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Home › Research › Topics › intestinal

intestinal

273 studies tagged intestinal, dated 1995-01-01 to 2026-10-23. Bibliography: BibTeX (.bib) · RIS (.ris)

Newest in this topic

  1. Evidence that the perinatal maternal microbiome mediates metabolite signaling programs that drive sex-specific microglial metabolic alterations and Alzheimer’s disease susceptibility 2026-10-23
  2. Change in gut microbiome precedes symptomatic Alzheimer’s disease and is correlated with amyloid-beta accumulation in the brain 2026-10-19
  3. The Gut–Liver–Brain Axis in Neurodegeneration: Unraveling Metabolic–Immune Crosstalk from Peripheral Sensing to Central Vulnerability 2026-10-08

Studies

273 studies carry this tag.

Date range

1995 to 2026

Top journals

  • Journal of Alzheimer's disease : JAD 13
  • Scientific reports 8
  • Nutrients 7
  • Brain, behavior, and immunity 6
  • Frontiers in cellular and infection microbiology 6

168 journals in all.

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. Gut mycobiome and its interaction with diet, gut bacteria and alzheimer's disease markers in subjects with mild cognitive impairment: A pilot study

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. EBioMedicine 2020-08-30 Disease mechanisms

    Compared to CN counterparts, patients with MCI have higher proportion of families Sclerotiniaceae, Phaffomyceteceae, Trichocomaceae, Cystofilobasidiaceae, Togniniaceae and genera Botrytis, Kazachstania, Phaeoacremonium and Cladosporium and lower abundance of Meyerozyma.

  2. Gut Microbiota and Dysbiosis in Alzheimer's Disease: Implications for Pathogenesis and Treatment

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Molecular neurobiology 2020-08-23 Disease mechanisms

    Understanding how gut flora influences gut-brain communications has been the subject of significant research over the past decade.

  3. The Intestinal Barrier and Current Techniques for the Assessment of Gut Permeability

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Cells 2020-08-17 Disease mechanisms

    The intestinal barrier is essential in human health and constitutes the interface between the outside and the internal milieu of the body.

  4. The Microbiome as a Modifier of Neurodegenerative Disease Risk

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Cell host & microbe 2020-08-01 Disease mechanisms

    The gut microbiome is increasingly implicated in modifying susceptibility to and progression of neurodegenerative diseases (NDs).

  5. Gut dysbiosis contributes to amyloid pathology, associated with C/EBPβ/AEP signaling activation in Alzheimer's disease mouse model

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Science advances 2020-07-29 Disease mechanisms

    The gut-brain axis is bidirectional, and gut microbiota influence brain disorders including Alzheimer's disease (AD).

  6. Dysbiosis, gut barrier dysfunction and inflammation in dementia: a pilot study

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. BMC Geriatrics 2020-07-20 Disease mechanisms

    Dementia was associated with dysbiosis characterized by differences in beta diversity and changes in taxonomic composition.

  7. The Gut Microbiome as a Component of the Gut-Brain Axis in Cognitive Health

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Biological research for nursing 2020-07-17 Disease mechanisms

    Common themes in the current literature include GMB components; interactions on cognitive development; effects of GMB-gut-brain interactions on cognition, mild cognitive impairment and Alzheimer's disease; effects of GMB interactions with physiologic stress on cognition in critical care; and GMB modification for improved cognition.

  8. Gut Microbiota: Implications in Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Journal of clinical medicine 2020-06-29 Disease mechanisms

    Alzheimer's disease (AD), the most common cause of dementia, is a neurodegenerative disease that seriously threatens human health and life quality.

  9. Inflammatory bowel disease is associated with higher dementia risk: a nationwide longitudinal study

    ✓ Peer-reviewed alzhub usefulness score 69 out of 100. Gut 2020-06-23 Disease mechanisms

    This population-based cohort study demonstrates significant association between IBD and subsequent development of dementia.

  10. Opioid system influences gut-brain axis: Dysbiosis and related alterations

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Pharmacological research 2020-06-03 Disease mechanisms

    Opioid drugs are widely used to treat chronic pain, but their misuse can lead to tolerance, dependence, and addiction and have created a significant public health problem.

  11. Rapid improvement in Alzheimer's disease symptoms following fecal microbiota transplantation: a case report

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. The Journal of international medical research 2020-06-01 Disease mechanisms

    Alzheimer's disease (AD), the most common form of dementia, is a leading cause of death and a major cause of morbidity in older people.

