Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
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Immature dentate granule cells (imGCs) arising from adult hippocampal neurogenesis contribute to plasticity and unique brain functions in rodents 1,2 and are dysregulated in multiple human neurological disorders 3-5 .
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As the size of genome-wide association studies increase, the number of associated trait loci identified inevitably increase.
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Dementia in Alzheimer's disease progresses alongside neurodegeneration 1-4 , but the specific events that cause neuronal dysfunction and death remain poorly understood.
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Liver-generated plasma apolipoprotein E (apoE) does not enter the brain but nonetheless correlates with Alzheimer's disease (AD) risk and AD biomarker levels.
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The human brain vasculature is of great medical importance: its dysfunction causes disability and death 1 , and the specialized structure it forms-the blood-brain barrier-impedes the treatment of nearly all brain disorders 2,3 .
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45/100
Insulin resistance (IR) contributes to the pathophysiology of diabetes, dementia, viral infection, and cardiovascular disease.
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AD was associated with lower PRS for premorbid cognitive performance, intelligence, and educational attainment.
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APOE4 is a strong genetic risk factor for Alzheimer's disease and Dementia with Lewy bodies; however, how its expression impacts pathogenic pathways in a human-relevant system is not clear.
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Familial Alzheimer's disease (FAD) is caused by autosomal dominant mutations in the PSEN1, PSEN2 or APP genes, giving rise to considerable clinical and pathological heterogeneity in FAD.
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The strategies of classifying APP, PSEN1, and PSEN2 variants varied substantially in the previous studies.
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We identify novel genome-wide significant associations between DNA variants in TMEM106B and CSF levels of NfL, and between CPOX and YKL-40.
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Our analyses demonstrate lower retinal capillary densities in early disease, in cognitively normal APOE ε4 gene carriers.
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Protein aggregation is the hallmark of neurodegeneration, but the molecular mechanisms underlying late-onset Alzheimer's disease (AD) are unclear.
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Genetic association studies have identified 44 common genome-wide significant risk loci for late-onset Alzheimer's disease (LOAD).
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We describe a human single-nuclei transcriptomic atlas for the substantia nigra (SN), generated by sequencing approximately 17,000 nuclei from matched cortical and SN samples.
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Our results demonstrate that novel AD biomarker candidates are identified and confirmed by proteomic studies of brain tissue and biofluids, providing a rich resource for large-scale biomarker validation for the AD community.
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Psychiatric disorders are associated with accelerated aging and enhanced risk for neurodegenerative disorders.
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The role of non-neuronal cells in Alzheimer's disease progression has not been fully elucidated.
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Presenilin1 (PSEN1) gene is the most common known genetic cause of early-onset familial Alzheimer's disease.
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We report a case of EOAD having a pathogenic PSEN1 (Trp165Cys) confirmed with in silico and in vitro predictions.
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45/100
Ninety per cent of the human population has been right-handed since the Paleolithic, yet the brain signature and genetic basis of handedness remain poorly characterized.
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Circulating long noncoding RNAs (lncRNAs) might serve as biomarkers for different pathological conditions.
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45/100
Genome-wide association studies (GWAS) originally identified ATP-binding cassette, sub-family A, member 7 (ABCA7), as a novel risk gene of Alzheimer's disease (AD).
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We use a genome-wide association of 1 million parental lifespans of genotyped subjects and data on mortality risk factors to validate previously unreplicated findings near CDKN2B-AS1 , ATXN2/BRAP , FURIN/FES , ZW10 , PSORS1C3 , and 13q21.31, and identify and replicate novel findings near ABO , ZC3HC1 , and IGF2R .
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The genetic risk score for TL was associated with higher risk of AD [log-odds ratio (OR) = 0.003 for per TL-decreasing allele; 95% confidence interval (CI): 0.001, 0.005, p = 0.005].
From across this topic
9 of the 933 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 9. The same 9 appear here every time.
- Association of genetic scores related to insulin resistance with neurological outcomes in ancestrally diverse cohorts from the Trans-Omics for Precision Medicine (TOPMed) program
- Genetic architecture of vitamin B12 and folate levels uncovered applying deeply sequenced large datasets
- Apolipoprotein E affects amyloid formation but not amyloid growth in vitro: mechanistic implications for apoE4 enhanced amyloid burden and risk for Alzheimer's disease
- Astrocyte transcriptomic changes along the spatiotemporal progression of Alzheimer's disease
- Human brain single nucleus cell type enrichments in neurodegenerative diseases
- Multivariate blood biomarkers capture resilience and resistance phenotypes across the Alzheimer’s disease spectrum
- ApoE2, ApoE3, and ApoE4 Differentially Stimulate APP Transcription and Aβ Secretion
- Ethnic differences in the frequency of β-amyloid deposition in cognitively normal individuals
- APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline