% alzhub.org topic: down
% Source: https://alzhub.org/topic/down
% 534 entries, in the order the page lists them. Built from alzhub.org's own records.
% 0 entries have no readable author in the source record and carry no author field.

@article{valay2026-d4bf18aa,
  author  = {Valay, L. and Kasri, A. and Fontaine, V. and Camporesi, E. and Bigou, S. and Brinkmalm, G. and Piotrowska, D. and Dancette, L. and others},
  title   = {{Differential endothelial cell remodeling in Down syndrome and APP duplication drives distinct blood brain barrier dysfunction}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.10.29.762815},
  url     = {https://doi.org/10.64898/2026.10.29.762815}
}

@article{vanderlip2026-42825390,
  author  = {Vanderlip, C. R. and Hartley, S. L. and Krinsky-McHale, S. and Hom, C. and Brickman, A. M. and Petersen, M. E. and Head, E. and Stark, C. E. L. and others},
  title   = {{Memory and Plasma pTau217 Refine Prognosis in Down Syndrome}},
  journal = {Annals of neurology},
  year    = {2026},
  doi     = {10.1002/ana.78366},
  pmid    = {42825390},
  url     = {https://doi.org/10.1002/ana.78366}
}

@article{zammit2026-42928420,
  author  = {Zammit, M. D. and Hartley, S. L. and Christian, B. T. and Rafii, M. S.},
  title   = {{Tau extent is associated with lower cognition in Down syndrome-related Alzheimer's disease}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2026},
  doi     = {10.1002/alz.71925},
  pmid    = {42928420},
  url     = {https://doi.org/10.1002/alz.71925}
}

@article{stafstrom2026-0b7e245a,
  author  = {Stafstrom, Carl E. and Shao, Li‐Rong},
  title   = {{Epilepsy Mechanisms in Down Syndrome: Genetic and Pathophysiological Perspectives Across the Lifespan}},
  journal = {Journal of Clinical Medicine},
  year    = {2026},
  doi     = {10.3390/jcm15197471},
  pmid    = {42881935},
  url     = {https://doi.org/10.3390/jcm15197471}
}

@article{stafstrom2026-42881935,
  author  = {Stafstrom, C. E. and Shao, L. R.},
  title   = {{Epilepsy Mechanisms in Down Syndrome: Genetic and Pathophysiological Perspectives Across the Lifespan}},
  journal = {Journal of clinical medicine},
  year    = {2026},
  doi     = {10.3390/jcm15197471},
  pmid    = {42881935},
  url     = {https://doi.org/10.3390/jcm15197471}
}

@article{sirinimnualkul2026-0b24ddbe,
  author  = {Sirinimnualkul, Naphat and Perera, Bhathika and O'Regan, David John},
  title   = {{Sleep Health in Adults with Intellectual Disability: Recent Advances and Persistent Evidence Gaps}},
  journal = {Current Treatment Options in Neurology},
  year    = {2026},
  doi     = {10.1007/s11940-026-00892-8},
  url     = {https://doi.org/10.1007/s11940-026-00892-8}
}

@article{santoro2026-10090373,
  author  = {Santoro, Jonathan Douglas and Abdel‐Latif, Sara and Banerjee, Abhik K. and Mager, Hannah and Silverman, Mackenzie and Kazerooni, Lilia and Otey, Samuel T. and Yousuf, Mariam M and others},
  title   = {{Phosphorylated tau 217 in young adults with Down syndrome and Down syndrome regression disorder}},
  journal = {Communications Medicine},
  year    = {2026},
  doi     = {10.1038/s43856-026-01921-y},
  pmid    = {42897209},
  url     = {https://doi.org/10.1038/s43856-026-01921-y}
}

@article{santoro2026-42897209,
  author  = {Santoro, J. D. and Abdel-Latif, S. and Banerjee, A. K. and Mager, H. and Silverman, M. and Kazerooni, L. and Otey, S. T. and Yousuf, M. M. and others},
  title   = {{Phosphorylated tau 217 in young adults with Down syndrome and Down syndrome regression disorder}},
  journal = {Communications medicine},
  year    = {2026},
  doi     = {10.1038/s43856-026-01921-y},
  pmid    = {42897209},
  url     = {https://doi.org/10.1038/s43856-026-01921-y}
}

@article{karim2026-9885f5da,
  author  = {Karim, F. and Chavez-Jacobo, N. P. and Liang, C. and Head, E. and Mukherjee, J.},
  title   = {{Down syndrome postmortem brains exhibit reduction in [ 18 F]nifene binding to α4β2* nicotinic acetylcholinergic receptors}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.09.09.750420},
  url     = {https://doi.org/10.64898/2026.09.09.750420}
}

@article{cervantesgonzalez2026-42768868,
  author  = {Cervantes González, A. and Morcillo-Nieto, A. O. and Serrano, S. and Benejam, B. and Videla, L. and Barroeta, I. and Fernández, S. and Del Hoyo Soriano, L. and others},
  title   = {{Changes in serum β-synuclein precede blood biomarkers of Alzheimer pathology in Down syndrome}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2026},
  doi     = {10.1002/alz.71860},
  pmid    = {42768868},
  url     = {https://doi.org/10.1002/alz.71860}
}

@article{wagemann2026-42679336,
  author  = {Wagemann, O. and Nuebling, G. S. and Sandkühler, K. and Wlasich, E. and Loosli, S. V. and Prix, C. and Stockbauer, A. C. and Marth, L. and others},
  title   = {{Longitudinal Dynamics of the Blood Proteome Within the Alzheimer Spectrum in Down Syndrome}},
  journal = {Neurology},
  year    = {2026},
  doi     = {10.1212/wnl.0000000000218494},
  pmid    = {42679336},
  url     = {https://doi.org/10.1212/wnl.0000000000218494}
}

@article{pereiradasilva2026-42721539,
  author  = {Pereira da Silva, A. M. and Tudella, G. C. N. and Lee, A. M. and Santos, D. H. and Cukiert, C. M. and Perry, G.},
  title   = {{Epilepsy and subsequent dementia in adults with down syndrome: a propensity score-matched cohort study using federated electronic health records}},
  journal = {Seizure},
  year    = {2026},
  doi     = {10.1016/j.seizure.2026.08.023},
  pmid    = {42721539},
  url     = {https://doi.org/10.1016/j.seizure.2026.08.023}
}

@article{marti2026-32527300,
  author  = {Marti, M. B. and Morrison, S. D. and Pars, S. and Al-mhanawi, B. and Noakes, P. G. and Wolvetang, E. J. and Shaker, M. R.},
  title   = {{Oligodendrocyte Enriched Brain Organoids Reveal Impaired Oligodendroglial Maturation and Altered Neural Network Activity in Down Syndrome}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.08.27.747500},
  url     = {https://doi.org/10.64898/2026.08.27.747500}
}

@article{nubling2026-42609160,
  author  = {Nübling, G. and Marth, L. and Sandkühler, K. and Stockbauer, A. and Wlasich, E. and Jäck, A. and Wagemann, O. and Kustermann, J. and others},
  title   = {{Frailty in Adults With Down Syndrome: Cognitive, Functional and Biomarker Associations}},
  journal = {Journal of intellectual disability research : JIDR},
  year    = {2026},
  doi     = {10.1111/jir.70162},
  pmid    = {42609160},
  url     = {https://doi.org/10.1111/jir.70162}
}

@article{didomenico2026-42532345,
  author  = {Di Domenico, F. and Barone, E. and Perluigi, M.},
  title   = {{BACH1/HO-1 axis dysregulation links Down syndrome to Alzheimer-like neurodegeneration}},
  journal = {Neurochemistry international},
  year    = {2026},
  doi     = {10.1016/j.neuint.2026.106232},
  pmid    = {42532345},
  url     = {https://doi.org/10.1016/j.neuint.2026.106232}
}

@article{kiely2026-d02e0979,
  author  = {Kiely, Fintan and Faherty, Clodagh and Mulhern, Eithne},
  title   = {{Early behavioural and adaptive markers of dementia in adults with Down syndrome}},
  journal = {International Journal of Intellectual Disability},
  year    = {2026},
  doi     = {10.22271/27103889.2026.v7.i2a.92},
  url     = {https://doi.org/10.22271/27103889.2026.v7.i2a.92}
}

@article{akgun2026-42334274,
  author  = {Akgün, E. and Minoshima, S.},
  title   = {{Pearls and Pitfalls of 18F-FDG PET/CT for Suspected Alzheimer's Disease in Patient with Down Syndrome}},
  journal = {Molecular imaging and radionuclide therapy},
  year    = {2026},
  doi     = {10.4274/mirt.galenos.2026.13285},
  pmid    = {42334274},
  url     = {https://doi.org/10.4274/mirt.galenos.2026.13285}
}

@article{flemingbatayneh2026-42244445,
  author  = {Fleming-Batayneh, V. L. and Helsel, B. C. and Ptomey, L. T. and Handen, B. L. and Mapstone, M. and Petersen, M. and Krinsky-McHale, S. J. and Hom, C. L. and others},
  title   = {{Inflammation Associated With Obesity, Aging, and Amyloid Burden in Adults With Down Syndrome}},
  journal = {Obesity (Silver Spring, Md.)},
  year    = {2026},
  doi     = {10.1002/oby.70229},
  pmid    = {42244445},
  url     = {https://doi.org/10.1002/oby.70229}
}

@article{wisch2026-41205623,
  author  = {Wisch, J. K. and Jiao, Z. and Kennedy, J. T. and Cohen, A. D. and Schlachetzki, Z. and Petersen, M. and Handen, B. L. and Christian, B. T. and others},
  title   = {{Imaging and plasma biomarkers for pathological accumulation in Down syndrome}},
  journal = {Brain : a journal of neurology},
  year    = {2026},
  doi     = {10.1093/brain/awaf418},
  pmid    = {41205623},
  url     = {https://doi.org/10.1093/brain/awaf418}
}

@article{chung2026-42096659,
  author  = {Chung, P. A. and Fleming, V. L. and Reid, K. J. and Plante, D. T. and Hom, C. L. and Ances, B. M. and Handen, B. L. and Christian, B. T. and others},
  title   = {{Circadian Rest-Activity Rhythms, Cognition, and Alzheimer Disease Dementia in Adults With Down Syndrome}},
  journal = {Neurology},
  year    = {2026},
  doi     = {10.1212/wnl.0000000000214938},
  pmid    = {42096659},
  url     = {https://doi.org/10.1212/wnl.0000000000214938}
}

@article{pittaras2026-4cc26495,
  author  = {Pittaras, Elsa and Kurashige, Tula and Peroulas, Sadie and Lopez, Stella and Chan, Lauren and Heller, Craig H.},
  title   = {{0076 Effect of a Tryptophan Enriched Diet on Mood, Cognition, Sleep and Their Associated Neurotransmitters/Hormones in a Mouse Model of Down Syndrome}},
  journal = {SLEEP},
  year    = {2026},
  doi     = {10.1093/sleep/zsag091.0076},
  url     = {https://doi.org/10.1093/sleep/zsag091.0076}
}

@article{chung2026-02ad0ff8,
  author  = {Chung, Paul A. and Fleming, Victoria and Reid, K and Plante, D and Hom, Christy L. and Ances, Beau M. and Handen, B and Christian, Bradley T. and others},
  title   = {{B31-13 Circadian Rest-Activity Rhythm and Alzheimer’s Disease Biomarkers in Adults With Down Syndrome}},
  journal = {American Journal of Respiratory and Critical Care Medicine},
  year    = {2026},
  doi     = {10.1093/ajrccm/aamag162.6475},
  url     = {https://doi.org/10.1093/ajrccm/aamag162.6475}
}

@article{crans2026-42078116,
  author  = {Crans, René A. J. and Fructuoso, Marta and Cardozo, Karen Bascon and Recaioglu, Hatice and Sotelo-Fonseca, Jesus and Vermeiren, Yannick and Strydom, André and Van Dam, Debby and others},
  title   = {{Common pathogenic mechanisms in the hippocampus across neurodegenerative dementias: Alzheimer’s disease, Down syndrome, and Parkinson’s disease}},
  journal = {npj Dementia},
  year    = {2026},
  doi     = {10.1038/s44400-026-00075-x},
  pmid    = {42078116},
  url     = {https://doi.org/10.1038/s44400-026-00075-x}
}

@article{tramutola2026-42072161,
  author  = {Tramutola, A. and Lanzillotta, C. and Di Domenico, F. and Barone, E. and Perluigi, M.},
  title   = {{Loss of Proteostasis and Early-Onset Neurodegeneration in Down Syndrome: From Mechanisms to Interventions}},
  journal = {Antioxidants (Basel, Switzerland)},
  year    = {2026},
  doi     = {10.3390/antiox15040520},
  pmid    = {42072161},
  url     = {https://doi.org/10.3390/antiox15040520}
}

@article{bourin2026-5d481cbc,
  author  = {Bourin, Michel},
  title   = {{The Genetics and Mechanisms of Alzheimer's Disease in Down Syndrome}},
  journal = {Journal of Mental Health Disorders},
  year    = {2026},
  doi     = {10.33696/mentalhealth.6.069},
  url     = {https://doi.org/10.33696/mentalhealth.6.069}
}

@article{pascual2026-41865347,
  author  = {Pascual, JR. and Rivera, I. and Nguyen, H. and Ngo, P. T. and Hoang, A. and Andrews, E. J. and Rouanet, J. and Wright, S. T. and others},
  title   = {{Neuropathological measures of increased tau phosphorylation across the Down syndrome lifespan}},
  journal = {Acta neuropathologica},
  year    = {2026},
  doi     = {10.1007/s00401-026-02994-8},
  pmid    = {41865347},
  url     = {https://doi.org/10.1007/s00401-026-02994-8}
}

@article{tramutola2026-08b5b6ac,
  author  = {Tramutola, A. and Lanzillotta, C. and Di Domenico, F. and Barone, E. and Perluigi, M.},
  title   = {{Loss of Proteostasis and Abnormal Aging in Down Syndrome: From Mechanisms to Interventions}},
  journal = {Antioxidants (Basel, Switzerland)},
  year    = {2026},
  doi     = {10.20944/preprints202603.1305.v1},
  url     = {https://doi.org/10.20944/preprints202603.1305.v1}
}

@article{silva2026-2fa394a3,
  author  = {Silva, Marina Nascimento and Nassif, Lívia Silva and Guerra‐Júnior, Augusto Afonso},
  title   = {{Vitamina E e outros antioxidantes na síndrome de Down para pacientes com demência: evidências iniciais com foco em marcadores genéticos}},
  journal = {Jornal de Assistência Farmacêutica e Farmacoeconomia},
  year    = {2026},
  doi     = {10.22563/2525-7323.2026.v11.e00332},
  url     = {https://doi.org/10.22563/2525-7323.2026.v11.e00332}
}

@article{suzuki2026-869f3368,
  author  = {Suzuki, Marisa and Chennu, Yamini and Olson, Paula and Holmes, Vic},
  title   = {{Evaluation of Memory Changes in Patient with Down Syndrome}},
  journal = {SteadFAST Case Reports in PA Studies},
  year    = {2026},
  doi     = {10.64918/20.500.12503/33514},
  url     = {https://doi.org/10.64918/20.500.12503/33514}
}

@article{pal2026-30252272,
  author  = {Pal, A. and Daley, S. F.},
  title   = {{Down Syndrome}},
  journal = {StatPearls Publishing, Treasure Island (FL)},
  year    = {2026},
  pmid    = {30252272}
}

@article{clina2026-41561734,
  author  = {Clina, J. G. and Helsel, B. C. and Hartley, S. L. and White, D. A. and Fleming-Batayneh, V. L. and Handen, B. and Christian, B. and Head, E. and others},
  title   = {{The impact of congenital heart disease on the timing of Alzheimer's disease in Down syndrome}},
  journal = {Alzheimer's \& dementia (Amsterdam, Netherlands)},
  year    = {2026},
  doi     = {10.1002/dad2.70257},
  pmid    = {41561734},
  url     = {https://doi.org/10.1002/dad2.70257}
}

@article{russell2026-41525055,
  author  = {Russell, Jason K and Schlachetzki, Zinayida and Ances, Beau M. and Rafii, Michael S. and Andrews, Howard F and Bell, Karen L. and Birn, Rasmus M. and others},
  title   = {{Concordance of Biological and Clinical Staging of Alzheimer Disease Pathology in Down Syndrome}},
  journal = {JAMA Neurology},
  year    = {2026},
  doi     = {10.1001/jamaneurol.2025.5261},
  pmid    = {41525055},
  url     = {https://doi.org/10.1001/jamaneurol.2025.5261}
}

@article{head2026-41505228,
  author  = {Head, Elizabeth and Cohen, Ann D. and Fortea, Juan and McGlinchey, Eimear},
  title   = {{Novel insights into Alzheimer's disease through the study of individuals with Down syndrome}},
  journal = {Alzheimer s \& Dementia},
  year    = {2026},
  doi     = {10.1002/alz.71074},
  pmid    = {41505228},
  url     = {https://doi.org/10.1002/alz.71074}
}

@article{ganguly2025-f226c855,
  author  = {Ganguly, Bani Bandana and Kadam, Nitin N.},
  title   = {{Impact of Triplicated DYRK1A on Neurogenesis and Intellectual Disability in Down Syndrome and Therapeutic Potential}},
  journal = {Gene Expression},
  year    = {2025},
  doi     = {10.14218/ge.2025.00051},
  url     = {https://doi.org/10.14218/ge.2025.00051}
}

@article{song2025-f89d89bf,
  author  = {Song, Z. and Morgan, S. E. and Zaman, S.},
  title   = {{Multi-dimensional attention framework for personalized Alzheimer’s disease progression prediction across sporadic and genetic risk cohorts}},
  journal = {medRxiv},
  year    = {2025},
  doi     = {10.64898/2025.12.13.25342199},
  url     = {https://doi.org/10.64898/2025.12.13.25342199}
}

@article{sherif2025-41448156,
  author  = {Sherif, Hayat M and Clark, Lindsay R. and Chin, Nathaniel A. and Hartley, Sigan L. and Christian, Bradley T. and Ketchum, Fred B.},
  title   = {{Adaptation of a Protocol for Disclosure of Amyloid PET Results for Adults with Down Syndrome and Their Caregivers}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70858_100947},
  pmid    = {41448156},
  url     = {https://doi.org/10.1002/alz70858_100947}
}

@article{brothers2025-41444861,
  author  = {Brothers, Courtney E and Wisch, Julie K. and Handen, Benjamin L. and Lao, Patrick J. and Ances, Beau M. and Kennedy, James Tyler and Zammit, Matthew D. and Christian, Bradley T. and others},
  title   = {{Cardiovascular Risk Composite and Time of Amyloid Accumulation and Cognitive Decline in Down Syndrome Alzheimer's Disease}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70857_099395},
  pmid    = {41444861},
  url     = {https://doi.org/10.1002/alz70857_099395}
}

@article{maureblesa2025-41447445,
  author  = {Maure‐Blesa, Lucía and Pichot, Maria Borrell and Rodríguez‐Baz, Íñigo and Fernández, Patricia Carbonell and Arranz, Javier and Arriola‐Infante, José Enrique and Aranha, Mateus Rozalem and Bejanin, Alexandre and others},
  title   = {{Challenges in Managing Cerebral Amyloid Angiopathy in Alzheimer's Disease: Insights from a Case of Down Syndrome‐associated Alzheimer Disease (DSAD)}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70856_100856},
  pmid    = {41447445},
  url     = {https://doi.org/10.1002/alz70856_100856}
}

@article{arriolainfante2025-294a9f95,
  author  = {Arriola‐Infante, José Enrique and Morcillo-Nieto, Alejandra Omaira and Franquesa‐Mullerat, María and Zsadanyi, Sára E. and Vaqué‐Alcázar, Lídia and Aranha, Mateus Rozalem and Parra, Jose Allende and Zhao, Zili and others},
  title   = {{Distinct Sensitivity of MRI Versus [ 18 F]FDG‐PET To Detect Cerebral Changes Across the Alzheimer's Continuum in Down Syndrome: A Multimodal Imaging Study}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70856_107114},
  url     = {https://doi.org/10.1002/alz70856_107114}
}

@article{thorwald2025-41444200,
  author  = {Thorwald, Max Andrew and Godoy-Lugo, José Arquimides and Vermulst, Marc and Forman, Henry Jay and Head, Elizabeth and Finch, Caleb E.},
  title   = {{Down syndrome with Alzheimer's disease brains have increased iron and associated lipid peroxidation consistent with ferroptosis}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70855_105930},
  pmid    = {41444200},
  url     = {https://doi.org/10.1002/alz70855_105930}
}

@article{morcillonieto2025-41433511,
  author  = {Morcillo-Nieto, Alejandra Omaira and Arriola‐Infante, José Enrique and Franquesa‐Mullerat, María and Zsadanyi, Sára E. and Vaqué‐Alcázar, Lídia and Aranha, Mateus Rozalem and Parra, Jose Allende and Zhao, Zili and others},
  title   = {{Early Detection of White Matter Integrity Changes in Down Syndrome: The Promise of PSMD as a Sensitive Biomarker}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70862_109982},
  pmid    = {41433511},
  url     = {https://doi.org/10.1002/alz70862_109982}
}

@article{morcillonieto2025-89e62d72,
  author  = {Morcillo-Nieto, Alejandra Omaira and Arriola‐Infante, José Enrique and Franquesa‐Mullerat, María and Zsadanyi, Sára E. and Vaqué‐Alcázar, Lídia and Aranha, Mateus Rozalem and Parra, Jose Allende and Zhao, Zili and others},
  title   = {{Early Detection of White Matter Integrity Changes in Down Syndrome: The Promise of PSMD as a Sensitive Biomarker}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70856_106537},
  url     = {https://doi.org/10.1002/alz70856_106537}
}

@article{valencia2025-41449092,
  author  = {Valencia, Diana K. and Silverman, Wayne P. and Hartley, Sigan L. and Zaman, Shahid H. and Brickman, Adam and Lai, Florence Y. and Mapstone, Mark E. and Krinsky‐McHale, Sharon J. and others},
  title   = {{Factors Associated with Atypical Cognitive Trajectories in Older Adults with Down Syndrome}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70857_105703},
  pmid    = {41449092},
  url     = {https://doi.org/10.1002/alz70857_105703}
}

@article{taylor2025-41434168,
  author  = {Taylor, Lisa M. and Adams, Jenna N. and DiProspero, Natalie D. and McMillan, Liv C. and Sathishkumar, Mithra T. and Doran, Eric W. and Lai, Florence Y. and Rosas, H. Diana and others},
  title   = {{Functional connectivity differences in the default mode and frontoparietal networks in older adults with Down syndrome are related to obstructive sleep apnea}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70862_110032},
  pmid    = {41434168},
  url     = {https://doi.org/10.1002/alz70862_110032}
}

@article{taylor2025-ac6f6260,
  author  = {Taylor, Lisa M. and Adams, Jenna N. and DiProspero, Natalie D. and McMillan, Liv C. and Sathishkumar, Mithra T. and Doran, Eric W. and Lai, Florence Y. and Rosas, H. Diana and others},
  title   = {{Functional connectivity differences in the default mode and frontoparietal networks in older adults with Down syndrome are related to obstructive sleep apnea}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70856_105803},
  url     = {https://doi.org/10.1002/alz70856_105803}
}

@article{rahachowdhury2025-41449809,
  author  = {Raha‐Chowdhury, Ruma},
  title   = {{Identification of candidate serum protein biomarkers in Down's syndrome dementia}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70856_102904},
  pmid    = {41449809},
  url     = {https://doi.org/10.1002/alz70856_102904}
}

@article{linker2025-0b6c1de8,
  author  = {Linker, Alexandra and Hartley, Sigan L. and Zaman, Shahid H. and Fonseca, Luciana Mascarenhas},
  title   = {{Life Stress and Dementia Risk in Adults with Down Syndrome}},
  journal = {Innovation in Aging},
  year    = {2025},
  doi     = {10.1093/geroni/igaf122.3619},
  url     = {https://doi.org/10.1093/geroni/igaf122.3619}
}

@article{kennedy2025-41442130,
  author  = {Kennedy, James Tyler},
  title   = {{Mild premorbid intellectual impairment as a resilience factor in Down syndrome associated Alzheimer's disease}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70856_099392},
  pmid    = {41442130},
  url     = {https://doi.org/10.1002/alz70856_099392}
}

@article{mclachlan2025-41434190,
  author  = {McLachlan, Max and DiFilippo, Alexandra H and Bettcher, Brecca and LeMerise, Lisette and McVea, Andrew K and Zammit, Matthew D. and Hartley, Sigan L. and Bendlin, Barbara B. and others},
  title   = {{Relationship between tau and SV2A in the neurotypical population and translation to the Down syndrome population}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70862_110209},
  pmid    = {41434190},
  url     = {https://doi.org/10.1002/alz70862_110209}
}

@article{mclachlan2025-41450092,
  author  = {McLachlan, Max and DiFilippo, Alexandra H and Bettcher, Brecca and LeMerise, Lisette and McVea, Andrew K and Zammit, Matthew D. and Hartley, Sigan L. and Bendlin, Barbara B. and others},
  title   = {{Relationship between tau and SV2A in the neurotypical population and translation to the Down syndrome population}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70856_103321},
  pmid    = {41450092},
  url     = {https://doi.org/10.1002/alz70856_103321}
}

@article{videla2025-41518664,
  author  = {Videla, Laura and Benejam, Bessy and Barroeta, Isabel and Fernández, Susana and Arranz, Javier and Rodríguez‐Baz, Íñigo and Arriola‐Infante, José Enrique and Maure‐Blesa, Lucía and others},
  title   = {{The Down Alzheimer Barcelona Neuroimaging Initiative (DABNI): Ten Years of Progress in Understanding Alzheimer's in Down Syndrome}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70856_106426},
  pmid    = {41518664},
  url     = {https://doi.org/10.1002/alz70856_106426}
}

@article{didomenico2025-41269384,
  author  = {Di Domenico, F. and Greco, V. and Tramutola, A. and Rataj-Baniowska, M. and Barone, E. and Lanzillotta, C. and Pieroni, L. and Butterfield, D. A. and others},
  title   = {{Proteome Signature of Alzheimer-Like Phenotypes in Frontal Cortices From Young and Old Individuals With Down Syndrome}},
  journal = {Molecular neurobiology},
  year    = {2025},
  doi     = {10.1007/s12035-025-05432-0},
  pmid    = {41269384},
  url     = {https://doi.org/10.1007/s12035-025-05432-0}
}

@article{crans2025-7fc8ca4a,
  author  = {Crans, R. A. J. and Fructuoso, M. and Cardozo, K. B. and Recaioglu, H. and Fonseca, J. S. and Vermeiren, Y. and Strydom, A. and Dam, D. V. and others},
  title   = {{Common pathogenic mechanisms in the hippocampus across neurodegenerative dementias: Alzheimer's disease, Down syndrome, and Parkinson's disease}},
  journal = {NPJ dementia},
  year    = {2025},
  doi     = {10.21203/rs.3.rs-7703742/v1},
  url     = {https://doi.org/10.21203/rs.3.rs-7703742/v1}
}

@article{rubenstein2025-41105592,
  author  = {Rubenstein, E. and Tewolde, S. and Michals, A. and Fortea, J. and Jimenez, M. P. and Skotko, B. G. and Tripodis, Y. and Weuve, J. and others},
  title   = {{Novel predictors of Alzheimer's disease in Down syndrome identified using machine learning}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2025},
  doi     = {10.1177/13872877251385423},
  pmid    = {41105592},
  url     = {https://doi.org/10.1177/13872877251385423}
}

@article{clina2025-41100837,
  author  = {Clina, J. G. and Helsel, B. C. and Hartley, S. L. and Fleming-Batayneh, V. L. and Handen, B. and Christian, B. and Head, E. and Mapstone, M. and others},
  title   = {{The joint association of obesity and physical activity on cognitive function in Down syndrome}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2025},
  doi     = {10.1177/13872877251386474},
  pmid    = {41100837},
  url     = {https://doi.org/10.1177/13872877251386474}
}

@article{dass2025-41104603,
  author  = {Dass, D. and Dang, L. T. and Xicota, L. and Krinsky-McHale, S. and Kannappan, B. and Brickman, A. M. and Christian, B. T. and Head, E. and others},
  title   = {{Examination of metabolic syndrome in Down syndrome and association with dementia}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2025},
  doi     = {10.1002/alz.70799},
  pmid    = {41104603},
  url     = {https://doi.org/10.1002/alz.70799}
}

@article{abdelmoity2025-40977577,
  author  = {Abdelmoity, O. and Wisch, J. K. and Kennedy, J. T. and Goyal, M. and Vlassenko, A. and Flores, S. and Handen, B. L. and Head, E. and others},
  title   = {{Cross-Sectional FDG in Down Syndrome and Autosomal Dominant Alzheimer's Disease}},
  journal = {Annals of neurology},
  year    = {2025},
  doi     = {10.1002/ana.78002},
  pmid    = {40977577},
  url     = {https://doi.org/10.1002/ana.78002}
}

@article{rivera2025-01964e62,
  author  = {Rivera, Sofía Lucila Rodríguez and Martínez, Héctor R. and Cantú, José Antonio Infante and Osorio, Enrique Caro},
  title   = {{Exploring the relationship between epilepsy and neurodegenerative diseases}},
  journal = {Romanian Journal of Neurology},
  year    = {2025},
  doi     = {10.37897/rjn.2025.3.2},
  url     = {https://doi.org/10.37897/rjn.2025.3.2}
}

