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Home › Research › Topics › microbiome

microbiome

173 studies tagged microbiome, dated 1998-01-01 to 2026-10-23. Bibliography: BibTeX (.bib) · RIS (.ris)

Newest in this topic

  1. Evidence that the perinatal maternal microbiome mediates metabolite signaling programs that drive sex-specific microglial metabolic alterations and Alzheimer’s disease susceptibility 2026-10-23
  2. Change in gut microbiome precedes symptomatic Alzheimer’s disease and is correlated with amyloid-beta accumulation in the brain 2026-10-19
  3. The microbial soy metabolite S-equol mitigates cadmium neurotoxicity in mice 2026-10-06

Studies

173 studies carry this tag.

Date range

1998 to 2026

Top journals

  • Journal of Alzheimer's disease : JAD 13
  • Scientific reports 8
  • Molecular neurobiology 5
  • bioRxiv 5
  • Aging 4

104 journals in all.

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. Evidence that the perinatal maternal microbiome mediates metabolite signaling programs that drive sex-specific microglial metabolic alterations and Alzheimer’s disease susceptibility

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. Research Square 2026-10-23 Inflammation and the immune system

    Maternal microbiome-dependent programming of neuroimmune and metabolic pathways during early development may critically shape sex-specific susceptibility to Alzheimer’s disease (AD) later in life.

  2. Change in gut microbiome precedes symptomatic Alzheimer’s disease and is correlated with amyloid-beta accumulation in the brain

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. medRxiv 2026-10-19 Disease mechanisms

    Early Ap accumulation is associated with distinct gut microbial signatures and reduced neuroactive metabolic potential, identifying targets for potential preclinical AD intervention.

  3. The microbial soy metabolite S-equol mitigates cadmium neurotoxicity in mice

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. bioRxiv 2026-10-06 Disease mechanisms

    Environmental exposures are major but understudied determinants of chronic disease.

  4. Mapping Gut Dysbiosis in Alzheimer’s using ML

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. Research Square 2026-09-30 Disease mechanisms

    Alzheimer’s disease is a progressive, currently irreversible, neurodegenerative disorder associated with the accumulation of β-Amyloid (Aβ) plaques between cells and tau (τ) tangles within cells.

  5. Gut Microbiota–Host Metabolic Networks in Alzheimer’s Disease: From Pathological Mechanisms to Modulation by Traditional Chinese Medicine

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. Authorea Preprints 2026-09-29 Disease mechanisms

    Alzheimer’s disease (AD) is a neurodegenerative disorder characterized primarily by progressive cognitive impairment.

  6. Transthyretin Contributes to Hippocampal Blood-Brain Barrier Recovery Following Intestinal Inflammation, with Reduced Expression in Alzheimer’s Disease

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. bioRxiv 2026-09-04 Disease mechanisms

    These findings identify TTR as a contributor of adaptive neurovascular homeostasis during gut-derived neuroinflammation.

  7. The Gut-Brain Axis in Alzheimer’s Disease: Microbiota as a Key Contributor to Disease Pathogenesis

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. Preprints.org 2026-08-31 Disease mechanisms

    Alzheimer’s disease (AD) is a multifactorial neurodegenerative disorder influenced by genetic, environmental, and lifestyle factors.

  8. Gut community-level analysis reveals an altered balance between Phocaeicola vulgatus and Bacteroides fragilis in Alzheimer’s disease

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. bioRxiv 2026-08-13 Disease mechanisms

    Gut microbiome differences in Alzheimer’s disease (AD) are typically cataloged taxon by taxon, yet bacterial competition and cross-feeding make species’ roles dependent on the entire community.

  9. Gut Microbial Metabolism as a Dynamic Interface in Neurodegenerative Diseases

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. Metabolites 2026-08-07 Disease mechanisms

    Gut microbial metabolites serve as functional mediators of gut–brain communication, linking microbial alterations to neurodegenerative pathology.

  10. Gut microbiota mediates the association between aging and cognitive function: evidence from a population-based Kyotango study linking diet, Bifidobacterium, and Mini-Mental State Examination (MMSE) score

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. Research Square 2026-08-04 Disease mechanisms

    Our findings provide evidence that age-related changes in the gut microbiota, particularly reductions in Bifidobacterium , partially mediate cognitive decline in older adults.

