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You can call any of these for free. You do not need a diagnosis, an appointment, or a crisis to call — questions and plain exhaustion are reasons enough.

  • Alzheimer's Association 24/7 Helpline 800-272-3900 24 hours a day, 365 days a year Free, confidential support and information for people with dementia, caregivers, families and the public. Master's-level clinicians. Also Spanish.
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  • Alzheimer's Foundation of America (AFA) Helpline 866-232-8484 9:00 am - 9:00 pm ET, seven days a week Licensed social workers providing support, info and referrals. Also text message and web chat. Text: 646-586-5283

In a medical emergency, call 911. More numbers, and what each line does, on the help page.

Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.

Highest usefulness score first. Studies without a score come last.

  1. Brain-derived neurotrophic factor and its clinical implications

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Archives of medical science : AMS 2015-12-11 Risk factors

    Brain-derived neurotrophic factor (BDNF) plays an important role in neuronal survival and growth, serves as a neurotransmitter modulator, and participates in neuronal plasticity, which is essential for learning and memory.

  2. The Role of Oxidative Stress in Neurodegenerative Diseases

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Experimental neurobiology 2015-10-12 Disease mechanisms

    Oxidative stress is induced by an imbalanced redox states, involving either excessive generation of reactive oxygen species (ROS) or dysfunction of the antioxidant system.

  3. Neuroprotective Effects of Clostridium butyricum against Vascular Dementia in Mice via Metabolic Butyrate

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. BioMed research international 2015-10-07 Disease mechanisms

    Probiotics actively participate in neuropsychiatric disorders.

  4. Magnesium in Prevention and Therapy

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Nutrients 2015-09-23 Risk factors

    Magnesium is the fourth most abundant mineral in the body.

  5. Exenatide reduces TNF-α expression and improves hippocampal neuron numbers and memory in streptozotocin treated rats

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. European journal of pharmacology 2015-09-16 Drug development

    Recent studies suggest a possible link between type 2 diabetes and Alzheimer's disease (AD).

  6. Protective Effects of Physical Exercise in Alzheimer's Disease and Parkinson's Disease: A Narrative Review

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Journal of clinical neurology (Seoul, Korea) 2015-07-01 Prevention trials

    Alzheimer's disease (AD) and Parkinson's disease (PD) are devastating, frequent, and still incurable neurodegenerative diseases that manifest as cognitive and motor disorders.

  7. Long-chain omega-3 fatty acids and the brain: a review of the independent and shared effects of EPA, DPA and DHA

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Frontiers in aging neuroscience 2015-04-21 Prevention and risk

    Omega-3 polyunsaturated fatty acids (PUFAs) exhibit neuroprotective properties and represent a potential treatment for a variety of neurodegenerative and neurological disorders.

  8. Link between type 2 diabetes and Alzheimer's disease: from epidemiology to mechanism and treatment

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Clinical interventions in aging 2015-03-10 Drug development

    The aim of this paper is to provide a comprehensive review of the epidemiological evidence linking type 2 diabetes mellitus and its related conditions, including obesity, hyperinsulinemia, and metabolic syndrome, to Alzheimer's disease (AD).

  9. Cholesterol metabolism and homeostasis in the brain

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Protein & cell 2015-02-15 Vascular contributions

    Cholesterol is an essential component for neuronal physiology not only during development stage but also in the adult life.

  10. Edible mushrooms: improving human health and promoting quality life

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. International journal of microbiology 2015-01-20 Prevention and risk

    Mushrooms have been consumed since earliest history; ancient Greeks believed that mushrooms provided strength for warriors in battle, and the Romans perceived them as the "Food of the Gods."

  11. Crosstalk between advanced glycation end products (AGEs)-receptor RAGE axis and dipeptidyl peptidase-4-incretin system in diabetic vascular complications

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Cardiovascular diabetology 2015-01-13 Drug development

    Advanced glycation end products (AGEs) consist of heterogenous group of macroprotein derivatives, which are formed by non-enzymatic reaction between reducing sugars and amino groups of proteins, lipids and nucleic acids, and whose process has progressed at an accelerated rate under diabetes.

