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Home › Research › Topics › trem2

trem2

363 studies tagged trem2, dated 2000-05-01 to 2026-06-02. Bibliography: BibTeX (.bib) · RIS (.ris)

Newest in this topic

  1. Gain-of-function Modulation of TREM2 and its Impact on Amyloid-β and Tau Pathologies in Alzheimer's Disease: A Systematic Review and Meta-analysis of Animal Studies 2026-06-02
  2. The TREM2 agonistic antibody AL002 in early Alzheimer's disease: a phase 2 randomized trial 2026-03-05
  3. Decoding TREM2 Signaling Pathways 2026-01-09

Studies

363 studies carry this tag.

Date range

2000 to 2026

Top journals

  • Molecular neurodegeneration 26
  • Neurobiology of aging 16
  • Neuron 10
  • The Journal of experimental medicine 10
  • Acta neuropathologica 9

147 journals in all.

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. Mechanism of STMN2 cryptic splice-polyadenylation and its correction for TDP-43 proteinopathies

    ✓ Peer-reviewed alzhub usefulness score 60 out of 100. Science (New York, N.Y.) 2023-03-16 Brain tissue and pathology

    Loss of nuclear TDP-43 is a hallmark of neurodegeneration in TDP-43 proteinopathies, including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).

  2. TREM2+ macrophages suppress CD8+ T-cell infiltration after transarterial chemoembolisation in hepatocellular carcinoma

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. Journal of hepatology 2023-03-06 TREM2 and immune genetics

    & aims The immune landscape of hepatocellular carcinoma (HCC) following transarterial chemoembolisation (TACE) remains to be clarified.

  3. TREM2 mediates physical exercise-promoted neural functional recovery in rats with ischemic stroke via microglia-promoted white matter repair

    ✓ Peer-reviewed alzhub usefulness score 44 out of 100. Journal of neuroinflammation 2023-02-25 TREM2 and immune genetics

    The repair of white matter injury is of significant importance for functional recovery after ischemic stroke, and the up-regulation of triggering receptors expressed on myeloid cells 2 (TREM2) after ischemic stroke is neuroprotective and implicated in remyelination.

  4. A Trem2R47H mouse model without cryptic splicing drives age- and disease-dependent tissue damage and synaptic loss in response to plaques

    ✓ Peer-reviewed alzhub usefulness score 44 out of 100. Molecular neurodegeneration 2023-02-17 TREM2 and immune genetics

    Unfortunately, many current Trem2 R47H mouse models are associated with cryptic mRNA splicing of the mutant allele that produces a confounding reduction in protein product.

  5. TREM2 Inhibits Tau Hyperphosphorylation and Neuronal Apoptosis via the PI3K/Akt/GSK-3β Signaling Pathway In vivo and In vitro

    ✓ Peer-reviewed alzhub usefulness score 44 out of 100. Molecular neurobiology 2023-01-20 TREM2 and immune genetics

    Triggering receptor expressed on myeloid cells-2 (TREM2), a cell surface receptor mainly expressed on microglia, has been shown to play a critical role in Alzheimer's disease (AD) pathogenesis and progression.

  6. TREM2 Regulates the Removal of Apoptotic Cells and Inflammatory Processes during the Progression of NAFLD

    ✓ Peer-reviewed alzhub usefulness score 49 out of 100. Cells 2023-01-17 TREM2 and immune genetics

    Nonalcoholic fatty liver disease (NAFLD) is the most common liver pathology worldwide.

  7. A TREM2-activating antibody with a blood-brain barrier transport vehicle enhances microglial metabolism in Alzheimer's disease models

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. Nature neuroscience 2023-01-12 TREM2 and immune genetics

    Loss-of-function variants of TREM2 are associated with increased risk of Alzheimer's disease (AD), suggesting that activation of this innate immune receptor may be a useful therapeutic strategy.