@article{santoro2025-40923238,
  author  = {Santoro, Stephanie L. and Spognardi, Alexa Gozdiff and Bregman, Caroline and Cottrell, Clorinda and Oey, Elizabeth and Pulsifer, Margaret B. and Skotko, Brian G. and Torres, Amy and others},
  title   = {{Use of a Screening Tool for Dementia in a Down Syndrome Specialty Clinic}},
  journal = {American Journal of Medical Genetics Part A},
  year    = {2025},
  doi     = {10.1002/ajmg.a.64251},
  pmid    = {40923238},
  url     = {https://doi.org/10.1002/ajmg.a.64251}
}

@article{gomes2025-40959651,
  author  = {Gomes, F. C. and Bertelli, B. P. and de Souza, C. P. and Santos, D. R. O. and de Melo-Neto, J. S. and ÉC, Pavarino and Goloni-Bertollo, E. M.},
  title   = {{HSPA13 gene and microRNA-155: relationship between Down syndrome and Alzheimer's disease}},
  journal = {Dementia \& neuropsychologia},
  year    = {2025},
  doi     = {10.1590/1980-5764-dn-2024-0239},
  pmid    = {40959651},
  url     = {https://doi.org/10.1590/1980-5764-dn-2024-0239}
}

@article{higgins2026-40903895,
  author  = {Higgins, A. and Tewolde, S. and Page, S. D. and Rubenstein, E.},
  title   = {{The Occurrence of Obstructive Sleep Apnea and Its Association With Alzheimer Dementia in Medicaid-Enrolled Adults With Down Syndrome, 2011-2019}},
  journal = {American journal of medical genetics. Part A},
  year    = {2026},
  doi     = {10.1002/ajmg.a.64241},
  pmid    = {40903895},
  url     = {https://doi.org/10.1002/ajmg.a.64241}
}

@article{yoon2025-40794806,
  author  = {Yoon, D. M. and Plante, D. and Fleming, V. and Handen, B. and Lao, P. and Peven, J. and Christian, B. and Okonkwo, O. and others},
  title   = {{Preliminary Investigation of Obstructive Sleep Apnea and Alzheimer's Disease in Down Syndrome}},
  journal = {Sleep},
  year    = {2025},
  doi     = {10.1093/sleep/zpaf044},
  pmid    = {40794806},
  url     = {https://doi.org/10.1093/sleep/zpaf044}
}

@article{yoon2025-40917568,
  author  = {Yoon, D. M. and Plante, D. T. and Fleming, V. and Handen, B. and Lao, P. and Peven, J. and Christian, B. and Okonkwo, O. and others},
  title   = {{Preliminary investigation of obstructive sleep apnea and Alzheimer's disease in down syndrome}},
  journal = {Sleep advances : a journal of the Sleep Research Society},
  year    = {2025},
  doi     = {10.1093/sleepadvances/zpaf044},
  pmid    = {40917568},
  url     = {https://doi.org/10.1093/sleepadvances/zpaf044}
}

@article{lanzillotta2025-40684658,
  author  = {Lanzillotta, C. and Prestia, F. and Greco, V. and Iavarone, F. and Cordella, F. and Sette, C. and Forte, E. and Tramutola, A. and others},
  title   = {{Enhancing protein O-GlcNAcylation in down syndrome mice mitigates memory dysfunctions through the rescue of mitochondrial bioenergetics, stress responses and pathological markers}},
  journal = {Redox biology},
  year    = {2025},
  doi     = {10.1016/j.redox.2025.103769},
  pmid    = {40684658},
  url     = {https://doi.org/10.1016/j.redox.2025.103769}
}

@article{lisgaras2025-40642994,
  author  = {Lisgaras, Christos Panagiotis and Giménez, Sandra and Carmona‐Iragui, María and Maure‐Blesa, Lucía and Blessing, Esther and Fortea, Juan and Osorio, Ricardo S.},
  title   = {{High‐frequency oscillations >250 Hz in people with Down syndrome and associated Alzheimer's disease dementia}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz.70386},
  pmid    = {40642994},
  url     = {https://doi.org/10.1002/alz.70386}
}

@article{montoliugaya2025-40595720,
  author  = {Montoliu-Gaya, L. and Bian, S. and Dammer, E. B. and Alcolea, D. and Sauer, M. and Martá-Ariza, M. and Ashton, N. J. and Belbin, O. and others},
  title   = {{Proteomic analysis of Down syndrome cerebrospinal fluid compared to late-onset and autosomal dominant Alzheimer´s disease}},
  journal = {Nature communications},
  year    = {2025},
  doi     = {10.1038/s41467-025-61054-z},
  pmid    = {40595720},
  url     = {https://doi.org/10.1038/s41467-025-61054-z}
}

@article{moka2025-a67d150e,
  author  = {Moka, Rajasekhar and Sudheer, Manjima and Kumar, Prabodh},
  title   = {{Unraveling the Genetic and Phenotypic Complexity of Down Syndrome from Trisomy 21 to Comorbid Conditions}},
  journal = {International Journal of Genetics and Genomics},
  year    = {2025},
  doi     = {10.11648/j.ijgg.20251302.14},
  url     = {https://doi.org/10.11648/j.ijgg.20251302.14}
}

@article{bernhardt2025-40528443,
  author  = {Bernhardt, A. M. and Í, Rodríguez-Baz and Aldecoa, I. and Arranz, J. and Arriola-Infante, J. E. and Maure-Blesa, L. and Carmona-Iragui, M. and Longen, S. and others},
  title   = {{Alpha-synuclein co-pathology in Down syndrome-associated Alzheimer's disease}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2025},
  doi     = {10.1002/alz.70342},
  pmid    = {40528443},
  url     = {https://doi.org/10.1002/alz.70342}
}

@article{barroeta2025-40528298,
  author  = {Barroeta, Isabel and Videla, Laura and Carmona‐Iragui, María and Fortea, Juan and Rafii, Michael S.},
  title   = {{Current advances and unmet needs in Alzheimer's disease trials for individuals with Down syndrome: Navigating new therapeutic frontiers}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz.70258},
  pmid    = {40528298},
  url     = {https://doi.org/10.1002/alz.70258}
}

@article{soriano2025-40528393,
  author  = {Soriano, Laura del Hoyo and Sandkühler, Katja and Videla, Laura and Benejam, Bessy and Carmona‐Iragui, María and Wlasich, Elisabeth and Kustermann, Julia and Barroeta, Isabel and others},
  title   = {{Discrepancies in assessing intellectual disability levels in adults with Down syndrome: Implications for dementia diagnosis}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz.70307},
  pmid    = {40528393},
  url     = {https://doi.org/10.1002/alz.70307}
}

@article{rosas2025-40474237,
  author  = {Rosas, H. D. and Lai, F. and Mercaldo, N.},
  title   = {{Lipoprotein(a) levels in Down syndrome: A conundrum}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2025},
  doi     = {10.1002/alz.70338},
  pmid    = {40474237},
  url     = {https://doi.org/10.1002/alz.70338}
}

@article{videla2025-40528282,
  author  = {Videla, L. and Benejam, B. and Barroeta, I. and Fernandez, S. and Altuna, M. and Arranz, J. and Í, Rodríguez-Baz and Arriola-Infante, J. E. and others},
  title   = {{The Down Alzheimer Barcelona Neuroimaging Initiative (DABNI) and its contributions to understanding Alzheimer's disease in Down syndrome: A decade of discovery}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2025},
  doi     = {10.1002/alz.70259},
  pmid    = {40528282},
  url     = {https://doi.org/10.1002/alz.70259}
}

@article{schworer2025-40254895,
  author  = {Schworer, E. K. and Handen, B. L. and Krinsky-McHale, S. and Hom, C. L. and Clare, I. C. H. and Harp, J. P. and Pulsifer, M. B. and Mapstone, M. and others},
  title   = {{Modified Cued Recall Test: Longitudinal Analysis of Test Versions and Item Recall in Adults With Down Syndrome}},
  journal = {Journal of intellectual disability research : JIDR},
  year    = {2025},
  doi     = {10.1111/jir.13237},
  pmid    = {40254895},
  url     = {https://doi.org/10.1111/jir.13237}
}

@article{zuo2025-40249934,
  author  = {Zuo, X.},
  title   = {{Mitochondrial Imbalance in Down Syndrome: A Driver of Accelerated Brain Aging?}},
  journal = {Aging and disease},
  year    = {2025},
  doi     = {10.14336/ad.2025.0189},
  pmid    = {40249934},
  url     = {https://doi.org/10.14336/ad.2025.0189}
}

@article{cordeiro2025-40179214,
  author  = {Cordeiro, A. M. T. and Singulani, M. P. and Talib, L. L. and Forlenza, O. V.},
  title   = {{Down syndrome and Alzheimer's disease: Oxidative stress in the neurodegenerative process}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2025},
  doi     = {10.1177/13872877251326291},
  pmid    = {40179214},
  url     = {https://doi.org/10.1177/13872877251326291}
}

@article{mclachlan2025-40189783,
  author  = {McLachlan, M. and Bettcher, B. and McVea, A. and DiFilippo, A. and Zammit, M. and LeMerise, L. and Rouanet, J. and Price, J. and others},
  title   = {{The striatum is an early, accurate indicator of amyloid burden using [11C]PiB in Down syndrome: Comparison of two radiotracers}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2025},
  doi     = {10.1002/alz.70141},
  pmid    = {40189783},
  url     = {https://doi.org/10.1002/alz.70141}
}

@article{zammit2025-8ec63439,
  author  = {Zammit, M. D. and Price, J. C. and Christian, B. T. and Rafii, M. S. and {Alzheimer’s Biomarker Consortium – Down Syndrome}},
  title   = {{A head-to-head comparison of multiple amyloid PET radiotracers for Down syndrome clinical trials}},
  journal = {medRxiv},
  year    = {2025},
  doi     = {10.1101/2025.03.18.25324200},
  url     = {https://doi.org/10.1101/2025.03.18.25324200}
}

@article{arriolainfante2025-40084922,
  author  = {Arriola-Infante, J. E. and Morcillo-Nieto, A. O. and Zsadanyi, S. E. and Franquesa-Mullerat, M. and Vaqué-Alcázar, L. and Rozalem-Aranha, M. and Arranz, J. and Í, Rodríguez-Baz and others},
  title   = {{Regional Brain Metabolism across the Alzheimer's Disease Continuum in Down Syndrome}},
  journal = {Annals of neurology},
  year    = {2025},
  doi     = {10.1002/ana.27226},
  pmid    = {40084922},
  url     = {https://doi.org/10.1002/ana.27226}
}

@article{dohl2025-40042516,
  author  = {Dohl, J. and Treadwell, Z. and Norris, C. and Head, E.},
  title   = {{Calcineurin inhibition may prevent Alzheimer disease in people with Down syndrome}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2025},
  doi     = {10.1002/alz.70034},
  pmid    = {40042516},
  url     = {https://doi.org/10.1002/alz.70034}
}

@article{cuello2025-40340070,
  author  = {Cuello, A. C. and Do Carmo, S.},
  title   = {{The dependence of basal forebrain cholinergic neurons on NGF: The case in Alzheimer pathology}},
  journal = {Handbook of clinical neurology},
  year    = {2025},
  doi     = {10.1016/b978-0-443-19088-9.00010-x},
  pmid    = {40340070},
  url     = {https://doi.org/10.1016/b978-0-443-19088-9.00010-x}
}

@article{i2025-39689339,
  author  = {Í, Rodríguez-Baz and Benejam, B. and Morcillo-Nieto, A. O. and Vaqué-Alcázar, L. and Arriola-Infante, J. E. and Camacho, V. and Aranha, M. R. and Carmona-Iragui, M. and others},
  title   = {{Posterior Cortical Atrophy Due to Alzheimer Disease in a Person With Down Syndrome: A Case Report}},
  journal = {Neurology},
  year    = {2025},
  doi     = {10.1212/wnl.0000000000210179},
  pmid    = {39689339},
  url     = {https://doi.org/10.1212/wnl.0000000000210179}
}

@article{mclachlan2024-c829b099,
  author  = {McLachlan, M. and Bettcher, B. and McVea, A. and DiFillipo, A. and Zammit, M. and LeMerise, L. and Rouanet, J. and Price, J. and others},
  title   = {{The striatum is an early, accurate indicator of amyloid burden using [11C]PiB in Down syndrome: comparison of two radiotracers}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2024},
  doi     = {10.1101/2024.12.04.24318526},
  url     = {https://doi.org/10.1101/2024.12.04.24318526}
}

@article{huang2024-39533897,
  author  = {Huang, T. and Lam, X. J. and Lim, C. T. and Jusoh, N. and Fakurazi, S. and Cheah, P. S. and Ling, K. H.},
  title   = {{Understanding perspectives and research trends in Down syndrome neuropathogenesis: A bibliometric analysis}},
  journal = {Journal of intellectual disabilities : JOID},
  year    = {2024},
  doi     = {10.1177/17446295241299160},
  pmid    = {39533897},
  url     = {https://doi.org/10.1177/17446295241299160}
}

@article{castellani2025-39532243,
  author  = {Castellani, R. J. and Jamshidi, P. and Plascencia-Villa, G. and Perry, G.},
  title   = {{The Amyloid Cascade Hypothesis: A Conclusion in Search of Support}},
  journal = {The American journal of pathology},
  year    = {2025},
  doi     = {10.1016/j.ajpath.2024.10.014},
  pmid    = {39532243},
  url     = {https://doi.org/10.1016/j.ajpath.2024.10.014}
}

@article{xicota2024-39500037,
  author  = {Xicota, L. and Dang, L. T. and Lee, A. and Krinsky-McHale, S. and Pang, D. and Melilli, L. and O'Bryant, S. and Henson, R. L. and others},
  title   = {{The effects of mosaicism on biological and clinical markers of Alzheimer's disease in adults with Down syndrome}},
  journal = {EBioMedicine},
  year    = {2024},
  doi     = {10.1016/j.ebiom.2024.105433},
  pmid    = {39500037},
  url     = {https://doi.org/10.1016/j.ebiom.2024.105433}
}

@article{huer2025-39384617,
  author  = {Hüer, T. and Weitzel, M. and Giebel, G. D. and Raszke, P. and Wasem, J. and Levin, J. and Nübling, G. and Wagemann, O. and others},
  title   = {{[Alzheimer's dementia in people with Down syndrome : Results of guideline-assisted expert interviews on healthcare deficits in the diagnostics and treatment as well as solution approaches]}},
  journal = {Zeitschrift fur Gerontologie und Geriatrie},
  year    = {2025},
  doi     = {10.1007/s00391-024-02371-8},
  pmid    = {39384617},
  url     = {https://doi.org/10.1007/s00391-024-02371-8}
}

@article{rosas2024-39583646,
  author  = {Rosas, H. D. and Mercaldo, N. D. and Hasimoglu, Y. and Petersen, M. and Lewis, L. R. and Lai, F. and Powell, D. and Dhungana, A. and others},
  title   = {{Association of plasma neurofilament light chain with microstructural white matter changes in Down syndrome}},
  journal = {Alzheimer's \& dementia (Amsterdam, Netherlands)},
  year    = {2024},
  doi     = {10.1002/dad2.70023},
  pmid    = {39583646},
  url     = {https://doi.org/10.1002/dad2.70023}
}

@article{liu2024-39158850,
  author  = {Liu, L. and Saba, A. and Pascual, JR. and Miller, M. B. and Hennessey, E. L. and Lott, I. T. and Brickman, A. M. and Wilcock, D. M. and others},
  title   = {{Lecanemab and Vascular-Amyloid Deposition in Brains of People With Down Syndrome}},
  journal = {JAMA neurology},
  year    = {2024},
  doi     = {10.1001/jamaneurol.2024.2579},
  pmid    = {39158850},
  url     = {https://doi.org/10.1001/jamaneurol.2024.2579}
}

@article{azimzadeh2024-39307112,
  author  = {Azimzadeh, M. and Cheah, P. S. and Ling, K. H.},
  title   = {{Brain insulin resistance in Down syndrome: Involvement of PI3K-Akt/mTOR axis in early-onset of Alzheimer's disease and its potential as a therapeutic target}},
  journal = {Biochemical and biophysical research communications},
  year    = {2024},
  doi     = {10.1016/j.bbrc.2024.150713},
  pmid    = {39307112},
  url     = {https://doi.org/10.1016/j.bbrc.2024.150713}
}

@article{rubenstein2024-39312235,
  author  = {Rubenstein, E. and Tewolde, S. and Michals, A. and Weuve, J. and Fortea, J. and Fox, M. P. and Pescador Jimenez, M. and Scott, A. and others},
  title   = {{Alzheimer Dementia Among Individuals With Down Syndrome}},
  journal = {JAMA network open},
  year    = {2024},
  doi     = {10.1001/jamanetworkopen.2024.35018},
  pmid    = {39312235},
  url     = {https://doi.org/10.1001/jamanetworkopen.2024.35018}
}

@article{schworer2024-f00bce0d,
  author  = {Schworer, E. K. and Zammit, M. D. and Wang, J. and Handen, B. L. and Betthauser, T. and Laymon, C. M. and Tudorascu, D. L. and Cohen, A. D. and others},
  title   = {{Amyloid age and tau PET timeline to symptomatic Alzheimer’s disease in Down syndrome}},
  journal = {medRxiv},
  year    = {2024},
  doi     = {10.1101/2024.08.08.24311702},
  url     = {https://doi.org/10.1101/2024.08.08.24311702}
}

@article{perry2024-39127343,
  author  = {Perry, J. C. and Vann, S. D.},
  title   = {{Reduction in neurons immunoreactive for calcium-binding proteins in the anteroventral thalamic nuclei of individuals with Down syndrome}},
  journal = {Neuroscience},
  year    = {2024},
  doi     = {10.1016/j.neuroscience.2024.08.004},
  pmid    = {39127343},
  url     = {https://doi.org/10.1016/j.neuroscience.2024.08.004}
}

@article{zsadanyi2024-39074338,
  author  = {Zsadanyi, S. E. and Morcillo-Nieto, A. O. and Aranha, M. R. and Aragón, I. and Arriola-Infante, J. E. and Vaqué-Alcázar, L. and Montal, V. and Pegueroles, J. and others},
  title   = {{Associations of Microbleeds and Their Topography With Imaging and CSF Biomarkers of Alzheimer Pathology in Individuals With Down Syndrome}},
  journal = {Neurology},
  year    = {2024},
  doi     = {10.1212/wnl.0000000000209676},
  pmid    = {39074338},
  url     = {https://doi.org/10.1212/wnl.0000000000209676}
}

@article{schuy2024-39669604,
  author  = {Schuy, J. and Sæther, K. B. and Lisfeld, J. and Ek, M. and Grochowski, C. M. and Lun, M. Y. and Hastie, A. and Rudolph, S. and others},
  title   = {{A combination of long- and short-read genomics reveals frequent p-arm breakpoints within chromosome 21 complex genomic rearrangements}},
  journal = {Genetics in medicine open},
  year    = {2024},
  doi     = {10.1016/j.gimo.2024.101863},
  pmid    = {39669604},
  url     = {https://doi.org/10.1016/j.gimo.2024.101863}
}

@article{krasny2024-38940611,
  author  = {Krasny, S. and Yan, C. and Hartley, S. L. and Handen, B. L. and Wisch, J. K. and Boehrwinkle, A. H. and Ances, B. M. and Rafii, M. S. and others},
  title   = {{Assessing amyloid PET positivity and cognitive function in Down syndrome to guide clinical trials targeting amyloid}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2024},
  doi     = {10.1002/alz.14068},
  pmid    = {38940611},
  url     = {https://doi.org/10.1002/alz.14068}
}

@article{kwetsie2024-38759134,
  author  = {Kwetsie, H. and van Schaijk, M. and Van Der Lee, S. and Maes-Festen, D. and Ten Hoopen, L. W. and van Haelst, M. M. and Coesmans, M. and Van Den Berg, E. and others},
  title   = {{Dementia in Rare Genetic Neurodevelopmental Disorders: A Systematic Literature Review}},
  journal = {Neurology},
  year    = {2024},
  doi     = {10.1212/wnl.0000000000209413},
  pmid    = {38759134},
  url     = {https://doi.org/10.1212/wnl.0000000000209413}
}

@article{lanzillotta2024-38705491,
  author  = {Lanzillotta, C. and Baniowska, M. R. and Prestia, F. and Sette, C. and Nalesso, V. and Perluigi, M. and Barone, E. and Duchon, A. and others},
  title   = {{Shaping down syndrome brain cognitive and molecular changes due to aging using adult animals from the Ts66Yah murine model}},
  journal = {Neurobiology of disease},
  year    = {2024},
  doi     = {10.1016/j.nbd.2024.106523},
  pmid    = {38705491},
  url     = {https://doi.org/10.1016/j.nbd.2024.106523}
}

@article{wisch2024-38631766,
  author  = {Wisch, J. K. and McKay, N. S. and Boerwinkle, A. H. and Kennedy, J. and Flores, S. and Handen, B. L. and Christian, B. T. and Head, E. and others},
  title   = {{Comparison of tau spread in people with Down syndrome versus autosomal-dominant Alzheimer's disease: a cross-sectional study}},
  journal = {The Lancet. Neurology},
  year    = {2024},
  doi     = {10.1016/s1474-4422(24)00084-x},
  pmid    = {38631766},
  url     = {https://doi.org/10.1016/s1474-4422(24)00084-x}
}

@article{gujjala2024-77053260,
  author  = {Gujjala, V. A. and Klimek, I. and Abyadeh, M. and Tyshkovskiy, A. and Oz, N. and Castro, J. P. and Gladyshev, V. N. and Newton, J. and others},
  title   = {{A disease similarity approach identifies short-lived Niemann-Pick type C disease mice with accelerated brain aging as a novel mouse model for Alzheimer’s disease and aging research}},
  journal = {bioRxiv},
  year    = {2024},
  doi     = {10.1101/2024.04.19.590328},
  url     = {https://doi.org/10.1101/2024.04.19.590328}
}

@article{fernandez2024-38553642,
  author  = {Fernandez, A. and Hoq, M. R. and Hallinan, G. I. and Li, D. and Bharath, SR. and Vago, F. S. and Zhang, X. and Ozcan, K. A. and others},
  title   = {{Cryo-EM structures of amyloid-β and tau filaments in Down syndrome}},
  journal = {Nature structural \& molecular biology},
  year    = {2024},
  doi     = {10.1038/s41594-024-01252-3},
  pmid    = {38553642},
  url     = {https://doi.org/10.1038/s41594-024-01252-3}
}

@article{hillerstrom2024-38480678,
  author  = {Hillerstrom, Hampus and Fisher, Richard Alan and Janicki, Matthew P. and Chicoine, Brian Allen and Christian, Bradley T. and Esbensen, Anna J. and Esralew, Lucille and Fortea, Juan and others},
  title   = {{Adapting prescribing criteria for amyloid‐targeted antibodies for adults with Down syndrome}},
  journal = {Alzheimer s \& Dementia},
  year    = {2024},
  doi     = {10.1002/alz.13778},
  pmid    = {38480678},
  url     = {https://doi.org/10.1002/alz.13778}
}

@article{altuna2024-38398452,
  author  = {Altuna, M. and Estanga, A. and Garrido, A. and Saldias, J. and Cañada, M. and Echeverria, M. and JÁ, Larrea and Ayo, P. and others},
  title   = {{Down Syndrome-Basque Alzheimer Initiative (DS-BAI): Clinic-Biological Cohort}},
  journal = {Journal of clinical medicine},
  year    = {2024},
  doi     = {10.3390/jcm13041139},
  pmid    = {38398452},
  url     = {https://doi.org/10.3390/jcm13041139}
}

@article{perry2024-ed68acdf,
  author  = {Perry, J. C. and Vann, S. D.},
  title   = {{Reduction in neurons immunoreactive for parvalbumin, calretinin and calbindin in the anteroventral thalamic nuclei of individuals with Down syndrome}},
  journal = {bioRxiv},
  year    = {2024},
  doi     = {10.1101/2024.02.01.578360},
  url     = {https://doi.org/10.1101/2024.02.01.578360}
}

@article{edwards2023-e40cb7d2,
  author  = {Edwards, N. C. and Lao, P. J. and Alshikho, M. J. and Ericsson, O. M. and Rizvi, B. and Petersen, M. E. and O’Bryant, S. and Flores-Aguilar, L. and others},
  title   = {{Cerebrovascular disease drives Alzheimer plasma biomarker concentrations in adults with Down syndrome}},
  journal = {medRxiv},
  year    = {2023},
  doi     = {10.1101/2023.11.28.23298693},
  url     = {https://doi.org/10.1101/2023.11.28.23298693}
}

@article{conceicao2023-37788381,
  author  = {Conceição, A. S. G. G. and Sant Ana, L. F. G. and Mattar, G. P. and de Fátima R Silva, M. and Ramos, A. R. and Oliveira, A. M. and Carvalho, C. L. and Gonçalves, O. R. and others},
  title   = {{Balance and Gait: Associations With Cognitive Impairment and Dementia in Individuals With Down Syndrome}},
  journal = {Alzheimer disease and associated disorders},
  year    = {2023},
  doi     = {10.1097/wad.0000000000000580},
  pmid    = {37788381},
  url     = {https://doi.org/10.1097/wad.0000000000000580}
}

@article{prevot2023-37261390,
  author  = {Prévot, V. and Tena-Sempere, M. and Pitteloud, N.},
  title   = {{New Horizons: Gonadotropin-Releasing Hormone and Cognition}},
  journal = {The Journal of clinical endocrinology and metabolism},
  year    = {2023},
  doi     = {10.1210/clinem/dgad319},
  pmid    = {37261390},
  url     = {https://doi.org/10.1210/clinem/dgad319}
}

@article{giallongo2023-91e8db9c,
  author  = {Giallongo, S. and Talianova, V. and Tropea, E. and Ferrigno, J. and Caltabiano, R. and Broggi, G. and Distefano, A. and Alanazi, A. and others},
  title   = {{Aging Exacerbates Oxidative Stress and Liver Fibrosis in an Ani-Mal Model of Down Syndrome}},
  journal = {Aging},
  year    = {2023},
  doi     = {10.20944/preprints202309.0105.v1},
  url     = {https://doi.org/10.20944/preprints202309.0105.v1}
}

@article{bernstein2023-37524128,
  author  = {Bernstein, H. G. and Smalla, K. H. and Keilhoff, G. and Dobrowolny, H. and Kreutz, M. R. and Steiner, J.},
  title   = {{The many "Neurofaces" of Prohibitins 1 and 2: Crucial for the healthy brain, dysregulated in numerous brain disorders}},
  journal = {Journal of chemical neuroanatomy},
  year    = {2023},
  doi     = {10.1016/j.jchemneu.2023.102321},
  pmid    = {37524128},
  url     = {https://doi.org/10.1016/j.jchemneu.2023.102321}
}

@article{im2023-37494443,
  author  = {Im, E. and Jiang, Y. and Stavrides, P. H. and Darji, S. and Erdjument-Bromage, H. and Neubert, T. A. and Choi, J. Y. and Wegiel, J. and others},
  title   = {{Lysosomal dysfunction in Down syndrome and Alzheimer mouse models is caused by v-ATPase inhibition by Tyr682-phosphorylated APP βCTF}},
  journal = {Science advances},
  year    = {2023},
  doi     = {10.1126/sciadv.adg1925},
  pmid    = {37494443},
  url     = {https://doi.org/10.1126/sciadv.adg1925}
}

@article{chen2023-37042072,
  author  = {Chen, X. Q. and Sawa, M. and Becker, A. and Karachentsev, D. and Zuo, X. and Rynearson, K. D. and Tanzi, R. E. and Mobley, W. C.},
  title   = {{Retromer Proteins Reduced in Down Syndrome and the Dp16 Model: Impact of APP Dose and Preclinical Studies of a γ-Secretase Modulator}},
  journal = {Annals of neurology},
  year    = {2023},
  doi     = {10.1002/ana.26659},
  pmid    = {37042072},
  url     = {https://doi.org/10.1002/ana.26659}
}

@article{stern2023-cdf6b8dd,
  author  = {Stern, A. M. and Van Pelt, K. L. and Liu, L. and Anderson, A. K. and Ostaszewski, B. and Mapstone, M. and O’Bryant, S. and Petersen, M. E. and others},
  title   = {{Plasma NT1-tau and Aβ42correlate with age and cognitive function in two large Down syndrome cohorts}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2023},
  doi     = {10.1101/2023.03.10.23287109},
  url     = {https://doi.org/10.1101/2023.03.10.23287109}
}

@article{landes2023-36780546,
  author  = {Landes, S. D. and Finan, J. M. and Turk, M. A.},
  title   = {{Reporting Down syndrome on the death certificate for Alzheimer disease/unspecified dementia deaths}},
  journal = {PloS one},
  year    = {2023},
  doi     = {10.1371/journal.pone.0281763},
  pmid    = {36780546},
  url     = {https://doi.org/10.1371/journal.pone.0281763}
}

@article{czerminski2022-36817096,
  author  = {Czerminski, J. T. and King, O. D. and Lawrence, J. B.},
  title   = {{Large-scale organoid study suggests effects of trisomy 21 on early fetal neurodevelopment are more subtle than variability between isogenic lines and experiments}},
  journal = {Frontiers in neuroscience},
  year    = {2022},
  doi     = {10.3389/fnins.2022.972201},
  pmid    = {36817096},
  url     = {https://doi.org/10.3389/fnins.2022.972201}
}

@article{lorenzon2023-36692980,
  author  = {Lorenzon, N. and Musoles-Lleó, J. and Turrisi, F. and Gomis-González, M. and De La Torre, R. and Dierssen, M.},
  title   = {{State-of-the-art therapy for Down syndrome}},
  journal = {Developmental medicine and child neurology},
  year    = {2023},
  doi     = {10.1111/dmcn.15517},
  pmid    = {36692980},
  url     = {https://doi.org/10.1111/dmcn.15517}
}

