Home › Research › TREM2 and immune genetics
TREM2 regulates obesity-induced insulin resistance via adipose tissue remodeling in mice of high-fat feeding
Liu C, Li P, Li H, Wang S, Ding L, Wang H, Ye H, Jin Y et al.. Journal of translational medicine, 2019-09-02
Topic: Brain proteins, microglia and lab models
Background Adipose tissue remodeling plays a significant role in obesity-induced insulin resistance. Published studies reported that level of trigger receptor expressed on myeloid cells 2 (TREM2) in adipose tissue is up-regulated in animal models of obesity. This study aims to investigate whether TREM2 regulates obesity-induced insulin resistance via modulating adipose tissue remodeling in mice of high-fat diet (HFD).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Liu, C., Li, P., Li, H., Wang, S., Ding, L., Wang, H., et al. (2019). TREM2 regulates obesity-induced insulin resistance via adipose tissue remodeling in mice of high-fat feeding. Journal of translational medicine. https://doi.org/10.1186/s12967-019-2050-9
Vancouver
Liu C, Li P, Li H, Wang S, Ding L, Wang H, et al. TREM2 regulates obesity-induced insulin resistance via adipose tissue remodeling in mice of high-fat feeding. Journal of translational medicine. 2019. doi:10.1186/s12967-019-2050-9. PMID: 31477129.
BibTeX
@article{liu2019-31477129,
author = {Liu, C. and Li, P. and Li, H. and Wang, S. and Ding, L. and Wang, H. and Ye, H. and Jin, Y. and others},
title = {{TREM2 regulates obesity-induced insulin resistance via adipose tissue remodeling in mice of high-fat feeding}},
journal = {Journal of translational medicine},
year = {2019},
doi = {10.1186/s12967-019-2050-9},
pmid = {31477129},
url = {https://doi.org/10.1186/s12967-019-2050-9}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
Key findings
- Published studies reported that level of trigger receptor expressed on myeloid cells 2 (TREM2) in adipose tissue is up-regulated in animal models of obesity.
- This study aims to investigate whether TREM2 regulates obesity-induced insulin resistance via modulating adipose tissue remodeling in mice of high-fat diet (HFD).
- Methods Wild-type (WT) and TREM2 -/- mice were both fed with a controlled-fat diet (CFD) or HFD for 12 weeks and studied for obesity and insulin resistance.
- Meanwhile, epididymal adipose tissue (EAT) was examined for morphological and pathological changes to determine adipose tissue remodeling.
Why it matters
In mice fed a high-fat diet, the study investigated whether TREM2 regulates obesity-induced insulin resistance through adipose tissue remodeling. It is about obesity and insulin resistance in mice, not Alzheimer's disease, so it has no implications for treating, curing or preventing Alzheimer's.
New to this subject? Start with our plain-English guide: Genetics →
Study details
- Evidence strengthLow
How this study scored 43/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of translational medicine) |
| Journal's citation record | 2 / 4 | Journal of Translational Medicine: journal h-index 190 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2019 — within 10 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Laboratory or animal study (title names “mice”) — scores zero |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 4 / 7 | Cited 70 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 7.8 citations a year over 9 year(s) since 2019 |
| Impact for its field and year | 3 / 6 | Cited 4.5× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 3 other studies in this library |
| Still being cited | 2 / 4 | Cited 35 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Qiang Shu: h-index 48 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Zhejiang University: institution h-index 1,040 (OpenAlex) |
| Multicenter collaboration | 1 / 3 | OpenAlex lists 3 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 31477129) |
| Free to read | 2 / 2 | Free to read |
| Total | 43 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1186/s12967-019-2050-9
- PubMed: 31477129
- Original source →
- Free full text: Journal of Translational Medicine →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Related
Studies in the library that share something with this one. The line above each title says what.
Studies this one cites
Referenced by this study and also in the alzhub library, so you can read them here.
Later studies that cite this one
3 studies in the alzhub library list this one in their references.
Related studies in TREM2 and immune genetics
Also tagged “r47h”
363 studies in the library carry the topic tag “r47h”; these are this study's neighbours in a fixed, alphabetical-by-hash tour of them, not the closest in content. All 363 tagged studies.