-01 to 2026-06-02. Bibliography: BibTeX (.bib) · RIS (.ris)

Newest in this topic

  1. Gain-of-function Modulation of TREM2 and its Impact on Amyloid-β and Tau Pathologies in Alzheimer's Disease: A Systematic Review and Meta-analysis of Animal Studies 2026-06-02
  2. The TREM2 agonistic antibody AL002 in early Alzheimer's disease: a phase 2 randomized trial 2026-03-05
  3. Decoding TREM2 Signaling Pathways 2026-01-09

Studies

363 studies carry this tag.

Date range

2000 to 2026

Top journals

  • Molecular neurodegeneration 26
  • Neurobiology of aging 16
  • Neuron 10
  • The Journal of experimental medicine 10
  • Acta neuropathologica 9

147 journals in all.

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. Trem2 Deletion Reduces Late-Stage Amyloid Plaque Accumulation, Elevates the Aβ42:Aβ40 Ratio, and Exacerbates Axonal Dystrophy and Dendritic Spine Loss in the PS2APP Alzheimer's Mouse Model

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. The Journal of neuroscience : the official journal of the Society for Neuroscience 2020-01-24 TREM2 and immune genetics

    TREM2 is an Alzheimer's disease (AD) risk gene expressed in microglia.

  2. An Altered Relationship between Soluble TREM2 and Inflammatory Markers in Young Adults with Down Syndrome: A Preliminary Report

    ✓ Peer-reviewed alzhub usefulness score 44 out of 100. Journal of immunology (Baltimore, Md. : 1950) 2020-01-20 TREM2 and immune genetics

    Individuals with Down syndrome (DS) develop Alzheimer's disease (AD)-related neuropathology, characterized by amyloid plaques with amyloid β (Aβ) and neurofibrillary tangles with tau accumulation.

  3. Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 66 out of 100. Nature medicine 2020-01-13 TREM2 and immune genetics

    Glia have been implicated in Alzheimer's disease (AD) pathogenesis.

  4. TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. Neuron 2020-01-02 TREM2 and immune genetics

    Loss-of-function (LOF) variants of TREM2, an immune receptor expressed in microglia, increase Alzheimer's disease risk.

  5. Soluble TREM2 and Inflammatory Proteins in Alzheimer's Disease Cerebrospinal Fluid

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Journal of Alzheimer's disease : JAD 2020-01-01 TREM2 and immune genetics

    The present study explores the associations of soluble TREM2, an important regulator of microglial activity linked to Alzheimer's disease (AD), with other known inflammatory proteins in cerebrospinal fluid (CSF).

  6. A locked immunometabolic switch underlies TREM2 R47H loss of function in human iPSC-derived microglia

    ✓ Peer-reviewed alzhub usefulness score 49 out of 100. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019-12-23 TREM2 and immune genetics

    Loss-of-function genetic variants of triggering receptor expressed on myeloid cells 2 (TREM2) are linked with an enhanced risk of developing dementias.

  7. Transcriptome landscape of myeloid cells in human skin reveals diversity, rare populations and putative DC progenitors

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Journal of dermatological science 2019-11-29 TREM2 and immune genetics

    The heterogeneous functions of dermal myeloid cells in antigen presentation, and scavenging pathogens and cell debris places them centrally in cutaneous inflammation.

  8. Distinct Signaling Pathways Regulate TREM2 Phagocytic and NFκB Antagonistic Activities

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. Frontiers in cellular neuroscience 2019-10-10 TREM2 and immune genetics

    Several genetic variants of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) have been shown to increase the risk of developing Alzheimer's disease (AD) supporting a role of microglia and immune cells in the pathobiology of AD.

  9. TREM2 regulates obesity-induced insulin resistance via adipose tissue remodeling in mice of high-fat feeding

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Journal of translational medicine 2019-09-02 TREM2 and immune genetics

    Adipose tissue remodeling plays a significant role in obesity-induced insulin resistance.

  10. Increased soluble TREM2 in cerebrospinal fluid is associated with reduced cognitive and clinical decline in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. Science translational medicine 2019-08-01 Mild cognitive impairment

    Loss of function of TREM2, a key receptor selectively expressed by microglia in the brain, contributes to the development of Alzheimer's disease (AD).

  11. The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer's disease risk

    ✓ Peer-reviewed alzhub usefulness score 54 out of 100. Science translational medicine 2019-08-01 Genetics

    Soluble triggering receptor expressed on myeloid cells 2 (sTREM2) in cerebrospinal fluid (CSF) has been associated with Alzheimer's disease (AD).

  12. TREM2 deficiency aggravates α-synuclein-induced neurodegeneration and neuroinflammation in Parkinson's disease models

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019-08-01 Risk genes beyond APOE

    Variants in the gene encoding the triggering receptor expressed on myeloid cells 2 (TREM2) are known to increase the risk of developing Alzheimer disease and Parkinson's disease (PD).

  13. Impact of TREM2 risk variants on brain region-specific immune activation and plaque microenvironment in Alzheimer's disease patient brain samples

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. Acta neuropathologica 2019-07-26 TREM2 and immune genetics

    Identification of multiple immune-related genetic risk factors for sporadic AD (sAD) have put the immune system center stage in mechanisms underlying this disorder.

  14. The Emerging Role of Triggering Receptor Expressed on Myeloid Cells 2 as a Target for Immunomodulation in Ischemic Stroke

    ✓ Peer-reviewed alzhub usefulness score 42 out of 100. Frontiers in immunology 2019-07-17 TREM2 and immune genetics

    Stroke is the second most common cause of death and permanent disability.

  15. TREM2 Acts Downstream of CD33 in Modulating Microglial Pathology in Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 56 out of 100. Neuron 2019-07-10 TREM2 and immune genetics

    The microglial receptors CD33 and TREM2 have been associated with risk for Alzheimer's disease (AD).

  16. Efficacy and mechanism of cGAMP to suppress Alzheimer's disease by elevating TREM2

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Brain, behavior, and immunity 2019-07-05 TREM2 and immune genetics

    Innate immune responses are considered to play crucial roles in the progression of Alzheimer's disease (AD).

  17. TREM2 is required for microglial instruction of astrocytic synaptic engulfment in neurodevelopment

    ✓ Peer-reviewed alzhub usefulness score 44 out of 100. Glia 2019-07-02 TREM2 and immune genetics

    Variants in the microglial receptor TREM2 confer risk for multiple neurodegenerative diseases.

  18. Lipid-Associated Macrophages Control Metabolic Homeostasis in a Trem2-Dependent Manner

    ✓ Peer-reviewed alzhub usefulness score 61 out of 100. Cell 2019-06-27 TREM2 and immune genetics

    Immune cells residing in white adipose tissue have been highlighted as important factors contributing to the pathogenesis of metabolic diseases, but the molecular regulators that drive adipose tissue immune cell remodeling during obesity remain largely unknown.

  19. TREM2 function impedes tau seeding in neuritic plaques

    ✓ Peer-reviewed alzhub usefulness score 59 out of 100. Nature neuroscience 2019-06-24 TREM2 and immune genetics

    Variants in the triggering receptor expressed on myeloid cells 2 (TREM2) have been associated with increased risk for sporadic, late-onset Alzheimer's disease.

  20. Microglial Trem2 induces synaptic impairment at early stage and prevents amyloidosis at late stage in APP/PS1 mice

    ✓ Peer-reviewed alzhub usefulness score 42 out of 100. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019-06-20 TREM2 and immune genetics

    Triggering receptor expressed in myeloid cells (TREM)2 is a genetic high-risk factor for sporadic Alzheimer's disease (AD) and is considered a potential target for AD diagnosis and therapy, although its role in the different stages of AD remains controversial.

  21. Opposite microglial activation stages upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism

    ✓ Peer-reviewed alzhub usefulness score 51 out of 100. EMBO molecular medicine 2019-06-01 TREM2 and immune genetics

    Microglia adopt numerous fates with homeostatic microglia (HM) and a microglial neurodegenerative phenotype (MGnD) representing two opposite ends.

  22. TREM2 Attenuates Aβ1-42-Mediated Neuroinflammation in BV-2 Cells by Downregulating TLR Signaling

    ✓ Peer-reviewed alzhub usefulness score 37 out of 100. Neurochemical research 2019-05-27 TREM2 and immune genetics

    The pathogenesis of late-onset Alzheimer's disease (LOAD) mainly involves abnormal accumulation of extracellular β-amyloid (Aβ) and the consequent neurotoxic effects.

  23. Aminophospholipids are signal-transducing TREM2 ligands on apoptotic cells

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. Scientific reports 2019-05-17 TREM2 and immune genetics

    Variants of triggering receptor expressed on myeloid cells 2 (TREM2) are associated with an increased incidence of Alzheimer's disease, as well as other neurodegenerative disorders.

  24. TREM2 brain transcript-specific studies in AD and TREM2 mutation carriers

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. Molecular neurodegeneration 2019-05-08 Risk genes beyond APOE

    Low frequency coding variants in TREM2 are associated with Alzheimer disease (AD) risk and cerebrospinal fluid (CSF) TREM2 protein levels are different between AD cases and controls.

