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Home › Research › Topics › down

down

534 studies tagged down, dated 1975-09-01 to 2026-10-30. Bibliography: BibTeX (.bib) · RIS (.ris)

Newest in this topic

  1. Differential endothelial cell remodeling in Down syndrome and APP duplication drives distinct blood brain barrier dysfunction 2026-10-30
  2. Memory and Plasma pTau217 Refine Prognosis in Down Syndrome 2026-10-02
  3. Tau extent is associated with lower cognition in Down syndrome-related Alzheimer's disease 2026-10-01

Studies

534 studies carry this tag.

Date range

1975 to 2026

Top journals

  • Proceedings of the National Academy of Sciences of the United States of America 21
  • Alzheimer s & Dementia 20
  • Alzheimer's & dementia : the journal of the Alzheimer's Association 15
  • Neurology 14
  • Neuroscience letters 14

239 journals in all.

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. Differential endothelial cell remodeling in Down syndrome and APP duplication drives distinct blood brain barrier dysfunction

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. bioRxiv 2026-10-30 Down syndrome and Alzheimer's

    An extra copy of the amyloid precursor protein gene (APP) is present in Down syndrome (DS) and APP duplication (APPdup), increasing the risk of Alzheimer disease (AD) and cerebral amyloid angiopathy (CAA).

  2. Memory and Plasma pTau217 Refine Prognosis in Down Syndrome

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Annals of neurology 2026-10-02 Down syndrome and Alzheimer's

    Individuals with Down syndrome (DS) are at high risk for Alzheimer's disease (AD), yet accessible tools for routine clinical screening of AD in individuals with DS remain limited.

  3. Tau extent is associated with lower cognition in Down syndrome-related Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2026-10-01 Down syndrome and Alzheimer's

    This first evaluation of 18 F-MK6240 in DS demonstrates its suitability as a sensitive biomarker for Alzheimer's disease tau pathology.

  4. Epilepsy Mechanisms in Down Syndrome: Genetic and Pathophysiological Perspectives Across the Lifespan

    ✓ Peer-reviewed alzhub usefulness score 32 out of 100. Journal of Clinical Medicine 2026-09-25 Down syndrome and Alzheimer's

    Down syndrome (trisomy 21) is the most common genetic cause of intellectual disability.

  5. Epilepsy Mechanisms in Down Syndrome: Genetic and Pathophysiological Perspectives Across the Lifespan

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Journal of clinical medicine 2026-09-25 Down syndrome and Alzheimer's

    Down syndrome (trisomy 21) is the most common genetic cause of intellectual disability.

  6. Sleep Health in Adults with Intellectual Disability: Recent Advances and Persistent Evidence Gaps

    ✓ Peer-reviewed alzhub usefulness score 42 out of 100. Current Treatment Options in Neurology 2026-09-25 Down syndrome and Alzheimer's

    Recent Findings Recent observational data in adults with Down syndrome indicate that obstructive sleep apnoea is associated with adverse cardiometabolic, mortality and Alzheimer disease outcomes.

  7. Phosphorylated tau 217 in young adults with Down syndrome and Down syndrome regression disorder

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Communications Medicine 2026-09-21 Down syndrome and Alzheimer's

    These findings provide no evidence of a group-level Alzheimer-related p-tau217 elevation in young people with DSRD and support DSRD as a condition distinct from Alzheimer’s disease.

  8. Phosphorylated tau 217 in young adults with Down syndrome and Down syndrome regression disorder

    ✓ Peer-reviewed alzhub usefulness score 67 out of 100. Communications medicine 2026-09-21 Down syndrome and Alzheimer's

    These findings provide no evidence of a group-level Alzheimer-related p-tau217 elevation in young people with DSRD and support DSRD as a condition distinct from Alzheimer's disease.

  9. Down syndrome postmortem brains exhibit reduction in [ 18 F]nifene binding to α4β2* nicotinic acetylcholinergic receptors

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. bioRxiv 2026-09-15 Down syndrome and Alzheimer's

    Alzheimer’s disease (AD) pathology including amyloid beta (Aβ) plaques and tau tangles accumulate with age in Down Syndrome (DS).

