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Home › Research › Topic

Genetics and APOE

933 studies in this group. A computer grouped them by what their titles and summaries are about, not by a hand-made list. The name describes most of the group, not every study in it.

Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.

Highest usefulness score first. Studies without a score come last.

  1. Corroboration of a Major Role for Herpes Simplex Virus Type 1 in Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Frontiers in aging neuroscience 2018-10-19 Costs and economics

    Strong evidence has emerged recently for the concept that herpes simplex virus type 1 (HSV1) is a major risk for Alzheimer's disease (AD).

  2. Deep proteomic network analysis of Alzheimer's disease brain reveals alterations in RNA binding proteins and RNA splicing associated with disease

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Molecular neurodegeneration 2018-10-04 Genetics

    Further analysis of the AD brain proteome will continue to yield new insights into the biological basis of AD.

  3. A pathogenic PSEN2 p.His169Asn mutation associated with early-onset Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Clinical interventions in aging 2018-07-31 Risk genes beyond APOE

    A pathogenic mutation in the PSEN2 gene in a Korean patient associated with EOAD was identified.

  4. Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Nature Genetics 2018-04-01 Genetics

    Genetics can provide a systematic approach to discovering the tissues and cell types relevant for a complex disease or trait.

  5. Causal associations between risk factors and common diseases inferred from GWAS summary data

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Nature communications 2018-01-15 Genetics

    Health risk factors such as body mass index (BMI) and serum cholesterol are associated with many common diseases.

  6. Modifiable pathways in Alzheimer's disease: Mendelian randomisation analysis

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. BMJ (Clinical research ed.) 2017-12-06 Prevention and risk

    These results provide support that higher educational attainment is associated with a reduced risk of Alzheimer's disease.

  7. Impaired fasting glucose is associated with increased regional cerebral amyloid

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Neurobiology of aging 2016-05-07 Genetics

    The Alzheimer's disease risk gene apolipoprotein E epsilon 4 (APOE ε4) is associated with increased cerebral amyloid.

  8. Common polygenic variation enhances risk prediction for Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Brain : a journal of neurology 2015-10-21 Genetics

    The identification of subjects at high risk for Alzheimer's disease is important for prognosis and early intervention.

  9. Identification of PSEN2 mutation p.N141I in Argentine pedigrees with early-onset familial Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Neurobiology of aging 2015-06-15 Risk genes beyond APOE

    Presenilin 2 gene (PSEN2) mutations account for <5% of all early-onset familial Alzheimer's disease (EOFAD) cases and only 13 have strong evidence for pathogenicity.

  10. The effects of serum apolipoprotein E genetic variants and concentration on serum lipid parameters in haemodialysis patients

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Journal of Pharmacy and Pharmacology 2015-05-01 Genetics

    Our data indicated that the levels of triglyceride, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, apolipoprotein A-I (ApoA-I), ApoB, ApoE, lipoprotein (a) (Lp(a)) of mutant genotypes in ApoE c.61G &gt; A and c.761T &gt; A genetic variants were different from those subjects with wild genotype in HD patients and healthy controls.

  11. Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Nature 2015-02-01 Disease mechanisms

    Alzheimer's disease (AD) is a severe age-related neurodegenerative disorder characterized by accumulation of amyloid-β plaques and neurofibrillary tangles, synaptic and neuronal loss, and cognitive decline.

  12. ApoE Type 4 Allele Affects Cognitive Function of Aged Population in Tianjin City, China

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. American Journal of Alzheimer's Disease & Other Dementias® 2015-01-13 Genetics

    Apolipoprotein E type 4 allele (ApoE∊4) is known as a risk gene for the late-onset Alzheimer’s disease, and the relationship between ApoE∊4 and cognitive function of the elderly people has drawn the attention of the scientists.

  13. Obstructive sleep apnea in young infants with Down Syndrome evaluated in a Down Syndrome specialty clinic

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. American Journal of Medical Genetics Part A 2015-01-13 Risk factors

    Children with Down syndrome (DS) experience congenital and functional medical issues that predispose them to obstructive sleep apnea (OSA).

