alzhub.org
Get help now — free helplines

You can call any of these for free. You do not need a diagnosis, an appointment, or a crisis to call — questions and plain exhaustion are reasons enough.

  • Alzheimer's Association 24/7 Helpline 800-272-3900 24 hours a day, 365 days a year Free, confidential support and information for people with dementia, caregivers, families and the public. Master's-level clinicians. Also Spanish.
  • 988 Suicide & Crisis Lifeline 988 24/7 Call or text 988, or chat at 988lifeline.org. For anyone in emotional distress or a mental-health crisis, including caregivers.
  • Alzheimer's Foundation of America (AFA) Helpline 866-232-8484 9:00 am - 9:00 pm ET, seven days a week Licensed social workers providing support, info and referrals. Also text message and web chat. Text: 646-586-5283

In a medical emergency, call 911. More numbers, and what each line does, on the help page.

Home › Research › Topics › machine

machine

842 studies tagged machine, dated 1983-08-01 to 2026-09-25. Bibliography: BibTeX (.bib) · RIS (.ris)

Newest in this topic

  1. Diagnostic accuracy of remote self-administered digital cognitive assessment by clinical diagnosis and Alzheimer's disease PET imaging biomarkers 2026-09-25
  2. Multi-scale 3D CNN with imbalance-aware training for structural MRI-based six-class Alzheimer disease staging 2026-09-22
  3. T1 mapping in Alzheimer’s disease: a quantitative MRI study with amyloid-PET correlation 2026-09-21

Studies

842 studies carry this tag.

Date range

1983 to 2026

Top journals

  • Neurology 83
  • Journal of nuclear medicine : official publication, Society of Nuclear Medicine 42
  • Brain : a journal of neurology 34
  • NeuroImage 31
  • Alzheimer s & Dementia 30

283 journals in all.

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. The Alzheimer's Disease Centers' Uniform Data Set (UDS): the neuropsychologic test battery

    ✓ Peer-reviewed alzhub usefulness score 62 out of 100. Alzheimer disease and associated disorders 2009-04-01 Disparities

    The neuropsychologic test battery from the Uniform Data Set (UDS) of the Alzheimer's Disease Centers (ADC) program of the National Institute on Aging consists of brief measures of attention, processing speed, executive function, episodic memory, and language.

  2. Serial PIB and MRI in normal, mild cognitive impairment and Alzheimer's disease: implications for sequence of pathological events in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 75 out of 100. Brain : a journal of neurology 2009-03-31 Mild cognitive impairment

    The purpose of this study was to use serial imaging to gain insight into the sequence of pathologic events in Alzheimer's disease, and the clinical features associated with this sequence.

  3. Alzheimer disease: quantitative structural neuroimaging for detection and prediction of clinical and structural changes in mild cognitive impairment

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. Radiology 2009-02-06 Mild cognitive impairment

    Semiautomated, individually specific quantitative MR imaging methods can be used to identify a pattern of regional atrophy in MCI that is predictive of clinical decline.

  4. Regionally-specific diffusion tensor imaging in mild cognitive impairment and Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 58 out of 100. NeuroImage 2009-02-05 Mild cognitive impairment

    The fornix is a predominant outflow tract of the hippocampus and may be an important indicator of AD progression.

  5. Categorical and correlational analyses of baseline fluorodeoxyglucose positron emission tomography images from the Alzheimer's Disease Neuroimaging Initiative (ADNI)

    ✓ Peer-reviewed alzhub usefulness score 60 out of 100. NeuroImage 2009-01-21 Cognitive tests and assessment

    In mostly small single-center studies, Alzheimer's disease (AD) is associated with characteristic and progressive reductions in fluorodeoxyglucose positron emission tomography (PET) measurements of the regional cerebral metabolic rate for glucose (CMRgl).

