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Newest in this topic

  1. Evidence that the perinatal maternal microbiome mediates metabolite signaling programs that drive sex-specific microglial metabolic alterations and Alzheimer’s disease susceptibility 2026-10-23
  2. Change in gut microbiome precedes symptomatic Alzheimer’s disease and is correlated with amyloid-beta accumulation in the brain 2026-10-19
  3. The Gut–Liver–Brain Axis in Neurodegeneration: Unraveling Metabolic–Immune Crosstalk from Peripheral Sensing to Central Vulnerability 2026-10-08

Studies

273 studies carry this tag.

Date range

1995 to 2026

Top journals

  • Journal of Alzheimer's disease : JAD 13
  • Scientific reports 8
  • Nutrients 7
  • Brain, behavior, and immunity 6
  • Frontiers in cellular and infection microbiology 6

168 journals in all.

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. Brain-gut-microbiota axis in Parkinson's disease: A historical review and future perspective

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. Brain research bulletin 2022-03-01 Disease mechanisms

    Parkinson's disease (PD) is the second most common degenerative disease of the central nervous system (CNS) after Alzheimer's disease.

  2. The Potential Role of Gut Microbiota in Alzheimer's Disease: From Diagnosis to Treatment

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Nutrients 2022-02-05 Disease mechanisms

    Gut microbiota is emerging as a key regulator of many disease conditions and its dysregulation is implicated in the pathogenesis of several gastrointestinal and extraintestinal disorders.

  3. Gut microbiota in patients with Alzheimer's disease spectrum: a systematic review and meta-analysis

    ✓ Peer-reviewed alzhub usefulness score 79 out of 100. Aging 2022-01-14 Disease mechanisms

    Patients with AD spectrum demonstrated altered GM abundance, which was differentially mediated by countries and clinical stages.

  4. Gut microbiota regulate Alzheimer's disease pathologies and cognitive disorders via PUFA-associated neuroinflammation

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Gut 2022-01-11 Disease mechanisms

    These findings support that a complex gut microbiome is required for behavioural defects, microglia activation and AD pathologies, the gut microbiome contributes to pathologies in an AD mouse model and that dysbiosis of the human microbiome might be a risk factor for AD.

  5. A Comprehensive Review on the Role of the Gut Microbiome in Human Neurological Disorders

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Clinical microbiology reviews 2022-01-05 Disease mechanisms

    The human body is full of an extensive number of commensal microbes, consisting of bacteria, viruses, and fungi, collectively termed the human microbiome.

  6. Diet Patterns, the Gut Microbiome, and Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Journal of Alzheimer's disease : JAD 2022 Disease mechanisms

    Given the complex bidirectional communication system that exists between the gut microbiome and the brain, there is growing interest in the gut microbiome as a novel and potentially modifiable risk factor for Alzheimer's disease (AD).

  7. Gut Microbiota as a Hidden Player in the Pathogenesis of Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Journal of Alzheimer's disease : JAD 2022 Disease mechanisms

    Alzheimer's disease (AD), the most common neurodegenerative disorder, is accompanied by cognitive impairment and shows representative pathological features, including senile plaques and neurofibrillary tangles in the brain.

  8. Periodontitis-related salivary microbiota aggravates Alzheimer's disease via gut-brain axis crosstalk

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Gut microbes 2022 Disease mechanisms

    The oral cavity is the initial chamber of digestive tract; the saliva swallowed daily contains an estimated 1.5 × 1012 oral bacteria.

  9. Relationship Between Plasma Neurofilament Light Chain, Gut Microbiota, and Dementia: A Cross-Sectional Study

    ✓ Peer-reviewed alzhub usefulness score 66 out of 100. Journal of Alzheimer's disease : JAD 2022 Biomarkers

    We analyzed 128 participants (women: 59%, mean age: 74 years).

  10. Relationship Between the Gut Microbiota and Alzheimer's Disease: A Systematic Review

    ✓ Peer-reviewed alzhub usefulness score 63 out of 100. Journal of Alzheimer's disease : JAD 2022 Disease mechanisms

    Eight observational studies were selected, carried out in humans and, therefore, suitable for inclusion in this review.

