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Home › Research › Topics › trem2

trem2

363 studies tagged trem2, dated 2000-05-01 to 2026-06-02. Bibliography: BibTeX (.bib) · RIS (.ris)

Newest in this topic

  1. Gain-of-function Modulation of TREM2 and its Impact on Amyloid-β and Tau Pathologies in Alzheimer's Disease: A Systematic Review and Meta-analysis of Animal Studies 2026-06-02
  2. The TREM2 agonistic antibody AL002 in early Alzheimer's disease: a phase 2 randomized trial 2026-03-05
  3. Decoding TREM2 Signaling Pathways 2026-01-09

Studies

363 studies carry this tag.

Date range

2000 to 2026

Top journals

  • Molecular neurodegeneration 26
  • Neurobiology of aging 16
  • Neuron 10
  • The Journal of experimental medicine 10
  • Acta neuropathologica 9

147 journals in all.

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. A genome-wide gene-expression analysis and database in transgenic mice during development of amyloid or tau pathology

    ✓ Peer-reviewed alzhub usefulness score 49 out of 100. Cell reports 2015-01-22 TREM2 and immune genetics

    We provide microarray data comparing genome-wide differential expression and pathology throughout life in four lines of "amyloid" transgenic mice (mutant human APP, PSEN1, or APP/PSEN1) and "TAU" transgenic mice (mutant human MAPT gene).

  2. The triggering receptor expressed on myeloid cells 2 (TREM2) is associated with enhanced inflammation, neuropathological lesions and increased risk for Alzheimer's dementia

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2014-12-09 TREM2 and immune genetics

    The TREM2 variant is associated with: (i) AD (odds ratio: 4.76; P = .014); (ii) increased density of amyloid plaques and neurofibrillary tangles in multiple brain regions; (iii) increased TREM2 (P = .041) and TYROBP (P = .006) gene expression; (iv) decreased TREM2 protein levels (P = .016); and (v) upregulation of proinflammatory cytokines (regulated on activation, norma

  3. TREM2 Protein Expression Changes Correlate with Alzheimer's Disease Neurodegenerative Pathologies in Post-Mortem Temporal Cortices

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Brain pathology (Zurich, Switzerland) 2014-11-11 TREM2 and immune genetics

    Triggering receptor expressed by myeloid cells 2 (TREM2), a member of the immunoglobulin superfamily, has anti-inflammatory phagocytic function in myeloid cells.

  4. What happens to microglial TREM2 in Alzheimer's disease: Immunoregulatory turned into immunopathogenic?

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Neuroscience 2014-10-02 TREM2 and immune genetics

    Microglia play major roles in initiation, coordination and execution of innate immunity in the brain.

  5. The rare TREM2 R47H variant exerts only a modest effect on Alzheimer disease risk

    ✓ Peer-reviewed alzhub usefulness score 65 out of 100. Neurology 2014-09-03 TREM2 and immune genetics

    Meta-analysis of the 2 family-based and the 5 case-control cohorts yielded a p value of 0.0029, while the overall summary estimate (using case-control data only) resulted in an odds ratio of 1.67 (95% confidence interval 0.95-2.92) for the association between the TREM2 R47H and increased AD risk.

  6. R47H TREM2 variant increases risk of typical early-onset Alzheimer's disease but not of prion or frontotemporal dementia

    ✓ Peer-reviewed alzhub usefulness score 56 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2014-08-23 TREM2 and immune genetics

    We confirm only p.R47H as a risk factor for AD (odds ratio or OR = 2.19; 95% confidence interval or CI = 1.04-4.51; P = .03). p.R47H does not significantly alter risk for frontotemporal dementia (OR = 0.81), variant or sporadic CJD (OR = 1.06 95%CI = 0.66-1.69) in our cohorts.

  7. Triggering receptor expressed on myeloid cells 2 (TREM2) promotes adipogenesis and diet-induced obesity

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Diabetes 2014-08-11 TREM2 and immune genetics

    Triggering receptor expressed on myeloid cells 2 (TREM2) is known to be involved in the anti-inflammatory response and osteoclast development.