  10. Changes in serum β-synuclein precede blood biomarkers of Alzheimer pathology in Down syndrome

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2026-09-01 Down syndrome and Alzheimer's

    There is a need for early, objective markers of Alzheimer's disease (AD)-related synapse dysfunction in adults with Down syndrome (DS).

  11. Longitudinal Dynamics of the Blood Proteome Within the Alzheimer Spectrum in Down Syndrome

    ✓ Peer-reviewed alzhub usefulness score 51 out of 100. Neurology 2026-09-01 Down syndrome and Alzheimer's

    In DS, longitudinal characterization of all previously identified proteins revealed distinct trajectories over time and an association of baseline levels with future cognitive decline.

  12. Epilepsy and subsequent dementia in adults with down syndrome: a propensity score-matched cohort study using federated electronic health records

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. Seizure 2026-08-28 Down syndrome and Alzheimer's

    Epilepsy was associated with higher subsequent recording of dementia and mortality over 2 years.

  13. Oligodendrocyte Enriched Brain Organoids Reveal Impaired Oligodendroglial Maturation and Altered Neural Network Activity in Down Syndrome

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. bioRxiv 2026-08-28 Down syndrome and Alzheimer's

    Individuals with Down syndrome (DS) display developmental delay, intellectual disability, premature brain ageing, and an increased risk of Alzheimer-like neurodegeneration.

  14. Frailty in Adults With Down Syndrome: Cognitive, Functional and Biomarker Associations

    ✓ Peer-reviewed alzhub usefulness score 37 out of 100. Journal of intellectual disability research : JIDR 2026-08-18 Down syndrome and Alzheimer's

    Frailty in DS is associated with both ID severity and acquired cognitive decline.

  15. BACH1/HO-1 axis dysregulation links Down syndrome to Alzheimer-like neurodegeneration

    ✓ Peer-reviewed alzhub usefulness score 31 out of 100. Neurochemistry international 2026-07-30 Down syndrome and Alzheimer's

    Down syndrome (DS), caused by trisomy of chromosome 21, is characterized by early-onset oxidative stress, impaired neuronal development, and an increased risk of Alzheimer's disease (AD)-like neuropathology.

  16. Early behavioural and adaptive markers of dementia in adults with Down syndrome

    ✓ Peer-reviewed alzhub usefulness score 32 out of 100. International Journal of Intellectual Disability 2026-07-01 Down syndrome and Alzheimer's

    How do clinicians distinguish early-stage dementia from the expected cognitive variability seen in ageing adults with Down syndrome?

  17. Pearls and Pitfalls of 18F-FDG PET/CT for Suspected Alzheimer's Disease in Patient with Down Syndrome

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Molecular imaging and radionuclide therapy 2026-06-23 Down syndrome and Alzheimer's

    Dementia in individuals with Down syndrome (DS) is the leading cause of early-onset cognitive decline occurring before the age of 50.

  18. Inflammation Associated With Obesity, Aging, and Amyloid Burden in Adults With Down Syndrome

    ✓ Peer-reviewed alzhub usefulness score 37 out of 100. Obesity (Silver Spring, Md.) 2026-06-05 Down syndrome and Alzheimer's

    The majority of the participants met criteria for obesity.

  19. Imaging and plasma biomarkers for pathological accumulation in Down syndrome

    ✓ Peer-reviewed alzhub usefulness score 59 out of 100. Brain : a journal of neurology 2026-06-01 Down syndrome and Alzheimer's

    These results suggest that all adults with Down syndrome should be screened for Alzheimer's disease pathology starting shortly before age 40 years and considered for clinical trials.

  20. Circadian Rest-Activity Rhythms, Cognition, and Alzheimer Disease Dementia in Adults With Down Syndrome

    ✓ Peer-reviewed alzhub usefulness score 56 out of 100. Neurology 2026-05-07 Down syndrome and Alzheimer's

    Of 115 participants (mean age 40.0 ± 9.2 years; 43.5% female), higher interdaily stability was associated with higher DSMSE scores B = 20.6 (95% CI 5.0-36.2).