  12. Improved serum leptin and ghrelin following bariatric surgery predict better postoperative cognitive function

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Journal of clinical neurology (Seoul, Korea) 2015-01-02 Cognitive tests and assessment

    Improvements in leptin and ghrelin levels following bariatric surgery appear to contribute to postoperative cognitive benefits.

  13. Wilson's disease and other neurological copper disorders

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. The Lancet. Neurology 2015-01-01 Risk genes beyond APOE

    The copper metabolism disorder Wilson's disease was first defined in 1912.

  14. The GLP-1 Receptor Agonist Liraglutide Improves Memory Function and Increases Hippocampal CA1 Neuronal Numbers in a Senescence-Accelerated Mouse Model of Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Journal of Alzheimer's disease : JAD 2015-01-01 Drug development

    Recent studies indicate that glucagon-like peptide 1 (GLP-1) receptor agonists, currently used in the management of type 2 diabetes, exhibit neurotrophic and neuroprotective effects in amyloid-β (Aβ) toxicity models of Alzheimer's disease (AD).

  15. New concepts in nutraceuticals as alternative for pharmaceuticals

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. International journal of preventive medicine 2014-12-01 Brain scans and imaging

    Nutraceuticals are products, which other than nutrition are also used as medicine.

  16. The role of iron in brain ageing and neurodegenerative disorders

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. The Lancet. Neurology 2014-10-01 Vascular contributions

    In the CNS, iron in several proteins is involved in many important processes such as oxygen transportation, oxidative phosphorylation, myelin production, and the synthesis and metabolism of neurotransmitters.

  17. Effects of several quinones on insulin aggregation

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Scientific reports 2014-07-10 Treatments

    Protein misfolding and aggregation are associated with more than twenty diseases, such as neurodegenerative diseases and metabolic diseases.

  18. Insulin as a Bridge between Type 2 Diabetes and Alzheimer Disease - How Anti-Diabetics Could be a Solution for Dementia

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Frontiers in endocrinology 2014-07-08 Drug development

    Type 2 diabetes (T2D) and Alzheimer disease (AD) are two major health issues nowadays.

  19. The Unexpected Uses of Urso- and Tauroursodeoxycholic Acid in the Treatment of Non-liver Diseases

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Global advances in health and medicine 2014-05-01 Brain scans and imaging

    Tauroursodeoxycholic acid (TUDCA) is the taurine conjugate of ursodeoxycholic acid (UDCA), a US Food and Drug Administration-approved hydrophilic bile acid for the treatment of certain cholestatic liver diseases.

  20. GSK-3 as potential target for therapeutic intervention in cancer

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Oncotarget 2014-05-01 Risk factors

    The serine/threonine kinase glycogen synthase kinase-3 (GSK-3) was initially identified and studied in the regulation of glycogen synthesis.

  21. The role of lipid peroxidation in neurological disorders

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Journal of clinical biochemistry and nutrition 2014-04-09 Down syndrome and Alzheimer's

    There has been much evidence demonstrating the involvement of oxidative stress in the pathology of neurological disorders.

  22. The nature, significance, and glucagon-like peptide-1 analog treatment of brain insulin resistance in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2014-02-01 Drug development

    Alzheimer's disease (AD) is an age-related neurodegenerative disease leading over the course of decades to the most common form of dementia.

  23. The incretin hormones glucagonlike peptide 1 and glucose-dependent insulinotropic polypeptide are neuroprotective in mouse models of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2014-02-01 Drug development

    The incretin hormones glucagonlike peptide 1 and glucose-dependent insulinotropic polypeptide (GIP) have been developed to treat type 2 diabetes and also act as growth factors.

  24. Liraglutide can reverse memory impairment, synaptic loss and reduce plaque load in aged APP/PS1 mice, a model of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Neuropharmacology 2013-08-21 Drug development

    Type 2 diabetes is a risk factor in the development of Alzheimer's disease (AD).

  25. Oxidative stress, mitochondrial damage and neurodegenerative diseases

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Neural regeneration research 2013-07-01 Disease mechanisms

    Oxidative stress and mitochondrial damage have been implicated in the pathogenesis of several neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis.

From across this topic

10 of the 1,048 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.

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