  14. Polarization of the effects of autoimmune and neurodegenerative risk alleles in leukocytes

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Science (New York, N.Y.) 2014-05-01 Disparities

    To extend our understanding of the genetic basis of human immune function and dysfunction, we performed an expression quantitative trait locus (eQTL) study of purified CD4(+) T cells and monocytes, representing adaptive and innate immunity, in a multi-ethnic cohort of 461 healthy individuals.

  15. Consistent decrease in global DNA methylation and hydroxymethylation in the hippocampus of Alzheimer's disease patients

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Neurobiology of aging 2013-04-09 Genetics

    Epigenetic dysregulation of gene expression is thought to be critically involved in the pathophysiology of Alzheimer's disease (AD).

  16. Cerebrospinal fluid APOE levels: an endophenotype for genetic studies for Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Human molecular genetics 2012-07-20 Genetics

    The apolipoprotein E (APOE) genotype is the major genetic risk factor for Alzheimer's disease (AD).

  17. An epigenetic blockade of cognitive functions in the neurodegenerating brain

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Nature 2012-02-29 Disease mechanisms

    Cognitive decline is a debilitating feature of most neurodegenerative diseases of the central nervous system, including Alzheimer's disease.

  18. Whole genome association study of brain-wide imaging phenotypes for identifying quantitative trait loci in MCI and AD: A study of the ADNI cohort

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. NeuroImage 2010-01-25 Genetics

    A genome-wide, whole brain approach to investigate genetic effects on neuroimaging phenotypes for identifying quantitative trait loci is described.

  19. Novel PSEN1 and PGRN mutations in early-onset familial frontotemporal dementia

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Neurobiology of aging 2008-03-07 Risk genes beyond APOE

    We identified two novel heterozygous mutations in two unrelated patients, Cys139Arg in the PGRN gene and Val412Ile in the PSEN1 gene.

  20. Structural Analysis of Missense Mutations on the Stability of APOE3 and APOE4

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Genes 2025-12-16 Genetics

    Based on the folding energy (ΔΔG) calculations, mutations G165W and L155W were particularly destabilizing in APOE4.

  21. Single-nucleus multi-omics identifies shared and distinct pathways in Pick's and Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Science advances 2025-11-12 Genetics

    The study of transcriptomic and epigenomic variations in neurodegenerative diseases, particularly tauopathies like Pick's disease (PiD) and Alzheimer's disease (AD), offers insights into their underlying regulatory mechanisms.

  22. ApoE is Secreted as a Lipid Nanoparticle by Mammalian Cells: Implications for Alzheimer's Disease Pathogenesis

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Biochemistry 2025-10-24 Genetics

    The brain is the most cholesterol-rich organ in the body, and ApoE is the main lipid carrier protein in the brain.

  23. APOE genotype and sex drive microbiome divergence after microbiome standardization in APOE-humanized mice

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. mSphere 2025-10-20 Genetics

    Previous studies in humans and humanized APOE mice have demonstrated APOE-genotype-specific differences in the GMB.

  24. Phosphodiesterase-5 Inhibition and Alzheimer's Disease Risk: A Mendelian Randomisation Study

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Aging cell 2025-10-13 Genetics

    While preclinical studies suggest that Phosphodiesterase 5 (PDE5) inhibition may reduce cognitive impairment, findings from observational studies on whether PDE5 inhibitors reduce Alzheimer's disease (AD) risk have been inconsistent.

  25. Brain somatic mutations in Alzheimer's disease: linking genetic mosaicism to neurodegeneration

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Molecular neurodegeneration 2025-10-09 Risk genes beyond APOE

    Somatic mutations are DNA sequence changes that occur in non-reproductive cells during an organism's life and are not inherited by offspring.

From across this topic

10 of the 933 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.

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