  21. 0076 Effect of a Tryptophan Enriched Diet on Mood, Cognition, Sleep and Their Associated Neurotransmitters/Hormones in a Mouse Model of Down Syndrome

    ✓ Peer-reviewed alzhub usefulness score 31 out of 100. SLEEP 2026-05-01 Down syndrome and Alzheimer's

    Our study is the first one showing that dietary supplements improve cognition and sleep in a mouse model of DS.

  22. B31-13 Circadian Rest-Activity Rhythm and Alzheimer’s Disease Biomarkers in Adults With Down Syndrome

    ✓ Peer-reviewed alzhub usefulness score 44 out of 100. American Journal of Respiratory and Critical Care Medicine 2026-05-01 Down syndrome and Alzheimer's

    These findings suggest that circadian rhythm disruption as measured via 24-hour RAR is associated with plasma and imaging biomarkers of AD in DS.

  23. Common pathogenic mechanisms in the hippocampus across neurodegenerative dementias: Alzheimer’s disease, Down syndrome, and Parkinson’s disease

    ✓ Peer-reviewed alzhub usefulness score 32 out of 100. npj Dementia 2026-04-29 Down syndrome and Alzheimer's

    For these neurodegenerative dementias, we observed that the chronological age did not align with their biological age, which was determined based on hippocampal transcript levels (i.e., transcriptional age).

  24. Loss of Proteostasis and Early-Onset Neurodegeneration in Down Syndrome: From Mechanisms to Interventions

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Antioxidants (Basel, Switzerland) 2026-04-21 Down syndrome and Alzheimer's

    Down syndrome (DS), caused by trisomy 21, is the most prevalent genetic condition associated with accelerated aging and near-universal development of early-onset Alzheimer's disease (AD).

  25. The Genetics and Mechanisms of Alzheimer's Disease in Down Syndrome

    ✓ Peer-reviewed alzhub usefulness score 26 out of 100. Journal of Mental Health Disorders 2026-04-18 Down syndrome and Alzheimer's

    Down syndrome (DS), caused by trisomy 21, is the most frequent genetic cause of intellectual disability worldwide.

  26. Neuropathological measures of increased tau phosphorylation across the Down syndrome lifespan

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Acta neuropathologica 2026-03-22 Down syndrome and Alzheimer's

    Individuals with Down syndrome (DS) have an increased risk of developing Alzheimer disease (AD), with nearly all individuals exhibiting AD neuropathology, including amyloid beta (Aβ) plaques and neurofibrillary tangles (NFT), by age 40 years.

  27. Loss of Proteostasis and Abnormal Aging in Down Syndrome: From Mechanisms to Interventions

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Antioxidants (Basel, Switzerland) 2026-03-17 Down syndrome and Alzheimer's

    Down syndrome (DS), caused by trisomy 21, is the most prevalent genetic condition associated with accelerated aging and near-universal development of early-onset Alzheimer’s disease (AD).

  28. Vitamina E e outros antioxidantes na síndrome de Down para pacientes com demência: evidências iniciais com foco em marcadores genéticos

    ✓ Peer-reviewed alzhub usefulness score 28 out of 100. Jornal de Assistência Farmacêutica e Farmacoeconomia 2026-02-27 Down syndrome and Alzheimer's

    No entanto, os resultados dos estudos clínicos apresentam divergências entre si, além de limitações metodológicas, pequeno tamanho amostral e variabilidade na definição dos desfechos.

  29. Evaluation of Memory Changes in Patient with Down Syndrome

    ✓ Peer-reviewed alzhub usefulness score 26 out of 100. SteadFAST Case Reports in PA Studies 2026-02-24 Down syndrome and Alzheimer's

    Down syndrome is one of the most common chromosomal abnormalities in humans in which an extra copy of chromosome 21 is present.

  30. Down Syndrome

    ✓ Peer-reviewed alzhub usefulness score 42 out of 100. StatPearls Publishing, Treasure Island (FL) 2026-02-20 Down syndrome and Alzheimer's

    Down syndrome is the most common viable autosomal trisomy, resulting from an extra copy of chromosome 21, and is the leading genetic cause of intellectual disability.