@article{boerwinkle2023-36517172,
  author  = {Boerwinkle, A. H. and Gordon, B. A. and Wisch, J. and Flores, S. and Henson, R. L. and Butt, O. H. and McKay, N. and Chen, C. D. and others},
  title   = {{Comparison of amyloid burden in individuals with Down syndrome versus autosomal dominant Alzheimer's disease: a cross-sectional study}},
  journal = {The Lancet. Neurology},
  year    = {2023},
  doi     = {10.1016/s1474-4422(22)00408-2},
  pmid    = {36517172},
  url     = {https://doi.org/10.1016/s1474-4422(22)00408-2}
}

@article{skotko2023-36437642,
  author  = {Skotko, B. G. and Krell, K. and Haugen, K. and Torres, A. and Nieves, A. and Dhand, A.},
  title   = {{Personal social networks of people with Down syndrome}},
  journal = {American journal of medical genetics. Part A},
  year    = {2023},
  doi     = {10.1002/ajmg.a.63059},
  pmid    = {36437642},
  url     = {https://doi.org/10.1002/ajmg.a.63059}
}

@article{lott2022-36419175,
  author  = {Lott, I. T. and Kirby, K. A. and Doran, E. and Grill, J. D.},
  title   = {{Research attitudes in families of individuals with Down syndrome: importance for clinical trials}},
  journal = {Alzheimer's research \& therapy},
  year    = {2022},
  doi     = {10.1186/s13195-022-01120-6},
  pmid    = {36419175},
  url     = {https://doi.org/10.1186/s13195-022-01120-6}
}

@article{ganguly2023-36371073,
  author  = {Ganguly, B. B. and Kadam, N. N.},
  title   = {{Therapeutics for mitochondrial dysfunction-linked diseases in Down syndrome}},
  journal = {Mitochondrion},
  year    = {2023},
  doi     = {10.1016/j.mito.2022.11.003},
  pmid    = {36371073},
  url     = {https://doi.org/10.1016/j.mito.2022.11.003}
}

@article{videla2022-35930282,
  author  = {Videla, L. and Benejam, B. and Pegueroles, J. and Carmona-Iragui, M. and Padilla, C. and Fernández, S. and Barroeta, I. and Altuna, M. and others},
  title   = {{Longitudinal Clinical and Cognitive Changes Along the Alzheimer Disease Continuum in Down Syndrome}},
  journal = {JAMA network open},
  year    = {2022},
  doi     = {10.1001/jamanetworkopen.2022.25573},
  pmid    = {35930282},
  url     = {https://doi.org/10.1001/jamanetworkopen.2022.25573}
}

@article{moreau2022-35740400,
  author  = {Moreau, M. and Carmona-Iragui, M. and Altuna, M. and Dalzon, L. and Barroeta, I. and Vilaire, M. and Durand, S. and Fortea, J. and others},
  title   = {{DYRK1A and Activity-Dependent Neuroprotective Protein Comparative Diagnosis Interest in Cerebrospinal Fluid and Plasma in the Context of Alzheimer-Related Cognitive Impairment in Down Syndrome Patients}},
  journal = {Biomedicines},
  year    = {2022},
  doi     = {10.3390/biomedicines10061380},
  pmid    = {35740400},
  url     = {https://doi.org/10.3390/biomedicines10061380}
}

@article{im2022-4ba4a0f3,
  author  = {Im, E. and Jiang, Y. and Stavrides, P. and Darji, S. and Erdjument-Bromage, H. and Neubert, T. A. and Choi, J. Y. and Wegiel, J. and others},
  title   = {{Lysosomal dysfunction in Down Syndrome and Alzheimer mouse models is caused by selective v-ATPase inhibition by Tyr 682 phosphorylated APP βCTF}},
  journal = {Science advances},
  year    = {2022},
  doi     = {10.1101/2022.06.02.494546},
  url     = {https://doi.org/10.1101/2022.06.02.494546}
}

@article{rafii2022-35532913,
  author  = {Rafii, M. S. and Sol, O. and Mobley, W. C. and Delpretti, S. and Skotko, B. G. and Burke, A. D. and Sabbagh, M. N. and Yuan, S. H. and others},
  title   = {{Safety, Tolerability, and Immunogenicity of the ACI-24 Vaccine in Adults With Down Syndrome: A Phase 1b Randomized Clinical Trial}},
  journal = {JAMA neurology},
  year    = {2022},
  doi     = {10.1001/jamaneurol.2022.0983},
  pmid    = {35532913},
  url     = {https://doi.org/10.1001/jamaneurol.2022.0983}
}

@article{czerminski2022-be7d48c0,
  author  = {Czerminski, J. T. and King, O. D. and Lawrence, J. B.},
  title   = {{Modeling Down syndrome neurodevelopment with isogenic cerebral organoids}},
  journal = {bioRxiv},
  year    = {2022},
  doi     = {10.1101/2022.05.25.493459},
  url     = {https://doi.org/10.1101/2022.05.25.493459}
}

@article{iulita2022-35604690,
  author  = {Iulita, M. F. and Garzón Chavez, D. and Klitgaard Christensen, M. and Valle Tamayo, N. and Plana-Ripoll, O. and Rasmussen, S. A. and Roqué Figuls, M. and Alcolea, D. and others},
  title   = {{Association of Alzheimer Disease With Life Expectancy in People With Down Syndrome}},
  journal = {JAMA network open},
  year    = {2022},
  doi     = {10.1001/jamanetworkopen.2022.12910},
  pmid    = {35604690},
  url     = {https://doi.org/10.1001/jamanetworkopen.2022.12910}
}

@article{martini2022-35472307,
  author  = {Martini, A. C. and Gross, T. J. and Head, E. and Mapstone, M.},
  title   = {{Beyond amyloid: Immune, cerebrovascular, and metabolic contributions to Alzheimer disease in people with Down syndrome}},
  journal = {Neuron},
  year    = {2022},
  doi     = {10.1016/j.neuron.2022.04.001},
  pmid    = {35472307},
  url     = {https://doi.org/10.1016/j.neuron.2022.04.001}
}

@article{oeckl2022-35340050,
  author  = {Oeckl, P. and Wagemann, O. and Halbgebauer, S. and Anderl-Straub, S. and Nuebling, G. and Prix, C. and Loosli, S. V. and Wlasich, E. and others},
  title   = {{Serum Beta-Synuclein Is Higher in Down Syndrome and Precedes Rise of pTau181}},
  journal = {Annals of neurology},
  year    = {2022},
  doi     = {10.1002/ana.26360},
  pmid    = {35340050},
  url     = {https://doi.org/10.1002/ana.26360}
}

@article{nubling2022-35320851,
  author  = {Nübling, G. and Wagemann, O. and Loosli, S. V. and Wlasich, E. and Danek, A. and Levin, J.},
  title   = {{[Diagnosing Alzheimer Dementia in People with Down Syndrome in Accordance with ICD, DSM V and A/T/N System]}},
  journal = {Fortschritte der Neurologie-Psychiatrie},
  year    = {2022},
  doi     = {10.1055/a-1771-6273},
  pmid    = {35320851},
  url     = {https://doi.org/10.1055/a-1771-6273}
}

@article{tao2021-34879376,
  author  = {Tao, X. and Che, Y. and Li, C. and Ruan, W. and Xu, J. and Yu, Y. and Yang, F. and Wang, J. and others},
  title   = {{Novel SNX13 Frameshift Variant in an Individual with Developmental Delay}},
  journal = {Cytogenetic and genome research},
  year    = {2021},
  doi     = {10.1159/000520296},
  pmid    = {34879376},
  url     = {https://doi.org/10.1159/000520296}
}

@article{perluigi2022-34812584,
  author  = {Perluigi, M. and Picca, A. and Montanari, E. and Calvani, R. and Marini, F. and Matassa, R. and Tramutola, A. and Villani, A. and others},
  title   = {{Aberrant crosstalk between insulin signaling and mTOR in young Down syndrome individuals revealed by neuronal-derived extracellular vesicles}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2022},
  doi     = {10.1002/alz.12499},
  pmid    = {34812584},
  url     = {https://doi.org/10.1002/alz.12499}
}

@article{fortea2021-34687637,
  author  = {Fortea, J. and Zaman, S. H. and Hartley, S. and Rafii, M. S. and Head, E. and Carmona-Iragui, M.},
  title   = {{Alzheimer's disease associated with Down syndrome: a genetic form of dementia}},
  journal = {The Lancet. Neurology},
  year    = {2021},
  doi     = {10.1016/s1474-4422(21)00245-3},
  pmid    = {34687637},
  url     = {https://doi.org/10.1016/s1474-4422(21)00245-3}
}

@article{lai2021-34573243,
  author  = {Lai, F. and Mercaldo, N. D. and Wang, C. M. and Hersch, M. S. and Hersch, G. G. and Rosas, H. D.},
  title   = {{Association between Hypothyroidism Onset and Alzheimer Disease Onset in Adults with Down Syndrome}},
  journal = {Brain sciences},
  year    = {2021},
  doi     = {10.3390/brainsci11091223},
  pmid    = {34573243},
  url     = {https://doi.org/10.3390/brainsci11091223}
}

@article{montal2021-34309066,
  author  = {Montal, V. and Barroeta, I. and Bejanin, A. and Pegueroles, J. and Carmona-Iragui, M. and Altuna, M. and Benejam, B. and Videla, L. and others},
  title   = {{Metabolite Signature of Alzheimer's Disease in Adults with Down Syndrome}},
  journal = {Annals of neurology},
  year    = {2021},
  doi     = {10.1002/ana.26178},
  pmid    = {34309066},
  url     = {https://doi.org/10.1002/ana.26178}
}

@article{bejanin2021-34228042,
  author  = {Bejanin, A. and Iulita, M. F. and Vilaplana, E. and Carmona-Iragui, M. and Benejam, B. and Videla, L. and Barroeta, I. and Fernandez, S. and others},
  title   = {{Association of Apolipoprotein E ɛ4 Allele With Clinical and Multimodal Biomarker Changes of Alzheimer Disease in Adults With Down Syndrome}},
  journal = {JAMA neurology},
  year    = {2021},
  doi     = {10.1001/jamaneurol.2021.1893},
  pmid    = {34228042},
  url     = {https://doi.org/10.1001/jamaneurol.2021.1893}
}

@article{fagan2021-34302786,
  author  = {Fagan, A. M. and Henson, R. L. and Li, Y. and Boerwinkle, A. H. and Xiong, C. and Bateman, R. J. and Goate, A. and Ances, B. M. and others},
  title   = {{Comparison of CSF biomarkers in Down syndrome and autosomal dominant Alzheimer's disease: a cross-sectional study}},
  journal = {The Lancet. Neurology},
  year    = {2021},
  doi     = {10.1016/s1474-4422(21)00139-3},
  pmid    = {34302786},
  url     = {https://doi.org/10.1016/s1474-4422(21)00139-3}
}

@article{mazzarino2021-34283828,
  author  = {Mazzarino, R. C. and Baresova, V. and Zikánová, M. and Duval, N. and Wilkinson, T. G. and Patterson, D. and Vacano, G. N.},
  title   = {{Transcriptome and metabolome analysis of crGART, a novel cell model of de novo purine synthesis deficiency: Alterations in CD36 expression and activity}},
  journal = {PloS one},
  year    = {2021},
  doi     = {10.1371/journal.pone.0247227},
  pmid    = {34283828},
  url     = {https://doi.org/10.1371/journal.pone.0247227}
}

@article{lai2021-34300282,
  author  = {Lai, F. and Mercaldo, N. and Wang, C. M. and Hersch, G. G. and Rosas, H. D.},
  title   = {{Association between Inflammatory Conditions and Alzheimer's Disease Age of Onset in Down Syndrome}},
  journal = {Journal of clinical medicine},
  year    = {2021},
  doi     = {10.3390/jcm10143116},
  pmid    = {34300282},
  url     = {https://doi.org/10.3390/jcm10143116}
}

@article{lleo2021-34183050,
  author  = {Lleó, A. and Carmona-Iragui, M. and Videla, L. and Fernández, S. and Benejam, B. and Pegueroles, J. and Barroeta, I. and Altuna, M. and others},
  title   = {{VAMP-2 is a surrogate cerebrospinal fluid marker of Alzheimer-related cognitive impairment in adults with Down syndrome}},
  journal = {Alzheimer's research \& therapy},
  year    = {2021},
  doi     = {10.1186/s13195-021-00861-0},
  pmid    = {34183050},
  url     = {https://doi.org/10.1186/s13195-021-00861-0}
}

@article{lleo2021-870cda97,
  author  = {Lleó, A. and Carmona-Iragui, M. and Videla, L. and Fernández, S. and Benejam, B. and Pegueroles, J. and Barroeta, I. and Altuna, M. and others},
  title   = {{VAMP-2 Is a Surrogate Cerebrospinal Fluid Marker of Alzheimer-related Cognitive Impairment in Adults With Down Syndrome}},
  journal = {Alzheimer's research \& therapy},
  year    = {2021},
  doi     = {10.21203/rs.3.rs-340117/v1},
  url     = {https://doi.org/10.21203/rs.3.rs-340117/v1}
}

@article{chen2021-33691783,
  author  = {Chen, X. Q. and Das, U. and Park, G. and Mobley, W. C.},
  title   = {{Normal levels of KIF5 but reduced KLC1 levels in both Alzheimer disease and Alzheimer disease in Down syndrome: evidence suggesting defects in anterograde transport}},
  journal = {Alzheimer's research \& therapy},
  year    = {2021},
  doi     = {10.1186/s13195-021-00796-6},
  pmid    = {33691783},
  url     = {https://doi.org/10.1186/s13195-021-00796-6}
}

@article{filippone2021-33547827,
  author  = {Filippone, A. and Praticò, D.},
  title   = {{Endosome Dysregulation in Down Syndrome: A Potential Contributor to Alzheimer Disease Pathology}},
  journal = {Annals of neurology},
  year    = {2021},
  doi     = {10.1002/ana.26042},
  pmid    = {33547827},
  url     = {https://doi.org/10.1002/ana.26042}
}

@article{lanzillotta2021-33516914,
  author  = {Lanzillotta, C. and Tramutola, A. and Di Giacomo, G. and Marini, F. and Butterfield, D. A. and Di Domenico, F. and Perluigi, M. and Barone, E.},
  title   = {{Insulin resistance, oxidative stress and mitochondrial defects in Ts65dn mice brain: A harmful synergistic path in down syndrome}},
  journal = {Free radical biology \& medicine},
  year    = {2021},
  doi     = {10.1016/j.freeradbiomed.2021.01.042},
  pmid    = {33516914},
  url     = {https://doi.org/10.1016/j.freeradbiomed.2021.01.042}
}

@article{rosas2020-33204811,
  author  = {Rosas, H. D. and Hsu, E. and Mercaldo, N. D. and Lai, F. and Pulsifer, M. and Keator, D. and Brickman, A. M. and Price, J. and others},
  title   = {{Alzheimer-related altered white matter microstructural integrity in Down syndrome: A model for sporadic AD?}},
  journal = {Alzheimer's \& dementia (Amsterdam, Netherlands)},
  year    = {2020},
  doi     = {10.1002/dad2.12040},
  pmid    = {33204811},
  url     = {https://doi.org/10.1002/dad2.12040}
}

@article{lemoine2020-a970244c,
  author  = {Lemoine, L. and Ledreux, A. and Mufson, E. J. and Perez, S. E. and Simic, G. and Doran, E. and Lott, I. and Carroll, S. and others},
  title   = {{Regional binding of tau and amyloid PET tracers in Down Syndrome autopsy brain tissue}},
  journal = {Molecular neurodegeneration},
  year    = {2020},
  doi     = {10.21203/rs.3.rs-48040/v2},
  url     = {https://doi.org/10.21203/rs.3.rs-48040/v2}
}

@article{lao2020-32944999,
  author  = {Lao, P. J. and Gutierrez, J. and Keator, D. and Rizvi, B. and Banerjee, A. and Igwe, K. C. and Laing, K. K. and Sathishkumar, M. and others},
  title   = {{Alzheimer-Related Cerebrovascular Disease in Down Syndrome}},
  journal = {Annals of neurology},
  year    = {2020},
  doi     = {10.1002/ana.25905},
  pmid    = {32944999},
  url     = {https://doi.org/10.1002/ana.25905}
}

@article{tsou2020-33079159,
  author  = {Tsou, A. Y. and Bulova, P. and Capone, G. and Chicoine, B. and Gelaro, B. and Harville, T. O. and Martin, B. A. and McGuire, D. E. and others},
  title   = {{Medical Care of Adults With Down Syndrome: A Clinical Guideline}},
  journal = {JAMA},
  year    = {2020},
  doi     = {10.1001/jama.2020.17024},
  pmid    = {33079159},
  url     = {https://doi.org/10.1001/jama.2020.17024}
}

@article{martinezcue2020-32962300,
  author  = {Martínez-Cué, C. and Rueda, N.},
  title   = {{Signalling Pathways Implicated in Alzheimer's Disease Neurodegeneration in Individuals with and without Down Syndrome}},
  journal = {International journal of molecular sciences},
  year    = {2020},
  doi     = {10.3390/ijms21186906},
  pmid    = {32962300},
  url     = {https://doi.org/10.3390/ijms21186906}
}

@article{dsouza2020-32986108,
  author  = {D'Souza, H. and Mason, L. and Mok, K. Y. and Startin, C. M. and Hamburg, S. and Hithersay, R. and Baksh, R. A. and Hardy, J. and others},
  title   = {{Differential Associations of Apolipoprotein E ε4 Genotype With Attentional Abilities Across the Life Span of Individuals With Down Syndrome}},
  journal = {JAMA network open},
  year    = {2020},
  doi     = {10.1001/jamanetworkopen.2020.18221},
  pmid    = {32986108},
  url     = {https://doi.org/10.1001/jamanetworkopen.2020.18221}
}

@article{perluigi2020-32839417,
  author  = {Perluigi, M. and Tramutola, A. and Pagnotta, S. and Barone, E. and Butterfield, D. A.},
  title   = {{The BACH1/Nrf2 Axis in Brain in Down Syndrome and Transition to Alzheimer Disease-Like Neuropathology and Dementia}},
  journal = {Antioxidants (Basel, Switzerland)},
  year    = {2020},
  doi     = {10.3390/antiox9090779},
  pmid    = {32839417},
  url     = {https://doi.org/10.3390/antiox9090779}
}

@article{belbin2020-32807227,
  author  = {Belbin, O. and Xiao, M. F. and Xu, D. and Carmona-Iragui, M. and Pegueroles, J. and Benejam, B. and Videla, L. and Fernández, S. and others},
  title   = {{Cerebrospinal fluid profile of NPTX2 supports role of Alzheimer's disease-related inhibitory circuit dysfunction in adults with Down syndrome}},
  journal = {Molecular neurodegeneration},
  year    = {2020},
  doi     = {10.1186/s13024-020-00398-0},
  pmid    = {32807227},
  url     = {https://doi.org/10.1186/s13024-020-00398-0}
}

@article{massaccesi2020-32814082,
  author  = {Massaccesi, L. and Galliera, E. and Corsi Romanelli, M. M.},
  title   = {{Erythrocytes as markers of oxidative stress related pathologies}},
  journal = {Mechanisms of ageing and development},
  year    = {2020},
  doi     = {10.1016/j.mad.2020.111333},
  pmid    = {32814082},
  url     = {https://doi.org/10.1016/j.mad.2020.111333}
}

@article{lanzillotta2021-32795489,
  author  = {Lanzillotta, C. and Zuliani, I. and Tramutola, A. and Barone, E. and Blarzino, C. and Folgiero, V. and Caforio, M. and Valentini, D. and others},
  title   = {{Chronic PERK induction promotes Alzheimer-like neuropathology in Down syndrome: Insights for therapeutic intervention}},
  journal = {Progress in neurobiology},
  year    = {2021},
  doi     = {10.1016/j.pneurobio.2020.101892},
  pmid    = {32795489},
  url     = {https://doi.org/10.1016/j.pneurobio.2020.101892}
}

@article{alic2021-32647257,
  author  = {Alić, I. and Goh, P. A. and Murray, A. and Portelius, E. and Gkanatsiou, E. and Gough, G. and Mok, K. Y. and Koschut, D. and others},
  title   = {{Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human brain}},
  journal = {Molecular psychiatry},
  year    = {2021},
  doi     = {10.1038/s41380-020-0806-5},
  pmid    = {32647257},
  url     = {https://doi.org/10.1038/s41380-020-0806-5}
}

@article{mazzarino2020-d179f205,
  author  = {Mazzarino, R. C. and Baresova, V. and Zikánová, M. and Duval, N. and Wilkinson, T. G. and Patterson, D. and Vacano, G. N.},
  title   = {{Transcriptome and metabolome analysis of crGART, a novel cell model of de novo purine synthesis deficiency: Alterations in CD36 expression and activity}},
  journal = {PloS one},
  year    = {2020},
  doi     = {10.1101/2020.06.23.167924},
  url     = {https://doi.org/10.1101/2020.06.23.167924}
}

@article{rondal2020-32607419,
  author  = {Rondal, J. A.},
  title   = {{Down syndrome: A curative prospect?}},
  journal = {AIMS neuroscience},
  year    = {2020},
  doi     = {10.3934/neuroscience.2020012},
  pmid    = {32607419},
  url     = {https://doi.org/10.3934/neuroscience.2020012}
}

@article{fortea2020-32593336,
  author  = {Fortea, Juan and Vilaplana, Eduard and Carmona‐Iragui, María and Benejam, Bessy and Videla, Laura and Barroeta, Isabel and Fernández, Susana and Altuna, Miren and Pegueroles, Jordi and Montal, Víctor and Valldeneu, Sílvia and Giménez, Sandra and González‐Ortiz, Sofía and Muñoz, Laia and Estellés, Teresa and Illán‐Gala, Ignacio and Belbin, Olivia and Camacho, Valle and Wilson, Liam Reese and Annus, Tiina and Osorio, Ricardo S. and Videla, Sebastián and Lehmann, Sylvain and Holland, Anthony John and Alcolea, Daniel Andres and Clarimón, Jordi and Zaman, Shahid H. and Blesa, Rafael and Lleó, Alberto},
  title   = {{Clinical and biomarker changes of Alzheimer's disease in adults with Down syndrome: a cross-sectional study}},
  journal = {The Lancet},
  year    = {2020},
  doi     = {10.1016/s0140-6736(20)30689-9},
  pmid    = {32593336},
  url     = {https://doi.org/10.1016/s0140-6736(20)30689-9}
}

@article{antonarakis2020-32029743,
  author  = {Antonarakis, S. E. and Skotko, B. G. and Rafii, M. S. and Strydom, A. and Pape, S. E. and Bianchi, D. W. and Sherman, S. L. and Reeves, R. H.},
  title   = {{Down syndrome}},
  journal = {Nature reviews. Disease primers},
  year    = {2020},
  doi     = {10.1038/s41572-019-0143-7},
  pmid    = {32029743},
  url     = {https://doi.org/10.1038/s41572-019-0143-7}
}

@article{alic2020-405f180f,
  author  = {Alić, I. and Goh, P. A. and Murray, A. and Portelius, E. and Gkanatsiou, E. and Gough, G. and Mok, K. Y. and Koschut, D. and others},
  title   = {{“Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene-dose-sensitive AD-suppressor in human brain”}},
  journal = {Molecular psychiatry},
  year    = {2020},
  doi     = {10.1101/2020.01.29.918037},
  url     = {https://doi.org/10.1101/2020.01.29.918037}
}

@article{tramutola2020-31987911,
  author  = {Tramutola, A. and Lanzillotta, C. and Di Domenico, F. and Head, E. and Butterfield, D. A. and Perluigi, M. and Barone, E.},
  title   = {{Brain insulin resistance triggers early onset Alzheimer disease in Down syndrome}},
  journal = {Neurobiology of disease},
  year    = {2020},
  doi     = {10.1016/j.nbd.2020.104772},
  pmid    = {31987911},
  url     = {https://doi.org/10.1016/j.nbd.2020.104772}
}

@article{arenas2020-31902793,
  author  = {Arenas, F. and Castro, F. and Nuñez, S. and Gay, G. and Garcia-Ruiz, C. and Fernandez-Checa, J. C.},
  title   = {{STARD1 and NPC1 expression as pathological markers associated with astrogliosis in post-mortem brains from patients with Alzheimer's disease and Down syndrome}},
  journal = {Aging},
  year    = {2020},
  doi     = {10.18632/aging.102641},
  pmid    = {31902793},
  url     = {https://doi.org/10.18632/aging.102641}
}

@article{lessovschlaggar2019-31842726,
  author  = {Lessov-Schlaggar, C. N. and Del Rosario, O. L. and Morris, J. C. and Ances, B. M. and Schlaggar, B. L. and Constantino, J. N.},
  title   = {{Adaptation of the Clinical Dementia Rating Scale for adults with Down syndrome}},
  journal = {Journal of neurodevelopmental disorders},
  year    = {2019},
  doi     = {10.1186/s11689-019-9300-2},
  pmid    = {31842726},
  url     = {https://doi.org/10.1186/s11689-019-9300-2}
}

@article{viard2019-021316a1,
  author  = {Viard, J. and Loe-Mie, Y. and Daudin, R. and Khelfaoui, M. and Plancon, C. and Boland, A. and Tejedor, F. and Huganir, R. L. and others},
  title   = {{Chr21 protein-protein interactions: enrichment in products involved in intellectual disabilities, autism and Late Onset Alzheimer Disease}},
  journal = {bioRxiv},
  year    = {2019},
  doi     = {10.1101/2019.12.11.872606},
  url     = {https://doi.org/10.1101/2019.12.11.872606}
}

@article{santoro2020-31767984,
  author  = {Santoro, S. L. and Cannon, S. and Capone, G. and Franklin, C. and Hart, S. J. and Hobensack, V. and Kishnani, P. S. and Macklin, E. A. and others},
  title   = {{Unexplained regression in Down syndrome: 35 cases from an international Down syndrome database}},
  journal = {Genetics in medicine : official journal of the American College of Medical Genetics},
  year    = {2020},
  doi     = {10.1038/s41436-019-0706-8},
  pmid    = {31767984},
  url     = {https://doi.org/10.1038/s41436-019-0706-8}
}

@article{mak2019-31909173,
  author  = {Mak, E. and Bickerton, A. and Padilla, C. and Walpert, M. J. and Annus, T. and Wilson, L. R. and Hong, Y. T. and Fryer, T. D. and others},
  title   = {{Longitudinal trajectories of amyloid deposition, cortical thickness, and tau in Down syndrome: A deep-phenotyping case report}},
  journal = {Alzheimer's \& dementia (Amsterdam, Netherlands)},
  year    = {2019},
  doi     = {10.1016/j.dadm.2019.04.006},
  pmid    = {31909173},
  url     = {https://doi.org/10.1016/j.dadm.2019.04.006}
}

@article{lauterborn2020-31410926,
  author  = {Lauterborn, J. C. and Cox, C. D. and Chan, S. W. and Vanderklish, P. W. and Lynch, G. and Gall, C. M.},
  title   = {{Synaptic actin stabilization protein loss in Down syndrome and Alzheimer disease}},
  journal = {Brain pathology (Zurich, Switzerland)},
  year    = {2020},
  doi     = {10.1111/bpa.12779},
  pmid    = {31410926},
  url     = {https://doi.org/10.1111/bpa.12779}
}

@article{diazderada2019-31081501,
  author  = {Díaz de Rada, P. and Machado, V. and Villas, C. and Alfonso, M.},
  title   = {{[Bilateral hip fracture in a patient with Down syndrome]}},
  journal = {Anales del sistema sanitario de Navarra},
  year    = {2019},
  doi     = {10.23938/assn.0634},
  pmid    = {31081501},
  url     = {https://doi.org/10.23938/assn.0634}
}

@article{carmonairagui2019-31278851,
  author  = {Carmona-Iragui, M. and Videla, L. and Lleó, A. and Fortea, J.},
  title   = {{Down syndrome, Alzheimer disease, and cerebral amyloid angiopathy: The complex triangle of brain amyloidosis}},
  journal = {Developmental neurobiology},
  year    = {2019},
  doi     = {10.1002/dneu.22709},
  pmid    = {31278851},
  url     = {https://doi.org/10.1002/dneu.22709}
}

@article{baburamani2019-31102269,
  author  = {Baburamani, A. A. and Patkee, P. A. and Arichi, T. and Rutherford, M. A.},
  title   = {{New approaches to studying early brain development in Down syndrome}},
  journal = {Developmental medicine and child neurology},
  year    = {2019},
  doi     = {10.1111/dmcn.14260},
  pmid    = {31102269},
  url     = {https://doi.org/10.1111/dmcn.14260}
}

@article{chen2019-31133787,
  author  = {Chen, X. Q. and Mobley, W. C.},
  title   = {{Exploring the Pathogenesis of Alzheimer Disease in Basal Forebrain Cholinergic Neurons: Converging Insights From Alternative Hypotheses}},
  journal = {Frontiers in neuroscience},
  year    = {2019},
  doi     = {10.3389/fnins.2019.00446},
  pmid    = {31133787},
  url     = {https://doi.org/10.3389/fnins.2019.00446}
}

@article{shinomoto2019-30951523,
  author  = {Shinomoto, M. and Kasai, T. and Tatebe, H. and Kondo, M. and Ohmichi, T. and Morimoto, M. and Chiyonobu, T. and Terada, N. and others},
  title   = {{Plasma neurofilament light chain: A potential prognostic biomarker of dementia in adult Down syndrome patients}},
  journal = {PloS one},
  year    = {2019},
  doi     = {10.1371/journal.pone.0211575},
  pmid    = {30951523},
  url     = {https://doi.org/10.1371/journal.pone.0211575}
}

@article{lott2019-30733618,
  author  = {Lott, I. T. and Head, E.},
  title   = {{Dementia in Down syndrome: unique insights for Alzheimer disease research}},
  journal = {Nature reviews. Neurology},
  year    = {2019},
  doi     = {10.1038/s41582-018-0132-6},
  pmid    = {30733618},
  url     = {https://doi.org/10.1038/s41582-018-0132-6}
}

@article{franceschi2019-30768754,
  author  = {Franceschi, C. and Garagnani, P. and Gensous, N. and Bacalini, M. G. and Conte, M. and Salvioli, S.},
  title   = {{Accelerated bio-cognitive aging in Down syndrome: State of the art and possible deceleration strategies}},
  journal = {Aging cell},
  year    = {2019},
  doi     = {10.1111/acel.12903},
  pmid    = {30768754},
  url     = {https://doi.org/10.1111/acel.12903}
}

@article{hithersay2019-30452522,
  author  = {Hithersay, R. and Startin, C. M. and Hamburg, S. and Mok, K. Y. and Hardy, J. and Fisher, E. M. C. and Tybulewicz, V. L. J. and Nizetic, D. and others},
  title   = {{Association of Dementia With Mortality Among Adults With Down Syndrome Older Than 35 Years}},
  journal = {JAMA neurology},
  year    = {2019},
  doi     = {10.1001/jamaneurol.2018.3616},
  pmid    = {30452522},
  url     = {https://doi.org/10.1001/jamaneurol.2018.3616}
}

@article{helman2019-30452414,
  author  = {Helman, A. M. and Siever, M. and McCarty, K. L. and Lott, I. T. and Doran, E. and Abner, E. L. and Schmitt, F. A. and Head, E.},
  title   = {{Microbleeds and Cerebral Amyloid Angiopathy in the Brains of People with Down Syndrome with Alzheimer's Disease}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2019},
  doi     = {10.3233/jad-180589},
  pmid    = {30452414},
  url     = {https://doi.org/10.3233/jad-180589}
}

@article{tramutola2018-30410750,
  author  = {Tramutola, A. and Lanzillotta, C. and Barone, E. and Arena, A. and Zuliani, I. and Mosca, L. and Blarzino, C. and Butterfield, D. A. and others},
  title   = {{Intranasal rapamycin ameliorates Alzheimer-like cognitive decline in a mouse model of Down syndrome}},
  journal = {Translational neurodegeneration},
  year    = {2018},
  doi     = {10.1186/s40035-018-0133-9},
  pmid    = {30410750},
  url     = {https://doi.org/10.1186/s40035-018-0133-9}
}

@article{bayen2018-30032260,
  author  = {Bayen, E. and Possin, K. L. and Chen, Y. and Cleret de Langavant, L. and Yaffe, K.},
  title   = {{Prevalence of Aging, Dementia, and Multimorbidity in Older Adults With Down Syndrome}},
  journal = {JAMA neurology},
  year    = {2018},
  doi     = {10.1001/jamaneurol.2018.2210},
  pmid    = {30032260},
  url     = {https://doi.org/10.1001/jamaneurol.2018.2210}
}

@article{reeves2019-30800043,
  author  = {Reeves, R. H. and Delabar, J. and Potier, M. C. and Bhattacharyya, A. and Head, E. and Lemere, C. and Dekker, A. D. and De Deyn, P. and others},
  title   = {{Paving the Way for Therapy: The Second International Conference of the Trisomy 21 Research Society}},
  journal = {Molecular syndromology},
  year    = {2019},
  doi     = {10.1159/000494231},
  pmid    = {30800043},
  url     = {https://doi.org/10.1159/000494231}
}

@article{schoeppe2019-30279085,
  author  = {Schoeppe, F. and Rossi, A. and Levin, J. and Reiser, M. and Stoecklein, S. and Ertl-Wagner, B.},
  title   = {{Increased cerebral microbleeds and cortical superficial siderosis in pediatric patients with Down syndrome}},
  journal = {European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society},
  year    = {2019},
  doi     = {10.1016/j.ejpn.2018.09.004},
  pmid    = {30279085},
  url     = {https://doi.org/10.1016/j.ejpn.2018.09.004}
}

@article{arai2019-30086988,
  author  = {Arai, Y. and Iwasaki, Y. and Suzuki, T. and Ide, S. and Kaga, M.},
  title   = {{Elimination of amyloid precursor protein in senile plaques in the brain of a patient with Alzheimer-type dementia and Down syndrome}},
  journal = {Brain \& development},
  year    = {2019},
  doi     = {10.1016/j.braindev.2018.07.017},
  pmid    = {30086988},
  url     = {https://doi.org/10.1016/j.braindev.2018.07.017}
}

@article{head2018-29977201,
  author  = {Head, E. and Powell, D. K. and Schmitt, F. A.},
  title   = {{Metabolic and Vascular Imaging Biomarkers in Down Syndrome Provide Unique Insights Into Brain Aging and Alzheimer Disease Pathogenesis}},
  journal = {Frontiers in aging neuroscience},
  year    = {2018},
  doi     = {10.3389/fnagi.2018.00191},
  pmid    = {29977201},
  url     = {https://doi.org/10.3389/fnagi.2018.00191}
}

@article{ovchinnikov2018-29861166,
  author  = {Ovchinnikov, D. A. and Korn, O. and Virshup, I. and Wells, C. A. and Wolvetang, E. J.},
  title   = {{The Impact of APP on Alzheimer-like Pathogenesis and Gene Expression in Down Syndrome iPSC-Derived Neurons}},
  journal = {Stem cell reports},
  year    = {2018},
  doi     = {10.1016/j.stemcr.2018.05.004},
  pmid    = {29861166},
  url     = {https://doi.org/10.1016/j.stemcr.2018.05.004}
}

@article{franceschi2018-29662881,
  author  = {Franceschi, C. and Garagnani, P. and Morsiani, C. and Conte, M. and Santoro, A. and Grignolio, A. and Monti, D. and Capri, M. and others},
  title   = {{The Continuum of Aging and Age-Related Diseases: Common Mechanisms but Different Rates}},
  journal = {Frontiers in medicine},
  year    = {2018},
  doi     = {10.3389/fmed.2018.00061},
  pmid    = {29662881},
  url     = {https://doi.org/10.3389/fmed.2018.00061}
}

@article{cohen2018-29477284,
  author  = {Cohen, A. D. and McDade, E. and Christian, B. and Price, J. and Mathis, C. and Klunk, W. and Handen, B. L.},
  title   = {{Early striatal amyloid deposition distinguishes Down syndrome and autosomal dominant Alzheimer's disease from late-onset amyloid deposition}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2018},
  doi     = {10.1016/j.jalz.2018.01.002},
  pmid    = {29477284},
  url     = {https://doi.org/10.1016/j.jalz.2018.01.002}
}

@article{lao2018-29254096,
  author  = {Lao, P. J. and Handen, B. L. and Betthauser, T. J. and Mihaila, I. and Hartley, S. L. and Cohen, A. D. and Tudorascu, D. L. and Bulova, P. D. and others},
  title   = {{Alzheimer-Like Pattern of Hypometabolism Emerges with Elevated Amyloid-β Burden in Down Syndrome}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2018},
  doi     = {10.3233/jad-170720},
  pmid    = {29254096},
  url     = {https://doi.org/10.3233/jad-170720}
}

@article{head2017-29195510,
  author  = {Head, E. and Phelan, M. J. and Doran, E. and Kim, R. C. and Poon, W. W. and Schmitt, F. A. and Lott, I. T.},
  title   = {{Cerebrovascular pathology in Down syndrome and Alzheimer disease}},
  journal = {Acta neuropathologica communications},
  year    = {2017},
  doi     = {10.1186/s40478-017-0499-4},
  pmid    = {29195510},
  url     = {https://doi.org/10.1186/s40478-017-0499-4}
}

@article{colella2018-29406914,
  author  = {Colella, M. and Stilo, C. and Cocchella, A. and Bianchini, D. and Pilotto, A. and Del Sette, P. and Musolino, R.},
  title   = {{Cerebral vasoreactivity and intima-media thickness in Down syndrome: A case-control study}},
  journal = {Journal of the neurological sciences},
  year    = {2018},
  doi     = {10.1016/j.jns.2017.11.013},
  pmid    = {29406914},
  url     = {https://doi.org/10.1016/j.jns.2017.11.013}
}

@article{chen2018-29031834,
  author  = {Chen, X. Q. and Sawa, M. and Mobley, W. C.},
  title   = {{Dysregulation of neurotrophin signaling in the pathogenesis of Alzheimer disease and of Alzheimer disease in Down syndrome}},
  journal = {Free radical biology \& medicine},
  year    = {2018},
  doi     = {10.1016/j.freeradbiomed.2017.10.341},
  pmid    = {29031834},
  url     = {https://doi.org/10.1016/j.freeradbiomed.2017.10.341}
}

@article{sosa2017-28677143,
  author  = {Sosa, L. J. and Cáceres, A. and Dupraz, S. and Oksdath, M. and Quiroga, S. and Lorenzo, A.},
  title   = {{The physiological role of the amyloid precursor protein as an adhesion molecule in the developing nervous system}},
  journal = {Journal of neurochemistry},
  year    = {2017},
  doi     = {10.1111/jnc.14122},
  pmid    = {28677143},
  url     = {https://doi.org/10.1111/jnc.14122}
}

@article{didomenico2018-28807816,
  author  = {Di Domenico, F. and Tramutola, A. and Foppoli, C. and Head, E. and Perluigi, M. and Butterfield, D. A.},
  title   = {{mTOR in Down syndrome: Role in Aß and tau neuropathology and transition to Alzheimer disease-like dementia}},
  journal = {Free radical biology \& medicine},
  year    = {2018},
  doi     = {10.1016/j.freeradbiomed.2017.08.009},
  pmid    = {28807816},
  url     = {https://doi.org/10.1016/j.freeradbiomed.2017.08.009}
}

@article{barone2018-28705658,
  author  = {Barone, E. and Arena, A. and Head, E. and Butterfield, D. A. and Perluigi, M.},
  title   = {{Disturbance of redox homeostasis in Down Syndrome: Role of iron dysmetabolism}},
  journal = {Free radical biology \& medicine},
  year    = {2018},
  doi     = {10.1016/j.freeradbiomed.2017.07.009},
  pmid    = {28705658},
  url     = {https://doi.org/10.1016/j.freeradbiomed.2017.07.009}
}

@article{mccarron2017-28664561,
  author  = {McCarron, M. and McCallion, P. and Reilly, E. and Dunne, P. and Carroll, R. and Mulryan, N.},
  title   = {{A prospective 20-year longitudinal follow-up of dementia in persons with Down syndrome}},
  journal = {Journal of intellectual disability research : JIDR},
  year    = {2017},
  doi     = {10.1111/jir.12390},
  pmid    = {28664561},
  url     = {https://doi.org/10.1111/jir.12390}
}

@article{milenkovic2018-28455903,
  author  = {Milenkovic, I. and Jarc, J. and Dassler, E. and Aronica, E. and Iyer, A. and Adle-Biassette, H. and Scharrer, A. and Reischer, T. and others},
  title   = {{The physiological phosphorylation of tau is critically changed in fetal brains of individuals with Down syndrome}},
  journal = {Neuropathology and applied neurobiology},
  year    = {2018},
  doi     = {10.1111/nan.12406},
  pmid    = {28455903},
  url     = {https://doi.org/10.1111/nan.12406}
}

@article{levine2017-28385551,
  author  = {LeVine, H. and Spielmann, H. P. and Matveev, S. and Cauvi, F. M. and Murphy, M. P. and Beckett, T. L. and McCarty, K. and Lott, I. T. and others},
  title   = {{Down syndrome: age-dependence of PiB binding in postmortem frontal cortex across the lifespan}},
  journal = {Neurobiology of aging},
  year    = {2017},
  doi     = {10.1016/j.neurobiolaging.2017.03.005},
  pmid    = {28385551},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2017.03.005}
}

@article{brownjohn2017-28285880,
  author  = {Brownjohn, P. W. and Smith, J. and Portelius, E. and Serneels, L. and Kvartsberg, H. and De Strooper, B. and Blennow, K. and Zetterberg, H. and others},
  title   = {{Phenotypic Screening Identifies Modulators of Amyloid Precursor Protein Processing in Human Stem Cell Models of Alzheimer's Disease}},
  journal = {Stem cell reports},
  year    = {2017},
  doi     = {10.1016/j.stemcr.2017.02.006},
  pmid    = {28285880},
  url     = {https://doi.org/10.1016/j.stemcr.2017.02.006}
}

@article{gholipour2017-28109983,
  author  = {Gholipour, T. and Mitchell, S. and Sarkis, R. A. and Chemali, Z.},
  title   = {{The clinical and neurobehavioral course of Down syndrome and dementia with or without new-onset epilepsy}},
  journal = {Epilepsy \& behavior : E\&B},
  year    = {2017},
  doi     = {10.1016/j.yebeh.2016.12.014},
  pmid    = {28109983},
  url     = {https://doi.org/10.1016/j.yebeh.2016.12.014}
}

@article{klosowska2017-28551695,
  author  = {Kłosowska, A. and Ćwiklińska, A. and Kuchta, A. and Berlińska, A. and Jankowski, M. and Wierzba, J.},
  title   = {{Down syndrome, increased risk of dementia and lipid disturbances}},
  journal = {Developmental period medicine},
  year    = {2017},
  pmid    = {28551695}
}

@article{carmonairagui2017-27858714,
  author  = {Carmona-Iragui, M. and Santos, T. and Videla, S. and Fernández, S. and Benejam, B. and Videla, L. and Alcolea, D. and Blennow, K. and others},
  title   = {{Feasibility of Lumbar Puncture in the Study of Cerebrospinal Fluid Biomarkers for Alzheimer's Disease in Subjects with Down Syndrome}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2017},
  doi     = {10.3233/jad-160827},
  pmid    = {27858714},
  url     = {https://doi.org/10.3233/jad-160827}
}

@article{mondragonrodriguez2017-27539594,
  author  = {Mondragón-Rodríguez, S. and Perry, G. and Pena-Ortega, F. and Williams, S.},
  title   = {{Tau, Amyloid Beta and Deep Brain Stimulation: Aiming to Restore Cognitive Deficit in Alzheimer's Disease}},
  journal = {Current Alzheimer research},
  year    = {2017},
  doi     = {10.2174/1567205013666160819131336},
  pmid    = {27539594},
  url     = {https://doi.org/10.2174/1567205013666160819131336}
}

@article{antonarakis2017-28029161,
  author  = {Antonarakis, S. E.},
  title   = {{Down syndrome and the complexity of genome dosage imbalance}},
  journal = {Nature reviews. Genetics},
  year    = {2017},
  doi     = {10.1038/nrg.2016.154},
  pmid    = {28029161},
  url     = {https://doi.org/10.1038/nrg.2016.154}
}

@article{barone2017-27838436,
  author  = {Barone, E. and Head, E. and Butterfield, D. A. and Perluigi, M.},
  title   = {{HNE-modified proteins in Down syndrome: Involvement in development of Alzheimer disease neuropathology}},
  journal = {Free radical biology \& medicine},
  year    = {2017},
  doi     = {10.1016/j.freeradbiomed.2016.10.508},
  pmid    = {27838436},
  url     = {https://doi.org/10.1016/j.freeradbiomed.2016.10.508}
}

@article{tramutola2017-27627691,
  author  = {Tramutola, A. and Di Domenico, F. and Barone, E. and Arena, A. and Giorgi, A. and di Francesco, L. and Schininà, M. E. and Coccia, R. and others},
  title   = {{Polyubiquitinylation Profile in Down Syndrome Brain Before and After the Development of Alzheimer Neuropathology}},
  journal = {Antioxidants \& redox signaling},
  year    = {2017},
  doi     = {10.1089/ars.2016.6686},
  pmid    = {27627691},
  url     = {https://doi.org/10.1089/ars.2016.6686}
}

@article{raju2016-27803687,
  author  = {Raju, H. B. and Tsinoremas, N. F. and Capobianco, E.},
  title   = {{Emerging Putative Associations between Non-Coding RNAs and Protein-Coding Genes in Neuropathic Pain: Added Value from Reusing Microarray Data}},
  journal = {Frontiers in neurology},
  year    = {2016},
  doi     = {10.3389/fneur.2016.00168},
  pmid    = {27803687},
  url     = {https://doi.org/10.3389/fneur.2016.00168}
}

@article{delhoyo2016-27799900,
  author  = {Del Hoyo, L. and Xicota, L. and Langohr, K. and Sánchez-Benavides, G. and de Sola, S. and Cuenca-Royo, A. and Rodriguez, J. and Rodríguez-Morató, J. and others},
  title   = {{VNTR-DAT1 and COMTVal158Met Genotypes Modulate Mental Flexibility and Adaptive Behavior Skills in Down Syndrome}},
  journal = {Frontiers in behavioral neuroscience},
  year    = {2016},
  doi     = {10.3389/fnbeh.2016.00193},
  pmid    = {27799900},
  url     = {https://doi.org/10.3389/fnbeh.2016.00193}
}

@article{lepeta2016-27333343,
  author  = {Lepeta, K. and Lourenco, M. V. and Schweitzer, B. C. and Martino Adami, P. V. and Banerjee, P. and Catuara-Solarz, S. and de La Fuente Revenga, M. and Guillem, A. M. and others},
  title   = {{Synaptopathies: synaptic dysfunction in neurological disorders - A review from students to students}},
  journal = {Journal of neurochemistry},
  year    = {2016},
  doi     = {10.1111/jnc.13713},
  pmid    = {27333343},
  url     = {https://doi.org/10.1111/jnc.13713}
}

@article{cooper2016-27473843,
  author  = {Cooper, S. A. and Ademola, T. and Caslake, M. and Douglas, E. and Evans, J. and Greenlaw, N. and Haig, C. and Hassiotis, A. and others},
  title   = {{Towards onset prevention of cognition decline in adults with Down syndrome (The TOP-COG study): A pilot randomised controlled trial}},
  journal = {Trials},
  year    = {2016},
  doi     = {10.1186/s13063-016-1370-9},
  pmid    = {27473843},
  url     = {https://doi.org/10.1186/s13063-016-1370-9}
}

@article{dick2016-26704220,
  author  = {Dick, M. B. and Doran, E. and Phelan, M. and Lott, I. T.},
  title   = {{Cognitive Profiles on the Severe Impairment Battery Are Similar in Alzheimer Disease and Down Syndrome With Dementia}},
  journal = {Alzheimer disease and associated disorders},
  year    = {2016},
  doi     = {10.1097/wad.0000000000000132},
  pmid    = {26704220},
  url     = {https://doi.org/10.1097/wad.0000000000000132}
}

@article{lin2016-27330972,
  author  = {Lin, A. L. and Powell, D. and Caban-Holt, A. and Jicha, G. and Robertson, W. and Gold, B. T. and Davis, R. and Abner, E. and others},
  title   = {{(1)H-MRS metabolites in adults with Down syndrome: Effects of dementia}},
  journal = {NeuroImage. Clinical},
  year    = {2016},
  doi     = {10.1016/j.nicl.2016.06.001},
  pmid    = {27330972},
  url     = {https://doi.org/10.1016/j.nicl.2016.06.001}
}

@article{matthews2016-28642933,
  author  = {Matthews, D. C. and Lukic, A. S. and Andrews, R. D. and Marendic, B. and Brewer, J. and Rissman, R. A. and Mosconi, L. and Strother, S. C. and others},
  title   = {{Dissociation of Down syndrome and Alzheimer's disease effects with imaging}},
  journal = {Alzheimer's \& dementia (New York, N. Y.)},
  year    = {2016},
  doi     = {10.1016/j.trci.2016.02.004},
  pmid    = {28642933},
  url     = {https://doi.org/10.1016/j.trci.2016.02.004}
}

@article{ballard2016-27302127,
  author  = {Ballard, C. and Mobley, W. and Hardy, J. and Williams, G. and Corbett, A.},
  title   = {{Dementia in Down's syndrome}},
  journal = {The Lancet. Neurology},
  year    = {2016},
  doi     = {10.1016/s1474-4422(16)00063-6},
  pmid    = {27302127},
  url     = {https://doi.org/10.1016/s1474-4422(16)00063-6}
}

@article{cecchini2016-26730728,
  author  = {Cecchini, M. P. and Viviani, D. and Sandri, M. and Hähner, A. and Hummel, T. and Zancanaro, C.},
  title   = {{Olfaction in People with Down Syndrome: A Comprehensive Assessment across Four Decades of Age}},
  journal = {PloS one},
  year    = {2016},
  doi     = {10.1371/journal.pone.0146486},
  pmid    = {26730728},
  url     = {https://doi.org/10.1371/journal.pone.0146486}
}

@article{head2016-26651341,
  author  = {Head, E. and Lott, I. T. and Wilcock, D. M. and Lemere, C. A.},
  title   = {{Aging in Down Syndrome and the Development of Alzheimer's Disease Neuropathology}},
  journal = {Current Alzheimer research},
  year    = {2016},
  doi     = {10.2174/1567205012666151020114607},
  pmid    = {26651341},
  url     = {https://doi.org/10.2174/1567205012666151020114607}
}

@article{hamlett2016-26391050,
  author  = {Hamlett, E. D. and Boger, H. A. and Ledreux, A. and Kelley, C. M. and Mufson, E. J. and Falangola, M. F. and Guilfoyle, D. N. and Nixon, R. A. and others},
  title   = {{Cognitive Impairment, Neuroimaging, and Alzheimer Neuropathology in Mouse Models of Down Syndrome}},
  journal = {Current Alzheimer research},
  year    = {2016},
  doi     = {10.2174/1567205012666150921095505},
  pmid    = {26391050},
  url     = {https://doi.org/10.2174/1567205012666150921095505}
}

@article{czerska2016-26670350,
  author  = {Czerska, M. and Zieliński, M. and Gromadzińska, J.},
  title   = {{Isoprostanes - A novel major group of oxidative stress markers}},
  journal = {International journal of occupational medicine and environmental health},
  year    = {2016},
  doi     = {10.13075/ijomeh.1896.00596},
  pmid    = {26670350},
  url     = {https://doi.org/10.13075/ijomeh.1896.00596}
}

@article{jiang2016-26923405,
  author  = {Jiang, Y. and Rigoglioso, A. and Peterhoff, C. M. and Pawlik, M. and Sato, Y. and Bleiwas, C. and Stavrides, P. and Smiley, J. F. and others},
  title   = {{Partial BACE1 reduction in a Down syndrome mouse model blocks Alzheimer-related endosomal anomalies and cholinergic neurodegeneration: role of APP-CTF}},
  journal = {Neurobiology of aging},
  year    = {2016},
  doi     = {10.1016/j.neurobiolaging.2015.11.013},
  pmid    = {26923405},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2015.11.013}
}

@article{chu2016-26448035,
  author  = {Chu, J. and Wisniewski, T. and Praticò, D.},
  title   = {{GATA1-mediated transcriptional regulation of the γ-secretase activating protein increases Aβ formation in Down syndrome}},
  journal = {Annals of neurology},
  year    = {2016},
  doi     = {10.1002/ana.24540},
  pmid    = {26448035},
  url     = {https://doi.org/10.1002/ana.24540}
}

@article{choong2015-26528151,
  author  = {Choong, X. Y. and Tosh, J. L. and Pulford, L. J. and Fisher, E. M.},
  title   = {{Dissecting Alzheimer disease in Down syndrome using mouse models}},
  journal = {Frontiers in behavioral neuroscience},
  year    = {2015},
  doi     = {10.3389/fnbeh.2015.00268},
  pmid    = {26528151},
  url     = {https://doi.org/10.3389/fnbeh.2015.00268}
}

@article{wiseman2015-26243569,
  author  = {Wiseman, F. K. and Al-Janabi, T. and Hardy, J. and Karmiloff-Smith, A. and Nizetic, D. and Tybulewicz, V. L. and Fisher, E. M. and Strydom, A.},
  title   = {{A genetic cause of Alzheimer disease: mechanistic insights from Down syndrome}},
  journal = {Nature reviews. Neuroscience},
  year    = {2015},
  doi     = {10.1038/nrn3983},
  pmid    = {26243569},
  url     = {https://doi.org/10.1038/nrn3983}
}

@article{lao2016-26079411,
  author  = {Lao, P. J. and Betthauser, T. J. and Hillmer, A. T. and Price, J. C. and Klunk, W. E. and Mihaila, I. and Higgins, A. T. and Bulova, P. D. and others},
  title   = {{The effects of normal aging on amyloid-β deposition in nondemented adults with Down syndrome as imaged by carbon 11-labeled Pittsburgh compound B}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2016},
  doi     = {10.1016/j.jalz.2015.05.013},
  pmid    = {26079411},
  url     = {https://doi.org/10.1016/j.jalz.2015.05.013}
}

@article{delviva2015-26057435,
  author  = {Del Viva, M. M. and Tozzi, A. and Bargagna, S. and Cioni, G.},
  title   = {{Motion perception deficit in Down Syndrome}},
  journal = {Neuropsychologia},
  year    = {2015},
  doi     = {10.1016/j.neuropsychologia.2015.06.005},
  pmid    = {26057435},
  url     = {https://doi.org/10.1016/j.neuropsychologia.2015.06.005}
}

@article{foley2015-25984682,
  author  = {Foley, K. R. and Bourke, J. and Einfeld, S. L. and Tonge, B. J. and Jacoby, P. and Leonard, H.},
  title   = {{Patterns of depressive symptoms and social relating behaviors differ over time from other behavioral domains for young people with Down syndrome}},
  journal = {Medicine},
  year    = {2015},
  doi     = {10.1097/md.0000000000000710},
  pmid    = {25984682},
  url     = {https://doi.org/10.1097/md.0000000000000710}
}

@article{alleralvarez2017-25661268,
  author  = {Aller-Alvarez, J. S. and Menéndez-González, M. and Ribacoba-Montero, R. and Salvado, M. and Vega, V. and Suárez-Moro, R. and Sueiras, M. and Toledo, M. and others},
  title   = {{Myoclonic epilepsy in Down syndrome and Alzheimer disease}},
  journal = {Neurologia (Barcelona, Spain)},
  year    = {2017},
  doi     = {10.1016/j.nrl.2014.12.008},
  pmid    = {25661268},
  url     = {https://doi.org/10.1016/j.nrl.2014.12.008}
}

@article{chohan2015-25255260,
  author  = {Chohan, M. O. and Bragina, O. and Kazim, S. F. and Statom, G. and Baazaoui, N. and Bragin, D. and Iqbal, K. and Nemoto, E. and others},
  title   = {{Enhancement of neurogenesis and memory by a neurotrophic peptide in mild to moderate traumatic brain injury}},
  journal = {Neurosurgery},
  year    = {2015},
  doi     = {10.1227/neu.0000000000000577},
  pmid    = {25255260},
  url     = {https://doi.org/10.1227/neu.0000000000000577}
}

@article{didomenico2015-25391381,
  author  = {Di Domenico, F. and Pupo, G. and Mancuso, C. and Barone, E. and Paolini, F. and Arena, A. and Blarzino, C. and Schmitt, F. A. and others},
  title   = {{Bach1 overexpression in Down syndrome correlates with the alteration of the HO-1/BVR-a system: insights for transition to Alzheimer's disease}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2015},
  doi     = {10.3233/jad-141254},
  pmid    = {25391381},
  url     = {https://doi.org/10.3233/jad-141254}
}

@article{polychronidou2015-25416974,
  author  = {Polychronidou, E. and Vlachakis, D. and Vlamos, P. and Baumann, M. and Kossida, S.},
  title   = {{Notch signaling and ageing}},
  journal = {Advances in experimental medicine and biology},
  year    = {2015},
  doi     = {10.1007/978-3-319-08927-0_6},
  pmid    = {25416974},
  url     = {https://doi.org/10.1007/978-3-319-08927-0_6}
}

@article{montoya2014-25767303,
  author  = {Montoya, J. C. and Fajardo, D. and Peña, A. and Sánchez, A. and Domínguez, M. C. and Satizábal, J. M. and García-Vallejo, F.},
  title   = {{Global differential expression of genes located in the Down Syndrome Critical Region in normal human brain}},
  journal = {Colombia medica (Cali, Colombia)},
  year    = {2014},
  doi     = {10.25100/cm.v45i4.1640},
  pmid    = {25767303},
  url     = {https://doi.org/10.25100/cm.v45i4.1640}
}

@article{butterfield2014-25242166,
  author  = {Butterfield, D. A. and Di Domenico, F. and Swomley, A. M. and Head, E. and Perluigi, M.},
  title   = {{Redox proteomics analysis to decipher the neurobiology of Alzheimer-like neurodegeneration: overlaps in Down's syndrome and Alzheimer's disease brain}},
  journal = {The Biochemical journal},
  year    = {2014},
  doi     = {10.1042/bj20140772},
  pmid    = {25242166},
  url     = {https://doi.org/10.1042/bj20140772}
}

@article{foucourt2014-25264830,
  author  = {Foucourt, A. and Hédou, D. and Dubouilh-Benard, C. and Girard, A. and Taverne, T. and Casagrande, A. S. and Désiré, L. and Leblond, B. and others},
  title   = {{Design and synthesis of thiazolo[5,4-f]quinazolines as DYRK1A inhibitors, part II}},
  journal = {Molecules (Basel, Switzerland)},
  year    = {2014},
  doi     = {10.3390/molecules191015411},
  pmid    = {25264830},
  url     = {https://doi.org/10.3390/molecules191015411}
}

@article{karlsen2014-25220902,
  author  = {Karlsen, A. S. and Korbo, S. and Uylings, H. B. and Pakkenberg, B.},
  title   = {{A stereological study of the mediodorsal thalamic nucleus in Down syndrome}},
  journal = {Neuroscience},
  year    = {2014},
  doi     = {10.1016/j.neuroscience.2014.08.046},
  pmid    = {25220902},
  url     = {https://doi.org/10.1016/j.neuroscience.2014.08.046}
}

@article{cenini2014-25151119,
  author  = {Cenini, G. and Fiorini, A. and Sultana, R. and Perluigi, M. and Cai, J. and Klein, J. B. and Head, E. and Butterfield, D. A.},
  title   = {{An investigation of the molecular mechanisms engaged before and after the development of Alzheimer disease neuropathology in Down syndrome: a proteomics approach}},
  journal = {Free radical biology \& medicine},
  year    = {2014},
  doi     = {10.1016/j.freeradbiomed.2014.08.006},
  pmid    = {25151119},
  url     = {https://doi.org/10.1016/j.freeradbiomed.2014.08.006}
}

@article{iyer2014-24918639,
  author  = {Iyer, A. M. and van Scheppingen, J. and Milenkovic, I. and Anink, J. J. and Adle-Biassette, H. and Kovacs, G. G. and Aronica, E.},
  title   = {{mTOR Hyperactivation in down syndrome hippocampus appears early during development}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {2014},
  doi     = {10.1097/nen.0000000000000083},
  pmid    = {24918639},
  url     = {https://doi.org/10.1097/nen.0000000000000083}
}

@article{portelius2014-24992945,
  author  = {Portelius, E. and Soininen, H. and Andreasson, U. and Zetterberg, H. and Persson, R. and Karlsson, G. and Blennow, K. and Herukka, S. K. and others},
  title   = {{Exploring Alzheimer molecular pathology in Down's syndrome cerebrospinal fluid}},
  journal = {Neuro-degenerative diseases},
  year    = {2014},
  doi     = {10.1159/000358800},
  pmid    = {24992945},
  url     = {https://doi.org/10.1159/000358800}
}

@article{zhang2015-24935721,
  author  = {Zhang, X. and Wu, Y. and Duan, X. and Chen, W. and Zou, H. and Zhang, M. and Zhang, S. and Cai, F. and others},
  title   = {{Upregulation of SET expression by BACE1 and its implications in Down syndrome}},
  journal = {Molecular neurobiology},
  year    = {2015},
  doi     = {10.1007/s12035-014-8782-x},
  pmid    = {24935721},
  url     = {https://doi.org/10.1007/s12035-014-8782-x}
}

@article{muchova2014-24908086,
  author  = {Muchová, J. and Žitňanová, I. and Ďuračková, Z.},
  title   = {{Oxidative stress and Down syndrome. Do antioxidants play a role in therapy?}},
  journal = {Physiological research},
  year    = {2014},
  doi     = {10.33549/physiolres.932722},
  pmid    = {24908086},
  url     = {https://doi.org/10.33549/physiolres.932722}
}

@article{cooper2014-24888381,
  author  = {Cooper, S. A. and Caslake, M. and Evans, J. and Hassiotis, A. and Jahoda, A. and McConnachie, A. and Morrison, J. and Ring, H. and others},
  title   = {{Toward onset prevention of cognitive decline in adults with Down syndrome (the TOP-COG study): study protocol for a randomized controlled trial}},
  journal = {Trials},
  year    = {2014},
  doi     = {10.1186/1745-6215-15-202},
  pmid    = {24888381},
  url     = {https://doi.org/10.1186/1745-6215-15-202}
}

@article{perluigi2014-24735980,
  author  = {Perluigi, M. and Pupo, G. and Tramutola, A. and Cini, C. and Coccia, R. and Barone, E. and Head, E. and Butterfield, D. A. and others},
  title   = {{Neuropathological role of PI3K/Akt/mTOR axis in Down syndrome brain}},
  journal = {Biochimica et biophysica acta},
  year    = {2014},
  doi     = {10.1016/j.bbadis.2014.04.007},
  pmid    = {24735980},
  url     = {https://doi.org/10.1016/j.bbadis.2014.04.007}
}

@article{didomenico2014-24675226,
  author  = {Di Domenico, F. and Pupo, G. and Tramutola, A. and Giorgi, A. and Schininà, M. E. and Coccia, R. and Head, E. and Butterfield, D. A. and others},
  title   = {{Redox proteomics analysis of HNE-modified proteins in Down syndrome brain: clues for understanding the development of Alzheimer disease}},
  journal = {Free radical biology \& medicine},
  year    = {2014},
  doi     = {10.1016/j.freeradbiomed.2014.03.027},
  pmid    = {24675226},
  url     = {https://doi.org/10.1016/j.freeradbiomed.2014.03.027}
}

@article{mondragonrodriguez2014-24033439,
  author  = {Mondragón-Rodríguez, S. and Perry, G. and Luna-Muñoz, J. and Acevedo-Aquino, M. C. and Williams, S.},
  title   = {{Phosphorylation of tau protein at sites Ser(396-404) is one of the earliest events in Alzheimer's disease and Down syndrome}},
  journal = {Neuropathology and applied neurobiology},
  year    = {2014},
  doi     = {10.1111/nan.12084},
  pmid    = {24033439},
  url     = {https://doi.org/10.1111/nan.12084}
}

@article{costa2014-24152324,
  author  = {Costa, A. C.},
  title   = {{The glutamatergic hypothesis for Down syndrome: the potential use of N-methyl-D-aspartate receptor antagonists to enhance cognition and decelerate neurodegeneration}},
  journal = {CNS \& neurological disorders drug targets},
  year    = {2014},
  doi     = {10.2174/18715273113126660183},
  pmid    = {24152324},
  url     = {https://doi.org/10.2174/18715273113126660183}
}

@article{martin2014-24927707,
  author  = {Martin, S. B. and Dowling, A. L. and Lianekhammy, J. and Lott, I. T. and Doran, E. and Murphy, M. P. and Beckett, T. L. and Schmitt, F. A. and others},
  title   = {{Synaptophysin and synaptojanin-1 in Down syndrome are differentially affected by Alzheimer's disease}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2014},
  doi     = {10.3233/jad-140795},
  pmid    = {24927707},
  url     = {https://doi.org/10.3233/jad-140795}
}

@article{facchinetti2014-24262202,
  author  = {Facchinetti, P. and Dorard, E. and Contremoulins, V. and Gaillard, M. C. and Déglon, N. and Sazdovitch, V. and Guihenneuc-Jouyaux, C. and Brouillet, E. and others},
  title   = {{SET translocation is associated with increase in caspase cleaved amyloid precursor protein in CA1 of Alzheimer and Down syndrome patients}},
  journal = {Neurobiology of aging},
  year    = {2014},
  doi     = {10.1016/j.neurobiolaging.2013.08.039},
  pmid    = {24262202},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2013.08.039}
}

@article{fernandez2013-24558640,
  author  = {Fernandez, F. and Edgin, J. O.},
  title   = {{Poor Sleep as a Precursor to Cognitive Decline in Down Syndrome : A Hypothesis}},
  journal = {Journal of Alzheimer's disease \& Parkinsonism},
  year    = {2013},
  doi     = {10.4172/2161-0460.1000124},
  pmid    = {24558640},
  url     = {https://doi.org/10.4172/2161-0460.1000124}
}

@article{wilcock2013-23866266,
  author  = {Wilcock, D. M. and Griffin, W. S.},
  title   = {{Down's syndrome, neuroinflammation, and Alzheimer neuropathogenesis}},
  journal = {Journal of neuroinflammation},
  year    = {2013},
  doi     = {10.1186/1742-2094-10-84},
  pmid    = {23866266},
  url     = {https://doi.org/10.1186/1742-2094-10-84}
}

@article{frost2013-23747948,
  author  = {Frost, J. L. and Le, K. X. and Cynis, H. and Ekpo, E. and Kleinschmidt, M. and Palmour, R. M. and Ervin, F. R. and Snigdha, S. and others},
  title   = {{Pyroglutamate-3 amyloid-β deposition in the brains of humans, non-human primates, canines, and Alzheimer disease-like transgenic mouse models}},
  journal = {The American journal of pathology},
  year    = {2013},
  doi     = {10.1016/j.ajpath.2013.05.005},
  pmid    = {23747948},
  url     = {https://doi.org/10.1016/j.ajpath.2013.05.005}
}

@article{bernstein2013-23604405,
  author  = {Bernstein, H. G. and Stricker, R. and Dobrowolny, H. and Steiner, J. and Bogerts, B. and Trübner, K. and Reiser, G.},
  title   = {{Nardilysin in human brain diseases: both friend and foe}},
  journal = {Amino acids},
  year    = {2013},
  doi     = {10.1007/s00726-013-1499-8},
  pmid    = {23604405},
  url     = {https://doi.org/10.1007/s00726-013-1499-8}
}

@article{hunter2013-23574942,
  author  = {Hunter, M. P. and Russo, A. and O'Bryan, J. P.},
  title   = {{Emerging roles for intersectin (ITSN) in regulating signaling and disease pathways}},
  journal = {International journal of molecular sciences},
  year    = {2013},
  doi     = {10.3390/ijms14047829},
  pmid    = {23574942},
  url     = {https://doi.org/10.3390/ijms14047829}
}

@article{goodman2013-23495233,
  author  = {Goodman, M. J. and Brixner, D. I.},
  title   = {{New therapies for treating Down syndrome require quality of life measurement}},
  journal = {American journal of medical genetics. Part A},
  year    = {2013},
  doi     = {10.1002/ajmg.a.35705},
  pmid    = {23495233},
  url     = {https://doi.org/10.1002/ajmg.a.35705}
}

@article{thinnes2013-23419876,
  author  = {Thinnes, F. P.},
  title   = {{New findings concerning vertebrate porin II--on the relevance of glycine motifs of type-1 VDAC}},
  journal = {Molecular genetics and metabolism},
  year    = {2013},
  doi     = {10.1016/j.ymgme.2013.01.008},
  pmid    = {23419876},
  url     = {https://doi.org/10.1016/j.ymgme.2013.01.008}
}

@article{keeney2013-23027708,
  author  = {Keeney, J. T. and Swomley, A. M. and Förster, S. and Harris, J. L. and Sultana, R. and Butterfield, D. A.},
  title   = {{Apolipoprotein A-I: insights from redox proteomics for its role in neurodegeneration}},
  journal = {Proteomics. Clinical applications},
  year    = {2013},
  doi     = {10.1002/prca.201200087},
  pmid    = {23027708},
  url     = {https://doi.org/10.1002/prca.201200087}
}

@article{head2012-25285303,
  author  = {Head, E. and Powell, D. and Gold, B. T. and Schmitt, F. A.},
  title   = {{Alzheimer's Disease in Down Syndrome}},
  journal = {European journal of neurodegenerative disease},
  year    = {2012},
  pmid    = {25285303}
}

@article{moro2012-23143229,
  author  = {Moro, M. L. and Giaccone, G. and Lombardi, R. and Indaco, A. and Uggetti, A. and Morbin, M. and Saccucci, S. and Di Fede, G. and others},
  title   = {{APP mutations in the Aβ coding region are associated with abundant cerebral deposition of Aβ38}},
  journal = {Acta neuropathologica},
  year    = {2012},
  doi     = {10.1007/s00401-012-1061-x},
  pmid    = {23143229},
  url     = {https://doi.org/10.1007/s00401-012-1061-x}
}

@article{cadieuxdion2013-22978711,
  author  = {Cadieux-Dion, M. and Andermann, E. and Lachance-Touchette, P. and Ansorge, O. and Meloche, C. and Barnabé, A. and Kuzniecky, R. I. and Andermann, F. and others},
  title   = {{Recurrent mutations in DNAJC5 cause autosomal dominant Kufs disease}},
  journal = {Clinical genetics},
  year    = {2013},
  doi     = {10.1111/cge.12020},
  pmid    = {22978711},
  url     = {https://doi.org/10.1111/cge.12020}
}

@article{mohler2012-22898099,
  author  = {Möhler, H.},
  title   = {{Cognitive enhancement by pharmacological and behavioral interventions: the murine Down syndrome model}},
  journal = {Biochemical pharmacology},
  year    = {2012},
  doi     = {10.1016/j.bcp.2012.06.028},
  pmid    = {22898099},
  url     = {https://doi.org/10.1016/j.bcp.2012.06.028}
}

@article{tian2012-22907312,
  author  = {Tian, C. Y. and Zhang, C. L. and Gu, F. and Ma, Y. J.},
  title   = {{[Function of intersectin in endocytosis and exocytosis]}},
  journal = {Sheng li xue bao : [Acta physiologica Sinica]},
  year    = {2012},
  pmid    = {22907312}
}

@article{rakowskianderson2012-22546913,
  author  = {Rakowski-Anderson, T. and Wong, H. and Rothermel, B. and Cain, P. and Lavilla, C. and Pullium, J. K. and Hoeffer, C.},
  title   = {{Fecal corticosterone levels in RCAN1 mutant mice}},
  journal = {Comparative medicine},
  year    = {2012},
  pmid    = {22546913}
}

@article{kleschevnikov2012-22541294,
  author  = {Kleschevnikov, A. M. and Belichenko, P. V. and Salehi, A. and Wu, C.},
  title   = {{Discoveries in Down syndrome: moving basic science to clinical care}},
  journal = {Progress in brain research},
  year    = {2012},
  doi     = {10.1016/b978-0-444-54299-1.00010-8},
  pmid    = {22541294},
  url     = {https://doi.org/10.1016/b978-0-444-54299-1.00010-8}
}

@article{zhang2012-22126738,
  author  = {Zhang, L. and Fu, D. and Belichenko, P. V. and Liu, C. and Kleschevnikov, A. M. and Pao, A. and Liang, P. and Clapcote, S. J. and others},
  title   = {{Genetic analysis of Down syndrome facilitated by mouse chromosome engineering}},
  journal = {Bioengineered bugs},
  year    = {2012},
  doi     = {10.4161/bbug.3.1.17696},
  pmid    = {22126738},
  url     = {https://doi.org/10.4161/bbug.3.1.17696}
}

@article{pagano2012-22411251,
  author  = {Pagano, G. and Castello, G.},
  title   = {{Oxidative stress and mitochondrial dysfunction in Down syndrome}},
  journal = {Advances in experimental medicine and biology},
  year    = {2012},
  doi     = {10.1007/978-1-4614-0653-2_22},
  pmid    = {22411251},
  url     = {https://doi.org/10.1007/978-1-4614-0653-2_22}
}

@article{delatorre2012-22541285,
  author  = {de la Torre, R. and Dierssen, M.},
  title   = {{Therapeutic approaches in the improvement of cognitive performance in Down syndrome: past, present, and future}},
  journal = {Progress in brain research},
  year    = {2012},
  doi     = {10.1016/b978-0-444-54299-1.00001-7},
  pmid    = {22541285},
  url     = {https://doi.org/10.1016/b978-0-444-54299-1.00001-7}
}

@article{lott2012-22206998,
  author  = {Lott, I. T.},
  title   = {{Antioxidants in Down syndrome}},
  journal = {Biochimica et biophysica acta},
  year    = {2012},
  doi     = {10.1016/j.bbadis.2011.12.010},
  pmid    = {22206998},
  url     = {https://doi.org/10.1016/j.bbadis.2011.12.010}
}

@article{perluigi2012-22203843,
  author  = {Perluigi, M. and Butterfield, D. A.},
  title   = {{Oxidative Stress and Down Syndrome: A Route toward Alzheimer-Like Dementia}},
  journal = {Current gerontology and geriatrics research},
  year    = {2012},
  doi     = {10.1155/2012/724904},
  pmid    = {22203843},
  url     = {https://doi.org/10.1155/2012/724904}
}

@article{sabbagh2011-22084131,
  author  = {Sabbagh, M. N. and Fleisher, A. and Chen, K. and Rogers, J. and Berk, C. and Reiman, E. and Pontecorvo, M. and Mintun, M. and others},
  title   = {{Positron emission tomography and neuropathologic estimates of fibrillar amyloid-β in a patient with Down syndrome and Alzheimer disease}},
  journal = {Archives of neurology},
  year    = {2011},
  doi     = {10.1001/archneurol.2011.535},
  pmid    = {22084131},
  url     = {https://doi.org/10.1001/archneurol.2011.535}
}

@article{cenini2012-22009041,
  author  = {Cenini, G. and Dowling, A. L. and Beckett, T. L. and Barone, E. and Mancuso, C. and Murphy, M. P. and Levine, H. and Lott, I. T. and others},
  title   = {{Association between frontal cortex oxidative damage and beta-amyloid as a function of age in Down syndrome}},
  journal = {Biochimica et biophysica acta},
  year    = {2012},
  doi     = {10.1016/j.bbadis.2011.10.001},
  pmid    = {22009041},
  url     = {https://doi.org/10.1016/j.bbadis.2011.10.001}
}

@article{coskun2012-21871538,
  author  = {Coskun, P. and Wyrembak, J. and Schriner, S. E. and Chen, H. W. and Marciniack, C. and Laferla, F. and Wallace, D. C.},
  title   = {{A mitochondrial etiology of Alzheimer and Parkinson disease}},
  journal = {Biochimica et biophysica acta},
  year    = {2012},
  doi     = {10.1016/j.bbagen.2011.08.008},
  pmid    = {21871538},
  url     = {https://doi.org/10.1016/j.bbagen.2011.08.008}
}

@article{lott2011-21739598,
  author  = {Lott, I. T. and Doran, E. and Nguyen, V. Q. and Tournay, A. and Head, E. and Gillen, D. L.},
  title   = {{Down syndrome and dementia: a randomized, controlled trial of antioxidant supplementation}},
  journal = {American journal of medical genetics. Part A},
  year    = {2011},
  doi     = {10.1002/ajmg.a.34114},
  pmid    = {21739598},
  url     = {https://doi.org/10.1002/ajmg.a.34114}
}

@article{nelson2011-21670401,
  author  = {Nelson, L. D. and Siddarth, P. and Kepe, V. and Scheibel, K. E. and Huang, S. C. and Barrio, JR. and Small, G. W.},
  title   = {{Positron emission tomography of brain β-amyloid and τ levels in adults with Down syndrome}},
  journal = {Archives of neurology},
  year    = {2011},
  doi     = {10.1001/archneurol.2011.104},
  pmid    = {21670401},
  url     = {https://doi.org/10.1001/archneurol.2011.104}
}

@article{tiano2012-21601315,
  author  = {Tiano, L. and Padella, L. and Santoro, L. and Carnevali, P. and Principi, F. and Brugè, F. and Gabrielli, O. and Littarru, G. P.},
  title   = {{Prolonged coenzyme Q10 treatment in Down syndrome patients: effect on DNA oxidation}},
  journal = {Neurobiology of aging},
  year    = {2012},
  doi     = {10.1016/j.neurobiolaging.2011.03.025},
  pmid    = {21601315},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2011.03.025}
}

@article{karlsen2011-21427166,
  author  = {Karlsen, A. S. and Pakkenberg, B.},
  title   = {{Total numbers of neurons and glial cells in cortex and basal ganglia of aged brains with Down syndrome--a stereological study}},
  journal = {Cerebral cortex (New York, N.Y. : 1991)},
  year    = {2011},
  doi     = {10.1093/cercor/bhr033},
  pmid    = {21427166},
  url     = {https://doi.org/10.1093/cercor/bhr033}
}

@article{landt2011-21403005,
  author  = {Landt, J. and D'Abrera, J. C. and Holland, A. J. and Aigbirhio, F. I. and Fryer, T. D. and Canales, R. and Hong, Y. T. and Menon, D. K. and others},
  title   = {{Using positron emission tomography and Carbon 11-labeled Pittsburgh Compound B to image Brain Fibrillar β-amyloid in adults with down syndrome: safety, acceptability, and feasibility}},
  journal = {Archives of neurology},
  year    = {2011},
  doi     = {10.1001/archneurol.2011.36},
  pmid    = {21403005},
  url     = {https://doi.org/10.1001/archneurol.2011.36}
}

@article{kondoh2011-21495523,
  author  = {Kondoh, T. and Kanno, A. and Itoh, H. and Nakashima, M. and Honda, R. and Kojima, M. and Noguchi, M. and Nakane, H. and others},
  title   = {{Donepezil significantly improves abilities in daily lives of female Down syndrome patients with severe cognitive impairment: a 24-week randomized, double-blind, placebo-controlled trial}},
  journal = {International journal of psychiatry in medicine},
  year    = {2011},
  doi     = {10.2190/pm.41.1.g},
  pmid    = {21495523},
  url     = {https://doi.org/10.2190/pm.41.1.g}
}

@article{wegiel2011-21157379,
  author  = {Wegiel, J. and Kaczmarski, W. and Barua, M. and Kuchna, I. and Nowicki, K. and Wang, K. C. and Yang, S. M. and others},
  title   = {{Link between DYRK1A overexpression and several-fold enhancement of neurofibrillary degeneration with 3-repeat tau protein in Down syndrome}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {2011},
  doi     = {10.1097/nen.0b013e318202bfa1},
  pmid    = {21157379},
  url     = {https://doi.org/10.1097/nen.0b013e318202bfa1}
}

@article{wegiel2011-21156028,
  author  = {Wegiel, J. and Gong, C. X. and Hwang, Y. W.},
  title   = {{The role of DYRK1A in neurodegenerative diseases}},
  journal = {The FEBS journal},
  year    = {2011},
  doi     = {10.1111/j.1742-4658.2010.07955.x},
  pmid    = {21156028},
  url     = {https://doi.org/10.1111/j.1742-4658.2010.07955.x}
}

@article{schupf2010-21041786,
  author  = {Schupf, N. and Zigman, W. B. and Tang, M. X. and Pang, D. and Mayeux, R. and Mehta, P. and Silverman, W.},
  title   = {{Change in plasma Aß peptides and onset of dementia in adults with Down syndrome}},
  journal = {Neurology},
  year    = {2010},
  doi     = {10.1212/wnl.0b013e3181fb448b},
  pmid    = {21041786},
  url     = {https://doi.org/10.1212/wnl.0b013e3181fb448b}
}

@article{lott2010-20494326,
  author  = {Lott, I. T. and Dierssen, M.},
  title   = {{Cognitive deficits and associated neurological complications in individuals with Down's syndrome}},
  journal = {The Lancet. Neurology},
  year    = {2010},
  doi     = {10.1016/s1474-4422(10)70112-5},
  pmid    = {20494326},
  url     = {https://doi.org/10.1016/s1474-4422(10)70112-5}
}

@article{lanfranchi2010-20202074,
  author  = {Lanfranchi, S. and Jerman, O. and Dal Pont, E. and Alberti, A. and Vianello, R.},
  title   = {{Executive function in adolescents with Down Syndrome}},
  journal = {Journal of intellectual disability research : JIDR},
  year    = {2010},
  doi     = {10.1111/j.1365-2788.2010.01262.x},
  pmid    = {20202074},
  url     = {https://doi.org/10.1111/j.1365-2788.2010.01262.x}
}

@article{contestabile2010-20097253,
  author  = {Contestabile, A. and Benfenati, F. and Gasparini, L.},
  title   = {{Communication breaks-Down: from neurodevelopment defects to cognitive disabilities in Down syndrome}},
  journal = {Progress in neurobiology},
  year    = {2010},
  doi     = {10.1016/j.pneurobio.2010.01.003},
  pmid    = {20097253},
  url     = {https://doi.org/10.1016/j.pneurobio.2010.01.003}
}

@article{vostrov2010-20205906,
  author  = {Vostrov, A. A. and Taheny, M. J. and Izkhakov, N. and Quitschke, W. W.},
  title   = {{A nuclear factor-binding domain in the 5'-untranslated region of the amyloid precursor protein promoter: implications for the regulation of gene expression}},
  journal = {BMC research notes},
  year    = {2010},
  doi     = {10.1186/1756-0500-3-4},
  pmid    = {20205906},
  url     = {https://doi.org/10.1186/1756-0500-3-4}
}

@article{granic2010-20032300,
  author  = {Granic, A. and Padmanabhan, J. and Norden, M. and Potter, H.},
  title   = {{Alzheimer Abeta peptide induces chromosome mis-segregation and aneuploidy, including trisomy 21: requirement for tau and APP}},
  journal = {Molecular biology of the cell},
  year    = {2010},
  doi     = {10.1091/mbc.e09-10-0850},
  pmid    = {20032300},
  url     = {https://doi.org/10.1091/mbc.e09-10-0850}
}

@article{dogliotti2010-20006980,
  author  = {Dogliotti, G. and Galliera, E. and Dozio, E. and Vianello, E. and Villa, R. E. and Licastro, F. and Barajon, I. and Corsi, M. M.},
  title   = {{Okadaic acid induces apoptosis in Down syndrome fibroblasts}},
  journal = {Toxicology in vitro : an international journal published in association with BIBRA},
  year    = {2010},
  doi     = {10.1016/j.tiv.2009.12.012},
  pmid    = {20006980},
  url     = {https://doi.org/10.1016/j.tiv.2009.12.012}
}

@article{lippa2009-20008652,
  author  = {Lippa, C. F. and Rosso, A. L. and Stutzbach, L. D. and Neumann, M. and Lee, V. M. and Trojanowski, J. Q.},
  title   = {{Transactive response DNA-binding protein 43 burden in familial Alzheimer disease and Down syndrome}},
  journal = {Archives of neurology},
  year    = {2009},
  doi     = {10.1001/archneurol.2009.277},
  pmid    = {20008652},
  url     = {https://doi.org/10.1001/archneurol.2009.277}
}

@article{kolla2010-19902006,
  author  = {Kolla, V. and Jenö, P. and Moes, S. and Tercanli, S. and Lapaire, O. and Choolani, M. and Hahn, S.},
  title   = {{Quantitative proteomics analysis of maternal plasma in Down syndrome pregnancies using isobaric tagging reagent (iTRAQ)}},
  journal = {Journal of biomedicine \& biotechnology},
  year    = {2010},
  doi     = {10.1155/2010/952047},
  pmid    = {19902006},
  url     = {https://doi.org/10.1155/2010/952047}
}

@article{azkona2010-19840121,
  author  = {Azkona, G. and Amador-Arjona, A. and Obradors-Tarragó, C. and Varea, E. and Arqué, G. and Pinacho, R. and Fillat, C. and de la Luna, S. and others},
  title   = {{Characterization of a mouse model overexpressing beta-site APP-cleaving enzyme 2 reveals a new role for BACE2}},
  journal = {Genes, brain, and behavior},
  year    = {2010},
  doi     = {10.1111/j.1601-183x.2009.00538.x},
  pmid    = {19840121},
  url     = {https://doi.org/10.1111/j.1601-183x.2009.00538.x}
}

@article{kishnani2009-19606472,
  author  = {Kishnani, P. S. and Sommer, B. R. and Handen, B. L. and Seltzer, B. and Capone, G. T. and Spiridigliozzi, G. A. and Heller, J. H. and Richardson, S. and others},
  title   = {{The efficacy, safety, and tolerability of donepezil for the treatment of young adults with Down syndrome}},
  journal = {American journal of medical genetics. Part A},
  year    = {2009},
  doi     = {10.1002/ajmg.a.32953},
  pmid    = {19606472},
  url     = {https://doi.org/10.1002/ajmg.a.32953}
}

@article{korbel2009-19597142,
  author  = {Korbel, J. O. and Tirosh-Wagner, T. and Urban, A. E. and Chen, X. N. and Kasowski, M. and Dai, L. and Grubert, F. and Erdman, C. and others},
  title   = {{The genetic architecture of Down syndrome phenotypes revealed by high-resolution analysis of human segmental trisomies}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2009},
  doi     = {10.1073/pnas.0813248106},
  pmid    = {19597142},
  url     = {https://doi.org/10.1073/pnas.0813248106}
}

@article{porayette2009-19542221,
  author  = {Porayette, P. and Gallego, M. J. and Kaltcheva, M. M. and Bowen, R. L. and Vadakkadath Meethal, S. and Atwood, C. S.},
  title   = {{Differential processing of amyloid-beta precursor protein directs human embryonic stem cell proliferation and differentiation into neuronal precursor cells}},
  journal = {The Journal of biological chemistry},
  year    = {2009},
  doi     = {10.1074/jbc.m109.026328},
  pmid    = {19542221},
  url     = {https://doi.org/10.1074/jbc.m109.026328}
}

@article{sarsoza2009-19360426,
  author  = {Sarsoza, F. and Saing, T. and Kayed, R. and Dahlin, R. and Dick, M. and Broadwater-Hollifield, C. and Mobley, S. and Lott, I. and others},
  title   = {{A fibril-specific, conformation-dependent antibody recognizes a subset of Abeta plaques in Alzheimer disease, Down syndrome and Tg2576 transgenic mouse brain}},
  journal = {Acta neuropathologica},
  year    = {2009},
  doi     = {10.1007/s00401-009-0530-3},
  pmid    = {19360426},
  url     = {https://doi.org/10.1007/s00401-009-0530-3}
}

@article{cairney2009-19419698,
  author  = {Cairney, C. J. and Sanguinetti, G. and Ranghini, E. and Chantry, A. D. and Nostro, M. C. and Bhattacharyya, A. and Svendsen, C. N. and Keith, W. N. and others},
  title   = {{A systems biology approach to Down syndrome: identification of Notch/Wnt dysregulation in a model of stem cells aging}},
  journal = {Biochimica et biophysica acta},
  year    = {2009},
  doi     = {10.1016/j.bbadis.2009.01.015},
  pmid    = {19419698},
  url     = {https://doi.org/10.1016/j.bbadis.2009.01.015}
}

@article{prinzen2009-19196476,
  author  = {Prinzen, C. and Trümbach, D. and Wurst, W. and Endres, K. and Postina, R. and Fahrenholz, F.},
  title   = {{Differential gene expression in ADAM10 and mutant ADAM10 transgenic mice}},
  journal = {BMC genomics},
  year    = {2009},
  doi     = {10.1186/1471-2164-10-66},
  pmid    = {19196476},
  url     = {https://doi.org/10.1186/1471-2164-10-66}
}

@article{kusters2009-19250275,
  author  = {Kusters, M. A. and Verstegen, R. H. and Gemen, E. F. and de Vries, E.},
  title   = {{Intrinsic defect of the immune system in children with Down syndrome: a review}},
  journal = {Clinical and experimental immunology},
  year    = {2009},
  doi     = {10.1111/j.1365-2249.2009.03890.x},
  pmid    = {19250275},
  url     = {https://doi.org/10.1111/j.1365-2249.2009.03890.x}
}

@article{rasmussen2008-19006076,
  author  = {Rasmussen, S. A. and Whitehead, N. and Collier, S. A. and Frías, J. L.},
  title   = {{Setting a public health research agenda for Down syndrome: summary of a meeting sponsored by the Centers for Disease Control and Prevention and the National Down Syndrome Society}},
  journal = {American journal of medical genetics. Part A},
  year    = {2008},
  doi     = {10.1002/ajmg.a.32581},
  pmid    = {19006076},
  url     = {https://doi.org/10.1002/ajmg.a.32581}
}

@article{wang2009-19001410,
  author  = {Wang, Y. and Mulligan, C. and Denyer, G. and Delom, F. and Dagna-Bricarelli, F. and Tybulewicz, V. L. and Fisher, E. M. and Griffiths, W. J. and others},
  title   = {{Quantitative proteomics characterization of a mouse embryonic stem cell model of Down syndrome}},
  journal = {Molecular \& cellular proteomics : MCP},
  year    = {2009},
  doi     = {10.1074/mcp.m800256-mcp200},
  pmid    = {19001410},
  url     = {https://doi.org/10.1074/mcp.m800256-mcp200}
}

@article{sitz2008-18938227,
  author  = {Sitz, J. H. and Baumgärtel, K. and Hämmerle, B. and Papadopoulos, C. and Hekerman, P. and Tejedor, F. J. and Becker, W. and Lutz, B.},
  title   = {{The Down syndrome candidate dual-specificity tyrosine phosphorylation-regulated kinase 1A phosphorylates the neurodegeneration-related septin 4}},
  journal = {Neuroscience},
  year    = {2008},
  doi     = {10.1016/j.neuroscience.2008.09.034},
  pmid    = {18938227},
  url     = {https://doi.org/10.1016/j.neuroscience.2008.09.034}
}

@article{staropoli2008-18623069,
  author  = {Staropoli, J. F.},
  title   = {{Tumorigenesis and neurodegeneration: two sides of the same coin?}},
  journal = {BioEssays : news and reviews in molecular, cellular and developmental biology},
  year    = {2008},
  doi     = {10.1002/bies.20784},
  pmid    = {18623069},
  url     = {https://doi.org/10.1002/bies.20784}
}

@article{shi2008-18658135,
  author  = {Shi, J. and Zhang, T. and Zhou, C. and Chohan, M. O. and Gu, X. and Wegiel, J. and Zhou, J. and Hwang, Y. W. and others},
  title   = {{Increased dosage of Dyrk1A alters alternative splicing factor (ASF)-regulated alternative splicing of tau in Down syndrome}},
  journal = {The Journal of biological chemistry},
  year    = {2008},
  doi     = {10.1074/jbc.m802645200},
  pmid    = {18658135},
  url     = {https://doi.org/10.1074/jbc.m802645200}
}

@article{cataldo2008-18535180,
  author  = {Cataldo, A. M. and Mathews, P. M. and Boiteau, A. B. and Hassinger, L. C. and Peterhoff, C. M. and Jiang, Y. and Mullaney, K. and Neve, R. L. and others},
  title   = {{Down syndrome fibroblast model of Alzheimer-related endosome pathology: accelerated endocytosis promotes late endocytic defects}},
  journal = {The American journal of pathology},
  year    = {2008},
  doi     = {10.2353/ajpath.2008.071053},
  pmid    = {18535180},
  url     = {https://doi.org/10.2353/ajpath.2008.071053}
}

@article{varga2008-18565815,
  author  = {Varga, P. and V Oláh, A. and Oláh, E.},
  title   = {{[Biochemical alterations in patients with Down syndrome]}},
  journal = {Orvosi hetilap},
  year    = {2008},
  doi     = {10.1556/oh.2008.28327},
  pmid    = {18565815},
  url     = {https://doi.org/10.1556/oh.2008.28327}
}

@article{jenkins2008-18478592,
  author  = {Jenkins, E. C. and Tassone, F. and Ye, L. and Gu, H. and Xi, M. and Velinov, M. and Brown, W. T. and Hagerman, R. J. and others},
  title   = {{Reduced telomere length in older men with premutation alleles of the fragile X mental retardation 1 gene}},
  journal = {American journal of medical genetics. Part A},
  year    = {2008},
  doi     = {10.1002/ajmg.a.32342},
  pmid    = {18478592},
  url     = {https://doi.org/10.1002/ajmg.a.32342}
}

@article{liu2008-18509201,
  author  = {Liu, F. and Liang, Z. and Wegiel, J. and Hwang, Y. W. and Iqbal, K. and Grundke-Iqbal, I. and Ramakrishna, N. and Gong, C. X.},
  title   = {{Overexpression of Dyrk1A contributes to neurofibrillary degeneration in Down syndrome}},
  journal = {FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year    = {2008},
  doi     = {10.1096/fj.07-104539},
  pmid    = {18509201},
  url     = {https://doi.org/10.1096/fj.07-104539}
}

@article{martin2008-18431258,
  author  = {Martin, L. J.},
  title   = {{DNA damage and repair: relevance to mechanisms of neurodegeneration}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {2008},
  doi     = {10.1097/nen.0b013e31816ff780},
  pmid    = {18431258},
  url     = {https://doi.org/10.1097/nen.0b013e31816ff780}
}

@article{ringman2008-18332257,
  author  = {Ringman, J. M. and Rao, P. N. and Lu, P. H. and Cederbaum, S.},
  title   = {{Mosaicism for trisomy 21 in a patient with young-onset dementia: a case report and brief literature review}},
  journal = {Archives of neurology},
  year    = {2008},
  doi     = {10.1001/archneur.65.3.412},
  pmid    = {18332257},
  url     = {https://doi.org/10.1001/archneur.65.3.412}
}

@article{tiano2008-19096112,
  author  = {Tiano, L. and Padella, L. and Carnevali, P. and Gabrielli, O. and Bruge, F. and Principi, F. and Littarru, G. P.},
  title   = {{Coenzyme Q10 and oxidative imbalance in Down syndrome: biochemical and clinical aspects}},
  journal = {BioFactors (Oxford, England)},
  year    = {2008},
  doi     = {10.1002/biof.5520320119},
  pmid    = {19096112},
  url     = {https://doi.org/10.1002/biof.5520320119}
}

@article{cheon2008-18163181,
  author  = {Cheon, M. S. and Dierssen, M. and Kim, S. H. and Lubec, G.},
  title   = {{Protein expression of BACE1, BACE2 and APP in Down syndrome brains}},
  journal = {Amino acids},
  year    = {2008},
  doi     = {10.1007/s00726-007-0618-9},
  pmid    = {18163181},
  url     = {https://doi.org/10.1007/s00726-007-0618-9}
}

@article{crespel2007-17961983,
  author  = {Crespel, A. and Gonzalez, V. and Coubes, P. and Gelisse, P.},
  title   = {{Senile myoclonic epilepsy of Genton: two cases in Down syndrome with dementia and late onset epilepsy}},
  journal = {Epilepsy research},
  year    = {2007},
  doi     = {10.1016/j.eplepsyres.2007.09.002},
  pmid    = {17961983},
  url     = {https://doi.org/10.1016/j.eplepsyres.2007.09.002}
}

@article{lockstone2007-17950572,
  author  = {Lockstone, H. E. and Harris, L. W. and Swatton, J. E. and Wayland, M. T. and Holland, A. J. and Bahn, S.},
  title   = {{Gene expression profiling in the adult Down syndrome brain}},
  journal = {Genomics},
  year    = {2007},
  doi     = {10.1016/j.ygeno.2007.08.005},
  pmid    = {17950572},
  url     = {https://doi.org/10.1016/j.ygeno.2007.08.005}
}

@article{ryoo2007-17906291,
  author  = {Ryoo, SR. and Jeong, H. K. and Radnaabazar, C. and Yoo, J. J. and Cho, H. J. and Lee, H. W. and Kim, I. S. and Cheon, Y. H. and others},
  title   = {{DYRK1A-mediated hyperphosphorylation of Tau. A functional link between Down syndrome and Alzheimer disease}},
  journal = {The Journal of biological chemistry},
  year    = {2007},
  doi     = {10.1074/jbc.m707358200},
  pmid    = {17906291},
  url     = {https://doi.org/10.1074/jbc.m707358200}
}

@article{banerjee2007-17902044,
  author  = {Banerjee, D. and Nandagopal, K.},
  title   = {{Potential interaction between the GARS-AIRS-GART Gene and CP2/LBP-1c/LSF transcription factor in Down syndrome-related Alzheimer disease}},
  journal = {Cellular and molecular neurobiology},
  year    = {2007},
  doi     = {10.1007/s10571-007-9217-2},
  pmid    = {17902044},
  url     = {https://doi.org/10.1007/s10571-007-9217-2}
}

@article{deb2007-17845241,
  author  = {Deb, S. and Hare, M. and Prior, L.},
  title   = {{Symptoms of dementia among adults with Down's syndrome: a qualitative study}},
  journal = {Journal of intellectual disability research : JIDR},
  year    = {2007},
  doi     = {10.1111/j.1365-2788.2007.00956.x},
  pmid    = {17845241},
  url     = {https://doi.org/10.1111/j.1365-2788.2007.00956.x}
}

@article{barnhart2007-17712035,
  author  = {Barnhart, R. C. and Connolly, B.},
  title   = {{Aging and Down syndrome: implications for physical therapy}},
  journal = {Physical therapy},
  year    = {2007},
  doi     = {10.2522/ptj.20060334},
  pmid    = {17712035},
  url     = {https://doi.org/10.2522/ptj.20060334}
}

@article{rozovski2007-17635843,
  author  = {Rozovski, U. and Jonish-Grossman, A. and Bar-Shira, A. and Ochshorn, Y. and Goldstein, M. and Yaron, Y.},
  title   = {{Genome-wide expression analysis of cultured trophoblast with trisomy 21 karyotype}},
  journal = {Human reproduction (Oxford, England)},
  year    = {2007},
  doi     = {10.1093/humrep/dem214},
  pmid    = {17635843},
  url     = {https://doi.org/10.1093/humrep/dem214}
}

@article{schupf2007-17620492,
  author  = {Schupf, N. and Patel, B. and Pang, D. and Zigman, W. B. and Silverman, W. and Mehta, P. D. and Mayeux, R.},
  title   = {{Elevated plasma beta-amyloid peptide Abeta(42) levels, incident dementia, and mortality in Down syndrome}},
  journal = {Archives of neurology},
  year    = {2007},
  doi     = {10.1001/archneur.64.7.1007},
  pmid    = {17620492},
  url     = {https://doi.org/10.1001/archneur.64.7.1007}
}

@article{visootsak2007-17389125,
  author  = {Visootsak, J. and Sherman, S.},
  title   = {{Neuropsychiatric and behavioral aspects of trisomy 21}},
  journal = {Current psychiatry reports},
  year    = {2007},
  doi     = {10.1007/s11920-007-0083-x},
  pmid    = {17389125},
  url     = {https://doi.org/10.1007/s11920-007-0083-x}
}

@article{byard2007-17961872,
  author  = {Byard, R. W.},
  title   = {{Forensic issues in Down syndrome fatalities}},
  journal = {Journal of forensic and legal medicine},
  year    = {2007},
  doi     = {10.1016/j.jflm.2007.01.001},
  pmid    = {17961872},
  url     = {https://doi.org/10.1016/j.jflm.2007.01.001}
}

@article{head2007-17361036,
  author  = {Head, E. and Lott, I. T. and Patterson, D. and Doran, E. and Haier, R. J.},
  title   = {{Possible compensatory events in adult Down syndrome brain prior to the development of Alzheimer disease neuropathology: targets for nonpharmacological intervention}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2007},
  doi     = {10.3233/jad-2007-11110},
  pmid    = {17361036},
  url     = {https://doi.org/10.3233/jad-2007-11110}
}

@article{mehta2007-17275850,
  author  = {Mehta, P. D. and Capone, G. and Jewell, A. and Freedland, R. L.},
  title   = {{Increased amyloid beta protein levels in children and adolescents with Down syndrome}},
  journal = {Journal of the neurological sciences},
  year    = {2007},
  doi     = {10.1016/j.jns.2006.12.010},
  pmid    = {17275850},
  url     = {https://doi.org/10.1016/j.jns.2006.12.010}
}

@article{yoo2007-17221321,
  author  = {Yoo, J. H. and Valdovinos, M. G. and Williams, D. C.},
  title   = {{Relevance of donepezil in enhancing learning and memory in special populations: a review of the literature}},
  journal = {Journal of autism and developmental disorders},
  year    = {2007},
  doi     = {10.1007/s10803-006-0322-8},
  pmid    = {17221321},
  url     = {https://doi.org/10.1007/s10803-006-0322-8}
}

@article{lott2006-17168651,
  author  = {Lott, I. T. and Head, E. and Doran, E. and Busciglio, J.},
  title   = {{Beta-amyloid, oxidative stress and down syndrome}},
  journal = {Current Alzheimer research},
  year    = {2006},
  doi     = {10.2174/156720506779025305},
  pmid    = {17168651},
  url     = {https://doi.org/10.2174/156720506779025305}
}

@article{kimura2007-17135279,
  author  = {Kimura, R. and Kamino, K. and Yamamoto, M. and Nuripa, A. and Kida, T. and Kazui, H. and Hashimoto, R. and Tanaka, T. and others},
  title   = {{The DYRK1A gene, encoded in chromosome 21 Down syndrome critical region, bridges between beta-amyloid production and tau phosphorylation in Alzheimer disease}},
  journal = {Human molecular genetics},
  year    = {2007},
  doi     = {10.1093/hmg/ddl437},
  pmid    = {17135279},
  url     = {https://doi.org/10.1093/hmg/ddl437}
}

@article{desimone2006-16987746,
  author  = {De Simone, R. and Daquin, G. and Genton, P.},
  title   = {{Senile myoclonic epilepsy in Down syndrome: a video and EEG presentation of two cases}},
  journal = {Epileptic disorders : international epilepsy journal with videotape},
  year    = {2006},
  doi     = {10.1684/j.1950-6945.2006.tb00191.x},
  pmid    = {16987746},
  url     = {https://doi.org/10.1684/j.1950-6945.2006.tb00191.x}
}

@article{nardone2006-16931146,
  author  = {Nardone, R. and Marth, R. and Ausserer, H. and Bratti, A. and Tezzon, F.},
  title   = {{Reduced short latency afferent inhibition in patients with Down syndrome and Alzheimer-type dementia}},
  journal = {Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology},
  year    = {2006},
  doi     = {10.1016/j.clinph.2006.07.134},
  pmid    = {16931146},
  url     = {https://doi.org/10.1016/j.clinph.2006.07.134}
}

@article{altiay2006-16970855,
  author  = {Altiay, S. and Kaya, M. and Karasalihoglu, S. and Gultekin, A. and Oner, N. and Biner, B.},
  title   = {{99mTc-HMPAO brain perfusion single-photon emission computed tomography in children with Down syndrome: relationship to epilepsy, thyroid functions, and congenital heart disease}},
  journal = {Journal of child neurology},
  year    = {2006},
  doi     = {10.1177/08830738060210070901},
  pmid    = {16970855},
  url     = {https://doi.org/10.1177/08830738060210070901}
}

@article{lott2006-19595881,
  author  = {Lott, I. T. and Doran, E. and Walsh, D. M. and Hill, M. A.},
  title   = {{Telemedicine, dementia and Down syndrome: implications for Alzheimer disease}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2006},
  doi     = {10.1016/j.jalz.2006.04.001},
  pmid    = {19595881},
  url     = {https://doi.org/10.1016/j.jalz.2006.04.001}
}

@article{pueschel2006-16621446,
  author  = {Pueschel, S. M.},
  title   = {{The effect of acetyl-L-carnitine administration on persons with Down syndrome}},
  journal = {Research in developmental disabilities},
  year    = {2006},
  doi     = {10.1016/j.ridd.2004.07.009},
  pmid    = {16621446},
  url     = {https://doi.org/10.1016/j.ridd.2004.07.009}
}

@article{moreira2006-16432155,
  author  = {Moreira, P. I. and Honda, K. and Zhu, X. and Nunomura, A. and Casadesus, G. and Smith, M. A. and Perry, G.},
  title   = {{Brain and brawn: parallels in oxidative strength}},
  journal = {Neurology},
  year    = {2006},
  doi     = {10.1212/01.wnl.0000192307.15103.83},
  pmid    = {16432155},
  url     = {https://doi.org/10.1212/01.wnl.0000192307.15103.83}
}

@article{vanleeuwen2006-16432153,
  author  = {van Leeuwen, F. W. and van Tijn, P. and Sonnemans, M. A. and Hobo, B. and Mann, D. M. and Van Broeckhoven, C. and Kumar-Singh, S. and Cras, P. and others},
  title   = {{Frameshift proteins in autosomal dominant forms of Alzheimer disease and other tauopathies}},
  journal = {Neurology},
  year    = {2006},
  doi     = {10.1212/01.wnl.0000193882.46003.6d},
  pmid    = {16432153},
  url     = {https://doi.org/10.1212/01.wnl.0000193882.46003.6d}
}

@article{tabaton2006-16914851,
  author  = {Tabaton, M. and Gambetti, P.},
  title   = {{Soluble amyloid-beta in the brain: the scarlet pimpernel}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2006},
  doi     = {10.3233/jad-2006-9s315},
  pmid    = {16914851},
  url     = {https://doi.org/10.3233/jad-2006-9s315}
}

@article{beacher2005-16330724,
  author  = {Beacher, F. and Simmons, A. and Daly, E. and Prasher, V. and Adams, C. and Margallo-Lana, M. L. and Morris, R. and Lovestone, S. and others},
  title   = {{Hippocampal myo-inositol and cognitive ability in adults with Down syndrome: an in vivo proton magnetic resonance spectroscopy study}},
  journal = {Archives of general psychiatry},
  year    = {2005},
  doi     = {10.1001/archpsyc.62.12.1360},
  pmid    = {16330724},
  url     = {https://doi.org/10.1001/archpsyc.62.12.1360}
}

@article{ferrer2005-16242644,
  author  = {Ferrer, I. and Barrachina, M. and Puig, B. and Martínez de Lagrán, M. and Martí, E. and Avila, J. and Dierssen, M.},
  title   = {{Constitutive Dyrk1A is abnormally expressed in Alzheimer disease, Down syndrome, Pick disease, and related transgenic models}},
  journal = {Neurobiology of disease},
  year    = {2005},
  doi     = {10.1016/j.nbd.2005.03.020},
  pmid    = {16242644},
  url     = {https://doi.org/10.1016/j.nbd.2005.03.020}
}

@article{fischer2005-16126912,
  author  = {Fischer, D. F. and van Dijk, R. and Sluijs, J. A. and Nair, S. M. and Racchi, M. and Levelt, C. N. and van Leeuwen, F. W. and Hol, E. M.},
  title   = {{Activation of the Notch pathway in Down syndrome: cross-talk of Notch and APP}},
  journal = {FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year    = {2005},
  doi     = {10.1096/fj.04-3395.com},
  pmid    = {16126912},
  url     = {https://doi.org/10.1096/fj.04-3395.com}
}

@article{tomidokoro2005-16091362,
  author  = {Tomidokoro, Y. and Lashley, T. and Rostagno, A. and Neubert, T. A. and Bojsen-Møller, M. and Braendgaard, H. and Plant, G. and Holton, J. and others},
  title   = {{Familial Danish dementia: co-existence of Danish and Alzheimer amyloid subunits (ADan AND Abeta) in the absence of compact plaques}},
  journal = {The Journal of biological chemistry},
  year    = {2005},
  doi     = {10.1074/jbc.m504038200},
  pmid    = {16091362},
  url     = {https://doi.org/10.1074/jbc.m504038200}
}

@article{dominguez2005-15987683,
  author  = {Dominguez, D. and Tournoy, J. and Hartmann, D. and Huth, T. and Cryns, K. and Deforce, S. and Serneels, L. and Camacho, I. E. and others},
  title   = {{Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice}},
  journal = {The Journal of biological chemistry},
  year    = {2005},
  doi     = {10.1074/jbc.m505249200},
  pmid    = {15987683},
  url     = {https://doi.org/10.1074/jbc.m505249200}
}

@article{menendez2005-15862185,
  author  = {Menéndez, M.},
  title   = {{Down syndrome, Alzheimer's disease and seizures}},
  journal = {Brain \& development},
  year    = {2005},
  doi     = {10.1016/j.braindev.2004.07.008},
  pmid    = {15862185},
  url     = {https://doi.org/10.1016/j.braindev.2004.07.008}
}

@article{lott2005-15639317,
  author  = {Lott, I. T. and Head, E.},
  title   = {{Alzheimer disease and Down syndrome: factors in pathogenesis}},
  journal = {Neurobiology of aging},
  year    = {2005},
  doi     = {10.1016/j.neurobiolaging.2004.08.005},
  pmid    = {15639317},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2004.08.005}
}

@article{nelson2005-15795053,
  author  = {Nelson, L. and Johnson, J. K. and Freedman, M. and Lott, I. and Groot, J. and Chang, M. and Milgram, N. W. and Head, E.},
  title   = {{Learning and memory as a function of age in Down syndrome: a study using animal-based tasks}},
  journal = {Progress in neuro-psychopharmacology \& biological psychiatry},
  year    = {2005},
  doi     = {10.1016/j.pnpbp.2004.12.009},
  pmid    = {15795053},
  url     = {https://doi.org/10.1016/j.pnpbp.2004.12.009}
}

@article{frackowiak2005-15715088,
  author  = {Frackowiak, J. and Potempska, A. and LeVine, H. and Haske, T. and Dickson, D. and Mazur-Kolecka, B.},
  title   = {{Extracellular deposits of A beta produced in cultures of Alzheimer disease brain vascular smooth muscle cells}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {2005},
  doi     = {10.1093/jnen/64.1.82},
  pmid    = {15715088},
  url     = {https://doi.org/10.1093/jnen/64.1.82}
}

@article{frederikse2004-15529118,
  author  = {Frederikse, P. H. and Yun, E. and Kao, H. T. and Zigler, J. S. and Sun, Q. and Qazi, A. S.},
  title   = {{Synapsin and synaptic vesicle protein expression during embryonic and post-natal lens fiber cell differentiation}},
  journal = {Molecular vision},
  year    = {2004},
  pmid    = {15529118}
}

@article{giacobini2004-15304240,
  author  = {Giacobini, E.},
  title   = {{Cholinesterase inhibitors: new roles and therapeutic alternatives}},
  journal = {Pharmacological research},
  year    = {2004},
  doi     = {10.1016/j.phrs.2003.11.017},
  pmid    = {15304240},
  url     = {https://doi.org/10.1016/j.phrs.2003.11.017}
}

@article{castro2004-15488240,
  author  = {Castro, R. M. and Landemberger, M. C. and Walz, R. and Carlotti, C. G. and Huang, N. and Cunha, D. R. and Moura, R. and Caballero, O. L. and others},
  title   = {{High capacity and low cost detection of prion protein gene variant alleles by denaturing HPLC}},
  journal = {Journal of neuroscience methods},
  year    = {2004},
  doi     = {10.1016/j.jneumeth.2004.05.001},
  pmid    = {15488240},
  url     = {https://doi.org/10.1016/j.jneumeth.2004.05.001}
}

@article{kowa2004-15215182,
  author  = {Kowa, H. and Sakakura, T. and Matsuura, Y. and Wakabayashi, T. and Mann, D. M. and Duff, K. and Tsuji, S. and Hashimoto, T. and others},
  title   = {{Mostly separate distributions of CLAC- versus Abeta40- or thioflavin S-reactivities in senile plaques reveal two distinct subpopulations of beta-amyloid deposits}},
  journal = {The American journal of pathology},
  year    = {2004},
  doi     = {10.1016/s0002-9440(10)63295-6},
  pmid    = {15215182},
  url     = {https://doi.org/10.1016/s0002-9440(10)63295-6}
}

@article{mrak2004-15290893,
  author  = {Mrak, R. E. and Griffin, W. S.},
  title   = {{Trisomy 21 and the brain}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {2004},
  doi     = {10.1093/jnen/63.7.679},
  pmid    = {15290893},
  url     = {https://doi.org/10.1093/jnen/63.7.679}
}

@article{ristow2004-15175861,
  author  = {Ristow, M.},
  title   = {{Neurodegenerative disorders associated with diabetes mellitus}},
  journal = {Journal of molecular medicine (Berlin, Germany)},
  year    = {2004},
  doi     = {10.1007/s00109-004-0552-1},
  pmid    = {15175861},
  url     = {https://doi.org/10.1007/s00109-004-0552-1}
}

@article{rofina2004-15478464,
  author  = {Rofina, J. E. and Singh, K. and Skoumalova-Vesela, A. and van Ederen, A. M. and van Asten, A. J. and Wilhelm, J. and Gruys, E.},
  title   = {{Histochemical accumulation of oxidative damage products is associated with Alzheimer-like pathology in the canine}},
  journal = {Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis},
  year    = {2004},
  doi     = {10.1080/13506120412331285779},
  pmid    = {15478464},
  url     = {https://doi.org/10.1080/13506120412331285779}
}

@article{margallolana2004-15184603,
  author  = {Margallo-Lana, M. and Morris, C. M. and Gibson, A. M. and Tan, A. L. and Kay, D. W. and Tyrer, S. P. and Moore, B. P. and Ballard, C. G.},
  title   = {{Influence of the amyloid precursor protein locus on dementia in Down syndrome}},
  journal = {Neurology},
  year    = {2004},
  doi     = {10.1212/01.wnl.0000129275.13169.be},
  pmid    = {15184603},
  url     = {https://doi.org/10.1212/01.wnl.0000129275.13169.be}
}

@article{bush2004-15000668,
  author  = {Bush, A. and Beail, N.},
  title   = {{Risk factors for dementia in people with down syndrome: issues in assessment and diagnosis}},
  journal = {American journal of mental retardation : AJMR},
  year    = {2004},
  doi     = {10.1352/0895-8017(2004)109<83:rffdip>2.0.co;2},
  pmid    = {15000668},
  url     = {https://doi.org/10.1352/0895-8017(2004)109<83:rffdip>2.0.co;2}
}

@article{zitnanova2004-14967170,
  author  = {Zitnanová, I. and Korytár, P. and Aruoma, O. I. and Sustrová, M. and Garaiová, I. and Muchová, J. and Kalnovicová, T. and others},
  title   = {{Uric acid and allantoin levels in Down syndrome: antioxidant and oxidative stress mechanisms?}},
  journal = {Clinica chimica acta; international journal of clinical chemistry},
  year    = {2004},
  doi     = {10.1016/j.cccn.2003.11.020},
  pmid    = {14967170},
  url     = {https://doi.org/10.1016/j.cccn.2003.11.020}
}

@article{kadota2004-15501590,
  author  = {Kadota, M. and Nishigaki, R. and Wang, C. C. and Toda, T. and Shirayoshi, Y. and Inoue, T. and Gojobori, T. and Ikeo, K. and others},
  title   = {{Proteomic signatures and aberrations of mouse embryonic stem cells containing a single human chromosome 21 in neuronal differentiation: an in vitro model of Down syndrome}},
  journal = {Neuroscience},
  year    = {2004},
  doi     = {10.1016/j.neuroscience.2004.06.081},
  pmid    = {15501590},
  url     = {https://doi.org/10.1016/j.neuroscience.2004.06.081}
}

@article{head2003-14533781,
  author  = {Head, E. and Lott, I. T. and Hof, P. R. and Bouras, C. and Su, J. H. and Kim, R. and Haier, R. and Cotman, C. W.},
  title   = {{Parallel compensatory and pathological events associated with tau pathology in middle aged individuals with Down syndrome}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {2003},
  doi     = {10.1093/jnen/62.9.917},
  pmid    = {14533781},
  url     = {https://doi.org/10.1093/jnen/62.9.917}
}

@article{deutsch2003-14520169,
  author  = {Deutsch, S. I. and Rosse, R. B. and Mastropaolo, J. and Chilton, M.},
  title   = {{Progressive worsening of adaptive functions in Down syndrome may be mediated by the complexing of soluble Abeta peptides with the alpha 7 nicotinic acetylcholine receptor: therapeutic implications}},
  journal = {Clinical neuropharmacology},
  year    = {2003},
  doi     = {10.1097/00002826-200309000-00013},
  pmid    = {14520169},
  url     = {https://doi.org/10.1097/00002826-200309000-00013}
}

