Get help now — free helplines

You can call any of these for free. You do not need a diagnosis, an appointment, or a crisis to call — questions and plain exhaustion are reasons enough.

  • Alzheimer's Association 24/7 Helpline 800-272-3900 24 hours a day, 365 days a year Free, confidential support and information for people with dementia, caregivers, families and the public. Master's-level clinicians. Also Spanish.
  • 988 Suicide & Crisis Lifeline 988 24/7 Call or text 988, or chat at 988lifeline.org. For anyone in emotional distress or a mental-health crisis, including caregivers.
  • Alzheimer's Foundation of America (AFA) Helpline 866-232-8484 9:00 am - 9:00 pm ET, seven days a week Licensed social workers providing support, info and referrals. Also text message and web chat. Text: 646-586-5283

In a medical emergency, call 911. More numbers, and what each line does, on the help page.

Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.

Highest usefulness score first. Studies without a score come last.

  1. Can Alzheimer's Disease Be Secondary to Type-2 Diabetes Mellitus?

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Cureus 2022-11-08 Risk factors

    Alzheimer's disease and insulin resistance are prevalent in older adults.

  2. Diet in the Prevention of Alzheimer's Disease: Current Knowledge and Future Research Requirements

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Nutrients 2022-10-30 Prevention and risk

    Alzheimer's disease is a progressive brain disease that is becoming a major health problem in today's world due to the aging population.

  3. Microbiome in Anxiety and Other Psychiatric Disorders

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. The Medical clinics of North America 2022-10-28 Disease mechanisms

    Initial studies suggested that the fluctuations in the quantity, variety, and composition of the gut microbiota can significantly affect disease processes.

  4. Dietary supplements in neurological diseases and brain aging

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Journal of preventive medicine and hygiene 2022-10-17 Prevention and risk

    A healthy diet shapes a healthy mind. Diet quality has a strong association with brain health.

  5. The emerging role of the microbiome in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. International review of neurobiology 2022-10-13 Disease mechanisms

    Alzheimer's disease (AD) is the most prevalent form of dementia and can be influenced by genetic and environmental factors.

  6. A Pathophysiological Intersection of Diabetes and Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. International journal of molecular sciences 2022-09-30 Risk factors

    Diabetes is among the most prevalent diseases of the modern world and is strongly linked to an increased risk of numerous neurodegenerative disorders, although the exact pathophysiological mechanisms are not clear yet.

  7. Enteric nervous system and intestinal epithelial regulation of the gut-brain axis

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. The Journal of allergy and clinical immunology 2022-09 Disease mechanisms

    The gut-brain axis describes a bidirectional interplay within the enteric environment between the intestinal epithelium, the mucosal immune system, and the microbiota with the enteric nervous system.

  8. Diet, Gut Microbiome, and Cognitive Decline

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Current nutrition reports 2022-08-26 Disease mechanisms

    An epidemic of age-associated cognitive decline, most commonly ascribed to neurodegenerative conditions such as Alzheimer's and Parkinson's disease, is causing healthcare costs to soar and devastating caregivers.

  9. Anti-Inflammatory Effects of GLP-1 Receptor Activation in the Brain in Neurodegenerative Diseases

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. International journal of molecular sciences 2022-08-24 Drug development

    The glucagon-like peptide-1 (GLP-1) is a pleiotropic hormone well known for its incretin effect in the glucose-dependent stimulation of insulin secretion.

  10. Liraglutide reduces oxidative stress and improves energy metabolism in methylglyoxal-induced SH-SY5Y cells

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Neurotoxicology 2022-08-17 Drug development

    Diabetes mellitus can result in severe complications, such as neurodegenerative diseases including cognitive impairment and dementia.

  11. Trans-Anethole Alleviates Trimethyltin Chloride-Induced Impairments in Long-Term Potentiation

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Pharmaceutics 2022-07-06 Disease mechanisms

    Trans-anethole is an aromatic compound that has been studied for its anti-inflammation, anticonvulsant, antinociceptive, and anticancer effects.

