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Home › Research › Topic

Genetics and APOE

933 studies in this group. A computer grouped them by what their titles and summaries are about, not by a hand-made list. The name describes most of the group, not every study in it.

Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.

Highest usefulness score first. Studies without a score come last.

  1. Crosslinking of apolipoprotein E by products of lipid peroxidation

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Journal of neuropathology and experimental neurology 1996-02 Genetics

    Apolipoprotein E (APOE) genotype and advancing aging are interacting ri sk factors in the expression of late onset and sporadic Alzheimer's Disease (AD).

  2. Apolipoprotein E and Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Annual review of neuroscience 1996 Genetics

    The apolipoprotein E locus (APOE) is associated with variations in the age of onset and risk of Alzheimer's disease.

  3. Apolipoprotein E, synaptic plasticity and Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Annals of medicine 1995-12 Genetics

    Apolipoprotein E (apoE) has been studied extensively with regard to its role in plasma lipoprotein lipid transport.

  4. Apolipoprotein E genotype, Alzheimer's pathologies and related gene expression in the aged population

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Brain research. Molecular brain research 1995-03 Genetics

    We have investigated the effect of genotypes of apolipoprotein E (ApoE) on the pathologies found in Alzheimer's disease (AD) and its related gene expression in 38 aged human brains obtained from consecutive autopsied cases.

  5. Tangier Disease

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Annals of Internal Medicine 1961-12-01 Brain scans and imaging

    RODBELLFREDRICKSON MDS: The nature of the proteins associated with dog and human chylomicrons.

  6. A comprehensive compilation of SUMO proteomics

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Nature reviews. Molecular cell biology 2016-07-20 Genetics

    Small ubiquitin-like modifiers (SUMOs) are essential for the regulation of several cellular processes and are potential therapeutic targets owing to their involvement in diseases such as cancer and Alzheimer disease.

  7. microRNA-33 Regulates ApoE Lipidation and Amyloid-β Metabolism in the Brain

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The Journal of neuroscience : the official journal of the Society for Neuroscience 2015-11-01 Drug development

    Dysregulation of amyloid-β (Aβ) metabolism is critical for Alzheimer's disease (AD) pathogenesis.

  8. The epigenetics of aging and neurodegeneration

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Progress in neurobiology 2015-06-11 Genetics

    Epigenetics is a quickly growing field encompassing mechanisms regulating gene expression that do not involve changes in the genotype.

  9. The human CHRNA7 and CHRFAM7A genes: A review of the genetics, regulation, and function

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neuropharmacology 2015-02-19 Genetics

    The human α7 neuronal nicotinic acetylcholine receptor gene (CHRNA7) is ubiquitously expressed in both the central nervous system and in the periphery.

  10. Sleep‐like behavior and 24‐h rhythm disruption in the Tc1 mouse model of Down syndrome

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Genes, Brain and Behavior 2015-02 Risk factors

    Down syndrome is a common disorder associated with intellectual disability in humans.

  11. Biomarkers of Parkinson's disease: present and future

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Metabolism: clinical and experimental 2014-10-31 Costs and economics

    Finally, the exposome concept is new in the biomarker discovery arena and it is suggested as a way to move forward in identifying biomarkers of neurological diseases.

  12. Apolipoprotein E: structure and function in lipid metabolism, neurobiology, and Alzheimer's diseases

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neurobiology of disease 2014-08-27 Genetics

    Apolipoprotein (apo) E is a multifunctional protein with central roles in lipid metabolism, neurobiology, and neurodegenerative diseases.

  13. Alzheimer's disease genetics: from the bench to the clinic

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neuron 2014-07-01 Genetics

    Alzheimer's disease (AD) is a clinically heterogeneous neurodegenerative disease with a strong genetic component.

  14. Apolipoprotein E and lipid homeostasis in the etiology and treatment of sporadic Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neurobiology of aging 2014-05-15 Biomarkers

    The discovery that the apolipoprotein E (apoE) ε4 allele is genetically linked to both sporadic and familial late-onset Alzheimer's disease (AD) raises the possibility that a dysfunction of the lipid transport system could seriously affect lipid homeostasis in the brain of AD subjects.

  15. The involvement of lipids in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of genetics and genomics = Yi chuan xue bao 2014-05-02 Biomarkers

    It has been estimated that Alzheimer's disease (AD), the most common form of dementia, will affect approximately 81 million individuals by 2040.

  16. ApoE and Aβ in Alzheimer's disease: accidental encounters or partners?

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neuron 2014-02-01 Genetics

    Among the three human apolipoprotein E (apoE) isoforms, apoE4 increases the risk of Alzheimer's disease (AD).

  17. Epidemiology and etiology of Alzheimer's disease: from genetic to non-genetic factors

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Current Alzheimer research 2013-10-01 Genetics

    At present, the etiology of Alzheimer's disease (AD) is still unclear, but both genetic and non-genetic factors are thought to take part in the etiopathogenesis of AD.

  18. The Alzheimer's disease mitochondrial cascade hypothesis: progress and perspectives

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Biochimica et biophysica acta 2013-09-23 Risk genes beyond APOE

    Ten years ago we first proposed the Alzheimer's disease (AD) mitochondrial cascade hypothesis.

  19. The vast complexity of primary open angle glaucoma: disease genes, risks, molecular mechanisms and pathobiology

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Progress in retinal and eye research 2013-09-19 Genetics

    Primary open angle glaucoma (POAG) is a complex progressive optic nerve neuropathy triggered by both environmental and genetic risk factors.

  20. Pathways to neurodegeneration: mechanistic insights from GWAS in Alzheimer's disease, Parkinson's disease, and related disorders

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. American journal of neurodegenerative disease 2013-09-18 Genetics

    Recently, GWAS of complex diseases and traits have focused less on individual susceptibility variants and instead have emphasized the biological pathways and networks revealed by genetic associations.

  21. CD33 Alzheimer's risk-altering polymorphism, CD33 expression, and exon 2 splicing

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The Journal of neuroscience : the official journal of the Society for Neuroscience 2013-08-01 Genetics

    Genome-wide association studies are identifying novel Alzheimer's disease (AD) risk factors.

  22. ApoE influences amyloid-β (Aβ) clearance despite minimal apoE/Aβ association in physiological conditions

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Proceedings of the National Academy of Sciences of the United States of America 2013-04-25 Tau biomarkers

    Apolipoprotein E gene (APOE) alleles may shift the onset of Alzheimer's disease (AD) through apoE protein isoforms changing the probability of amyloid-β (Aβ) accumulation.

  23. Expanded GGGGCC repeat RNA associated with amyotrophic lateral sclerosis and frontotemporal dementia causes neurodegeneration

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Proceedings of the National Academy of Sciences of the United States of America 2013-04-03 Brain scans and imaging

    Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) share phenotypic and pathologic overlap.

  24. Genetics of familial and sporadic Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Frontiers in bioscience (Elite edition) 2013-01-01 Genetics

    Alzheimer's disease (AD) is an age-related progressive neurodegenerative disorder.

  25. Adaptive downregulation of mitochondrial function in down syndrome

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Cell metabolism 2013-01-01 Down syndrome and Alzheimer's

    Mitochondrial dysfunction and oxidative stress are common features of Down syndrome (DS).

From across this topic

10 of the 933 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.

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