@article{percy2003-12833399,
  author  = {Percy, M. E. and Potyomkina, Z. and Dalton, A. J. and Fedor, B. and Mehta, P. and Andrews, D. F. and Mazzulli, T. and Murk, L. and others},
  title   = {{Relation between apolipoprotein E genotype, hepatitis B virus status, and thyroid status in a sample of older persons with Down syndrome}},
  journal = {American journal of medical genetics. Part A},
  year    = {2003},
  doi     = {10.1002/ajmg.a.20099},
  pmid    = {12833399},
  url     = {https://doi.org/10.1002/ajmg.a.20099}
}

@article{delbo2003-12796830,
  author  = {Del Bo, R. and Comi, G. P. and Giorda, R. and Crimi, M. and Locatelli, F. and Martinelli-Boneschi, F. and Pozzoli, U. and Castelli, E. and others},
  title   = {{The 129 codon polymorphism of the prion protein gene influences earlier cognitive performance in Down syndrome subjects}},
  journal = {Journal of neurology},
  year    = {2003},
  doi     = {10.1007/s00415-003-1057-5},
  pmid    = {12796830},
  url     = {https://doi.org/10.1007/s00415-003-1057-5}
}

@article{mehta2003-12757888,
  author  = {Mehta, P. D. and Mehta, S. P. and Fedor, B. and Patrick, B. A. and Emmerling, M. and Dalton, A. J.},
  title   = {{Plasma amyloid beta protein 1-42 levels are increased in old Down Syndrome but not in young Down Syndrome}},
  journal = {Neuroscience letters},
  year    = {2003},
  doi     = {10.1016/s0304-3940(03)00275-1},
  pmid    = {12757888},
  url     = {https://doi.org/10.1016/s0304-3940(03)00275-1}
}

@article{hirayama2003-12689696,
  author  = {Hirayama, A. and Horikoshi, Y. and Maeda, M. and Ito, M. and Takashima, S.},
  title   = {{Characteristic developmental expression of amyloid beta40, 42 and 43 in patients with Down syndrome}},
  journal = {Brain \& development},
  year    = {2003},
  doi     = {10.1016/s0387-7604(02)00209-7},
  pmid    = {12689696},
  url     = {https://doi.org/10.1016/s0387-7604(02)00209-7}
}

@article{hill2003-12639204,
  author  = {Hill, D. A. and Gridley, G. and Cnattingius, S. and Mellemkjaer, L. and Linet, M. and Adami, H. O. and Olsen, J. H. and Nyren, O. and others},
  title   = {{Mortality and cancer incidence among individuals with Down syndrome}},
  journal = {Archives of internal medicine},
  year    = {2003},
  doi     = {10.1001/archinte.163.6.705},
  pmid    = {12639204},
  url     = {https://doi.org/10.1001/archinte.163.6.705}
}

@article{bernstein2003-14707550,
  author  = {Bernstein, H. G. and Bukowska, A. and Krell, D. and Bogerts, B. and Ansorge, S. and Lendeckel, U.},
  title   = {{Comparative localization of ADAMs 10 and 15 in human cerebral cortex normal aging, Alzheimer disease and Down syndrome}},
  journal = {Journal of neurocytology},
  year    = {2003},
  doi     = {10.1023/b:neur.0000005600.61844.a6},
  pmid    = {14707550},
  url     = {https://doi.org/10.1023/b:neur.0000005600.61844.a6}
}

@article{shim2003-15068244,
  author  = {Shim, K. S. and Bergelson, J. M. and Furuse, M. and Ovod, V. and Krude, T. and Lubec, G.},
  title   = {{Reduction of chromatin assembly factor 1 p60 and C21orf2 protein, encoded on chromosome 21, in Down syndrome brain}},
  journal = {Journal of neural transmission. Supplementum},
  year    = {2003},
  doi     = {10.1007/978-3-7091-6721-2_10},
  pmid    = {15068244},
  url     = {https://doi.org/10.1007/978-3-7091-6721-2_10}
}

@article{frederikse2002-12466113,
  author  = {Frederikse, P. H. and Ren, X. O.},
  title   = {{Lens defects and age-related fiber cell degeneration in a mouse model of increased AbetaPP gene dosage in Down syndrome}},
  journal = {The American journal of pathology},
  year    = {2002},
  doi     = {10.1016/s0002-9440(10)64475-6},
  pmid    = {12466113},
  url     = {https://doi.org/10.1016/s0002-9440(10)64475-6}
}

@article{mccarron2002-12427167,
  author  = {McCarron, M. and Gill, M. and Lawlor, B. and Beagly, C.},
  title   = {{A pilot study of the reliability and validity of the Caregiver Activity Survey - Intellectual Disability (CAS-ID)}},
  journal = {Journal of intellectual disability research : JIDR},
  year    = {2002},
  doi     = {10.1046/j.1365-2788.2002.00437.x},
  pmid    = {12427167},
  url     = {https://doi.org/10.1046/j.1365-2788.2002.00437.x}
}

@article{bognar2002-12459318,
  author  = {Bognar, S. K. and Furac, I. and Kubat, M. and Cosović, C. and Demarin, V.},
  title   = {{Croatian population data for arylsulfatase a pseudodeficiency-associated mutations in healthy subjects, and in patients with Alzheimer-type dementia and Down syndrome}},
  journal = {Archives of medical research},
  year    = {2002},
  doi     = {10.1016/s0188-4409(02)00392-2},
  pmid    = {12459318},
  url     = {https://doi.org/10.1016/s0188-4409(02)00392-2}
}

@article{lott2002-12117361,
  author  = {Lott, I. T. and Osann, K. and Doran, E. and Nelson, L.},
  title   = {{Down syndrome and Alzheimer disease: response to donepezil}},
  journal = {Archives of neurology},
  year    = {2002},
  doi     = {10.1001/archneur.59.7.1133},
  pmid    = {12117361},
  url     = {https://doi.org/10.1001/archneur.59.7.1133}
}

@article{kim2002-12109594,
  author  = {Kim, S. H. and Shim, K. S. and Lubec, G.},
  title   = {{Human brain nascent polypeptide-associated complex alpha subunit is decreased in patients with Alzheimer' s disease and Down syndrome}},
  journal = {Journal of investigative medicine : the official publication of the American Federation for Clinical Research},
  year    = {2002},
  doi     = {10.2310/6650.2002.33287},
  pmid    = {12109594},
  url     = {https://doi.org/10.2310/6650.2002.33287}
}

@article{motonaga2002-12052539,
  author  = {Motonaga, K. and Itoh, M. and Becker, L. E. and Goto, Y. and Takashima, S.},
  title   = {{Elevated expression of beta-site amyloid precursor protein cleaving enzyme 2 in brains of patients with Down syndrome}},
  journal = {Neuroscience letters},
  year    = {2002},
  doi     = {10.1016/s0304-3940(02)00287-2},
  pmid    = {12052539},
  url     = {https://doi.org/10.1016/s0304-3940(02)00287-2}
}

@article{atack2002-11959401,
  author  = {Atack, JR. and Schapiro, M. B.},
  title   = {{Inositol monophosphatase activity in normal, Down syndrome and dementia of the Alzheimer type CSF}},
  journal = {Neurobiology of aging},
  year    = {2002},
  doi     = {10.1016/s0197-4580(01)00335-9},
  pmid    = {11959401},
  url     = {https://doi.org/10.1016/s0197-4580(01)00335-9}
}

@article{anderson2002-11895037,
  author  = {Anderson, S. J. and Barker, P. E. and Hadfield, M. G.},
  title   = {{Cytonectin expression in Alzheimer disease}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {2002},
  doi     = {10.1093/jnen/61.3.230},
  pmid    = {11895037},
  url     = {https://doi.org/10.1093/jnen/61.3.230}
}

@article{yang2002-11937181,
  author  = {Yang, Q. and Rasmussen, S. A. and Friedman, J. M.},
  title   = {{Mortality associated with Down's syndrome in the USA from 1983 to 1997: a population-based study}},
  journal = {Lancet (London, England)},
  year    = {2002},
  doi     = {10.1016/s0140-6736(02)08092-3},
  pmid    = {11937181},
  url     = {https://doi.org/10.1016/s0140-6736(02)08092-3}
}

@article{engidawork2001-11858695,
  author  = {Engidawork, E. and Lubec, G.},
  title   = {{Protein expression in Down syndrome brain}},
  journal = {Amino acids},
  year    = {2001},
  doi     = {10.1007/s007260170001},
  pmid    = {11858695},
  url     = {https://doi.org/10.1007/s007260170001}
}

@article{wegiel2002-11904752,
  author  = {Wegiel, J. and Kuchna, I. and Wisniewski, T. and de Leon, M. J. and Reisberg, B. and Pirttila, T. and Kivimaki, T. and Lehtimaki, T.},
  title   = {{Vascular fibrosis and calcification in the hippocampus in aging, Alzheimer disease, and Down syndrome}},
  journal = {Acta neuropathologica},
  year    = {2002},
  doi     = {10.1007/s00401-001-0471-y},
  pmid    = {11904752},
  url     = {https://doi.org/10.1007/s00401-001-0471-y}
}

@article{nizetic2001-11471193,
  author  = {Nizetić, D.},
  title   = {{Functional genomics of the Down syndrome}},
  journal = {Croatian medical journal},
  year    = {2001},
  pmid    = {11471193}
}

@article{anello2001-11403974,
  author  = {Anello, G. and Guéant, J. and Romano, C. and Barone, C. and Pettinato, R. and Pillot, T. and Rodriguez, R. and Romano, A. and others},
  title   = {{Allele varepsilon4 of apolipoprotein E gene is less frequent in Down syndrome patient of the Sicilian population and has no influence on the grade of mental retardation}},
  journal = {Neuroscience letters},
  year    = {2001},
  doi     = {10.1016/s0304-3940(01)01851-1},
  pmid    = {11403974},
  url     = {https://doi.org/10.1016/s0304-3940(01)01851-1}
}

@article{seidl2001-11417611,
  author  = {Seidl, R. and Bidmon, B. and Bajo, M. and Yoo, P. C. and Cairns, N. and LaCasse, E. C. and Lubec, G.},
  title   = {{Evidence for apoptosis in the fetal Down syndrome brain}},
  journal = {Journal of child neurology},
  year    = {2001},
  doi     = {10.1177/088307380101600610},
  pmid    = {11417611},
  url     = {https://doi.org/10.1177/088307380101600610}
}

@article{pinter2001-11294940,
  author  = {Pinter, J. D. and Brown, W. E. and Eliez, S. and Schmitt, J. E. and Capone, G. T. and Reiss, A. L.},
  title   = {{Amygdala and hippocampal volumes in children with Down syndrome: a high-resolution MRI study}},
  journal = {Neurology},
  year    = {2001},
  doi     = {10.1212/wnl.56.7.972},
  pmid    = {11294940},
  url     = {https://doi.org/10.1212/wnl.56.7.972}
}

@article{gyure2001-11260621,
  author  = {Gyure, K. A. and Durham, R. and Stewart, W. F. and Smialek, J. E. and Troncoso, J. C.},
  title   = {{Intraneuronal abeta-amyloid precedes development of amyloid plaques in Down syndrome}},
  journal = {Archives of pathology \& laboratory medicine},
  year    = {2001},
  doi     = {10.5858/2001-125-0489-iaapdo},
  pmid    = {11260621},
  url     = {https://doi.org/10.5858/2001-125-0489-iaapdo}
}

@article{temple2001-11168776,
  author  = {Temple, V. and Jozsvai, E. and Konstantareas, M. M. and Hewitt, T. A.},
  title   = {{Alzheimer dementia in Down's syndrome: the relevance of cognitive ability}},
  journal = {Journal of intellectual disability research : JIDR},
  year    = {2001},
  doi     = {10.1046/j.1365-2788.2001.00299.x},
  pmid    = {11168776},
  url     = {https://doi.org/10.1046/j.1365-2788.2001.00299.x}
}

@article{ghiso2001-12214074,
  author  = {Ghiso, J. and Frangione, B.},
  title   = {{Cerebral amyloidosis, amyloid angiopathy, and their relationship to stroke and dementia}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2001},
  doi     = {10.3233/jad-2001-3110},
  pmid    = {12214074},
  url     = {https://doi.org/10.3233/jad-2001-3110}
}

@article{seidl2001-11218066,
  author  = {Seidl, R. and Cairns, N. and Singewald, N. and Kaehler, S. T. and Lubec, G.},
  title   = {{Differences between GABA levels in Alzheimer's disease and Down syndrome with Alzheimer-like neuropathology}},
  journal = {Naunyn-Schmiedeberg's archives of pharmacology},
  year    = {2001},
  doi     = {10.1007/s002100000346},
  pmid    = {11218066},
  url     = {https://doi.org/10.1007/s002100000346}
}

@article{kitzmueller2001-11771744,
  author  = {Kitzmueller, E. and Greber, S. and Fountoulakis, M. and Lubec, G.},
  title   = {{Carbohydrate handling enzymes in fetal Down syndrome brain}},
  journal = {Journal of neural transmission. Supplementum},
  year    = {2001},
  doi     = {10.1007/978-3-7091-6262-0_16},
  pmid    = {11771744},
  url     = {https://doi.org/10.1007/978-3-7091-6262-0_16}
}

@article{roizen2001-11241881,
  author  = {Roizen, N. J.},
  title   = {{Down syndrome: progress in research}},
  journal = {Mental retardation and developmental disabilities research reviews},
  year    = {2001},
  doi     = {10.1002/1098-2779(200102)7:1<38::aid-mrdd1006>3.0.co;2-c},
  pmid    = {11241881},
  url     = {https://doi.org/10.1002/1098-2779(200102)7:1<38::aid-mrdd1006>3.0.co;2-c}
}

@article{nelson2001-11771763,
  author  = {Nelson, P. G. and McCune, S. K. and Ades, A. M. and Nelson, K. B.},
  title   = {{Glial-neurotrophic mechanisms in Down syndrome}},
  journal = {Journal of neural transmission. Supplementum},
  year    = {2001},
  doi     = {10.1007/978-3-7091-6262-0_7},
  pmid    = {11771763},
  url     = {https://doi.org/10.1007/978-3-7091-6262-0_7}
}

@article{gulesserian2001-11217146,
  author  = {Gulesserian, T. and Seidl, R. and Hardmeier, R. and Cairns, N. and Lubec, G.},
  title   = {{Superoxide dismutase SOD1, encoded on chromosome 21, but not SOD2 is overexpressed in brains of patients with Down syndrome}},
  journal = {Journal of investigative medicine : the official publication of the American Federation for Clinical Research},
  year    = {2001},
  doi     = {10.2310/6650.2001.34089},
  pmid    = {11217146},
  url     = {https://doi.org/10.2310/6650.2001.34089}
}

@article{seidl2001-11771748,
  author  = {Seidl, R. and Cairns, N. and Lubec, G.},
  title   = {{The brain in Down syndrome}},
  journal = {Journal of neural transmission. Supplementum},
  year    = {2001},
  doi     = {10.1007/978-3-7091-6262-0_20},
  pmid    = {11771748},
  url     = {https://doi.org/10.1007/978-3-7091-6262-0_20}
}

@article{engidawork2001-11771740,
  author  = {Engidawork, E. and Balic, N. and Juranville, J. F. and Fountoulakis, M. and Dierssen, M. and Lubec, G.},
  title   = {{Unaltered expression of Fas (CD95/APO-1), caspase-3, Bcl-2 and annexins in brains of fetal Down syndrome: evidence against increased apoptosis}},
  journal = {Journal of neural transmission. Supplementum},
  year    = {2001},
  doi     = {10.1007/978-3-7091-6262-0_12},
  pmid    = {11771740},
  url     = {https://doi.org/10.1007/978-3-7091-6262-0_12}
}

@article{devenny2000-11115020,
  author  = {Devenny, D. A. and Krinsky-McHale, S. J. and Sersen, G. and Silverman, W. P.},
  title   = {{Sequence of cognitive decline in dementia in adults with Down's syndrome}},
  journal = {Journal of intellectual disability research : JIDR},
  year    = {2000},
  doi     = {10.1046/j.1365-2788.2000.00305.x},
  pmid    = {11115020},
  url     = {https://doi.org/10.1046/j.1365-2788.2000.00305.x}
}

@article{petersen2000-10951459,
  author  = {Petersen, M. B. and Karadima, G. and Samaritaki, M. and Avramopoulos, D. and Vassilopoulos, D. and Mikkelsen, M.},
  title   = {{Association between presenilin-1 polymorphism and maternal meiosis II errors in Down syndrome}},
  journal = {American journal of medical genetics},
  year    = {2000},
  doi     = {10.1002/1096-8628(20000828)93:5<366::aid-ajmg5>3.0.co;2-g},
  pmid    = {10951459},
  url     = {https://doi.org/10.1002/1096-8628(20000828)93:5<366::aid-ajmg5>3.0.co;2-g}
}

@article{moalem2000-10861683,
  author  = {Moalem, S. and Percy, M. E. and Andrews, D. F. and Kruck, T. P. and Wong, S. and Dalton, A. J. and Mehta, P. and Fedor, B. and others},
  title   = {{Are hereditary hemochromatosis mutations involved in Alzheimer disease?}},
  journal = {American journal of medical genetics},
  year    = {2000},
  doi     = {10.1002/1096-8628(20000703)93:1<58::aid-ajmg10>3.0.co;2-l},
  pmid    = {10861683},
  url     = {https://doi.org/10.1002/1096-8628(20000703)93:1<58::aid-ajmg10>3.0.co;2-l}
}

@article{cataldo2000-10880397,
  author  = {Cataldo, A. M. and Peterhoff, C. M. and Troncoso, J. C. and Gomez-Isla, T. and Hyman, B. T. and Nixon, R. A.},
  title   = {{Endocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer's disease and Down syndrome: differential effects of APOE genotype and presenilin mutations}},
  journal = {The American journal of pathology},
  year    = {2000},
  doi     = {10.1016/s0002-9440(10)64538-5},
  pmid    = {10880397},
  url     = {https://doi.org/10.1016/s0002-9440(10)64538-5}
}

@article{anderson2000-10924764,
  author  = {Anderson, A. J. and Stoltzner, S. and Lai, F. and Su, J. and Nixon, R. A.},
  title   = {{Morphological and biochemical assessment of DNA damage and apoptosis in Down syndrome and Alzheimer disease, and effect of postmortem tissue archival on TUNEL}},
  journal = {Neurobiology of aging},
  year    = {2000},
  doi     = {10.1016/s0197-4580(00)00126-3},
  pmid    = {10924764},
  url     = {https://doi.org/10.1016/s0197-4580(00)00126-3}
}

@article{katada2000-10838108,
  author  = {Katada, A. and Hasegawa, S. and Ohira, D. and Kumagai, T. and Harashima, T. and Ozaki, H. and Suzuki, H.},
  title   = {{On chronological changes in the basic EEG rhythm in persons with Down syndrome - with special reference to slowing of alpha waves}},
  journal = {Brain \& development},
  year    = {2000},
  doi     = {10.1016/s0387-7604(00)00107-8},
  pmid    = {10838108},
  url     = {https://doi.org/10.1016/s0387-7604(00)00107-8}
}

@article{murphy2000-10837793,
  author  = {Murphy, E. J. and Schapiro, M. B. and Rapoport, S. I. and Shetty, H. U.},
  title   = {{Phospholipid composition and levels are altered in Down syndrome brain}},
  journal = {Brain research},
  year    = {2000},
  doi     = {10.1016/s0006-8993(00)02205-8},
  pmid    = {10837793},
  url     = {https://doi.org/10.1016/s0006-8993(00)02205-8}
}

@article{kline2000-10757522,
  author  = {Kline, J. and Kinney, A. and Levin, B. and Mayeux, R. and Schupf, N. and Warburton, D.},
  title   = {{Alzheimer's disease in the parents of women with trisomic spontaneous abortions}},
  journal = {Neuroreport},
  year    = {2000},
  doi     = {10.1097/00001756-200003200-00028},
  pmid    = {10757522},
  url     = {https://doi.org/10.1097/00001756-200003200-00028}
}

@article{solans2000-10965118,
  author  = {Solans, A. and Estivill, X. and de La Luna, S.},
  title   = {{A new aspartyl protease on 21q22.3, BACE2, is highly similar to Alzheimer's amyloid precursor protein beta-secretase}},
  journal = {Cytogenetics and cell genetics},
  year    = {2000},
  doi     = {10.1159/000015608},
  pmid    = {10965118},
  url     = {https://doi.org/10.1159/000015608}
}

@article{chapman2000-10899801,
  author  = {Chapman, R. S. and Hesketh, L. J.},
  title   = {{Behavioral phenotype of individuals with Down syndrome}},
  journal = {Mental retardation and developmental disabilities research reviews},
  year    = {2000},
  doi     = {10.1002/1098-2779(2000)6:2<84::aid-mrdd2>3.0.co;2-p},
  pmid    = {10899801},
  url     = {https://doi.org/10.1002/1098-2779(2000)6:2<84::aid-mrdd2>3.0.co;2-p}
}

@article{tyrrell1999-10581479,
  author  = {Tyrrell, J. and Cosgrave, M. and McPherson, J. and Hawi, Z. and Trulock, V. and Calvert, J. and Lawlor, B. and Gill, M.},
  title   = {{Presenilin 1 and alpha-1-antichymotrypsin polymorphisms in Down syndrome: no effect on the presence of dementia}},
  journal = {American journal of medical genetics},
  year    = {1999},
  doi     = {10.1002/(sici)1096-8628(19991215)88:6<616::aid-ajmg8>3.0.co;2-i},
  pmid    = {10581479},
  url     = {https://doi.org/10.1002/(sici)1096-8628(19991215)88:6<616::aid-ajmg8>3.0.co;2-i}
}

@article{mehta1999-10580699,
  author  = {Mehta, P. D. and Patrick, B. A. and Dalton, A. J. and Aisen, P. S. and Emmerling, M. E. and Sersen, E. A. and Wisniewski, H. M.},
  title   = {{Increased levels of tau-like protein in patients with Down syndrome}},
  journal = {Neuroscience letters},
  year    = {1999},
  doi     = {10.1016/s0304-3940(99)00754-5},
  pmid    = {10580699},
  url     = {https://doi.org/10.1016/s0304-3940(99)00754-5}
}

@article{angelopoulou1999-10576235,
  author  = {Angelopoulou, N. and Souftas, V. and Sakadamis, A. and Matziari, C. and Papameletiou, V. and Mandroukas, K.},
  title   = {{Gonadal function in young women with Down syndrome}},
  journal = {International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics},
  year    = {1999},
  doi     = {10.1016/s0020-7292(99)00123-x},
  pmid    = {10576235},
  url     = {https://doi.org/10.1016/s0020-7292(99)00123-x}
}

@article{frost1999-10505434,
  author  = {Frost, M. and Huffer, W. E. and Sze, C. I. and Badesch, D. and Cajade-Law, A. G. and Kleinschmidt-DeMasters, B. K.},
  title   = {{Cervical spine abnormalities in Down Syndrome}},
  journal = {Clinical neuropathology},
  year    = {1999},
  pmid    = {10505434}
}

@article{lai1999-10430422,
  author  = {Lai, F. and Kammann, E. and Rebeck, G. W. and Anderson, A. and Chen, Y. and Nixon, R. A.},
  title   = {{APOE genotype and gender effects on Alzheimer disease in 100 adults with Down syndrome}},
  journal = {Neurology},
  year    = {1999},
  doi     = {10.1212/wnl.53.2.331},
  pmid    = {10430422},
  url     = {https://doi.org/10.1212/wnl.53.2.331}
}

@article{vanallen1999-10559765,
  author  = {van Allen, M. I. and Fung, J. and Jurenka, S. B.},
  title   = {{Health care concerns and guidelines for adults with Down syndrome}},
  journal = {American journal of medical genetics},
  year    = {1999},
  doi     = {10.1002/(sici)1096-8628(19990625)89:2<100::aid-ajmg8>3.0.co;2-n},
  pmid    = {10559765},
  url     = {https://doi.org/10.1002/(sici)1096-8628(19990625)89:2<100::aid-ajmg8>3.0.co;2-n}
}

@article{wegiel1999-10588573,
  author  = {Weģiel, J. and Wísniewski, H. M. and Moryś, J. and Tarnawski, M. and Kuchna, I. and Dziewiatkowski, J. and Pirttilä, T. and Krivimäki, T. and others},
  title   = {{Neuronal loss and beta-amyloid removal in the amygdala of people with Down syndrome}},
  journal = {Neurobiology of aging},
  year    = {1999},
  doi     = {10.1016/s0197-4580(99)00060-3},
  pmid    = {10588573},
  url     = {https://doi.org/10.1016/s0197-4580(99)00060-3}
}

@article{seidl1999-10027687,
  author  = {Seidl, R. and Fang-Kircher, S. and Bidmon, B. and Cairns, N. and Lubec, G.},
  title   = {{Apoptosis-associated proteins p53 and APO-1/Fas (CD95) in brains of adult patients with Down syndrome}},
  journal = {Neuroscience letters},
  year    = {1999},
  doi     = {10.1016/s0304-3940(98)00945-8},
  pmid    = {10027687},
  url     = {https://doi.org/10.1016/s0304-3940(98)00945-8}
}

@article{trumble1999-9988915,
  author  = {Trumble, S.},
  title   = {{Dementia in Down syndrome. Untangling the threads}},
  journal = {Australian family physician},
  year    = {1999},
  pmid    = {9988915}
}

@article{delamonte1999-10666665,
  author  = {de la Monte, S. M.},
  title   = {{Molecular abnormalities of the brain in Down syndrome: relevance to Alzheimer's neurodegeneration}},
  journal = {Journal of neural transmission. Supplementum},
  year    = {1999},
  doi     = {10.1007/978-3-7091-6380-1_1},
  pmid    = {10666665},
  url     = {https://doi.org/10.1007/978-3-7091-6380-1_1}
}

@article{vanleeuwen1999-10666673,
  author  = {van Leeuwen, F. W. and Hol, E. M.},
  title   = {{Molecular misreading of genes in Down syndrome as a model for the Alzheimer type of neurodegeneration}},
  journal = {Journal of neural transmission. Supplementum},
  year    = {1999},
  doi     = {10.1007/978-3-7091-6380-1_9},
  pmid    = {10666673},
  url     = {https://doi.org/10.1007/978-3-7091-6380-1_9}
}

@article{seidl1999-10666683,
  author  = {Seidl, R. and Bajo, M. and Böhm, K. and LaCasse, E. C. and MacKenzie, A. E. and Cairns, N. and Lubec, G.},
  title   = {{Neuronal apoptosis inhibitory protein (NAIP)-like immunoreactivity in brains of adult patients with Down syndrome}},
  journal = {Journal of neural transmission. Supplementum},
  year    = {1999},
  doi     = {10.1007/978-3-7091-6380-1_19},
  pmid    = {10666683},
  url     = {https://doi.org/10.1007/978-3-7091-6380-1_19}
}

@article{seidl1999-10666678,
  author  = {Seidl, R. and Kaehler, S. T. and Prast, H. and Singewald, N. and Cairns, N. and Gratzer, M. and Lubec, G.},
  title   = {{Serotonin (5-HT) in brains of adult patients with Down syndrome}},
  journal = {Journal of neural transmission. Supplementum},
  year    = {1999},
  doi     = {10.1007/978-3-7091-6380-1_14},
  pmid    = {10666678},
  url     = {https://doi.org/10.1007/978-3-7091-6380-1_14}
}

@article{labudova1999-10210286,
  author  = {Labudova, O. and Cairns, N. and Koeck, T. and Kitzmueller, E. and Rink, H. and Lubec, G.},
  title   = {{Thyroid stimulating hormone-receptor overexpression in brain of patients with Down syndrome and Alzheimer's disease}},
  journal = {Life sciences},
  year    = {1999},
  doi     = {10.1016/s0024-3205(99)00030-2},
  pmid    = {10210286},
  url     = {https://doi.org/10.1016/s0024-3205(99)00030-2}
}

@article{jovanovic1998-9870557,
  author  = {Jovanovic, S. V. and Clements, D. and MacLeod, K.},
  title   = {{Biomarkers of oxidative stress are significantly elevated in Down syndrome}},
  journal = {Free radical biology \& medicine},
  year    = {1998},
  doi     = {10.1016/s0891-5849(98)00137-3},
  pmid    = {9870557},
  url     = {https://doi.org/10.1016/s0891-5849(98)00137-3}
}

@article{stahl1998-10198823,
  author  = {Stahl, T. and Goldammer, A. and Luschekina, E. and Beck, M. and Schliebs, R. and Bigl, V.},
  title   = {{Long-term basal forebrain cholinergic-rich grafts derived from trisomy 16 mice do not develop beta-amyloid pathology and neurodegeneration but demonstrate neuroinflammatory responses}},
  journal = {International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience},
  year    = {1998},
  doi     = {10.1016/s0736-5748(98)00085-9},
  pmid    = {10198823},
  url     = {https://doi.org/10.1016/s0736-5748(98)00085-9}
}

@article{hosoda1998-9825946,
  author  = {Hosoda, R. and Saido, T. C. and Otvos, L. and Arai, T. and Mann, D. M. and Lee, V. M. and Trojanowski, J. Q. and Iwatsubo, T.},
  title   = {{Quantification of modified amyloid beta peptides in Alzheimer disease and Down syndrome brains}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {1998},
  doi     = {10.1097/00005072-199811000-00012},
  pmid    = {9825946},
  url     = {https://doi.org/10.1097/00005072-199811000-00012}
}