  8. Upregulation of TREM2 ameliorates neuropathology and rescues spatial cognitive impairment in a transgenic mouse model of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 51 out of 100. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2014-07-22 TREM2 and immune genetics

    Triggering receptor expressed on myeloid cells 2 (TREM2) gene is a recently identified susceptibility gene for Alzheimer's disease (AD), as its low-frequency variants increase the risk of this disease with an odds ratio similar to that of an APOE ɛ4 allele.

  9. TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis

    ✓ Peer-reviewed alzhub usefulness score 58 out of 100. Science translational medicine 2014-07-01 Lewy body dementia

    Genetic variants in the triggering receptor expressed on myeloid cells 2 (TREM2) have been linked to Nasu-Hakola disease, Alzheimer's disease (AD), Parkinson's disease, amyotrophic lateral sclerosis, frontotemporal dementia (FTD), and FTD-like syndrome without bone involvement.

  10. Coding variants in TREM2 increase risk for Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 54 out of 100. Human molecular genetics 2014-06-04 Genetics

    The triggering receptor expressed on myeloid 2 (TREM2) is an immune phagocytic receptor expressed on brain microglia known to trigger phagocytosis and regulate the inflammatory response.

  11. Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. Molecular neurodegeneration 2014-06-03 TREM2 and immune genetics

    Recent genome-wide association studies linked variants in TREM2 to a strong increase in the odds of developing Alzheimer's disease.

  12. Investigation of TREM2, PLD3, and UNC5C variants in patients with Alzheimer's disease from mainland China

    ✓ Peer-reviewed alzhub usefulness score 44 out of 100. Neurobiology of aging 2014-05-01 TREM2 and immune genetics

    Recently, 3 rare coding variants significantly associated with Alzheimer's disease (AD) risk have been identified in western populations using whole exome sequencing method, including p.R47H in TREM2, p.V232M in PLD3, and p.T835M in UNC5C. To examine whether these variants are genetic risk factors in patients with AD from mainland China, we sequenced exon 2 of TREM2, exon 9 of PLD3, and exon 15 of UNC5C in Chinese Han population including 360 patients with AD and 400 control individuals.

  13. Homozygous TREM2 mutation in a family with atypical frontotemporal dementia

    ✓ Peer-reviewed alzhub usefulness score 51 out of 100. Neurobiology of aging 2014-04-18 TREM2 and immune genetics

    TREM2 mutations were first identified in Nasu-Hakola disease, a rare autosomal recessive disease characterized by recurrent fractures because of bone cysts and presenile dementia.

  14. TREM2 variant p.R47H as a risk factor for sporadic amyotrophic lateral sclerosis

    ✓ Peer-reviewed alzhub usefulness score 56 out of 100. JAMA neurology 2014-04-01 Risk genes beyond APOE

    Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease in which microglia play a significant and active role.

  15. Increased expression of TREM2 in peripheral blood of Alzheimer's disease patients

    ✓ Peer-reviewed alzhub usefulness score 44 out of 100. Journal of Alzheimer's disease : JAD 2014-01-01 TREM2 and immune genetics

    TREM2 has been reported to be associated with Alzheimer's disease (AD).

  16. Lack of genetic association between TREM2 and late-onset Alzheimer's disease in a Japanese population

    ✓ Peer-reviewed alzhub usefulness score 42 out of 100. Journal of Alzheimer's disease : JAD 2014-01-01 TREM2 and immune genetics

    Rare non-synonymous variants of TREM2 have recently been shown to be associated with Alzheimer's disease (AD) in Caucasians.

  17. Missense variant in TREML2 protects against Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 69 out of 100. Neurobiology of aging 2013-12-21 TREM2 and immune genetics

    TREM and TREM-like receptors are a structurally similar protein family encoded by genes clustered on chromosome 6p21.11.

  18. TREM2 and the neuroimmunology of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Biochemical pharmacology 2013-12-16 TREM2 and immune genetics

    Late-onset Alzheimer's disease (AD) is a sporadic disorder with increasing prevalence in aging.