  11. The Gut-Brain Axis Mechanism in Alzheimer’s Disease: From Animal Models to Clinical Translation and Innovative Treatment Strategies

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. Preprints.org 2026-07-30 Disease mechanisms

    Research on gut microbiota in Alzheimer’s disease (AD) has progressed from observational correlations to the validation of causal relationships.

  12. The Ocular Microbiome and Alzheimer’s Disease: Emerging Insights

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. Preprints.org 2026-07-22 Disease mechanisms

    Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by amyloid-β plaques, neurofibrillary tau tangles, neuroinflammation, and progressive cognitive decline.

  13. Development of a metabolomics-based index to monitor dietary effects on chronic inflammation: The Dietary Metabolomics Inflammation Index

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. bioRxiv 2026-07-06 Prevention and risk

    DMII provides a metabolomics-based framework for assessing diet-related chronic inflammation using metabolomics data.

  14. Microplastics-Induced Gut Microbiota Dysbiosis Accelerates Alzheimer's-Like Pathology and Cognitive Decline via the Gut-Brain Axis

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026-06-15 Disease mechanisms

    Alzheimer's disease (AD) is incurable and increasingly attributed to gene-environment interactions.

  15. The gut-brain axis in Alzheimer's disease: early detection, microbial metabolites, mechanisms, and therapeutic opportunities

    ✓ Peer-reviewed alzhub usefulness score 61 out of 100. Frontiers in molecular biosciences 2026-06-04 Disease mechanisms

    Alzheimer's disease (AD), the leading cause of dementia worldwide, imposes a growing clinical and societal burden, yet no therapies have been proven to alter its progression despite decades of intensive research.

  16. Alterations of gut microbiota in Down syndrome and their association with Alzheimer’s disease

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. bioRxiv 2026-04-04 Down syndrome and Alzheimer's

    Structured Abstract INTRODUCTION Adults with Down syndrome (DS) have a higher risk of developing Alzheimer’s disease (AD).

  17. The microbiota-gut-brain axis in mild cognitive impairment and Alzheimer's disease: a scoping review of human studies

    ✓ Peer-reviewed alzhub usefulness score 77 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2026-01 Disease mechanisms

    Alzheimer's disease (AD) is projected to become the highest-burden neurological disorder globally.

  18. Microbiome-targeted Alzheimer's interventions via gut-brain axis

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Frontiers in microbiology 2025-12-05 Disease mechanisms

    Alzheimer's disease (AD) is a progressive neurodegenerative disorder with limited treatment options, underscoring the need for novel therapeutic targets.

  19. Dietary fiber modulates gut microbiota and lipid metabolism ameliorating Alzheimer's pathology in 5xFAD mice

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Scientific reports 2025-11-26 Disease mechanisms

    The gut-brain axis plays a critical role in maintaining neuronal integrity and influencing the progression of Alzheimer's disease (AD).

  20. The Gut-Brain Axis in Alzheimer's Disease: Exploring Microbial Influences and Therapeutic Strategies

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Molecular neurobiology 2025-11-24 Disease mechanisms

    Microbiota residing in the human gastrointestinal tract play a critical role in maintaining homeostasis through immune regulation, metabolic activity, and signaling to the central nervous system.

  21. The Multinutrient Fortasyn Connect Influences Gut Microbiota and Intestinal Function in Early Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. Aging and disease 2025-11-13 Disease mechanisms

    Nutritional supplementation is emerging as a promising strategy to support clinical management of early Alzheimer's disease (AD), partly through modulation of the intestinal microbiome via the microbiota-gut-brain axis.

  22. Computerized cognitive training enhances cognitive function in Alzheimer's disease by downregulating Ruminococcus-TMAO pathway

    ✓ Peer-reviewed alzhub usefulness score 79 out of 100. Journal of translational medicine 2025-10-24 Cognitive tests and assessment

    Seventy-four participants completed the study.

  23. APOE genotype and sex drive microbiome divergence after microbiome standardization in APOE-humanized mice

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. mSphere 2025-10-20 Genetics

    Previous studies in humans and humanized APOE mice have demonstrated APOE-genotype-specific differences in the GMB.

