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Mediterranean Diet, Alzheimer Disease, and Vascular Mediation
Nikolaos Scarmeas, Yaakov Stern, Richard P Mayeux, Jose Alejandro Luchsinger. Archives of Neurology, 2006-10-10
Topic: Gut, metabolism and diet
Higher adherence to the MeDi was associated with lower risk for AD (odds ratio, 0.76; 95% confidence interval, 0.67-0.87; P<.001). Compared with subjects in the lowest MeDi tertile, subjects in the middle MeDi tertile had an odds ratio of 0.47 (95% confidence interval, 0.29-0.76) and those at the highest tertile an odds ratio of 0.32 (95% confidence interval, 0.17-0.59) for AD (P for trend <.001). Introduction of the vascular variables in the model did not change the magnitude of the association. We note once more that higher adherence to the MeDi is associated with a reduced risk for AD. The association does not seem to be mediated by vascular comorbidity. This could be the result of either other biological mechanisms (oxidative or inflammatory) being implicated or measurement error of the vascular variables.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Scarmeas, N., Stern, Y., Mayeux, R. P., & Luchsinger, J. A. (2006). Mediterranean Diet, Alzheimer Disease, and Vascular Mediation. Archives of Neurology. https://doi.org/10.1001/archneur.63.12.noc60109
Vancouver
Scarmeas N, Stern Y, Mayeux RP, Luchsinger JA. Mediterranean Diet, Alzheimer Disease, and Vascular Mediation. Archives of Neurology. 2006. doi:10.1001/archneur.63.12.noc60109. PMID: 17030648.
BibTeX
@article{scarmeas2006-17030648,
author = {Scarmeas, Nikolaos and Stern, Yaakov and Mayeux, Richard P and Luchsinger, Jose Alejandro},
title = {{Mediterranean Diet, Alzheimer Disease, and Vascular Mediation}},
journal = {Archives of Neurology},
year = {2006},
doi = {10.1001/archneur.63.12.noc60109},
pmid = {17030648},
url = {https://doi.org/10.1001/archneur.63.12.noc60109}
}
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Key findings
- Higher adherence to the MeDi was associated with lower risk for AD (odds ratio, 0.76; 95% confidence interval, 0.67-0.87; P<.001).
- Compared with subjects in the lowest MeDi tertile, subjects in the middle MeDi tertile had an odds ratio of 0.47 (95% confidence interval, 0.29-0.76) and those at the highest tertile an odds ratio of 0.32 (95% confidence interval, 0.17-0.59) for AD (P for trend <.001).
- Introduction of the vascular variables in the model did not change the magnitude of the association.
- We note once more that higher adherence to the MeDi is associated with a reduced risk for AD.
- The association does not seem to be mediated by vascular comorbidity.
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Study details
- Study designcase-control study
- Participants194
- Evidence strengthModerate
How this study scored 62/100
Published in a peer-reviewed journal, and it is a case-control study. Scored zero for effect reported and randomized / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multicenter collaboration, so those were left out: it earned 36 of the 58 points we could judge it on, which is 62 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Archives of Neurology) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 6 / 12 | A case-control study |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2006 — older than 20 years, still counted |
| Sample size | 2 / 4 | 194 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multicenter collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 17030648) |
| Free to read | 2 / 2 | Free to read |
| Points | 36 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 36 of the 58 points we could judge it on is 62 out of 100. |
| Total | 62 / 100 | — |
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