  8. TREM2hi resident macrophages protect the septic heart by maintaining cardiomyocyte homeostasis

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Nature metabolism 2023-01-12 TREM2 and immune genetics

    Sepsis-induced cardiomyopathy (SICM) is common in septic patients with a high mortality and is characterized by an abnormal immune response.

  9. sTREM2 is associated with amyloid-related p-tau increases and glucose hypermetabolism in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. EMBO molecular medicine 2023-01-09 TREM2 and immune genetics

    Microglial activation occurs early in Alzheimer's disease (AD) and previous studies reported both detrimental and protective effects of microglia on AD progression.

  10. TREM2 dependent and independent functions of microglia in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. Molecular neurodegeneration 2022-12-23 TREM2 and immune genetics

    Microglia are central players in brain innate immunity and have been the subject of extensive research in Alzheimer's disease (AD).

  11. Soluble TREM2 levels associate with conversion from mild cognitive impairment to Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. The Journal of clinical investigation 2022-12-15 TREM2 and immune genetics

    BACKGROUNDSoluble triggering receptor expressed on myeloid cells 2 (sTREM2) plays an important role in the clearance of pathological amyloid-β (Aβ) in Alzheimer's disease (AD).

  12. Prolonged hypernutrition impairs TREM2-dependent efferocytosis to license chronic liver inflammation and NASH development

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. Immunity 2022-12-14 TREM2 and immune genetics

    Obesity-induced chronic liver inflammation is a hallmark of nonalcoholic steatohepatitis (NASH)-an aggressive form of nonalcoholic fatty liver disease.

  13. Platinum-Based TREM2 Inhibitor Suppresses Tumors by Remodeling the Immunosuppressive Microenvironment

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Angewandte Chemie (International ed. in English) 2022-12-07 TREM2 and immune genetics

    Triggering receptor expressed on myeloid cells-2 (TREM2) is a key pro-tumorigenic marker of tumor-infiltrating macrophages, showing potent immunosuppressive activity in tumor microenvironment.

  14. TREM2 R47H variant and risk for Alzheimer's disease: assessment in a Greek population and updated meta-analysis

    ✓ Peer-reviewed alzhub usefulness score 70 out of 100. The International journal of neuroscience 2022-12-06 TREM2 and immune genetics

    The rs75932628 was associated with AD in the Greek sample.

  15. TREM2 activation alleviates neural damage via Akt/CREB/BDNF signalling after traumatic brain injury in mice

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Journal of neuroinflammation 2022-12-03 TREM2 and immune genetics

    Neuroinflammation is one of the most important processes in secondary injury after traumatic brain injury (TBI).

  16. TREM2-independent microgliosis promotes tau-mediated neurodegeneration in the presence of ApoE4

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. Neuron 2022-11-10 TREM2 and immune genetics

    In addition to tau and Aβ pathologies, inflammation plays an important role in Alzheimer's disease (AD).

  17. Plaque contact and unimpaired Trem2 is required for the microglial response to amyloid pathology

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Cell reports 2022-11-01 TREM2 and immune genetics

    Using spatial cell-type-enriched transcriptomics, we compare plaque-induced gene (PIG) expression in microglia-touching plaques, neighboring plaques, and far from plaques in an aged Alzheimer's mouse model with late plaque development.

  18. Nrf2 regulates the arginase 1+ microglia phenotype through the initiation of TREM2 transcription, ameliorating depression-like behavior in mice

    ✓ Peer-reviewed alzhub usefulness score 42 out of 100. Translational psychiatry 2022-10-31 TREM2 and immune genetics

    The expression of the triggering receptor on myeloid cell-2 (TREM2) knockdown in microglia from the lateral habenula (LHb) reportedly induces depression-like behaviors in mice.

  19. Soluble TREM2 and Alzheimer-related biomarker trajectories in the blood of patients with diabetes based on their cognitive status

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Diabetes research and clinical practice 2022-10-20 Tau biomarkers

    We aimed to elucidate the dynamics of blood biomarkers according to the severity of cognitive impairment in patients with type 2 diabetes mellitus (DM) and to identify useful biomarkers for diabetes-related dementia.