  31. The impact of congenital heart disease on the timing of Alzheimer's disease in Down syndrome

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Alzheimer's & dementia (Amsterdam, Netherlands) 2026-01-18 Down syndrome and Alzheimer's

    Presence of CHD may influence AD progression in DS.

  32. Concordance of Biological and Clinical Staging of Alzheimer Disease Pathology in Down Syndrome

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. JAMA Neurology 2026-01-12 Down syndrome and Alzheimer's

    This cross-sectional study examines data for participants in the Alzheimer Biomarker Consortium–Down Syndrome study to gauge the concordance of clinical and biological Alzheimer disease staging.

  33. Novel insights into Alzheimer's disease through the study of individuals with Down syndrome

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Alzheimer s & Dementia 2026-01-01 Down syndrome and Alzheimer's

    Novel insights into Alzheimer's disease through the study of individuals with Down syndromePeople with Down syndrome (DS) represent the largest genetically defined population at risk for Alzheimer's disease (AD). 1 Virtually all adults with DS develop AD neuropathology by midlife due to triplication of the amyloid precursor protein (APP) gene on chromosome 21.As medical advances and social integration have extended life expectancy into the 60s, AD has emerged as the major determinant of cognitive decline, morbidity, and mortality in this DS population. 2 What was once viewed as an inevitable consequence of aging in DS is now recognized as a unique scientific opportunity to uncover the earliest events that drive AD.The predictable and accelerated course of DS-associated AD (DSAD) provides an unparalleled window into the molecular and cellular origins of amyloid and tau pathology, neuroinflammation, cerebrovascular pathology, and neurodegeneration.

  34. Impact of Triplicated DYRK1A on Neurogenesis and Intellectual Disability in Down Syndrome and Therapeutic Potential

    ✓ Peer-reviewed alzhub usefulness score 28 out of 100. Gene Expression 2025-12-18 Genetics

    Full or partial trisomy of human chromosome 21 results in dysregulation of gene expression, leading to the manifestation of specific phenotypes described in individuals with Down syndrome (DS).

  35. Multi-dimensional attention framework for personalized Alzheimer’s disease progression prediction across sporadic and genetic risk cohorts

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. medRxiv 2025-12-17 Down syndrome and Alzheimer's

    Alzheimer’s disease manifests through heterogeneous progression patterns across diverse populations, yet current predictive models fail to capture this complexity while maintaining clinical interpretability.

  36. Adaptation of a Protocol for Disclosure of Amyloid PET Results for Adults with Down Syndrome and Their Caregivers

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Alzheimer s & Dementia 2025-12-01 Biomarkers

    Adults with DS are often supported by family caregiver(s), who face challenges including lack of awareness of the increased risk of developing AD, difficulty in obtaining a timely diagnosis, limited resources for psychosocial support, and lack of access to clinical trials.

  37. Cardiovascular Risk Composite and Time of Amyloid Accumulation and Cognitive Decline in Down Syndrome Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 44 out of 100. Alzheimer s & Dementia 2025-12-01 Down syndrome and Alzheimer's

    In partial correlations adjusted for age, there was a significant positive association between the cardiovascular composite (r = .156, p = .016) and resistance score; higher cardiovascular composite was associated with greater than expected Aβ for age.

  38. Challenges in Managing Cerebral Amyloid Angiopathy in Alzheimer's Disease: Insights from a Case of Down Syndrome‐associated Alzheimer Disease (DSAD)

    ✓ Peer-reviewed alzhub usefulness score 33 out of 100. Alzheimer s & Dementia 2025-12-01 Down syndrome and Alzheimer's

    During alteplase administration, the patient experienced clinical deterioration.

  39. Distinct Sensitivity of MRI Versus [ 18 F]FDG‐PET To Detect Cerebral Changes Across the Alzheimer's Continuum in Down Syndrome: A Multimodal Imaging Study

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Alzheimer s & Dementia 2025-12-01 Down syndrome and Alzheimer's

    Amyloid pathology in aDS individuals is linked to frontal‐predominant atrophy without clear hypometabolism.