  11. The Gut Microbiome and Alzheimer's Disease: A Growing Relationship

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Current Alzheimer research 2022 Disease mechanisms

    Evidence that the gut microbiota plays a key role in the pathogenesis of Alzheimer's disease is already unravelling.

  12. Effects of gut microbiota and probiotics on Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Translational neuroscience 2021-12-27 Disease mechanisms

    Alzheimer's disease (AD) is a progressive neurodegenerative disease with high morbidity, disability, and fatality rate, significantly increasing the global burden of public health.

  13. Periodontal Disease: The Good, The Bad, and The Unknown

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Frontiers in cellular and infection microbiology 2021-12-07 Disease mechanisms

    Periodontal disease is classically characterized by progressive destruction of the soft and hard tissues of the periodontal complex, mediated by an interplay between dysbiotic microbial communities and aberrant immune responses within gingival and periodontal tissues.

  14. Extra-virgin olive oil and the gut-brain axis: influence on gut microbiota, mucosal immunity, and cardiometabolic and cognitive health

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Nutrition reviews 2021-11-10 Disease mechanisms

    Extra-virgin olive oil (EVOO), a popular functional food and major source of fat in the Mediterranean diet, possesses a variety of healthful components, including monounsaturated fatty acids and bioactive phenolic compounds that, individually and collectively, exert beneficial effects on cardiometabolic markers of health and act as neuroprotective agents through their anti-inflammatory and antioxidant activities.

  15. Gut feelings: the microbiota-gut-brain axis on steroids

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. American journal of physiology. Gastrointestinal and liver physiology 2021-11-03 Disease mechanisms

    The intricate connection between central and enteric nervous systems is well established with emerging evidence linking gut microbiota function as a significant new contributor to gut-brain axis signaling.

  16. Oral frailty and neurodegeneration in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Neural regeneration research 2021-11 Clinical trials

    Frailty is a critical intermediate status of the aging process with a multidimensional and multisystem nature and at higher risk for adverse health-related outcomes, including falls, disability, hospitalizations, institutionalization, mortality, dementia, and Alzheimer's disease.

  17. Gut-brain axis: Synergistic approach

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Industrial psychiatry journal 2021-10-22 Disease mechanisms

    Since decades, there is a change in concept of the gut-brain axis.

  18. Introduction to the Special Issue "The Brain-Gut Axis"

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Cellular and molecular neurobiology 2021-10-15 Disease mechanisms

    This special Issue presents comprehensive and state-of-the-art advances in supporting the crucial role of the bidirectional interactions between the Brain-Gut Axis in health and diseases with an emphasis on the microbiome-gut-brain axis and its implications in variety of neurological disorders.

  19. Microbiota-Gut-Brain Axis and Epilepsy: A Review on Mechanisms and Potential Therapeutics

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Frontiers in immunology 2021-10-11 Disease mechanisms

    The gut-brain axis refers to the bidirectional communication between the gut and brain, and regulates intestinal homeostasis and the central nervous system via neural networks and neuroendocrine, immune, and inflammatory pathways.

  20. Interplay of gut microbiota and oxidative stress: Perspective on neurodegeneration and neuroprotection

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Journal of advanced research 2021-09-17 Disease mechanisms

    Recent research on the implications of gut microbiota on brain functions has helped to gather important information on the relationship between them.

  21. Gut dysbiosis, defective autophagy and altered immune responses in neurodegenerative diseases: Tales of a vicious cycle

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Pharmacology & therapeutics 2021-09-16 Disease mechanisms

    The human microbiota comprises trillions of symbiotic microorganisms and is involved in regulating gastrointestinal (GI), immune, nervous system and metabolic homeostasis.

  22. Identification of Faecalibacterium prausnitzii strains for gut microbiome-based intervention in Alzheimer's-type dementia

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Cell reports. Medicine 2021-09-14 Disease mechanisms

    Evidence linking the gut-brain axis to Alzheimer's disease (AD) is accumulating, but the characteristics of causally important microbes are poorly understood.

  23. Transplantation of gut microbiota derived from Alzheimer's disease mouse model impairs memory function and neurogenesis in C57BL/6 mice

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Brain, behavior, and immunity 2021-09-06 Disease mechanisms

    Alzheimer's disease (AD) is a neurodegenerative disease that causes memory and cognitive decline.