  12. Microbiota-gut-brain axis in health and disease: Is NLRP3 inflammasome at the crossroads of microbiota-gut-brain communications?

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Progress in neurobiology 2020-05-28 Disease mechanisms

    Growing evidence highlights the relevance of microbiota-gut-brain axis in the maintenance of brain homeostasis as well as in the pathophysiology of major neurological and psychiatric disorders, including Parkinson's disease (PD), Alzheimer's disease (AD), multiple sclerosis (MS), autism spectrum disorder (ASD) and major depressive disorder (MDD).

  13. The Role of the Gastrointestinal Mucus System in Intestinal Homeostasis: Implications for Neurological Disorders

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Frontiers in cellular and infection microbiology 2020-05-28 Disease mechanisms

    Mucus is integral to gut health and its properties may be affected in neurological disease.

  14. Therapeutic effect of GLP-1 engineered strain on mice model of Alzheimer's disease and Parkinson's disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. AMB Express 2020-04-24 Drug development

    Alzheimer's disease (AD) and Parkinson's disease (PD) are neurodegenerative diseases (NDD) characterized by progressive degeneration of the central nervous system, and few medications are available to halt the progression of AD and PD.

  15. Protective effects of Akkermansia muciniphila on cognitive deficits and amyloid pathology in a mouse model of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Nutrition & diabetes 2020-04-22 Disease mechanisms

    Akk effectively improved glucose tolerance, intestine barrier dysfunction and dyslipidemia in AD model mice.

  16. Fecal Microbiota Transplantation in Neurological Disorders

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Frontiers in cellular and infection microbiology 2020-03-24 Disease mechanisms

    Of 541 identified studies, 34 were included in the analysis.

  17. Gut microbiota and pro/prebiotics in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Aging 2020-03-19 Disease mechanisms

    Alzheimer's disease is characterized by the accumulation of amyloid and dysfunctional tau protein in the brain along with the final development of dementia.

  18. The Links Between the Gut Microbiome, Aging, Modern Lifestyle and Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Frontiers in cellular and infection microbiology 2020-03-18 Disease mechanisms

    Gut microbiome is a community of microorganisms in the gastrointestinal tract.

  19. New mechanism of neuroinflammation in Alzheimer's disease: The activation of NLRP3 inflammasome mediated by gut microbiota

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Progress in neuro-psychopharmacology & biological psychiatry 2020-02-04 Disease mechanisms

    Alzheimer's disease (AD) is a central degenerative disease characterized by cognitive impairment.

  20. The progress of gut microbiome research related to brain disorders

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Journal of neuroinflammation 2020-01-17 Disease mechanisms

    There is increasing evidence showing that the dynamic changes in the gut microbiota can alter brain physiology and behavior.

  21. CircNF1-419 improves the gut microbiome structure and function in AD-like mice

    ⚠ Retracted — do not rely on it alzhub usefulness score 12 out of 100. Aging 2020-01-06 Disease mechanisms

    Our pre-experiments found that the brain circRNA sequence profiles and gut microbiota in AD-like mice were changed, as circNF1-419 could enhance autophagy to ameliorate senile dementia in AD-like mice, so we conclude that there might some connections between circRNA and gut microbiome.

  22. Clinical and Bacterial Markers of Periodontitis and Their Association with Incident All-Cause and Alzheimer's Disease Dementia in a Large National Survey

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. Journal of Alzheimer's disease : JAD 2020-01-01 Costs and economics

    Microbial agents including periodontal pathogens have recently appeared as important actors in Alzheimer's disease (AD) pathology.

  23. Dysfunction of the Microbiota-Gut-Brain Axis in Neurodegenerative Disease: The Promise of Therapeutic Modulation With Prebiotics, Medicinal Herbs, Probiotics, and Synbiotics

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. Journal of Evidence-Based Integrative Medicine 2020-01-01 Disease mechanisms

    Recent data suggest gut microbiota dysbiosis as a contributing factor in neurodegenerative diseases, such as Parkinson's Disease (PD) and Alzheimer's Disease (AD), and these pathologies may manifest via the microbiota-gut-brain-axis, which comprises bidirectional communication through neuroimmune, neuroendocrine, and direct neural pathways such as the vagus nerve.

  24. Healthy Gut, Healthy Brain: The Gut Microbiome in Neurodegenerative Disorders

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Current topics in medicinal chemistry 2020 Disease mechanisms

    In the first part, we introduce the GBA and its relevance, followed by the changes occurring in the GBA during neurodegenerative disorders and then further discuss its role in the pathogenesis of these diseases.

