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Home › Research › Topic

Gut, metabolism and diet

1,048 studies in this group. A computer grouped them by what their titles and summaries are about, not by a hand-made list. The name describes most of the group, not every study in it.

Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.

Highest usefulness score first. Studies without a score come last.

  1. Multi-Target Neuroprotection by Syzygium aromaticum Ethyl Acetate Fraction Against Mercuric Chloride-Induced Hippocampal Toxicity: Insights from Network Pharmacology, Molecular Docking, and In Vivo Evaluation

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. F1000Res 2026-10-05 Vascular contributions

    Mercury remains a pervasive environmental neurotoxicant strongly implicated in hippocampal oxidative injury and dementia-related cognitive decline, yet safe multi-target agents against its neurotoxicity remain limited.

  2. Oxidative stress, aging, metabolism, SIRT1, and the gut microbiota: the neurocardiac basis of cognitive loss

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Medical gas research 2026-08-03 Disease mechanisms

    Cardiovascular disease and cognitive loss have a neurocardiac basis.

  3. Oral GLP-1 receptor agonist promotes astrocyte-neuron lactate and lipid transfer with neuroprotective effects

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Cell metabolism 2026-06-22 Drug development

    Glucagon-like peptide-1 receptor (GLP-1R) activation is widely assumed to regulate the metabolic disorder in Alzheimer's disease (AD).

  4. Microplastics-Induced Gut Microbiota Dysbiosis Accelerates Alzheimer's-Like Pathology and Cognitive Decline via the Gut-Brain Axis

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026-06-15 Disease mechanisms

    Alzheimer's disease (AD) is incurable and increasingly attributed to gene-environment interactions.

  5. Fasted-State Aerobic Exercise Enhances Cognition and Hippocampal BDNF Signaling in an Alzheimer's Disease Rat Model

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Neurochemical research 2025-12-20 Prevention trials

    Alzheimer's disease (AD) is a multifactorial disorder that demands a comprehensive management strategy.

  6. AMPK/SIRT1/PGC-1α Signaling Pathway: Molecular Mechanisms and Targeted Strategies From Energy Homeostasis Regulation to Disease Therapy

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. CNS neuroscience & therapeutics 2025-11-01 Drug development

    The AMPK/SIRT1/PGC-1α pathway represents a cornerstone target at the intersection of metabolism, aging, and disease.

  7. Microbiota-gut-brain axis dysregulation in Alzheimer's disease and its modulation through probiotic supplementation

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Brain, behavior, and immunity 2025-10-13 Disease mechanisms

    pAD patients showed intestinal inflammation, an altered GM profile, blood changes in the tryptophan metabolism, and reduced glutamate levels compared with HC (p-value < 0.049).

  8. Microbiota-derived lysophosphatidylcholine alleviates Alzheimer’s disease pathology via suppressing ferroptosis

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Cell Metabolism 2024-11-06 Disease mechanisms

    Alzheimer's disease (AD) is a pervasive neurodegenerative disorder, and new approaches for its prevention and therapy are critically needed.

  9. Role of glucagon-like peptide-1 receptor agonists in Alzheimer's disease and Parkinson's disease

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Journal of biomedical science 2024-11-05 Drug development

    Neurodegenerative diseases, including Alzheimer's Disease (AD) and Parkinson's Disease (PD) are common complications of diabetes, arising from insulin resistance, inflammation, and other pathological processes in the central nervous system.

  10. Efficacy and Safety of GLP-1 Medicines for Type 2 Diabetes and Obesity

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Diabetes care 2024-11-01 Drug development

    The development of glucagon-like peptide 1 receptor agonists (GLP-1RA) for type 2 diabetes and obesity was followed by data establishing the cardiorenal benefits of GLP-1RA in select patient populations.