  24. Nutrition, Gut Microbiota, and Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Frontiers in psychiatry 2021-08-05 Disease mechanisms

    Nutrition is known to play an important role in the pathogenesis of Alzheimer's disease.

  25. The Gut-Brain Axis: Literature Overview and Psychiatric Applications

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Federal practitioner : for the health care professionals of the VA, DoD, and PHS 2021-08 Disease mechanisms

    Clinicians are encouraged to consider patients' gut health when evaluating and treating psychiatric conditions, such as anxiety and depression.

  26. Fecal Microbiota Transplantation: A Microbiome Modulation Technique for Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Cureus 2021-07-20 Disease mechanisms

    Alzheimer's disease (AD) is the most common form of dementia and the fifth leading cause of death among the elderly.

  27. Chronic colitis exacerbates NLRP3-dependent neuroinflammation and cognitive impairment in middle-aged brain

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Journal of neuroinflammation 2021-07-06 Inflammation and the immune system

    Administration of DSS induced colitis, impaired spatial and recognition memory, activated microglia, and increased A1-like astrocyte numbers.

  28. The Relationship Between the Gut Microbiome and Neurodegenerative Diseases

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Neuroscience bulletin 2021-07-03 Disease mechanisms

    Many recent studies have shown that the gut microbiome plays important roles in human physiology and pathology.

  29. Western diet as a trigger of Alzheimer's disease: From metabolic syndrome and systemic inflammation to neuroinflammation and neurodegeneration

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Ageing research reviews 2021-06-30 Disease mechanisms

    An excess of saturated fatty acids and simple sugars in the diet is a known environmental risk factor of Alzheimer's disease (AD) but the holistic view of the interacting processes through which such diet may contribute to AD pathogenesis is missing.

  30. Regulation of Neurotransmitters by the Gut Microbiota and Effects on Cognition in Neurological Disorders

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Nutrients 2021-06-19 Disease mechanisms

    Emerging evidence indicates that gut microbiota is important in the regulation of brain activity and cognitive functions.

  31. The Oral-Gut-Brain AXIS: The Influence of Microbes in Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Frontiers in cellular neuroscience 2021-04-14 Disease mechanisms

    Alzheimer's disease (AD) is one of the most frequently diagnosed neurodegenerative disorders worldwide and poses a major challenge for both affected individuals and their caregivers.

  32. Microbiota-derived short chain fatty acids modulate microglia and promote Aβ plaque deposition

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. eLife 2021-04-13 Genetics

    Previous studies have identified a crucial role of the gut microbiome in modifying Alzheimer's disease (AD) progression.

  33. Does the epithelial barrier hypothesis explain the increase in allergy, autoimmunity and other chronic conditions?

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Nature reviews. Immunology 2021-04-12 Risk factors

    There has been a steep increase in allergic and autoimmune diseases, reaching epidemic proportions and now affecting more than one billion people worldwide.

  34. Periodontal dysbiosis associates with reduced CSF Aβ42 in cognitively normal elderly

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. Alzheimer's & dementia (Amsterdam, Netherlands) 2021-04-12 Tau biomarkers

    At genera and species levels, higher subgingival periodontal dysbiosis was associated with reduced CSF amyloid beta (Aβ)42 (P = 0.02 and 0.01) but not with P-tau.

  35. Mannan oligosaccharide attenuates cognitive and behavioral disorders in the 5xFAD Alzheimer's disease mouse model via regulating the gut microbiota-brain axis

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Brain, behavior, and immunity 2021-04-09 Disease mechanisms

    Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by cognitive deficits and psychiatric symptoms.

  36. Alterations in the Gut-Microbial-Inflammasome-Brain Axis in a Mouse Model of Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Cells 2021-04-01 Inflammation and the immune system

    Alzheimer's disease (AD), a progressive neurodegenerative disorder characterized by memory loss and cognitive decline, is a major cause of death and disability among the older population.

