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Home › Research › Topic

Genetics and APOE

933 studies in this group. A computer grouped them by what their titles and summaries are about, not by a hand-made list. The name describes most of the group, not every study in it.

Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.

Highest usefulness score first. Studies without a score come last.

  1. Single nucleus multiomics identifies ZEB1 and MAFB as candidate regulators of Alzheimer's disease-specific cis-regulatory elements

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Cell genomics 2023-02-02 Genetics

    Cell type-specific transcriptional differences between brain tissues from donors with Alzheimer's disease (AD) and unaffected controls have been well documented, but few studies have rigorously interrogated the regulatory mechanisms responsible for these alterations.

  2. Opposing Effects of ApoE2 and ApoE4 on Glycolytic Metabolism in Neuronal Aging Supports a Warburg Neuroprotective Cascade against Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Cells 2023-01-25 Genetics

    Apolipoprotein E4 (ApoE4) is the most recognized genetic risk factor for late-onset Alzheimer's disease (LOAD), whereas ApoE2 reduces the risk for LOAD.

  3. Droplet-based transcriptome profiling of individual synapses

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Nature biotechnology 2023-01-16 Genetics

    Synapses are crucial structures that mediate signal transmission between neurons in complex neural circuits and display considerable morphological and electrophysiological heterogeneity.

  4. Single-cell-led drug repurposing for Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Scientific reports 2023-01-05 Drug development

    Alzheimer's disease is the most common form of dementia.

  5. From degenerative disease to malignant tumors: Insight to the function of ApoE

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022-12-12 Genetics

    Apolipoprotein E (ApoE) is a multifunctional protein involved in lipid transport and lipoprotein metabolism, mediating lipid distribution/redistribution in tissues and cells.

  6. Differential Gene Expression and DNA Methylation in the Risk of Depression in LOAD Patients

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Biomolecules 2022-11-12 Genetics

    Depression is common among late-onset Alzheimer's Disease (LOAD) patients.

  7. A single-cell transcriptome atlas of glial diversity in the human hippocampus across the postnatal lifespan

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Cell stem cell 2022-11-03 Genetics

    The molecular diversity of glia in the human hippocampus and their temporal dynamics over the lifespan remain largely unknown.

  8. Potential of hsa-miR200a-3p and hsa-miR502-3p as blood-based biomarker for Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Molecular biology reports 2022-10-17 Biomarkers

    Firstly, we analyzed two microarray datasets related to AD (GSE48552, GSE129053) to identify the differentially expressed miRNAs, and two miRNAs were selected for further validation.

  9. APOE in the bullseye of neurodegenerative diseases: impact of the APOE genotype in Alzheimer's disease pathology and brain diseases

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Molecular neurodegeneration 2022-09-24 Genetics

    ApoE is the major lipid and cholesterol carrier in the CNS.

  10. Apolipoprotein E in Cardiometabolic and Neurological Health and Diseases

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. International journal of molecular sciences 2022-08-31 Genetics

    A preponderance of evidence obtained from genetically modified mice and human population studies reveals the association of apolipoprotein E (apoE) deficiency and polymorphisms with pathogenesis of numerous chronic diseases, including atherosclerosis, obesity/diabetes, and Alzheimer's disease.

  11. Influence of genetic and cardiometabolic risk factors in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Ageing research reviews 2022-08-28 Risk factors

    Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder.

  12. Discovery and validation of dominantly inherited Alzheimer's disease mutations in populations from Latin America

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Alzheimer's research & therapy 2022-08-05 Risk genes beyond APOE

    We identified five novel variants in the presenilin1 (PSEN1) gene from Brazilian and Mexican families.

  13. The role of genetic risk factors of Alzheimer's disease in synaptic dysfunction

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Seminars in cell & developmental biology 2022-07-30 Disease mechanisms

    Alzheimer's disease (AD) is a neurodegenerative disease characterized by the progressive deterioration of cognitive functions.

  14. A multi-hit hypothesis for an APOE4-dependent pathophysiological state

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. The European journal of neuroscience 2022-06-06 Genetics

    The APOE gene encoding the Apolipoprotein E protein is the single most significant genetic risk factor for late-onset Alzheimer's disease.

  15. Accelerated epigenetic aging in newborns with Down syndrome

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Aging cell 2022-06-06 Genetics

    Accelerated aging is a hallmark of Down syndrome (DS), with adults experiencing early-onset Alzheimer's disease and premature aging of the skin, hair, and immune and endocrine systems.

  16. Epigenetic ageing of the prefrontal cortex and cerebellum in humans and chimpanzees

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Epigenetics 2022-06-02 Genetics

    Epigenetic age has emerged as an important biomarker of biological ageing.

  17. TREM2 coding variants in Slovak Alzheimer's disease patients

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Journal of integrative neuroscience 2022-06-01 TREM2 and immune genetics

    Four out of 10 TREM2 mutant variants have been identified in the analyzed groups, namely rs75932628 C > T (R47H), rs142232675 C > T (D87N), rs143332484 C > T (R62H), and rs2234253 G > T (T96K).

  18. Genome-wide association of polygenic risk extremes for Alzheimer's disease in the UK Biobank

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Scientific reports 2022-05-19 Genetics

    In just over a decade, advances in genome-wide association studies (GWAS) have offered an approach to stratify individuals based on genetic risk for disease.

  19. Sleep, Pain, and Neurodegeneration: A Mendelian Randomization Study

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Frontiers in neurology 2022-05-02 Risk factors

    Our aim was to determine whether the genetic liability to sleep and pain-related traits have a causal effect on risk of neurodegeneration in individuals of predominantly European ancestry.

  20. Molecular recognition of the interaction between ApoE and the TREM2 protein

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Translational neuroscience 2022-04-29 Genetics

    Alzheimer's disease (AD) is the most common type of dementia.

  21. The genetic architecture of Alzheimer disease risk in the Ohio and Indiana Amish

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. HGG advances 2022-04-27 Genetics

    Alzheimer disease (AD) is the most common type of dementia and is currently estimated to affect 6.2 million Americans.

  22. Bridging the gap: Short structural variants in the genetics of anorexia nervosa

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. The International journal of eating disorders 2022-04-26 Genetics

    Anorexia nervosa (AN) is a devastating disorder with evidence of underexplored heritability.

  23. Polygenic risk score as a possible tool for identifying familial monogenic causes of complex diseases

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Genetics in medicine : official journal of the American College of Medical Genetics 2022-04-23 Genetics

    Monogenic causes of complex diseases were more prevalent among individuals with a parental disease history than in the rest of the population.

  24. Progressive cognitive impairment and familial spastic paraparesis due to PRESENILIN 1 mutation: anatomoclinical characterization

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Journal of neurology 2022-04-19 Risk genes beyond APOE

    The three female patients had an age of onset of symptoms of 38-51 years.

  25. PSEN1 G417S mutation in a Chinese pedigree causing early-onset parkinsonism with cognitive impairment

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Neurobiology of aging 2022-04-11 Risk genes beyond APOE

    Presenilin 1 (PSEN1) mutations are a major cause of familial Alzheimer's disease.

From across this topic

10 of the 933 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.

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