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TREM2, a DAP12-associated receptor, regulates osteoclast differentiation and function
Humphrey MB, Daws MR, Spusta SC, Niemi EC, Torchia JA, Lanier LL, Seaman WE, Nakamura MC.. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2005-10-20
Topic: Brain proteins, microglia and lab models
Unlabelled Deficiency of the signaling adapter protein DAP12 or its associated receptor TREM2 is associated with abnormal OC development in humans. Here we examine the role of TREM2 in mouse OC development and function, including migration and resorption in vitro. These results provide new evidence that TREM2 regulates OC function independent of its effects on multinucleated OC differentiation.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Humphrey, M. B., Daws, M. R., Spusta, S. C., Niemi, E. C., Torchia, J. A., Lanier, L. L., et al. (2006). TREM2, a DAP12-associated receptor, regulates osteoclast differentiation and function. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. https://doi.org/10.1359/jbmr.051016
Vancouver
Humphrey MB, Daws MR, Spusta SC, Niemi EC, Torchia JA, Lanier LL, et al. TREM2, a DAP12-associated receptor, regulates osteoclast differentiation and function. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2006. doi:10.1359/jbmr.051016. PMID: 16418779.
BibTeX
@article{humphrey2006-16418779,
author = {Humphrey, M. B. and Daws, M. R. and Spusta, S. C. and Niemi, E. C. and Torchia, J. A. and Lanier, L. L. and Seaman, W. E. and Nakamura, M. C.},
title = {{TREM2, a DAP12-associated receptor, regulates osteoclast differentiation and function}},
journal = {Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
year = {2006},
doi = {10.1359/jbmr.051016},
pmid = {16418779},
url = {https://doi.org/10.1359/jbmr.051016}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 8 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
Key findings
- Here we examine the role of TREM2 in mouse OC development and function, including migration and resorption in vitro.
- These results provide new evidence that TREM2 regulates OC function independent of its effects on multinucleated OC differentiation.
- Introduction TREM2 (triggering receptor expressed in myeloid cells-2) associates with the signaling adapter DAP12 in osteoclasts (OCs).
- Genetic mutation or deletion of either the TYROBP (DAP12) or TREM2 gene is associated with the human disorder of brain and bone, Nasu-Hakola disease.
Why it matters
In mice, TREM2 was found to regulate osteoclast function, and mutations in TREM2 or DAP12 are linked to a human bone disorder. This concerns bone biology, not Alzheimer's disease treatment or prevention.
New to this subject? Start with our plain-English guide: Genetics →
Study details
- Evidence strengthLow
How this study scored 44/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research) |
| Journal's citation record | 3 / 4 | Journal of Bone and Mineral Research: journal h-index 332 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2006 — older than 20 years, still counted |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 163 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 7.4 citations a year over 22 year(s) since 2006 |
| Impact for its field and year | 3 / 6 | Cited 4.4× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 3 / 6 | Cited by 20 other studies in this library |
| Still being cited | 2 / 4 | Cited 24 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Mary C. Nakamura: h-index 47 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University of California, San Francisco: institution h-index 1,915 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 3 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 16418779) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 44 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1359/jbmr.051016
- PubMed: 16418779
- Original source →
- Free full text: eScholarship (California Digital Library) →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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