  19. Heterozygous TREM2 mutations in frontotemporal dementia

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. Neurobiology of aging 2013-10-16 TREM2 and immune genetics

    A causative association was recently demonstrated between homozygous TREM2 mutations and frontotemporal dementia (FTD)-like syndrome and between heterozygous TREM2 exon2 genetic variations and late-onset Alzheimer's disease (AD).

  20. TREM2 and Neurodegenerative Disease

    ✓ Peer-reviewed alzhub usefulness score 51 out of 100. New England Journal of Medicine 2013-10-16 TREM2 and immune genetics

    We and other members of the Alzheimer’s Disease Genetics Consortium assembled multiple data sets from a total of 5896 black patients (1968 cases and 3928 controls).

  21. Triggering receptor expressed on myeloid cells 2 variant is rare in late-onset Alzheimer's disease in Han Chinese individuals

    ✓ Peer-reviewed alzhub usefulness score 51 out of 100. Neurobiology of aging 2013-10-11 TREM2 and immune genetics

    Recent studies have reported that a rare mutation of triggering receptor expressed on myeloid cells 2 gene (TREM2 [rs75932628-T]) has significantly increased the risk of late-onset Alzhemier's disease (LOAD) in European-descendent population.

  22. Investigating the role of rare heterozygous TREM2 variants in Alzheimer's disease and frontotemporal dementia

    ✓ Peer-reviewed alzhub usefulness score 64 out of 100. Neurobiology of aging 2013-10-09 TREM2 and immune genetics

    Homozygous mutations in exon 2 of TREM2, a gene involved in Nasu-Hakola disease, can cause frontotemporal dementia (FTD).

  23. Sequential proteolytic processing of the triggering receptor expressed on myeloid cells-2 (TREM2) protein by ectodomain shedding and γ-secretase-dependent intramembranous cleavage

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. The Journal of biological chemistry 2013-09-27 Risk genes beyond APOE

    Triggering receptor expressed on myeloid cells-2 (TREM2) and its signaling adaptor protein TYROBP/DAP12 play important roles in signal transduction in dendritic cells, osteoclasts, tissue macrophages, and microglia.

  24. Assessing the role of the TREM2 p.R47H variant as a risk factor for Alzheimer's disease and frontotemporal dementia

    ✓ Peer-reviewed alzhub usefulness score 74 out of 100. Neurobiology of aging 2013-09-13 TREM2 and immune genetics

    A non-synonymous genetic rare variant, rs75932628-T (p.R47H), in the TREM2 gene has recently been reported to be a strong genetic risk factor for Alzheimer's disease (AD).

  25. Novel compound heterozygous mutation in TREM2 found in a Turkish frontotemporal dementia-like family

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. Neurobiology of aging 2013-07-17 TREM2 and immune genetics

    Triggering receptor expressed on myeloid cells 2 (TREM2) homozygous mutations cause Nasu-Hakola disease, an early-onset recessive form of dementia preceded by bone cysts and fractures.

  26. Insights into TREM2 biology by network analysis of human brain gene expression data

    ✓ Peer-reviewed alzhub usefulness score 51 out of 100. Neurobiology of aging 2013-07-12 TREM2 and immune genetics

    Rare variants in TREM2 cause susceptibility to late-onset Alzheimer's disease.

  27. TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson's disease

    ✓ Peer-reviewed alzhub usefulness score 62 out of 100. Molecular neurodegeneration 2013-06-21 Risk factors

    Our results suggest that the TREM2 p.R47H substitution is a risk factor for frontotemporal dementia and Parkinson's disease in addition to Alzheimer's disease.

  28. Expression of the phagocytosis-essential protein TREM2 is down-regulated by an aluminum-induced miRNA-34a in a murine microglial cell line

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of inorganic biochemistry 2013-05-29 TREM2 and immune genetics

    One of the key classical pathological features of Alzheimer's disease (AD) is the progressive accumulation of amyloid beta (Aβ42) peptides and their coalescence into highly insoluble senile plaque cores.