  25. Investigation of Potential Brain Microbiome in Alzheimer's Disease: Implications of Study Bias

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Journal of Alzheimer's disease : JAD 2020 Disease mechanisms

    In both cohorts, few differences between the control and AD groups were observed in terms of alpha and beta diversities, phyla and genera proportions.

  26. Short-Chain Fatty Acids and Lipopolysaccharide as Mediators Between Gut Dysbiosis and Amyloid Pathology in Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Journal of Alzheimer's disease : JAD 2020-01-01 Brain scans and imaging

    We report a novel association between gut microbiota-related products and systemic inflammation with brain amyloidosis via endothelial dysfunction, suggesting that SCFAs and LPS represent candidate pathophysiologic links between the gut microbiota and AD pathology.

  27. Effect of Clostridium butyricum against Microglia-Mediated Neuroinflammation in Alzheimer's Disease via Regulating Gut Microbiota and Metabolites Butyrate

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Molecular nutrition & food research 2019-12-23 Disease mechanisms

    Scope Recent evidences demonstrate that abnormal gut microbiota (GM) might be involved in the pathogenesis of Alzheimer's disease (AD).

  28. The microbiome-gut-brain axis in acute and chronic brain diseases

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Current opinion in neurobiology 2019-12-06 Disease mechanisms

    The gut microbiome - the largest reservoir of microorganisms of the human body - is emerging as an important player in neurodevelopment and ageing as well as in brain diseases including stroke, Alzheimer's disease and Parkinson's disease.

  29. Modification of the gut microbiome to combat neurodegeneration

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Reviews in the neurosciences 2019-11-26 Disease mechanisms

    The gut microbiome was extensively researched for its biological variety and its potential role in propagating diseases outside of the gastrointestinal (GI) tract.

  30. The gut microbiome in neurological disorders

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. The Lancet. Neurology 2019-11-18 Disease mechanisms

    Research into the role of the gut microbiome in modulating brain function has rapidly increased over the past 10 years, albeit chiefly in animal models.

  31. Microbiota-gut-brain axis and toll-like receptors in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Computational and structural biotechnology journal 2019-10-24 Disease mechanisms

    Alzheimer's disease (AD) is a multifactorial disease which involves both the periphery and central nervous system (CNS).

  32. Exercise, diet and stress as modulators of gut microbiota: Implications for neurodegenerative diseases

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Neurobiology of disease 2019-10-16 Disease mechanisms

    The last decade has witnessed an exponentially growing interest in gut microbiota and the gut-brain axis in health and disease.

  33. The Microbiota-Gut-Brain Axis

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Physiological reviews 2019-10-01 Risk factors

    The importance of the gut-brain axis in maintaining homeostasis has long been appreciated.

  34. Time to test antibacterial therapy in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Brain : a journal of neurology 2019-10-01 Treatments

    Alzheimer's disease is associated with cerebral accumulation of amyloid-β peptide and hyperphosphorylated tau.

  35. Nutrition and immunology in mental health: Precision medicine and integrative approaches to address unmet clinical needs in psychiatric treatments

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. Brain, behavior, and immunity 2019-09-27 Prevention and risk

    The 'monoamine hypothesis' is insufficient in approaching the aetiology of psychiatric disorders or in developing novel therapies.

  36. Microbiome Influence in the Pathogenesis of Prion and Alzheimer's Diseases

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. International journal of molecular sciences 2019-09-23 Disease mechanisms

    Misfolded and abnormal β-sheets forms of wild-type proteins, such as cellular prion protein (PrPC) and amyloid beta (Aβ), are believed to be the vectors of neurodegenerative diseases, prion and Alzheimer's disease (AD), respectively.

  37. Regulation of Gut Microbiota and Metabolic Endotoxemia with Dietary Factors

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Nutrients 2019-09-23 Disease mechanisms

    Metabolic endotoxemia is a condition in which blood lipopolysaccharide (LPS) levels are elevated, regardless of the presence of obvious infection.

  38. The endotoxin hypothesis of neurodegeneration

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Journal of neuroinflammation 2019-09-13 Disease mechanisms

    The endotoxin hypothesis of neurodegeneration is the hypothesis that endotoxin causes or contributes to neurodegeneration.