  20. Chronic TREM2 activation exacerbates Aβ-associated tau seeding and spreading

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. The Journal of experimental medicine 2022-10-11 TREM2 and immune genetics

    Variants in the triggering receptor expressed on myeloid cells 2 (TREM2) gene are associated with increased risk for late-onset AD.

  21. TREM2 drives microglia response to amyloid-β via SYK-dependent and -independent pathways

    ✓ Peer-reviewed alzhub usefulness score 58 out of 100. Cell 2022-10-01 TREM2 and immune genetics

    Genetic studies have highlighted microglia as pivotal in orchestrating Alzheimer's disease (AD).

  22. Elevating microglia TREM2 reduces amyloid seeding and suppresses disease-associated microglia

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. The Journal of experimental medicine 2022-09-15 TREM2 and immune genetics

    TREM2 is exclusively expressed by microglia in the brain and is strongly linked to the risk for Alzheimer's disease (AD).

  23. A tetravalent TREM2 agonistic antibody reduced amyloid pathology in a mouse model of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. Science translational medicine 2022-09-07 TREM2 and immune genetics

    Triggering receptor expressed on myeloid cells 2 (TREM2) plays crucial roles in Alzheimer's disease (AD) by regulating microglia migration toward, and phagocytosis of oligomeric amyloid-β (oAβ) and amyloid plaques.

  24. TREM2/β-catenin attenuates NLRP3 inflammasome-mediated macrophage pyroptosis to promote bacterial clearance of pyogenic bacteria

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Cell death & disease 2022-09-06 TREM2 and immune genetics

    Triggering receptors expressed on myeloid cells 2 (TREM2) is considered a protective factor to protect host from bacterial infection, while how it elicits this role is unclear.

  25. Trem2 deletion enhances tau dispersion and pathology through microglia exosomes

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Molecular neurodegeneration 2022-09-02 TREM2 and immune genetics

    Variants in the microglial immune receptor TREM2 are associated with enhanced risk of onset in sporadic Alzheimer's disease (AD).

  26. Activation of TREM2 attenuates neuroinflammation via PI3K/Akt signaling pathway to improve postoperative cognitive dysfunction in mice

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Neuropharmacology 2022-08-27 TREM2 and immune genetics

    Postoperative cognitive dysfunction (POCD) is a common postoperative complication involving the central nervous system, but the underlying mechanism is not well understood.

  27. Microglial TYROBP/DAP12 in Alzheimer's disease: Transduction of physiological and pathological signals across TREM2

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. Molecular neurodegeneration 2022-08-24 TREM2 and immune genetics

    TYROBP (also known as DAP12 or KARAP) is a transmembrane adaptor protein initially described as a receptor-activating subunit component of natural killer (NK) cells.

  28. Spatiotemporal dynamics of macrophage heterogeneity and a potential function of Trem2hi macrophages in infarcted hearts

    ✓ Peer-reviewed alzhub usefulness score 54 out of 100. Nature communications 2022-08-06 TREM2 and immune genetics

    Heart failure (HF) is a frequent consequence of myocardial infarction (MI).

  29. TREM2 Promotes Immune Evasion by Mycobacterium tuberculosis in Human Macrophages

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. mBio 2022-08-04 TREM2 and immune genetics

    A recent study showed that TREM2 is a receptor for mycolic acids in the mycobacterial cell wall and inhibits macrophage activation.

  30. TREM2 macrophages induced by human lipids drive inflammation in acne lesions

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. Science immunology 2022-07-22 TREM2 and immune genetics

    Acne affects 1 in 10 people globally, often resulting in disfigurement.