  24. Microbiota-gut-brain axis dysregulation in Alzheimer's disease and its modulation through probiotic supplementation

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Brain, behavior, and immunity 2025-10-13 Disease mechanisms

    pAD patients showed intestinal inflammation, an altered GM profile, blood changes in the tryptophan metabolism, and reduced glutamate levels compared with HC (p-value < 0.049).

  25. Microbiota-gut-brain axis and probiotics: potential therapeutic strategies for treating Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 61 out of 100. Nutritional neuroscience 2025-10-11 Disease mechanisms

    The gut-brain axis explains that changes in the intestinal microbiota influence Alzheimer's disease (AD).

  26. Gut Microbiome Alterations in Mild Cognitive Impairment: Findings from the ALBION Greek Cohort

    ✓ Peer-reviewed alzhub usefulness score 66 out of 100. Microorganisms 2025-09-10 Disease mechanisms

    Emerging evidence suggests a potential role of gut dysbiosis in neurodegenerative disorders and, in particular, Alzheimer's disease (AD) pathology and cognitive decline.

  27. Gut-brain relationship in dementia and Alzheimer's disease: Impact on stress and immunity

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Ageing research reviews 2025-07-23 Disease mechanisms

    Alzheimer's disease (AD) is increasingly recognized as a condition shaped not only by central nervous system pathology but also by complex, bidirectional interactions between the gut, brain, and immune system.

  28. Compositional and functional gut microbiota alterations in mild cognitive impairment: links to Alzheimer's disease pathology

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. Alzheimer's research & therapy 2025-05-30 Disease mechanisms

    We identified 59 key microbial species linked to MCI and AD biomarkers.

  29. Gut Microbiota and Alzheimer Disease

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Acta neurologica Taiwanica 2025-03-28 Disease mechanisms

    The hallmarks of Alzheimer's disease (AD) include brain dysfunction and the buildup of amyloid and tau proteins.

  30. The complex relationship between gut microbiota and Alzheimer's disease: A systematic review

    ✓ Peer-reviewed alzhub usefulness score 64 out of 100. Ageing research reviews 2024-12-09 Disease mechanisms

    Alzheimer's disease (AD) is a progressive, degenerative disorder of the central nervous system.

  31. Microbiota-derived lysophosphatidylcholine alleviates Alzheimer’s disease pathology via suppressing ferroptosis

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Cell Metabolism 2024-11-06 Disease mechanisms

    Alzheimer's disease (AD) is a pervasive neurodegenerative disorder, and new approaches for its prevention and therapy are critically needed.

  32. GV-971 prevents severe acute pancreatitis by remodeling the microbiota-metabolic-immune axis

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. Nature communications 2024-09-27 Disease mechanisms

    Despite recent advances, severe acute pancreatitis (SAP) remains a lethal inflammation with limited treatment options.

  33. Gut microbiota metabolites: potential therapeutic targets for Alzheimer's disease?

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Frontiers in pharmacology 2024-09-17 Disease mechanisms

    The gut microbiota plays a crucial role in the pathogenesis of AD through continuous bidirectional communication via the microbiota-gut-brain axis.

  34. Alzheimer's disease-related presenilins are key to intestinal epithelial cell function and gut immune homoeostasis

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Gut 2024-09-09 Risk genes beyond APOE

    Psen1 expression was regulated in experimental gut inflammation and in patients with IBD.

  35. Multi-omics analysis of gut-brain axis reveals novel microbial and neurotransmitter signatures in patients with arteriosclerotic cerebral small vessel disease

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Pharmacological research 2024-09-06 Disease mechanisms

    Arteriosclerotic cerebral small vessel disease (aCSVD) is a major cause of stroke and dementia.

  36. Brain-Gut and Microbiota-Gut-Brain Communication in Type-2 Diabetes Linked Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Nutrients 2024-08-03 Disease mechanisms

    The gastrointestinal (GI) tract, home to the largest microbial population in the human body, plays a crucial role in overall health through various mechanisms.

  37. Metformin-induced changes in the gut microbiome and plasma metabolome are associated with cognition in men

    ✓ Peer-reviewed alzhub usefulness score 80 out of 100. Metabolism: clinical and experimental 2024-06-12 Drug development

    Several bacterial species belonging to the Proteobacteria (Escherichia coli) and Verrucomicrobia (Akkermansia muciniphila) phyla were positively associated with metformin treatment, while bacterial species belonging to the Firmicutes phylum (Romboutsia timonensis, Romboutsia ilealis) were negatively associated.