  29. Regulation of TREM2 expression by an NF-кB-sensitive miRNA-34a

    ✓ Peer-reviewed alzhub usefulness score 42 out of 100. Neuroreport 2013-04-01 Risk genes beyond APOE

    Genetic deficits and loss of function for the triggering receptor expressed in myeloid cells 2 (TREM2; encoded at chr6p21.1), a transmembrane spanning stimulatory receptor of the immunoglobulin/lectin-like gene superfamily, have been associated with deficiencies in phagocytosis and the innate immune system in Alzheimer's disease.

  30. TREM2 in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 44 out of 100. Molecular neurobiology 2013-02-14 TREM2 and immune genetics

    Recent works have demonstrated a rare functional variant (R47H) in triggering receptor expressed on myeloid cells (TREM) 2 gene, encoding TREM2 protein, increase susceptibility to late-onset Alzheimer's disease (AD), with an odds ratio similar to that of the apolipoprotein E ε4 allele.

  31. TREM2 is associated with the risk of Alzheimer's disease in Spanish population

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. Neurobiology of aging 2013-02-05 Genetics

    Two recent studies have reported the association of rs75932628-T in the TREM2 gene with the risk for Alzheimer's disease (AD).

  32. Attenuated inflammatory response in triggering receptor expressed on myeloid cells 2 (TREM2) knock-out mice following stroke

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. PloS one 2013-01-03 TREM2 and immune genetics

    Triggering receptor expressed on myeloid cells-2 (TREM2) is a microglial surface receptor involved in phagocytosis.

  33. TREM2 R47H variant as a risk factor for early-onset Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. Journal of Alzheimer's disease : JAD 2013-01-01 TREM2 and immune genetics

    The rs75932628-T variant of the gene encoding the triggering receptor expressed on myeloid cells 2 (TREM2) has recently been identified as a rare risk factor for late-onset Alzheimer's disease (AD).

  34. Using exome sequencing to reveal mutations in TREM2 presenting as a frontotemporal dementia-like syndrome without bone involvement

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. JAMA neurology 2013-01-01 Getting a diagnosis

    Our results show that TREM2 is responsible for an unexpectedly high number of dementia cases in our cohort, suggesting that this gene should be taken into account when mutations in other dementia genes are excluded.

  35. TREM2 variants in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 85 out of 100. The New England journal of medicine 2012-11-14 TREM2 and immune genetics

    Homozygous loss-of-function mutations in TREM2, encoding the triggering receptor expressed on myeloid cells 2 protein, have previously been associated with an autosomal recessive form of early-onset dementia.

  36. Variant of TREM2 associated with the risk of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 74 out of 100. The New England journal of medicine 2012-11-14 TREM2 and immune genetics

    Sequence variants, including the ε4 allele of apolipoprotein E, have been associated with the risk of the common late-onset form of Alzheimer's disease.

  37. TREM2 and β-catenin regulate bone homeostasis by controlling the rate of osteoclastogenesis

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. Journal of immunology (Baltimore, Md. : 1950) 2012-02-06 TREM2 and immune genetics

    TREM2 is an immunoreceptor expressed on osteoclasts (OC) and microglia that transmits intracellular signals through the adaptor DAP12.

  38. TREM‐2, triggering receptor expressed on myeloid cell‐2, negatively regulates TLR responses in dendritic cells

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. European Journal of Immunology 2011-09-28 TREM2 and immune genetics

    DCs play a key role in defense against infections and also in preventing inflammatory and autoimmune diseases.

  39. Nasu-Hakola disease with a splicing mutation of TREM2 in a Japanese family

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. European journal of neurology 2010-12-22 TREM2 and immune genetics

    Nasu-Hakola disease (NHD) is a rare autosomal recessive disorder, characterized by a combination of progressive presenile dementia and formation of multifocal bone cysts, caused by genetic mutations of DAP12 and TREM2, which constitute a receptor/adapter signaling complex expressed on osteoclasts, dendritic cells, macrophages, and microglia.

