Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
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Albiglutide, dulaglutide, exenatide, liraglutide, lixisenatide, orforglipron and semaglutide are glucagon-like peptide‑1 (GLP-1) receptor agonists.
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The funding showed that APP/PS1 mice have learning and memory impairment, and the glymphatic system is dysfunction.
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Synaptic plasticity impairment and behavioral deficits constitute classical pathological hallmarks in early-stage Alzheimer's disease (AD).
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The gut microbiota, consisting of trillions of microorganisms, plays a critical role in regulating host physiology, including metabolism, immune responses, and brain function.
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A high-fat diet (HFD) induces obesity and insulin resistance, which may exacerbate amyloid-β peptide (Aβ) pathology during Alzheimer's disease (AD) progression.
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The physiological actions of a gut hormone, glucagon-like peptide-1 (GLP-1), in Alzheimer's disease (AD) brain remain poorly understood, although GLP-1 receptor (GLP-1R) expression in this organ has been shown in several experimental studies.
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Alzheimer's disease (AD) is the most common neurodegenerative disease, characterized by memory loss, speech and motor defects, personality changes, and psychological disorders.
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Neurodegenerative diseases are severe, age-related conditions with complex etiologies that result in significant morbidity and mortality.
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43/100
The neurotoxicant trimethyltin (TMT) triggers cognitive impairment and hippocampal neurodegeneration.
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Behavioral analyses on APP/PS1 mice demonstrated that Semaglutide improved the cognitive capabilities, particularly in the learning and memory domains.
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Parkinson's disease (PD) is a prevalent neurodegenerative disease in which treatment often includes an exercise regimen.
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Microbes have inhabited the earth for hundreds of millions of years longer than humans.
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Obstructive sleep apnea (OSA) is a common clinical condition linked to cognitive impairment, mainly characterized by chronic intermittent hypoxia (CIH).
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The gut microbiota plays a crucial role in the pathogenesis of AD through continuous bidirectional communication via the microbiota-gut-brain axis.
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Psen1 expression was regulated in experimental gut inflammation and in patients with IBD.
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Arteriosclerotic cerebral small vessel disease (aCSVD) is a major cause of stroke and dementia.
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Semaglutide reduced body weight and improved glucose tolerance in 12-month-old male and female 5XFAD and APP/PS1 mice, consistent with pharmacological engagement of the GLP-1R. Nevertheless, amyloid plaque density was not different in the cerebral cortex, hippocampus, or subiculum of semaglutide-treated 12-month-old 5XFAD and APP/PS1 mice.
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43/100
The gastrointestinal (GI) tract, home to the largest microbial population in the human body, plays a crucial role in overall health through various mechanisms.
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Glucagon-like peptide-1 (GLP-1)-based drugs have been approved by the United States Food and Drug Administration (FDA) and are widely used to treat type 2 diabetes mellitus (T2DM) and obesity.
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Diabetes mellitus (DM) and Alzheimer's disease (AD) are two major health concerns that have seen a rising prevalence worldwide.
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One of the most challenging and controversial issues in microbiome research is related to gut microbial metabolism and neuropsychological disorders.
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There is growing evidence showing that adiponectin (APN) can improve Alzheimer's disease(AD)-like pathological changes by improving insulin resistance.
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An essential regulator of neurodegenerative conditions like Alzheimer's disease (AD) is the gut microbiota.
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Amylin is a systemic neuroendocrine hormone co-expressed and co-secreted with insulin by pancreatic β-cells.
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Alzheimer's disease is a progressive neurodegenerative disorder and the most common cause of dementia that principally affects older adults.
From across this topic
10 of the 1,048 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- The Role of Inflammation in Age-Related Sarcopenia
- Investigation of Potential Brain Microbiome in Alzheimer's Disease: Implications of Study Bias
- Constraint Based Metabolic Modeling Identifies Robust Biomarkers and Therapeutic Target Combinations in Alzheimer Disease
- Modified Mediterranean-ketogenic diet modulates gut microbiome and short-chain fatty acids in association with Alzheimer's disease markers in subjects with mild cognitive impairment
- Potential neuroprotective properties of epigallocatechin-3-gallate (EGCG)
- Insulin as a Bridge between Type 2 Diabetes and Alzheimer Disease - How Anti-Diabetics Could be a Solution for Dementia
- Effect of Clostridium butyricum against Microglia-Mediated Neuroinflammation in Alzheimer's Disease via Regulating Gut Microbiota and Metabolites Butyrate
- Protective effects of Akkermansia muciniphila on cognitive deficits and amyloid pathology in a mouse model of Alzheimer's disease
- Why pleiotropic interventions are needed for Alzheimer's disease
- The diabetes drug liraglutide ameliorates aberrant insulin receptor localisation and signalling in parallel with decreasing both amyloid-β plaque and glial pathology in a mouse model of Alzheimer's disease