  12. Signal pathways in the treatment of Alzheimer's disease with traditional Chinese medicine

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022-05-31 Disease mechanisms

    TCM could modulate signal pathways related to AD pathological progression, including NF-κB, Nrf2, JAK/STAT, ubiquitin-proteasome pathway, autophagy-lysosome pathway-related AMPK/mTOR, GSK-3/mTOR, and PI3K/Akt/mTOR, as well as SIRT1 and PPARα pathway.

  13. The Role of Microbiome in Brain Development and Neurodegenerative Diseases

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Molecules (Basel, Switzerland) 2022-05-25 Disease mechanisms

    Hundreds of billions of commensal microorganisms live in and on our bodies, most of which colonize the gut shortly after birth and stay there for the rest of our lives.

  14. A Review of ApoE4 Interference Targeting Mitophagy Molecular Pathways for Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Frontiers in aging neuroscience 2022-05-20 Genetics

    Alzheimer's disease (AD) is one of the major worldwide causes of dementia that is characterized by irreversible decline in learning, memory loss, and behavioral impairments.

  15. Biological mechanisms and possible primary prevention of depression

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. World journal of psychiatry 2022-05-19 Prevention and risk

    Individuals with unipolar depressive disorder (UDD) are having an increased risk of death and development of dementia in later life.

  16. Microbiota-gut-brain axis in the Alzheimer's disease pathology - an overview

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Neuroscience research 2022-05-14 Disease mechanisms

    Alzheimer's disease (AD) and related dementias (ADRD) are still a serious global public health concern more than a century after the German neuropathologist and psychiatrist Dr. Aloysius Alzheimer described the first case.

  17. Linking circadian rhythms to microbiome-gut-brain axis in aging-associated neurodegenerative diseases

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Ageing research reviews 2022-04-08 Disease mechanisms

    Emerging evidence suggests that both disruption of circadian rhythms and gut dysbiosis are closely related to aging-associated neurodegenerative diseases.

  18. Oleuropein-Rich Olive Leaf Extract Attenuates Neuroinflammation in the Alzheimer's Disease Mouse Model

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. ACS chemical neuroscience 2022-03-09 Inflammation and the immune system

    Alzheimer's disease (AD) is the most common form of dementia among several neurodegenerative disorders afflicting the elderly.

  19. Metformin in aging and aging-related diseases: clinical applications and relevant mechanisms

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Theranostics 2022-03-06 Drug development

    Aging is a natural process, which plays a critical role in the pathogenesis of a variety of diseases, i.e., aging-related diseases, such as diabetes, osteoarthritis, Alzheimer disease, cardiovascular diseases, cancers, obesity and other metabolic abnormalities.

  20. Metabolites of soil microorganisms modulate amyloid β production in Alzheimer's neurons

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Scientific reports 2022-03-02 Biomarkers

    Microbial flora is investigated to be related with neuropathological conditions in Alzheimer's disease (AD), and is attracting attention as a drug discovery resource.

  21. Diabetes: Risk factor and translational therapeutic implications for Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. The European journal of neuroscience 2022-02-23 Drug development

    Type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD) commonly co-occur.

  22. Glucagon-Like Peptide 1 Receptor Agonists - Potential Game Changers in the Treatment of Glaucoma?

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Frontiers in neuroscience 2022-02-21 Drug development

    Glaucoma is a common ocular neurodegenerative disease characterized by the progressive loss of retinal ganglion cells and their axons.

  23. Metformin in Alzheimer's disease: An overview of potential mechanisms, preclinical and clinical findings

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Biochemical pharmacology 2022-02-05 Drug development

    Alzheimer's disease (AD) is the most common neurodegenerative disorder worldwide.

  24. Effects of Glucagon-like peptide 1 (GLP-1) analogs in the hippocampus

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Vitamins and hormones 2022-02-04 Drug development

    The glucagon-like peptide-1 (GLP-1) is a pleiotropic hormone very well known for its incretin effect in the glucose-dependent stimulation of insulin secretion.

  25. Deciphering the Roles of Metformin in Alzheimer's Disease: A Snapshot

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Frontiers in pharmacology 2022-01-27 Drug development

    Alzheimer's disease (AD) is a prevalent neurodegenerative disease predominantly affecting millions of elderly people.

From across this topic

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