  6. FDG-PET changes in brain glucose metabolism from normal cognition to pathologically verified Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 59 out of 100. European journal of nuclear medicine and molecular imaging 2009-01-14 Getting a diagnosis

    Progressive CMRglc reductions on FDG-PET occur years in advance of clinical DAT symptoms in patients with pathologically verified disease.

  7. Amyloid imaging in aging and dementia: testing the amyloid hypothesis in vivo

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. Behavioural neurology 2009-01-01 Mild cognitive impairment

    Amyloid imaging represents a major advance in neuroscience, enabling the detection and quantification of pathologic protein aggregations in the brain.

  8. Carbon 11-labeled Pittsburgh Compound B and carbon 11-labeled (R)-PK11195 positron emission tomographic imaging in Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Archives of neurology 2009-01-01 Mild cognitive impairment

    These findings suggest that either microglial activation is limited to later stages of severe AD or [11C](R)-PK11195 is too insensitive to detect the level of microglial activation associated with mild to moderate AD.

  9. Microglial activation and amyloid deposition in mild cognitive impairment: a PET study

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. Neurology 2009-01-01 Inflammation and the immune system

    Activated microglia may play a role in the pathogenesis of Alzheimer disease (AD) as they cluster around beta-amyloid (Abeta) plaques.

  10. The cortical signature of prodromal AD: regional thinning predicts mild AD dementia

    ✓ Peer-reviewed alzhub usefulness score 67 out of 100. Neurology 2008-12-24 Brain scans and imaging

    Thinning in specific cortical areas known to be affected by Alzheimer disease (AD) is detectable in individuals with questionable AD dementia (QAD) and predicts conversion to mild AD dementia.

  11. Medial temporal lobe atrophy on MRI scans and the diagnosis of Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. Neurology 2008-12-01 Brain scans and imaging

    Medial temporal lobe atrophy (MTA) scores 1) distinguish probable Alzheimer disease (AD) and amnestic mild cognitive impairment (MCI) subjects from nonamnestic MCI and no cognitive impairment (NCI) subjects, 2) help predict diagnosis at baseline, and 3) predict transition from NCI to MCI and from MCI to probable AD.

  12. Automated mapping of hippocampal atrophy in 1-year repeat MRI data from 490 subjects with Alzheimer's disease, mild cognitive impairment, and elderly controls

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. NeuroImage 2008-11-08 Cognitive tests and assessment

    As one of the earliest structures to degenerate in Alzheimer's disease (AD), the hippocampus is the target of many studies of factors that influence rates of brain degeneration in the elderly.

  13. Imaging amyloid deposition in Lewy body diseases

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. Neurology 2008-09-01 Caregiving

    Global cortical amyloid burden is high in dementia with Lewy bodies (DLB) but low in Parkinson disease dementia.

  14. MRI measures of temporoparietal regions show differential rates of atrophy during prodromal AD

    ✓ Peer-reviewed alzhub usefulness score 51 out of 100. Neurology 2008-07-30 Brain scans and imaging

    These results demonstrate that temporoparietal regions show differential rates of atrophy on MRI during prodromal Alzheimer disease (AD).

  15. Tensor-based morphometry as a neuroimaging biomarker for Alzheimer's disease: an MRI study of 676 AD, MCI, and normal subjects

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. NeuroImage 2008-07-22 Cognitive tests and assessment

    In one of the largest brain MRI studies to date, we used tensor-based morphometry (TBM) to create 3D maps of structural atrophy in 676 subjects with Alzheimer's disease (AD), mild cognitive impairment (MCI), and healthy elderly controls, scanned as part of the Alzheimer's Disease Neuroimaging Initiative (ADNI).

  16. The Cortical Signature of Alzheimer's Disease: Regionally Specific Cortical Thinning Relates to Symptom Severity in Very Mild to Mild AD Dementia and is Detectable in Asymptomatic Amyloid-Positive Individuals

    ✓ Peer-reviewed alzhub usefulness score 58 out of 100. Cerebral Cortex 2008-07-16 Brain scans and imaging

    Alzheimer's disease (AD) is associated with neurodegeneration in vulnerable limbic and heteromodal regions of the cerebral cortex, detectable in vivo using magnetic resonance imaging.