  37. The oralome and its dysbiosis: New insights into oral microbiome-host interactions

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Computational and structural biotechnology journal 2021-02-27 Disease mechanisms

    The oralome is the summary of the dynamic interactions orchestrated between the ecological community of oral microorganisms (comprised of up to approximately 1000 species of bacteria, fungi, viruses, archaea and protozoa - the oral microbiome) that live in the oral cavity and the host.

  38. Structural and Functional Dysbiosis of Fecal Microbiota in Chinese Patients With Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Frontiers in cell and developmental biology 2021-02-04 Disease mechanisms

    Increasing evidence suggests that gut dysbiosis plays vital roles in a variety of gut-brain disorders, such as Alzheimer's disease (AD).

  39. Disorders of the enteric nervous system - a holistic view

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Nature reviews. Gastroenterology & hepatology 2021-01-29 Disease mechanisms

    The enteric nervous system (ENS) is the largest division of the peripheral nervous system and closely resembles components and functions of the central nervous system.

  40. Gut Microbiome Features of Chinese Patients Newly Diagnosed with Alzheimer’s Disease or Mild Cognitive Impairment

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Journal of Alzheimer s Disease 2021-01-29 Disease mechanisms

    Although there was no difference in the microbial α-diversity among the three groups, patients with AD or MCI had increased β-diversity compared with healthy controls.

  41. Dysbiosis and Alzheimer's Disease: Cause or Treatment Opportunity?

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Cellular and molecular neurobiology 2021-01-05 Disease mechanisms

    Recent investigations have increased the interest on the connection between the microorganisms inhabiting the gut (gut microbiota) and human health.

  42. Modulation of Gut-Brain Axis by Probiotics: A Promising Anti-depressant Approach

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Current neuropharmacology 2021 Disease mechanisms

    The human digestive system is embedded with trillions of microbes of various species and genera.

  43. Probiotic Supplementation Improves Cognitive Function and Mood with Changes in Gut Microbiota in Community-Dwelling Older Adults: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial

    ✓ Peer-reviewed alzhub usefulness score 77 out of 100. The journals of gerontology. Series A, Biological sciences and medical sciences 2021-01-01 Clinical trials

    Probiotics have been proposed to ameliorate cognitive impairment and depressive disorder via the gut-brain axis in patients and experimental animal models.

  44. The role of the microbiota-gut-brain axis in neuropsychiatric disorders

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) 2021 Disease mechanisms

    The microbiota-gut-brain axis is a bidirectional signaling mechanism between the gastrointestinal tract and the central nervous system.

  45. The Gut-Brain Axis: How Microbiota and Host Inflammasome Influence Brain Physiology and Pathology

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Frontiers in immunology 2020-12-10 Inflammation and the immune system

    The human microbiota has a fundamental role in host physiology and pathology.

  46. The impact of the microbiota-gut-brain axis on Alzheimer's disease pathophysiology

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Pharmacological research 2020-11-25 Disease mechanisms

    The gut microbiota is a complex ecosystem that comprises of more than 100 trillion symbiotic microbial cells.

  47. Metabolomics analysis of microbiota-gut-brain axis in neurodegenerative and psychiatric diseases

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Journal of pharmaceutical and biomedical analysis 2020-11-21 Disease mechanisms

    Gut microbiota represents a complex physiological ecosystem that influences the host health.

  48. Sex Differences in the Gut-Brain Axis: Implications for Mental Health

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Current psychiatry reports 2020-11-20 Disease mechanisms

    The purpose of this article is to highlight how sex differences in the gut-brain axis may contribute to the discrepancies in incidence of neurodevelopmental, psychiatric, and neurodegenerative disorders between females and males.

  49. Metabolic Network Analysis Reveals Altered Bile Acid Synthesis and Metabolism in Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. Cell reports. Medicine 2020-11-17 Disease mechanisms

    Increasing evidence suggests Alzheimer's disease (AD) pathophysiology is influenced by primary and secondary bile acids, the end product of cholesterol metabolism.

  50. Associations between gut microbiota and Alzheimer's disease, major depressive disorder, and schizophrenia

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Journal of neuroinflammation 2020-10-02 Genetics

    These data for the first time provide evidence of potential causal links between gut microbiome and AD, MDD, and SCZ.

From across this tag

8 of the 273 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 8. The same 8 appear here every time.

All topic tags with their study counts