  40. Down syndrome with Alzheimer's disease brains have increased iron and associated lipid peroxidation consistent with ferroptosis

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Alzheimer s & Dementia 2025-12-01 Down syndrome and Alzheimer's

    Iron was 2-fold higher in DSAD. Iron storage proteins and lipid peroxidation were increased in prefrontal cortex, but not in the cerebellum.

  41. Early Detection of White Matter Integrity Changes in Down Syndrome: The Promise of PSMD as a Sensitive Biomarker

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Alzheimer s & Dementia 2025-12-01 Down syndrome and Alzheimer's

    PSMD was more strongly associated with age in DS (rho=0.56; p <0.001) than in HC (rho=0.38, p <0.001; Figure 1A), with regression lines starting to diverge at age 42.

  42. Early Detection of White Matter Integrity Changes in Down Syndrome: The Promise of PSMD as a Sensitive Biomarker

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Alzheimer s & Dementia 2025-12-01 Down syndrome and Alzheimer's

    In DS, PSMD changed approximately 10‐15 years before the onset of AD symptoms and linearly increased with AD clinical stages, AD pathology, and SVD metrics.

  43. Factors Associated with Atypical Cognitive Trajectories in Older Adults with Down Syndrome

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Alzheimer s & Dementia 2025-12-01 Down syndrome and Alzheimer's

    = 49.17) had a higher incidence of psychotic disorder (p = .028) compared to non-progressors and progressors.

  44. Functional connectivity differences in the default mode and frontoparietal networks in older adults with Down syndrome are related to obstructive sleep apnea

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Alzheimer s & Dementia 2025-12-01 Down syndrome and Alzheimer's

    There was a significant interaction between OSA and diagnosis for within- and between-DMN FC (p-values<0.05).

  45. Functional connectivity differences in the default mode and frontoparietal networks in older adults with Down syndrome are related to obstructive sleep apnea

    ✓ Peer-reviewed alzhub usefulness score 35 out of 100. Alzheimer s & Dementia 2025-12-01 Down syndrome and Alzheimer's

    We observed higher within‐ and between‐DMN FC in the CS‐OSA compared to the CI‐OSA group; however, this difference was not observed between the CS‐nonOSA and CI‐nonOSA groups.

  46. Identification of candidate serum protein biomarkers in Down's syndrome dementia

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Alzheimer s & Dementia 2025-12-01 Down syndrome and Alzheimer's

    MOLDI-MS identified eighty-five proteins represented by multiple tryptic peptides, twenty-five of which showed significant differences between DS and controls, confirmed by WB and ELISA analysis.

  47. Life Stress and Dementia Risk in Adults with Down Syndrome

    ✓ Peer-reviewed alzhub usefulness score 30 out of 100. Innovation in Aging 2025-12-01 Down syndrome and Alzheimer's

    We found that a higher baseline sum of stress events was associated with greater risk of conversion from baseline stable cognition to mild cognitive impairment (MCI) or dementia at follow up, even when controlling for age, sex, premorbid level of intellectual disability, site, clinical latency between assessments, and the presence of anxiety or depression (odds ratio = 1.53, p = 0.021).

  48. Mild premorbid intellectual impairment as a resilience factor in Down syndrome associated Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Alzheimer s & Dementia 2025-12-01 Down syndrome and Alzheimer's

    Participant and visit numbers varied by measure, with 455 participants evaluated over 1178 data points.

  49. Relationship between tau and SV2A in the neurotypical population and translation to the Down syndrome population

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Alzheimer s & Dementia 2025-12-01 Down syndrome and Alzheimer's

    Understanding the distribution of SV2A in DS will provide insight on changes to synaptic density in populations with accelerated AD neuropathology.

  50. Relationship between tau and SV2A in the neurotypical population and translation to the Down syndrome population

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Alzheimer s & Dementia 2025-12-01 Down syndrome and Alzheimer's

    Understanding the distribution of SV2A in DS will provide insight on changes to synaptic density in populations with accelerated AD neuropathology.

From across this tag

7 of the 527 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 7. The same 7 appear here every time.

All topic tags with their study counts