  17. Ventricular enlargement as a possible measure of Alzheimer's disease progression validated using the Alzheimer's disease neuroimaging initiative database

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. Brain : a journal of neurology 2008-07-11 Mild cognitive impairment

    Ventricular enlargement may be an objective and sensitive measure of neuropathological change associated with mild cognitive impairment (MCI) and Alzheimer's disease (AD), suitable to assess disease progression for multi-centre studies.

  18. Decrease of evoked delta, theta and alpha coherences in Alzheimer patients during a visual oddball paradigm

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Brain research 2008-06-19 Brain scans and imaging

    In this study event related coherence of patients with Alzheimer type of dementia (AD) was analyzed by using a visual oddball paradigm as stimuli.

  19. Increased binding of peripheral benzodiazepine receptor in Alzheimer's disease measured by positron emission tomography with [11C]DAA1106

    ✓ Peer-reviewed alzhub usefulness score 44 out of 100. Biological psychiatry 2008-06-02 Inflammation and the immune system

    Peripheral benzodiazepine receptor (PBR) in the brain of Alzheimer's disease (AD) patients has been discussed in relation to the role of gliosis in AD.

  20. Evaluation of plasma Abeta(40) and Abeta(42) as predictors of conversion to Alzheimer's disease in patients with mild cognitive impairment

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Neurobiology of aging 2008-05-19 Mild cognitive impairment

    Numerous studies have shown a marked decrease of beta-amyloid(42) (Abeta(42)) in the cerebrospinal fluid (CSF) of patients with incipient Alzheimer's disease (AD).

  21. Discrimination between Alzheimer disease, mild cognitive impairment, and normal aging by using automated segmentation of the hippocampus

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Radiology 2008-05-05 Hippocampus size on brain scans

    This automated method can serve as an alternative to manual tracing and may thus prove useful in assisting with the diagnosis of AD.

  22. 123I-MIBG cardiac scintigraphy provides clues to the underlying neurodegenerative disorder in idiopathic REM sleep behavior disorder

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. Sleep 2008-05-01 Disease mechanisms

    Cardiac 123I-MIBG findings are similar among idiopathic RBD and the syndromes of PD and DLB, but differ from those of PSP and MSA.

  23. History of depression, depressive symptoms, and medial temporal lobe atrophy and the risk of Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. Neurology 2008-04-01 Brain scans and imaging

    This risk was not mediated by smaller hippocampal or amygdalar volumes.

  24. Personal mastery is associated with reduced sympathetic arousal in stressed Alzheimer caregivers

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 2008-04-01 Digital health tools

    Caregivers with higher mastery had less NE reactivity to the stressor task.

  25. Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 58 out of 100. Brain 2008-03-12 Brain scans and imaging

    The positron emission tomography (PET) radiotracer Pittsburgh Compound-B (PiB) binds with high affinity to beta-pleated sheet aggregates of the amyloid-beta (Abeta) peptide in vitro.

  26. The Alzheimer's disease neuroimaging initiative (ADNI): MRI methods

    ✓ Peer-reviewed alzhub usefulness score 72 out of 100. Journal of Magnetic Resonance Imaging 2008-02-26 Brain scans and imaging

    The Alzheimer's Disease Neuroimaging Initiative (ADNI) is a longitudinal multisite observational study of healthy elders, mild cognitive impairment (MCI), and Alzheimer's disease.

  27. 3D characterization of brain atrophy in Alzheimer's disease and mild cognitive impairment using tensor-based morphometry

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. NeuroImage 2008-02-21 Cognitive tests and assessment

    Tensor-based morphometry (TBM) creates three-dimensional maps of disease-related differences in brain structure, based on nonlinearly registering brain MRI scans to a common image template.