  11. Several lines of antioxidant defense against oxidative stress: antioxidant enzymes, nanomaterials with multiple enzyme-mimicking activities, and low-molecular-weight antioxidants

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Archives of toxicology 2024-03-14 Prevention and risk

    Given that there is a discrepancy between preclinical and clinical studies, approaches that may result in greater pharmacological and clinical success of low-molecular-weight antioxidant therapies are also subject to discussion.

  12. Tirzepatide prevents neurodegeneration through multiple molecular pathways

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Journal of translational medicine 2024-01-29 Drug development

    We demonstrated that TIR can ameliorate high glucose-induced neurodegeneration and overcome neuronal insulin resistance.

  13. Current understanding of the Alzheimer's disease-associated microbiome and therapeutic strategies

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Experimental & molecular medicine 2024-01-04 Disease mechanisms

    Alzheimer's disease (AD) is a fatal progressive neurodegenerative disease.

  14. Chiral nanoparticle-remodeled gut microbiota alleviates neurodegeneration via the gut-brain axis

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Nature aging 2023-11-09 Disease mechanisms

    Alzheimer's disease (AD) is characterized by amyloid-β accumulation in the brain and hyperphosphorylated tau aggregation, as well as neuroinflammation.

  15. The gut microbiome modulates the transformation of microglial subtypes

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Molecular psychiatry 2023-03-13 Disease mechanisms

    Clinical and animal studies have shown that gut microbiome disturbances can affect neural function and behaviors via the microbiota-gut-brain axis, and may be implicated in the pathogenesis of several brain diseases.

  16. ApoE isoform- and microbiota-dependent progression of neurodegeneration in a mouse model of tauopathy

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Science (New York, N.Y.) 2023-01-13 Disease mechanisms

    Tau-mediated neurodegeneration is a hallmark of Alzheimer's disease.

  17. Incretin-based therapy of metabolic disease

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Danish medical journal 2022-12-21 Drug development

    Recent studies show that incretin hormone analogues effectively control blood glucose while producing major weight losses and reducing the risk of all-cause mortality, myocardial infarction, stroke and kidney function impairment.

  18. Faecal microbiota transplant ameliorates gut dysbiosis and cognitive deficits in Huntington's disease mice

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Brain communications 2022-08-12 Disease mechanisms

    Huntington's disease is a neurodegenerative disorder involving psychiatric, cognitive and motor symptoms.

  19. Can exercise training teach us how to treat Alzheimer's disease?

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Ageing research reviews 2022-01-06 Prevention trials

    Alzheimer's disease (AD) is the most common cause of dementia and there is currently no cure.

  20. Restoring metabolism of myeloid cells reverses cognitive decline in ageing

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Nature 2021-01-20 Disease mechanisms

    Ageing is characterized by the development of persistent pro-inflammatory responses that contribute to atherosclerosis, metabolic syndrome, cancer and frailty 1-3 .

  21. Intestinal microbial dysbiosis aggravates the progression of Alzheimer's disease in Drosophila

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Nature communications 2017-06-20 Disease mechanisms

    Neuroinflammation caused by local deposits of Aβ 42 in the brain is key for the pathogenesis and progression of Alzheimer's disease.

  22. Impact of intermittent fasting on health and disease processes

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Ageing research reviews 2016-10-31 Risk factors

    Humans in modern societies typically consume food at least three times daily, while laboratory animals are fed ad libitum.

  23. Association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Neurobiology of aging 2016-08-31 Inflammation and the immune system

    Amy+ patients showed higher levels of pro-inflammatory cytokines (IL-6, CXCL2, NLRP3, and IL-1β) compared with both controls and with Amy- patients.

  24. Investigation of the effects of solid lipid curcumin on cognition and mood in a healthy older population

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Journal of Psychopharmacology 2014-10-02 Clinical trials

    Curcumin possesses many properties which may prevent or ameliorate pathological processes underlying age-related cognitive decline, dementia or mood disorders.

  25. Diet and Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Current neurology and neuroscience reports 2007-09 Prevention and risk

    Alzheimer's disease (AD) is increasing in prevalence.

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