  38. Microbiota-Gut-Brain Axis Dysregulation in Alzheimer's Disease: Multi-Pathway Effects and Therapeutic Potential

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Aging and disease 2024-05-07 Disease mechanisms

    An essential regulator of neurodegenerative conditions like Alzheimer's disease (AD) is the gut microbiota.

  39. Gut microbiota and its metabolites in Alzheimer's disease: from pathogenesis to treatment

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. PeerJ 2024-03-13 Disease mechanisms

    Regulating the gut flora ecological balance upregulates neurotrophic factor expression, regulates the microbiota-gut-brain (MGB) axis, and suppresses the inflammatory responses.

  40. Current understanding of the Alzheimer's disease-associated microbiome and therapeutic strategies

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Experimental & molecular medicine 2024-01-04 Disease mechanisms

    Alzheimer's disease (AD) is a fatal progressive neurodegenerative disease.

  41. Gut microbiota, circulating cytokines and dementia: a Mendelian randomization study

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Journal of neuroinflammation 2024-01-04 Genetics

    There were 20 positive and 16 negative causal effects between genetic liability in the gut microbiota and dementia.

  42. Gut Microbiome in Alzheimer's Disease: from Mice to Humans

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Current neuropharmacology 2024 Disease mechanisms

    Alzheimer's disease (AD) is the most prevalent type of dementia, but its etiopathogenesis is not yet fully understood.

  43. Magnesium-L-threonate treats Alzheimer's disease by modulating the microbiota-gut-brain axis

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Neural regeneration research 2023-12-21 Disease mechanisms

    JOURNAL/nrgr/04.03/01300535-202410000-00029/figure1/v/2024-02-06T055622Z/r/image-tiff Disturbances in the microbiota-gut-brain axis may contribute to the development of Alzheimer's disease.

  44. Pathways linking microbiota-gut-brain axis with neuroinflammatory mechanisms in Alzheimer's pathophysiology

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Microbiome research reports 2023-12-06 Disease mechanisms

    Disturbances in the local and peripheral immune systems are closely linked to a wide range of diseases.

  45. Microbiota from Alzheimer's patients induce deficits in cognition and hippocampal neurogenesis

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Brain : a journal of neurology 2023-12-01 Disease mechanisms

    Alzheimer's disease is a complex neurodegenerative disorder leading to a decline in cognitive function and mental health.

  46. Chiral nanoparticle-remodeled gut microbiota alleviates neurodegeneration via the gut-brain axis

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Nature aging 2023-11-09 Disease mechanisms

    Alzheimer's disease (AD) is characterized by amyloid-β accumulation in the brain and hyperphosphorylated tau aggregation, as well as neuroinflammation.

  47. Gut microbiome-targeted therapies for Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Gut microbes 2023-11-07 Disease mechanisms

    The advent of high-throughput 'omics' technologies has improved our knowledge of gut microbiome in human health and disease, including Alzheimer's disease (AD), a neurodegenerative disorder.

  48. Microbiome Alterations and Alzheimer's Disease: Modeling Strategies with Transgenic Mice

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Biomedicines 2023-06-27 Disease mechanisms

    In the last decade, the role of the microbiota-gut-brain axis has been gaining momentum in the context of many neurodegenerative and metabolic disorders, including Alzheimer's disease (AD) and diabetes, respectively.

  49. The intestinal microbiota as an ally in the treatment of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 70 out of 100. Gut microbiome (Cambridge, England) 2023-06-19 Disease mechanisms

    The evolution of the understanding of the intestinal microbiota and its influence on our organism leverages it as a potential protagonist in therapies aimed at diseases that affect not only the intestine but also neural pathways and the central nervous system itself.

  50. Gut microbiome composition may be an indicator of preclinical Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 59 out of 100. Science translational medicine 2023-06-14 Disease mechanisms

    Alzheimer's disease (AD) pathology is thought to progress from normal cognition through preclinical disease and ultimately to symptomatic AD with cognitive impairment.

From across this tag

4 of the 173 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 4. The same 4 appear here every time.

All topic tags with their study counts