  28. Multicenter standardized 18F-FDG PET diagnosis of mild cognitive impairment, Alzheimer's disease, and other dementias

    ✓ Peer-reviewed alzhub usefulness score 59 out of 100. Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2008-02-20 Getting a diagnosis

    Standardized automated analysis of (18)F-FDG PET scans may provide an objective and sensitive support to the clinical diagnosis in early dementia.

  29. Volumetric MRI and cognitive measures in Alzheimer disease : comparison of markers of progression

    ✓ Peer-reviewed alzhub usefulness score 59 out of 100. Journal of neurology 2008-02-18 Brain scans and imaging

    Rates of brain atrophy and/or ventricular enlargement were correlated with declining performance on cognitive scales.

  30. 11C PiB and structural MRI provide complementary information in imaging of Alzheimer's disease and amnestic mild cognitive impairment

    ✓ Peer-reviewed alzhub usefulness score 60 out of 100. Brain 2008-02-07 Brain scans and imaging

    Interestingly, we found no consistent differences in learning and memory performance between high versus low PiB cognitively normal or amnestic MCI subjects.

  31. Diffusion tensor imaging in mild cognitive impairment and Alzheimer's disease: a review

    ✓ Peer-reviewed alzhub usefulness score 44 out of 100. Current opinion in neurology 2008-02-01 Mild cognitive impairment

    Recent findings Mild cognitive impairment represents a transition phase between normal ageing and early Alzheimer's disease.

  32. Automatic classification of MR scans in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 60 out of 100. Brain : a journal of neurology 2008-01-17 Getting a diagnosis

    To be diagnostically useful, structural MRI must reliably distinguish Alzheimer's disease (AD) from normal aging in individual scans.

  33. Imaging of amyloid beta in Alzheimer's disease with 18F-BAY94-9172, a novel PET tracer: proof of mechanism

    ✓ Peer-reviewed alzhub usefulness score 59 out of 100. The Lancet. Neurology 2008-01-10 Getting a diagnosis

    (18)F-BAY94-9172 binding matched the reported post-mortem distribution of Abeta plaques.

  34. Neuropathological basis of magnetic resonance images in aging and dementia

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. Annals of neurology 2008-01-01 Brain tissue and pathology

    Magnetic resonance (MR) imaging is used widely for assessment of patients with cognitive impairment, but the pathological correlates are unclear, especially when multiple pathologies are present.

  35. PET imaging of amyloid deposition in patients with mild cognitive impairment

    ✓ Peer-reviewed alzhub usefulness score 49 out of 100. Neurobiology of Aging 2008 Brain scans and imaging

    Researchers evaluated twenty-one patients diagnosed with MCI using PET studies with (11)C-PIB and (18)F-fluoro-deoxy-glucose (FDG), cognitive assessments, and CSF sampling.

  36. Volumetric MRI vs clinical predictors of Alzheimer disease in mild cognitive impairment

    ✓ Peer-reviewed alzhub usefulness score 73 out of 100. Neurology 2008-01-01 Genetics

    In moderate stages of amnestic mild cognitive impairment, common cognitive tests provide better predictive accuracy than measures of whole brain, ventricular, entorhinal cortex, or hippocampal volumes for assessing progression to Alzheimer disease.

  37. Positron emission tomography imaging in dementia

    ✓ Peer-reviewed alzhub usefulness score 42 out of 100. The British journal of radiology 2007-12-01 Inflammation and the immune system

    Positron emission tomography (PET) is a well-established imaging modality.

  38. Reduced hippocampal functional connectivity in Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Archives of neurology 2007-10-01 Brain scans and imaging

    These findings suggest a functional disconnection between the hippocampus and other brain regions in patients with Alzheimer disease.