  25. Galectin-3, a novel endogenous TREM2 ligand, detrimentally regulates inflammatory response in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 56 out of 100. Acta neuropathologica 2019-04-20 TREM2 and immune genetics

    Alzheimer's disease (AD) is a progressive neurodegenerative disease in which the formation of extracellular aggregates of amyloid beta (Aβ) peptide, fibrillary tangles of intraneuronal tau and microglial activation are major pathological hallmarks.

  26. A Subset of TREM2+ Dermal Macrophages Secretes Oncostatin M to Maintain Hair Follicle Stem Cell Quiescence and Inhibit Hair Growth

    ✓ Peer-reviewed alzhub usefulness score 51 out of 100. Cell stem cell 2019-03-28 TREM2 and immune genetics

    Hair growth can be induced from resting mouse hair follicles by topical application of JAK inhibitors, suggesting that JAK-STAT signaling is required for maintaining hair follicle stem cells (HFSCs) in a quiescent state.

  27. Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer's disease model

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. Nature communications 2019-03-25 TREM2 and immune genetics

    Triggering receptor expressed on myeloid cells 2 (TREM2) is a microglial surface receptor genetically linked to the risk for Alzheimer's disease (AD).

  28. Imbalance of Microglial TLR4/TREM2 in LPS-Treated APP/PS1 Transgenic Mice: A Potential Link Between Alzheimer's Disease and Systemic Inflammation

    ✓ Peer-reviewed alzhub usefulness score 42 out of 100. Neurochemical research 2019-02-12 TREM2 and immune genetics

    Clinically, superimposed systemic inflammation generally has significant deleterious effects on the Alzheimer's disease (AD) progression.

  29. Transethnic meta-analysis of rare coding variants in PLCG2, ABI3, and TREM2 supports their general contribution to Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 61 out of 100. Translational psychiatry 2019-01-31 TREM2 and immune genetics

    Rare coding variants in TREM2, PLCG2, and ABI3 were recently associated with the susceptibility to Alzheimer's disease (AD) in Caucasians.

  30. TREM2 acts as a tumor suppressor in hepatocellular carcinoma by targeting the PI3K/Akt/β-catenin pathway

    ✓ Peer-reviewed alzhub usefulness score 42 out of 100. Oncogenesis 2019-01-25 TREM2 and immune genetics

    Triggering receptor expressed on myeloid cells 2 (TREM2) is involved in nonmalignant pathological processes.

  31. Up-Regulation of Trem2 Inhibits Hippocampal Neuronal Apoptosis and Alleviates Oxidative Stress in Epilepsy via the PI3K/Akt Pathway in Mice

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Neuroscience bulletin 2019-01-25 TREM2 and immune genetics

    Epilepsy is a chronic and severe neurological disorder that has negative effects on the autonomous activities of patients.

  32. Early increase of CSF sTREM2 in Alzheimer's disease is associated with tau related-neurodegeneration but not with amyloid-β pathology

    ✓ Peer-reviewed alzhub usefulness score 69 out of 100. Molecular neurodegeneration 2019-01-10 TREM2 and immune genetics

    TREM2 is a transmembrane receptor that is predominantly expressed by microglia in the central nervous system.

  33. Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE

    ✓ Peer-reviewed alzhub usefulness score 71 out of 100. Nature neuroscience 2019-01-07 TREM2 and immune genetics

    Coding variants in the triggering receptor expressed on myeloid cells 2 (TREM2) are associated with late-onset Alzheimer's disease (AD).

  34. TREM2 Variants and Neurodegenerative Diseases: A Systematic Review and Meta-Analysis

    ✓ Peer-reviewed alzhub usefulness score 63 out of 100. Journal of Alzheimer's disease : JAD 2019-01-01 TREM2 and immune genetics

    TREM2 (triggering receptor expressed on myeloid cells 2) gene variants were reported to increase the risk of Alzheimer's disease (AD) and even other neurodegenerative diseases (frontotemporal dementia (FTD), Parkinson's disease (PD) and amyotrophic lateral sclerosis (ALS)), but so far, no definite conclusion has been drawn.

  35. The Role of APOE and TREM2 in Alzheimer's Disease-Current Understanding and Perspectives

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. International journal of molecular sciences 2018-12-26 Genetics

    Alzheimer's disease (AD) is the leading cause of dementia worldwide.

  36. New insights into the role of TREM2 in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 54 out of 100. Molecular neurodegeneration 2018-12-20 TREM2 and immune genetics

    Alzheimer's disease (AD) is the leading cause of dementia.

  37. TREM2 triggers microglial density and age-related neuronal loss

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Glia 2018-12-11 TREM2 and immune genetics

    The microglial triggering receptor expressed on myeloid cells 2 (TREM2) signals via the activatory membrane adaptor molecule TYROBP.