  31. Circulating TREM2 as a noninvasive diagnostic biomarker for NASH in patients with elevated liver stiffness

    ✓ Peer-reviewed alzhub usefulness score 56 out of 100. Hepatology (Baltimore, Md.) 2022-07-14 TREM2 and immune genetics

    Reliable noninvasive biomarkers are an unmet clinical need for the diagnosis of NASH.

  32. TREM2-induced activation of microglia contributes to synaptic integrity in cognitively intact aged individuals with Alzheimer's neuropathology

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Brain pathology (Zurich, Switzerland) 2022-07-11 TREM2 and immune genetics

    The existence of individuals who remain cognitively intact despite presenting histopathological signs of Alzheimer's disease (AD), here referred to as "Nondemented with AD neuropathology" (NDAN), suggests that some mechanisms are triggered to resist cognitive impairment.

  33. Soluble TREM2 levels reflect the recruitment and expansion of TREM2+ macrophages that localize to fibrotic areas and limit NASH

    ✓ Peer-reviewed alzhub usefulness score 51 out of 100. Journal of hepatology 2022-06-21 TREM2 and immune genetics

    & aims Previous single-cell RNA-sequencing analyses have shown that Trem2-expressing macrophages are present in the liver during obesity, non-alcoholic steatohepatitis (NASH) and cirrhosis.

  34. LILRB2-mediated TREM2 signaling inhibition suppresses microglia functions

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. Molecular neurodegeneration 2022-06-18 TREM2 and immune genetics

    Microglia plays crucial roles in Alzheimer's disease (AD) development.

  35. Exploring the Impact of TREM2 in Tumor-Associated Macrophages

    ✓ Peer-reviewed alzhub usefulness score 44 out of 100. Vaccines 2022-06-14 TREM2 and immune genetics

    Tumor-associated macrophages (TAMs) represent a key component of the tumor microenvironment and are generally associated with immunosuppression and poor prognosis.

  36. Microglial mTOR Activation Upregulates Trem2 and Enhances β-Amyloid Plaque Clearance in the 5XFAD Alzheimer's Disease Model

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. The Journal of neuroscience : the official journal of the Society for Neuroscience 2022-06-07 TREM2 and immune genetics

    The mechanistic target of rapamycin (mTOR) signaling pathway plays a major role in key cellular processes including metabolism and differentiation; however, the role of mTOR in microglia and its importance in Alzheimer's disease (AD) have remained largely uncharacterized.

  37. TREM2 in the pathogenesis of AD: a lipid metabolism regulator and potential metabolic therapeutic target

    ✓ Peer-reviewed alzhub usefulness score 51 out of 100. Molecular neurodegeneration 2022-06-03 TREM2 and immune genetics

    Triggering receptor expressed on myeloid cells 2 (TREM2) is a single-pass transmembrane immune receptor that is mainly expressed on microglia in the brain and macrophages in the periphery.

  38. Soluble TREM2 in CSF and its association with other biomarkers and cognition in autosomal-dominant Alzheimer's disease: a longitudinal observational study

    ✓ Peer-reviewed alzhub usefulness score 71 out of 100. The Lancet. Neurology 2022-04-01 Brain scans and imaging

    Although studies in animal models suggest that TREM2 is protective against Alzheimer's pathology, its effect on tau pathology and its potential beneficial role in people with Alzheimer's disease is still unclear.

  39. Integrated Analysis Highlights the Immunosuppressive Role of TREM2+ Macrophages in Hepatocellular Carcinoma

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Frontiers in immunology 2022-03-14 TREM2 and immune genetics

    Recently, attention has been focused on the central role of TREM2 in diverse pathologies.

  40. Immunosuppressive TREM2(+) macrophages are associated with undesirable prognosis and responses to anti-PD-1 immunotherapy in non-small cell lung cancer

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. Cancer immunology, immunotherapy : CII 2022-03-12 TREM2 and immune genetics

    Immune checkpoint blockade (ICB) has been improving patient outcomes of non-small cell lung cancer (NSCLC), but its effectiveness is highly subjective to individual tumor microenvironment.