  39. The significance of medial temporal lobe atrophy: a postmortem MRI study in the very old

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. Neurology 2007-10-01 Brain scans and imaging

    Medial temporal lobe atrophy (MTA) on postmortem MRI is sensitive to primary degenerative hippocampal pathology in the very old, but not specific for Alzheimer-type pathology.

  40. Three-dimensional gray matter atrophy mapping in mild cognitive impairment and mild Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. Archives of neurology 2007-10-01 Cognitive tests and assessment

    Alzheimer disease (AD) is the most common form of dementia worldwide.

  41. FDG-PET improves accuracy in distinguishing frontotemporal dementia and Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 63 out of 100. Brain : a journal of neurology 2007-08-18 Getting a diagnosis

    Distinguishing Alzheimer's disease (AD) and frontotemporal dementia (FTD) currently relies on a clinical history and examination, but positron emission tomography with [(18)F] fluorodeoxyglucose (FDG-PET) shows different patterns of hypometabolism in these disorders that might aid differential diagnosis.

  42. Imaging of amyloid burden and distribution in cerebral amyloid angiopathy

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. Annals of Neurology 2007-08-07 Brain scans and imaging

    We conclude that PiB-positron emission tomography can detect cerebrovascular beta-amyloid and may serve as a method for identifying the extent of CAA in living subjects.

  43. Hippocampal shape analysis of Alzheimer disease based on machine learning methods

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. AJNR. American journal of neuroradiology 2007-08-01 Digital health tools

    Subtle and spatially complex deformation patterns of hippocampus between patients with AD and healthy control subjects can be detected by machine learning methods.

  44. Voxel-based morphometry to detect brain atrophy in progressive mild cognitive impairment

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. NeuroImage 2007-06-29 Mild cognitive impairment

    Recent research has shown an increased rate of conversion to dementia in subjects with mild cognitive impairment (MCI) compared to controls.

  45. Symmetric diffeomorphic image registration with cross-correlation: evaluating automated labeling of elderly and neurodegenerative brain

    ✓ Peer-reviewed alzhub usefulness score 61 out of 100. Medical image analysis 2007-06-23 Lewy body dementia

    One of the most challenging problems in modern neuroimaging is detailed characterization of neurodegeneration.

  46. 3D maps from multiple MRI illustrate changing atrophy patterns as subjects progress from mild cognitive impairment to Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. Brain : a journal of neurology 2007-05-28 Mild cognitive impairment

    Voxel-based morphometry (VBM) was used to assess patterns of grey matter atrophy in the aMCI subjects at each time-point compared to the control group.

  47. Diffusion tensor imaging in preclinical and presymptomatic carriers of familial Alzheimer's disease mutations

    ✓ Peer-reviewed alzhub usefulness score 59 out of 100. Brain : a journal of neurology 2007-05-23 Brain tissue and pathology

    Measures are needed that identify persons that will develop Alzheimer's disease in order to target them for preventative interventions.

  48. Imaging beta-amyloid burden in aging and dementia

    ✓ Peer-reviewed alzhub usefulness score 66 out of 100. Neurology 2007-05-01 Genetics

    Pittsburgh Compound B PET findings match histopathologic reports of beta-amyloid (Abeta) distribution in aging and dementia.

  49. Beta-amyloid imaging and memory in non-demented individuals: evidence for preclinical Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 51 out of 100. Brain 2007-04-05 Brain scans and imaging

    Beta-amyloid (Abeta) deposition is pathognomic for Alzheimer's disease (AD), but may occur in normal elderly people without apparent cognitive effect.

  50. Diffusion tensor imaging of cingulum fibers in mild cognitive impairment and Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 59 out of 100. Neurology 2007-01-01 Brain scans and imaging

    Assessment of the cingulum fibers using diffusion tensor imaging may aid early diagnosis of Alzheimer disease.

From across this tag

9 of the 838 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 9. The same 9 appear here every time.

All topic tags with their study counts