  38. Interplay between innate immunity and Alzheimer disease: APOE and TREM2 in the spotlight

    ✓ Peer-reviewed alzhub usefulness score 54 out of 100. Nature reviews. Immunology 2018-12-01 Genetics

    Alzheimer disease is more than a pure proteopathy.

  39. TREM2 in Alzheimer's Disease: Microglial Survival and Energy Metabolism

    ✓ Peer-reviewed alzhub usefulness score 44 out of 100. Frontiers in aging neuroscience 2018-11-23 TREM2 and immune genetics

    Alzheimer's disease (AD) is the leading cause of age-related dementia among the elderly population.

  40. Human stem cell-derived monocytes and microglia-like cells reveal impaired amyloid plaque clearance upon heterozygous or homozygous loss of TREM2

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2018-11-12 TREM2 and immune genetics

    Murine microglia expressing the Alzheimer's disease-linked TREM2 R47H mutation display variable decrease in phagocytosis, while impaired phagocytosis is reported following loss of TREM2.

  41. CSF concentrations of soluble TREM2 as a marker of microglial activation in HIV-1 infection

    ✓ Peer-reviewed alzhub usefulness score 51 out of 100. Neurology(R) neuroimmunology & neuroinflammation 2018-11-07 TREM2 and immune genetics

    CSF sTREM2 increased with systemic and CNS HIV-1 disease severity, with the highest levels found in patients with HIV-associated dementia (HAD).

  42. High-affinity interactions and signal transduction between Aβ oligomers and TREM2

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. EMBO molecular medicine 2018-11-01 TREM2 and immune genetics

    Rare coding variants in the triggering receptor expressed on myeloid cells 2 (TREM2) are associated with increased risk for Alzheimer's disease (AD), but how they confer this risk remains uncertain.

  43. TREM2 - a key player in microglial biology and Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 54 out of 100. Nature reviews. Neurology 2018-11-01 Risk genes beyond APOE

    Alzheimer disease (AD) is a debilitating dementia believed to result from the deposition of extracellular amyloid-β (Aβ)-containing plaques followed by the formation of neurofibrillary tangles.

  44. CSF soluble TREM2 as a measure of immune response along the Alzheimer's disease continuum

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. Neurobiology of aging 2018-10-25 TREM2 and immune genetics

    TREM2 was suggested to be an important regulator of microglia during neurodegeneration, but previous studies report conflicting results in relation to soluble TREM2 (sTREM2) in cerebrospinal fluid (CSF) when using clinical criteria to classify Alzheimer's disease (AD).

  45. Differential effects of partial and complete loss of TREM2 on microglial injury response and tauopathy

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. Proceedings of the National Academy of Sciences of the United States of America 2018-09-19 TREM2 and immune genetics

    Alzheimer's disease (AD), the most common form of dementia, is characterized by the abnormal accumulation of amyloid plaques and hyperphosphorylated tau aggregates, as well as microgliosis.

  46. The Trem2 R47H Alzheimer's risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans

    ✓ Peer-reviewed alzhub usefulness score 51 out of 100. Molecular neurodegeneration 2018-09-06 Risk genes beyond APOE

    The R47H variant of the Triggering Receptor Expressed on Myeloid cells 2 (TREM2) significantly increases the risk for late onset Alzheimer's disease.

  47. Soluble TREM2 changes during the clinical course of Alzheimer's disease: A meta-analysis

    ✓ Peer-reviewed alzhub usefulness score 63 out of 100. Neuroscience letters 2018-08-29 TREM2 and immune genetics

    Soluble triggering receptor expressed on myeloid cells 2 (sTREM2) is a potential and novel biomarker of neuroinflammation implicated in the onset and progression of Alzheimer's disease (AD).

  48. Cerebrospinal fluid soluble TREM2 levels in frontotemporal dementia differ by genetic and pathological subgroup

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. Alzheimer's research & therapy 2018-08-16 TREM2 and immune genetics

    Reliable biomarkers of frontotemporal dementia (FTD) are currently lacking.

  49. Microglial TREM2/DAP12 Signaling: A Double-Edged Sword in Neural Diseases

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. Frontiers in cellular neuroscience 2018-08-06 TREM2 and immune genetics

    Microglia are activated after neuronal injury and in neurodegenerative diseases, and trigger neuroinflammation in the central nervous system (CNS).

  50. Human Induced Pluripotent Stem Cell-Derived Microglia-Like Cells Harboring TREM2 Missense Mutations Show Specific Deficits in Phagocytosis

    ✓ Peer-reviewed alzhub usefulness score 49 out of 100. Cell reports 2018-08-01 TREM2 and immune genetics

    Dysfunction of microglia, the brain's immune cells, is linked to neurodegeneration.

From across this tag

10 of the 363 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.

All topic tags with their study counts