  39. Modified Mediterranean-ketogenic diet modulates gut microbiome and short-chain fatty acids in association with Alzheimer's disease markers in subjects with mild cognitive impairment

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. EBioMedicine 2019-08-30 Biomarkers

    At baseline, subjects with normal vs. impaired cognition show no notable difference in microbiome diversity but several unique microbial signatures are detected in subjects with mild cognitive impairment.

  40. Transfer of a healthy microbiota reduces amyloid and tau pathology in an Alzheimer's disease animal model

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Gut 2019-08-30 Disease mechanisms

    These results indicate that microbiota-mediated intestinal and systemic immune aberrations contribute to the pathogenesis of AD in ADLP APT mice, providing new insights into the relationship between the gut (colonic gene expression, gut permeability), blood (blood immune cell population) and brain (pathology) axis and AD (memory deficits).

  41. Suppression of gut dysbiosis by Bifidobacterium longum alleviates cognitive decline in 5XFAD transgenic and aged mice

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Scientific Reports 2019-08-14 Disease mechanisms

    To understand the role of commensal gut bacteria on the progression of cognitive decline in Alzheimer’s disease via the microbiota-gut-brain axis, we isolated anti-inflammatory Bifidobacterium longum (NK46) from human gut microbiota, which potently inhibited gut microbiota endotoxin production and suppressed NF-κB activation in lipopolysaccharide (LPS)-stimulated BV-2 cells, and examined whether NK46 could simultaneously alleviate gut dysbiosis and cognitive decline in male 5xFAD-transgenic (5XFAD-Tg, 6 months-old) and aged (18 months-old) mice.

  42. New treatment modalities in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. World journal of clinical cases 2019-07-26 Drug development

    Alzheimer's disease (AD) is still a major public health challenge without an effective treatment to prevent or stop it.

  43. Microorganisms, Tryptophan Metabolism, and Kynurenine Pathway: A Complex Interconnected Loop Influencing Human Health Status

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. International journal of tryptophan research : IJTR 2019-06-19 Disease mechanisms

    The kynurenine pathway is important in cellular energy generation and limiting cellular ageing as it degrades about 90% of dietary tryptophan into the essential co-factor NAD + (nicotinamide adenine dinucleotide).

  44. Antibiotics, gut microbiota, and Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Journal of neuroinflammation 2019-05-22 Disease mechanisms

    Alzheimer's disease (AD) is a neurodegenerative disease whose various pathophysiological aspects are still being investigated.

  45. The role of gut microbiota in pathogenesis of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Journal of applied microbiology 2019-04-15 Disease mechanisms

    This paper describes the effects of the gut microbiota on the pathogenesis of Alzheimer's pathology by evaluating the current original key findings and identifying gaps in the knowledge required for validation.

  46. APOE genotype influences the gut microbiome structure and function in humans and mice: relevance for Alzheimer's disease pathophysiology

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019-04-08 Disease mechanisms

    Apolipoprotein E ( APOE ) genotype is the strongest prevalent genetic risk factor for Alzheimer's disease (AD).

  47. Fructooligosaccharides Ameliorating Cognitive Deficits and Neurodegeneration in APP/PS1 Transgenic Mice through Modulating Gut Microbiota

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Journal of agricultural and food chemistry 2019-02-28 Drug development

    Alzheimer's disease (AD) is closely related to gut microbial alteration.

  48. Psychobiotics in mental health, neurodegenerative and neurodevelopmental disorders

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Journal of food and drug analysis 2019-02-10 Disease mechanisms

    Psychobiotics are a group of probiotics that affect the central nervous system (CNS) related functions and behaviors mediated by the gut-brain-axis (GBA) via immune, humoral, neural, and metabolic pathways to improve not only the gastrointestinal (GI) function but also the antidepressant and anxiolytic capacity.

  49. The role of the gut microbiota in development, function and disorders of the central nervous system and the enteric nervous system

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Journal of neuroendocrinology 2019-02-01 Disease mechanisms

    The gut microbiota has emerged as an environmental factor that modulates the development of the central nervous system (CNS) and the enteric nervous system (ENS).

  50. Porphyromonas gingivalis in Alzheimer's disease brains: Evidence for disease causation and treatment with small-molecule inhibitors

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Science advances 2019-01-23 Inflammation and the immune system

    Porphyromonas gingivalis , the keystone pathogen in chronic periodontitis, was identified in the brain of Alzheimer's disease patients.

From across this tag

7 of the 273 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 7. The same 7 appear here every time.

All topic tags with their study counts