  40. Dual induction of TREM2 and tolerance-related transcript, Tmem176b, in amyloid transgenic mice: implications for vaccine-based therapies for Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. ASN neuro 2010-07-12 TREM2 and immune genetics

    Vaccine-based autoimmune (anti-amyloid) treatments are currently being examined for their therapeutic potential in Alzheimer's disease.

  41. TREM2- and DAP12-dependent activation of PI3K requires DAP10 and is inhibited by SHIP1

    ✓ Peer-reviewed alzhub usefulness score 49 out of 100. Science signaling 2010-05-18 TREM2 and immune genetics

    The activation and fusion of macrophages and of osteoclasts require the adaptor molecule DNAX-activating protein of 12 kD (DAP12), which contains immunoreceptor tyrosine-based activation motifs (ITAMs).

  42. The surface-exposed chaperone, Hsp60, is an agonist of the microglial TREM2 receptor

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. Journal of neurochemistry 2009-04-29 TREM2 and immune genetics

    Triggering receptor expressed in myeloid (TREM) cells 2, a receptor expressed by myeloid cells, osteoclasts and microglia, is known to play a protective role in bones and brain.

  43. A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. Journal of neurochemistry 2009-03-19 TREM2 and immune genetics

    Following neuronal injury, microglia initiate repair by phagocytosing dead neurons without eliciting inflammation.

  44. TREM-2 (triggering receptor expressed on myeloid cells 2) is a phagocytic receptor for bacteria

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. The Journal of Cell Biology 2009-01-26 TREM2 and immune genetics

    Phagocytosis, which is essential for the immune response to pathogens, is initiated by specific interactions between pathogens and cell surface receptors expressed by phagocytes.

  45. Efficient colonic mucosal wound repair requires Trem2 signaling

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Proceedings of the National Academy of Sciences of the United States of America 2008-12-24 TREM2 and immune genetics

    The colonic epithelial lining undergoes constant replacement, driven by epithelial stem cells in crypts of Lieberkühn.

  46. TREM2 is upregulated in amyloid plaque-associated microglia in aged APP23 transgenic mice

    ✓ Peer-reviewed alzhub usefulness score 51 out of 100. Glia 2008-10-01 TREM2 and immune genetics

    Alzheimer's disease (AD) is characterized by extracellular deposits of amyloid-beta protein which attract dense clusters of microglial cells.

  47. Identification of soluble TREM-2 in the cerebrospinal fluid and its association with multiple sclerosis and CNS inflammation

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. Brain 2008-09-12 TREM2 and immune genetics

    Triggering receptor expressed on myeloid cells 2 (TREM-2) is a membrane-bound receptor expressed by microglia and macrophages.

  48. Mutations in TREM2 lead to pure early-onset dementia without bone cysts

    ✓ Peer-reviewed alzhub usefulness score 44 out of 100. Human mutation 2008-09-01 TREM2 and immune genetics

    A genome-wide screen using 382 STR markers to localize and identify the gene implicated in early-onset dementia (EOD) without bone cysts in a Lebanese family with three affected subjects was conducted.

  49. Developmental regulation of TREM2 and DAP12 expression in the murine CNS: implications for Nasu-Hakola disease

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Neurochemical research 2008-04-11 TREM2 and immune genetics

    Trem2 is an orphan, DAP12 associated receptor constitutively expressed in vivo by subsets of microglia in the healthy adult murine CNS and in vitro by subsets of oligodendrocytes in neonatal mixed glial cultures.

  50. The innate immune response to Salmonella enterica serovar Typhimurium by macrophages is dependent on TREM2-DAP12

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Infection and immunity 2008-04-07 TREM2 and immune genetics

    Macrophage recognition of Salmonella enterica serovar Typhimurium leads to a cascade of signaling events, including the activation of Src family and Syk kinases and the production of reactive oxygen species (ROS), which are critical for host innate defense during early stages of bacterial infection.

From across this tag

9 of the 363 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 9. The same 9 appear here every time.

All topic tags with their study counts