  41. TREM2 regulates purinergic receptor-mediated calcium signaling and motility in human iPSC-derived microglia

    ✓ Peer-reviewed alzhub usefulness score 49 out of 100. eLife 2022-02-22 TREM2 and immune genetics

    The membrane protein TREM2 (Triggering Receptor Expressed on Myeloid cells 2) regulates key microglial functions including phagocytosis and chemotaxis.

  42. Soluble TREM2 inhibits secondary nucleation of Aβ fibrillization and enhances cellular uptake of fibrillar Aβ

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. Proceedings of the National Academy of Sciences of the United States of America 2022-02-01 TREM2 and immune genetics

    Triggering receptor expressed on myeloid cells 2 (TREM2) is a single-pass transmembrane receptor of the immunoglobulin superfamily that is secreted in a soluble (sTREM2) form.

  43. Soluble TREM2: Innocent bystander or active player in neurological diseases?

    ✓ Peer-reviewed alzhub usefulness score 51 out of 100. Neurobiology of disease 2022-01-15 TREM2 and immune genetics

    Triggering receptor expressed on myeloid cells 2 (TREM2) is an innate immune receptor expressed by macrophages and microglia in the central nervous system (CNS).

  44. Loss of TREM2 rescues hyperactivation of microglia, but not lysosomal deficits and neurotoxicity in models of progranulin deficiency

    ✓ Peer-reviewed alzhub usefulness score 51 out of 100. The EMBO journal 2022-01-12 TREM2 and immune genetics

    Haploinsufficiency of the progranulin (PGRN)-encoding gene (GRN) causes frontotemporal lobar degeneration (GRN-FTLD) and results in microglial hyperactivation, TREM2 activation, lysosomal dysfunction, and TDP-43 deposition.

  45. Downregulation of TREM2 expression exacerbates neuroinflammatory responses through TLR4-mediated MAPK signaling pathway in a transgenic mouse model of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Molecular immunology 2021-12-24 TREM2 and immune genetics

    Activation of glial cells and neuroinflammation play an important role in the onset and development of Alzheimer's disease (AD).

  46. TREM2 interacts with TDP-43 and mediates microglial neuroprotection against TDP-43-related neurodegeneration

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. Nature neuroscience 2021-12-16 TREM2 and immune genetics

    Triggering receptor expressed on myeloid cell 2 (TREM2) is linked to risk of neurodegenerative disease.

  47. AD-linked R47H-TREM2 mutation induces disease-enhancing microglial states via AKT hyperactivation

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. Science translational medicine 2021-12-01 TREM2 and immune genetics

    The hemizygous R47H variant of triggering receptor expressed on myeloid cells 2 ( TREM2 ), a microglia-specific gene in the brain, increases risk for late-onset Alzheimer’s disease (AD).

  48. TREM2-independent oligodendrocyte, astrocyte, and T cell responses to tau and amyloid pathology in mouse models of Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 44 out of 100. Cell reports 2021-12-01 TREM2 and immune genetics

    Non-neuronal responses in neurodegenerative disease have received increasing attention as important contributors to disease pathogenesis and progression.

  49. Xenogeneic skin transplantation promotes angiogenesis and tissue regeneration through activated Trem2+ macrophages

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Science advances 2021-12-01 TREM2 and immune genetics

    Skin allo- and xenotransplantation are the standard treatment for major burns when donor sites for autografts are not available.

  50. Secretases in Alzheimer's disease: Novel insights into proteolysis of APP and TREM2

    ✓ Peer-reviewed alzhub usefulness score 44 out of 100. Current opinion in neurobiology 2021-10-22 TREM2 and immune genetics

    Secretases are a group of proteases that are major drug targets considered for the prevention and treatment of Alzheimer's disease (AD).

From across this tag

9 of the 363 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 9. The same 9 appear here every time.

All topic tags with their study counts