@article{wegiel1998-9737546,
  author  = {Wegiel, J. and Wisniewski, H. M. and Kuchna, I. and Tarnawski, M. and Badmajew, E. and Popovitch, E. and Kulczycki, J. and Dowjat, W. K. and others},
  title   = {{Cell-type-specific enhancement of amyloid-beta deposition in a novel presenilin-1 mutation (P117L)}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {1998},
  doi     = {10.1097/00005072-199809000-00004},
  pmid    = {9737546},
  url     = {https://doi.org/10.1097/00005072-199809000-00004}
}

@article{insausti1998-9792239,
  author  = {Insausti, A. M. and Megías, M. and Crespo, D. and Cruz-Orive, L. M. and Dierssen, M. and Vallina, I. F. and Insausti, R. and Flórez, J.},
  title   = {{Hippocampal volume and neuronal number in Ts65Dn mice: a murine model of Down syndrome}},
  journal = {Neuroscience letters},
  year    = {1998},
  doi     = {10.1016/s0304-3940(98)00641-7},
  pmid    = {9792239},
  url     = {https://doi.org/10.1016/s0304-3940(98)00641-7}
}

@article{griffin1998-9880042,
  author  = {Griffin, W. S. and Sheng, J. G. and McKenzie, J. E. and Royston, M. C. and Gentleman, S. M. and Brumback, R. A. and Cork, L. C. and Del Bigio, M. R. and others},
  title   = {{Life-long overexpression of S100beta in Down's syndrome: implications for Alzheimer pathogenesis}},
  journal = {Neurobiology of aging},
  year    = {1998},
  doi     = {10.1016/s0197-4580(98)00074-8},
  pmid    = {9880042},
  url     = {https://doi.org/10.1016/s0197-4580(98)00074-8}
}

@article{pawlak1998-11542339,
  author  = {Pawlak, W. and Kedziora, J. and Zolynski, K. and Kedziora-Kornatowska, K. and Blaszczyk, J. and Witkowski, P. and Zieleniewski, J.},
  title   = {{Effect of long term bed rest in men on enzymatic antioxidative defence and lipid peroxidation in erythrocytes}},
  journal = {Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology},
  year    = {1998},
  pmid    = {11542339}
}

@article{ezquerra1998-9665649,
  author  = {Ezquerra, M. and Ballesta, F. and Queralt, R. and Aledo, R. and Gómez, D. and Guitart, M. and Egozcue, J. and Ascaso, C. and others},
  title   = {{Apolipoprotein E epsilon 4 alleles and meiotic origin of non-disjunction in Down syndrome children and in their corresponding fathers and mothers}},
  journal = {Neuroscience letters},
  year    = {1998},
  doi     = {10.1016/s0304-3940(98)00251-1},
  pmid    = {9665649},
  url     = {https://doi.org/10.1016/s0304-3940(98)00251-1}
}

@article{korol1998-9537626,
  author  = {Korol, D. L. and Gold, P. E.},
  title   = {{Glucose, memory, and aging}},
  journal = {The American journal of clinical nutrition},
  year    = {1998},
  doi     = {10.1093/ajcn/67.4.764s},
  pmid    = {9537626},
  url     = {https://doi.org/10.1093/ajcn/67.4.764s}
}

@article{prasher1998-9506555,
  author  = {Prasher, V. P. and Farrer, M. J. and Kessling, A. M. and Fisher, E. M. and West, R. J. and Barber, P. C. and Butler, A. C.},
  title   = {{Molecular mapping of Alzheimer-type dementia in Down's syndrome}},
  journal = {Annals of neurology},
  year    = {1998},
  doi     = {10.1002/ana.410430316},
  pmid    = {9506555},
  url     = {https://doi.org/10.1002/ana.410430316}
}

@article{hon1998-9547957,
  author  = {Hon, J. and Huppert, F. A. and Holland, A. J. and Watson, P.},
  title   = {{The value of the Rivermead Behavioural Memory Test (Children's Version) in an epidemiological study of older adults with Down syndrome}},
  journal = {The British journal of clinical psychology},
  year    = {1998},
  doi     = {10.1111/j.2044-8260.1998.tb01276.x},
  pmid    = {9547957},
  url     = {https://doi.org/10.1111/j.2044-8260.1998.tb01276.x}
}

@article{schwab1998-9562502,
  author  = {Schwab, C. and McGeer, P. L.},
  title   = {{Tubulin immunopositive structures resembling intracellular neurofibrillary tangles}},
  journal = {Neurobiology of aging},
  year    = {1998},
  doi     = {10.1016/s0197-4580(97)00165-6},
  pmid    = {9562502},
  url     = {https://doi.org/10.1016/s0197-4580(97)00165-6}
}

@article{nelson1997-9356503,
  author  = {Nelson, P. G. and Fitzgerald, S. and Rapoport, S. I. and Neale, E. A. and Galdzicki, Z. and Dunlap, V. and Bowers, L. and v Agoston, D.},
  title   = {{Cerebral cortical astroglia from the trisomy 16 mouse, a model for down syndrome, produce neuronal cholinergic deficits in cell culture}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1997},
  doi     = {10.1073/pnas.94.23.12644},
  pmid    = {9356503},
  url     = {https://doi.org/10.1073/pnas.94.23.12644}
}

@article{seidl1997-9406888,
  author  = {Seidl, R. and Greber, S. and Schuller, E. and Bernert, G. and Cairns, N. and Lubec, G.},
  title   = {{Evidence against increased oxidative DNA-damage in Down syndrome}},
  journal = {Neuroscience letters},
  year    = {1997},
  doi     = {10.1016/s0304-3940(97)00748-9},
  pmid    = {9406888},
  url     = {https://doi.org/10.1016/s0304-3940(97)00748-9}
}

@article{rascontrincado1997-9424665,
  author  = {Rascón Trincado, M. V. and González Sarmiento, R. and Salazar A-Villalobos, V.},
  title   = {{[The apolipoprotein E genotype and Down's syndrome]}},
  journal = {Revista clinica espanola},
  year    = {1997},
  pmid    = {9424665}
}

@article{arai1997-9367293,
  author  = {Arai, Y. and Uchida, Y. and Takashima, S.},
  title   = {{Developmental immunohistochemistry of growth inhibitory factor in normal brains and brains of patients with Down syndrome}},
  journal = {Pediatric neurology},
  year    = {1997},
  doi     = {10.1016/s0887-8994(97)00085-4},
  pmid    = {9367293},
  url     = {https://doi.org/10.1016/s0887-8994(97)00085-4}
}

@article{rocco1997-9194955,
  author  = {Rocco, F. J. and Cronin-Golomb, A. and Lai, F.},
  title   = {{Alzheimer-like visual deficits in Down syndrome}},
  journal = {Alzheimer disease and associated disorders},
  year    = {1997},
  doi     = {10.1097/00002093-199706000-00005},
  pmid    = {9194955},
  url     = {https://doi.org/10.1097/00002093-199706000-00005}
}

@article{farrer1997-9189907,
  author  = {Farrer, M. J. and Crayton, L. and Davies, G. E. and Oliver, C. and Powell, J. and Holland, A. J. and Kessling, A. M.},
  title   = {{Allelic variability in D21S11, but not in APP or APOE, is associated with cognitive decline in Down syndrome}},
  journal = {Neuroreport},
  year    = {1997},
  doi     = {10.1097/00001756-199705060-00018},
  pmid    = {9189907},
  url     = {https://doi.org/10.1097/00001756-199705060-00018}
}

@article{kim1997-9200512,
  author  = {Kim, K. S. and Wegiel, J. and Sapienza, V. and Chen, J. and Hong, H. and Wisniewski, H. M.},
  title   = {{Immunoreactivity of presenilin-1 in human, rat and mouse brain}},
  journal = {Brain research},
  year    = {1997},
  doi     = {10.1016/s0006-8993(97)00243-6},
  pmid    = {9200512},
  url     = {https://doi.org/10.1016/s0006-8993(97)00243-6}
}

@article{takashima1997-9146996,
  author  = {Takashima, S.},
  title   = {{Down syndrome}},
  journal = {Current opinion in neurology},
  year    = {1997},
  doi     = {10.1097/00019052-199704000-00013},
  pmid    = {9146996},
  url     = {https://doi.org/10.1097/00019052-199704000-00013}
}

@article{schneider1997-9148245,
  author  = {Schneider, C. and Risser, D. and Kirchner, L. and Kitzmüller, E. and Cairns, N. and Prast, H. and Singewald, N. and Lubec, G.},
  title   = {{Similar deficits of central histaminergic system in patients with Down syndrome and Alzheimer disease}},
  journal = {Neuroscience letters},
  year    = {1997},
  doi     = {10.1016/s0304-3940(97)13379-1},
  pmid    = {9148245},
  url     = {https://doi.org/10.1016/s0304-3940(97)13379-1}
}

@article{delamonte1997-9138425,
  author  = {de la Monte, S. M. and Bloch, K. D.},
  title   = {{Aberrant expression of the constitutive endothelial nitric oxide synthase gene in Alzheimer disease}},
  journal = {Molecular and chemical neuropathology},
  year    = {1997},
  doi     = {10.1007/bf02815155},
  pmid    = {9138425},
  url     = {https://doi.org/10.1007/bf02815155}
}

@article{jenkins1997-9028448,
  author  = {Jenkins, E. C. and Schupf, N. and Genovese, M. and Ye, L. L. and Kapell, D. and Canto, B. and Harris, M. and Devenny, D. and others},
  title   = {{Increased low-level chromosome 21 mosaicism in older individuals with Down syndrome}},
  journal = {American journal of medical genetics},
  year    = {1997},
  doi     = {10.1002/(sici)1096-8628(19970120)68:2<147::aid-ajmg5>3.0.co;2-m},
  pmid    = {9028448},
  url     = {https://doi.org/10.1002/(sici)1096-8628(19970120)68:2<147::aid-ajmg5>3.0.co;2-m}
}

@article{visser1997-9017086,
  author  = {Visser, F. E. and Aldenkamp, A. P. and van Huffelen, A. C. and Kuilman, M. and Overweg, J. and van Wijk, J.},
  title   = {{Prospective study of the prevalence of Alzheimer-type dementia in institutionalized individuals with Down syndrome}},
  journal = {American journal of mental retardation : AJMR},
  year    = {1997},
  pmid    = {9017086}
}

@article{prasher1996-8970464,
  author  = {Prasher, V. P. and Barber, P. C. and West, R. and Glenholmes, P.},
  title   = {{The role of magnetic resonance imaging in the diagnosis of Alzheimer disease in adults with Down syndrome}},
  journal = {Archives of neurology},
  year    = {1996},
  doi     = {10.1001/archneur.1996.00550120122028},
  pmid    = {8970464},
  url     = {https://doi.org/10.1001/archneur.1996.00550120122028}
}

@article{diluca1996-8912490,
  author  = {Di Luca, M. and Pastorino, L. and Cattabeni, F. and Zanardi, R. and Scarone, S. and Racagni, G. and Smeraldi, E. and Perez, J.},
  title   = {{Abnormal pattern of platelet APP isoforms in Alzheimer disease and Down syndrome}},
  journal = {Archives of neurology},
  year    = {1996},
  doi     = {10.1001/archneur.1996.00550110114019},
  pmid    = {8912490},
  url     = {https://doi.org/10.1001/archneur.1996.00550110114019}
}

@article{dani1996-9116213,
  author  = {Dani, A. and Pietrini, P. and Furey, M. L. and McIntosh, A. R. and Grady, C. L. and Horwitz, B. and Freo, U. and Alexander, G. E. and others},
  title   = {{Brain cognition and metabolism in Down syndrome adults in association with development of dementia}},
  journal = {Neuroreport},
  year    = {1996},
  doi     = {10.1097/00001756-199611250-00026},
  pmid    = {9116213},
  url     = {https://doi.org/10.1097/00001756-199611250-00026}
}

@article{holtzman1996-8917591,
  author  = {Holtzman, D. M. and Santucci, D. and Kilbridge, J. and Chua-Couzens, J. and Fontana, D. J. and Daniels, S. E. and Johnson, R. M. and Chen, K. and others},
  title   = {{Developmental abnormalities and age-related neurodegeneration in a mouse model of Down syndrome}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1996},
  doi     = {10.1073/pnas.93.23.13333},
  pmid    = {8917591},
  url     = {https://doi.org/10.1073/pnas.93.23.13333}
}

@article{kaido1996-8870835,
  author  = {Kaido, M. and Fujimura, H. and Soga, F. and Toyooka, K. and Yoshikawa, H. and Nishimura, T. and Higashi, T. and Inui, K. and others},
  title   = {{Alzheimer-type pathology in a patient with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS)}},
  journal = {Acta neuropathologica},
  year    = {1996},
  doi     = {10.1007/s004010050524},
  pmid    = {8870835},
  url     = {https://doi.org/10.1007/s004010050524}
}

@article{bernert1996-8892394,
  author  = {Bernert, G. and Nemethova, M. and Herrera-Marschitz, M. and Cairns, N. and Lubec, G.},
  title   = {{Decreased cyclin dependent kinase in brain of patients with Down syndrome}},
  journal = {Neuroscience letters},
  year    = {1996},
  doi     = {10.1016/0304-3940(96)12988-8},
  pmid    = {8892394},
  url     = {https://doi.org/10.1016/0304-3940(96)12988-8}
}

@article{woodruffpak1996-9375181,
  author  = {Woodruff-Pak, D. S. and Papka, M.},
  title   = {{Huntington's disease and eyeblink classical conditioning: normal learning but abnormal timing}},
  journal = {Journal of the International Neuropsychological Society : JINS},
  year    = {1996},
  doi     = {10.1017/s135561770000134x},
  pmid    = {9375181},
  url     = {https://doi.org/10.1017/s135561770000134x}
}

@article{tyler1996-8656174,
  author  = {Tyler, C. V. and Shank, J. C.},
  title   = {{Dementia and Down syndrome}},
  journal = {The Journal of family practice},
  year    = {1996},
  pmid    = {8656174}
}

@article{wegiel1996-8740627,
  author  = {Wegiel, J. and Wisniewski, H. M. and Dziewiatkowski, J. and Popovitch, E. R. and Tarnawski, M.},
  title   = {{Differential susceptibility to neurofibrillary pathology among patients with Down syndrome}},
  journal = {Dementia (Basel, Switzerland)},
  year    = {1996},
  doi     = {10.1159/000106868},
  pmid    = {8740627},
  url     = {https://doi.org/10.1159/000106868}
}

@article{parshad1996-8643543,
  author  = {Parshad, R. P. and Sanford, K. K. and Price, F. M. and Melnick, L. K. and Nee, L. E. and Schapiro, M. B. and Tarone, R. E. and Robbins, J. H.},
  title   = {{Fluorescent light-induced chromatid breaks distinguish Alzheimer disease cells from normal cells in tissue culture}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1996},
  doi     = {10.1073/pnas.93.10.5146},
  pmid    = {8643543},
  url     = {https://doi.org/10.1073/pnas.93.10.5146}
}

@article{politoff1996-8866678,
  author  = {Politoff, A. L. and Stadter, R. P. and Monson, N. and Hass, P.},
  title   = {{Cognition-related EEG abnormalities in nondemented Down syndrome subjects}},
  journal = {Dementia (Basel, Switzerland)},
  year    = {1996},
  doi     = {10.1159/000106856},
  pmid    = {8866678},
  url     = {https://doi.org/10.1159/000106856}
}

@article{seidl1996-8710184,
  author  = {Seidl, R. and Beninati, S. and Cairns, N. and Singewald, N. and Risser, D. and Bavan, H. and Nemethova, M. and Lubec, G.},
  title   = {{Polyamines in frontal cortex of patients with Down syndrome and Alzheimer disease}},
  journal = {Neuroscience letters},
  year    = {1996},
  doi     = {10.1016/s0304-3940(96)12451-4},
  pmid    = {8710184},
  url     = {https://doi.org/10.1016/s0304-3940(96)12451-4}
}

@article{lemere1996-9173910,
  author  = {Lemere, Cynthia Ann and Blusztajn, Jan Krzysztof and Yamaguchi, Hiroki and Wisniewski, Thomas and Saido, Takaomi C. and Selkoe, Dennis J.},
  title   = {{Sequence of Deposition of Heterogeneous Amyloid β-Peptides and APO E in Down Syndrome: Implications for Initial Events in Amyloid Plaque Formation}},
  journal = {Neurobiology of Disease},
  year    = {1996},
  doi     = {10.1006/nbdi.1996.0003},
  pmid    = {9173910},
  url     = {https://doi.org/10.1006/nbdi.1996.0003}
}

@article{barnicoat1996-8721567,
  author  = {Barnicoat, A. J. and Bonneau, J. L. and Boyd, E. and Docherty, Z. and Fennell, S. J. and Huret, J. L. and King, M. and Maltby, E. L. and others},
  title   = {{Down syndrome with partial duplication and del (21) syndrome: study protocol and call for collaboration. Study I: Clinical assessment}},
  journal = {Clinical genetics},
  year    = {1996},
  doi     = {10.1111/j.1399-0004.1996.tb04319.x},
  pmid    = {8721567},
  url     = {https://doi.org/10.1111/j.1399-0004.1996.tb04319.x}
}

@article{risser1996-8834106,
  author  = {Risser, D. and You, Z. B. and Cairns, N. and Herrera-Marschitz, M. and Seidl, R. and Schneider, C. and Terenius, L. and Lubec, G.},
  title   = {{Endogenous opioids in frontal cortex of patients with Down syndrome}},
  journal = {Neuroscience letters},
  year    = {1996},
  doi     = {10.1016/0304-3940(95)12275-3},
  pmid    = {8834106},
  url     = {https://doi.org/10.1016/0304-3940(95)12275-3}
}

@article{zigman1996-8718994,
  author  = {Zigman, W. B. and Schupf, N. and Sersen, E. and Silverman, W.},
  title   = {{Prevalence of dementia in adults with and without Down syndrome}},
  journal = {American journal of mental retardation : AJMR},
  year    = {1996},
  pmid    = {8718994}
}

@article{lecuyer1995-8720368,
  author  = {Lécuyer, R.},
  title   = {{[Parapsychotic disorders in mentally handicapped (particularly in Down's syndrome)]}},
  journal = {Annales medico-psychologiques},
  year    = {1995},
  pmid    = {8720368}
}

@article{peeters1995-8583230,
  author  = {Peeters, M. A. and Salabelle, A. and Attal, N. and Rethore, M. O. and Mircher, C. and Laplane, D. and Lejeune, J.},
  title   = {{Excessive glutamine sensitivity in Alzheimer's disease and Down syndrome lymphocytes}},
  journal = {Journal of the neurological sciences},
  year    = {1995},
  doi     = {10.1016/0022-510x(95)00135-o},
  pmid    = {8583230},
  url     = {https://doi.org/10.1016/0022-510x(95)00135-o}
}

@article{reeves1995-7550346,
  author  = {Reeves, R. H. and Irving, N. G. and Moran, T. H. and Wohn, A. and Kitt, C. and Sisodia, S. S. and Schmidt, C. and Bronson, R. T. and others},
  title   = {{A mouse model for Down syndrome exhibits learning and behaviour deficits}},
  journal = {Nature genetics},
  year    = {1995},
  doi     = {10.1038/ng1095-177},
  pmid    = {7550346},
  url     = {https://doi.org/10.1038/ng1095-177}
}

@article{bambrick1995-7568199,
  author  = {Bambrick, L. L. and Yarowsky, P. J. and Krueger, B. K.},
  title   = {{Glutamate as a hippocampal neuron survival factor: an inherited defect in the trisomy 16 mouse}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1995},
  doi     = {10.1073/pnas.92.21.9692},
  pmid    = {7568199},
  url     = {https://doi.org/10.1073/pnas.92.21.9692}
}

@article{shonk1995-7651126,
  author  = {Shonk, T. and Ross, B. D.},
  title   = {{Role of increased cerebral myo-inositol in the dementia of Down syndrome}},
  journal = {Magnetic resonance in medicine},
  year    = {1995},
  doi     = {10.1002/mrm.1910330619},
  pmid    = {7651126},
  url     = {https://doi.org/10.1002/mrm.1910330619}
}

@article{nelson1995-7632429,
  author  = {Nelson, L. and Lott, I. and Touchette, P. and Satz, P. and D'Elia, L.},
  title   = {{Detection of Alzheimer disease in individuals with Down syndrome}},
  journal = {American journal of mental retardation : AJMR},
  year    = {1995},
  pmid    = {7632429}
}

@article{hyman1995-7724603,
  author  = {Hyman, B. T. and West, H. L. and Rebeck, G. W. and Buldyrev, S. V. and Mantegna, R. N. and Ukleja, M. and Havlin, S. and Stanley, H. E.},
  title   = {{Quantitative analysis of senile plaques in Alzheimer disease: observation of log-normal size distribution and molecular epidemiology of differences associated with apolipoprotein E genotype and trisomy 21 (Down syndrome)}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1995},
  doi     = {10.1073/pnas.92.8.3586},
  pmid    = {7724603},
  url     = {https://doi.org/10.1073/pnas.92.8.3586}
}

@article{johannsen1995-7879299,
  author  = {Johannsen, P. and Mai, J.},
  title   = {{[Alzheimer-type dementia and Down syndrome]}},
  journal = {Ugeskrift for laeger},
  year    = {1995},
  pmid    = {7879299}
}

@article{das1995-7701089,
  author  = {Das, J. P. and Mishra, R. K.},
  title   = {{Assessment of cognitive decline associated with aging: a comparison of individuals with Down syndrome and other etiologies}},
  journal = {Research in developmental disabilities},
  year    = {1995},
  doi     = {10.1016/0891-4222(94)00032-5},
  pmid    = {7701089},
  url     = {https://doi.org/10.1016/0891-4222(94)00032-5}
}

@article{suzuki1994-7761983,
  author  = {Suzuki, A. and Takashima, S. and Mizuguchi, M. and Kato, M. and Kunishita, T. and Tabira, T.},
  title   = {{High expression on Kunitz-type protease inhibitor-containing substances in the cerebral vessels of patients with Down syndrome}},
  journal = {The Tohoku journal of experimental medicine},
  year    = {1994},
  doi     = {10.1620/tjem.174.181},
  pmid    = {7761983},
  url     = {https://doi.org/10.1620/tjem.174.181}
}

@article{rasmussen1994-7803032,
  author  = {Rasmussen, D. E. and Sobsey, D.},
  title   = {{Age, adaptive behavior, and Alzheimer disease in Down syndrome: cross-sectional and longitudinal analyses}},
  journal = {American journal of mental retardation : AJMR},
  year    = {1994},
  pmid    = {7803032}
}

@article{caserta1994-7993528,
  author  = {Caserta, M. T.},
  title   = {{Neuropeptide Y immunoreactive neurons in murine trisomy 16 cortical cultures. Plasticity of expression and differentiation}},
  journal = {Molecular and chemical neuropathology},
  year    = {1994},
  doi     = {10.1007/bf03160106},
  pmid    = {7993528},
  url     = {https://doi.org/10.1007/bf03160106}
}

@article{reeves1994-8202493,
  author  = {Reeves, R. H. and Yao, J. and Crowley, M. R. and Buck, S. and Zhang, X. and Yarowsky, P. and Gearhart, J. D. and Hilt, D. C.},
  title   = {{Astrocytosis and axonal proliferation in the hippocampus of S100b transgenic mice}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1994},
  doi     = {10.1073/pnas.91.12.5359},
  pmid    = {8202493},
  url     = {https://doi.org/10.1073/pnas.91.12.5359}
}

@article{korenberg1994-8197171,
  author  = {Korenberg, JR. and Chen, X. N. and Schipper, R. and Sun, Z. and Gonsky, R. and Gerwehr, S. and Carpenter, N. and Daumer, C. and others},
  title   = {{Down syndrome phenotypes: the consequences of chromosomal imbalance}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1994},
  doi     = {10.1073/pnas.91.11.4997},
  pmid    = {8197171},
  url     = {https://doi.org/10.1073/pnas.91.11.4997}
}

@article{finch1994-7925750,
  author  = {Finch, C. E.},
  title   = {{The evolution of ovarian oocyte decline with aging and possible relationships to Down syndrome and Alzheimer disease}},
  journal = {Experimental gerontology},
  year    = {1994},
  doi     = {10.1016/0531-5565(94)90009-4},
  pmid    = {7925750},
  url     = {https://doi.org/10.1016/0531-5565(94)90009-4}
}

@article{zucco1994-8022691,
  author  = {Zucco, G. M. and Negrin, N. S.},
  title   = {{Olfactory deficits in Down subjects: a link with Alzheimer disease}},
  journal = {Perceptual and motor skills},
  year    = {1994},
  doi     = {10.2466/pms.1994.78.2.627},
  pmid    = {8022691},
  url     = {https://doi.org/10.2466/pms.1994.78.2.627}
}

@article{azari1994-8038869,
  author  = {Azari, N. P. and Pettigrew, K. D. and Pietrini, P. and Horwitz, B. and Schapiro, M. B.},
  title   = {{Detection of an Alzheimer disease pattern of cerebral metabolism in Down syndrome}},
  journal = {Dementia (Basel, Switzerland)},
  year    = {1994},
  doi     = {10.1159/000106700},
  pmid    = {8038869},
  url     = {https://doi.org/10.1159/000106700}
}

@article{defalco1994-8181206,
  author  = {De Falco, F. A. and D'Angelo, E. and Grimaldi, G. and Scafuro, F. and Sachez, F. and Caruso, G.},
  title   = {{[Effect of the chronic treatment with L-acetylcarnitine in Down's syndrome]}},
  journal = {La Clinica terapeutica},
  year    = {1994},
  pmid    = {8181206}
}

@article{sadovnick1994-8055252,
  author  = {Sadovnick, A. D. and Yee, I. M. and Hirst, C.},
  title   = {{The rate of the Down syndrome among offspring of women with Alzheimer disease}},
  journal = {Psychiatric genetics},
  year    = {1994},
  doi     = {10.1097/00041444-199422000-00004},
  pmid    = {8055252},
  url     = {https://doi.org/10.1097/00041444-199422000-00004}
}

@article{buxbaum1993-8267600,
  author  = {Buxbaum, J. D. and Christensen, J. L. and Ruefli, A. A. and Greengard, P. and Loring, J. F.},
  title   = {{Expression of APP in brains of transgenic mice containing the entire human APP gene}},
  journal = {Biochemical and biophysical research communications},
  year    = {1993},
  doi     = {10.1006/bbrc.1993.2527},
  pmid    = {8267600},
  url     = {https://doi.org/10.1006/bbrc.1993.2527}
}

@article{inestrosa1993-8295739,
  author  = {Inestrosa, N. C. and Alarcón, R. and Arriagada, J. and Donoso, A. and Alvarez, J.},
  title   = {{Platelet of Alzheimer patients: increased counts and subnormal uptake and accumulation of [14C]5-hydroxytryptamine}},
  journal = {Neuroscience letters},
  year    = {1993},
  doi     = {10.1016/0304-3940(93)90216-8},
  pmid    = {8295739},
  url     = {https://doi.org/10.1016/0304-3940(93)90216-8}
}

@article{sanford1993-8221609,
  author  = {Sanford, K. K. and Parshad, R. and Price, F. M. and Tarone, R. E. and Schapiro, M. B.},
  title   = {{X-ray-induced chromatid damage in cells from Down syndrome and Alzheimer disease patients in relation to DNA repair and cancer proneness}},
  journal = {Cancer genetics and cytogenetics},
  year    = {1993},
  doi     = {10.1016/0165-4608(93)90127-8},
  pmid    = {8221609},
  url     = {https://doi.org/10.1016/0165-4608(93)90127-8}
}

@article{mehta1993-8410055,
  author  = {Mehta, P. D. and Dalton, A. J. and Mehta, S. P. and Percy, M. E. and Sersen, E. A. and Wisniewski, H. M.},
  title   = {{Immunoglobulin G subclasses in older persons with Down syndrome}},
  journal = {Journal of the neurological sciences},
  year    = {1993},
  doi     = {10.1016/0022-510x(93)90172-u},
  pmid    = {8410055},
  url     = {https://doi.org/10.1016/0022-510x(93)90172-u}
}

@article{hayes1993-8493063,
  author  = {Hayes, A. and Batshaw, M. L.},
  title   = {{Down syndrome}},
  journal = {Pediatric clinics of North America},
  year    = {1993},
  doi     = {10.1016/s0031-3955(16)38548-0},
  pmid    = {8493063},
  url     = {https://doi.org/10.1016/s0031-3955(16)38548-0}
}

@article{goodison1993-8492138,
  author  = {Goodison, K. L. and Parhad, I. M. and White, C. L. and Sima, A. A. and Clark, A. W.},
  title   = {{Neuronal and glial gene expression in neocortex of Down's syndrome and Alzheimer's disease}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {1993},
  doi     = {10.1097/00005072-199305000-00002},
  pmid    = {8492138},
  url     = {https://doi.org/10.1097/00005072-199305000-00002}
}

@article{percy1993-8456829,
  author  = {Percy, M. E. and Markovic, V. D. and Dalton, A. J. and McLachlan, D. R. and Berg, J. M. and Rusk, A. C. and Somerville, M. J. and Chodakowski, B. and others},
  title   = {{Age-associated chromosome 21 loss in Down syndrome: possible relevance to mosaicism and Alzheimer disease}},
  journal = {American journal of medical genetics},
  year    = {1993},
  doi     = {10.1002/ajmg.1320450513},
  pmid    = {8456829},
  url     = {https://doi.org/10.1002/ajmg.1320450513}
}

@article{lemieux1993-8432528,
  author  = {Lemieux, N. and Malfoy, B. and Forrest, G. L.},
  title   = {{Human carbonyl reductase (CBR) localized to band 21q22.1 by high-resolution fluorescence in situ hybridization displays gene dosage effects in trisomy 21 cells}},
  journal = {Genomics},
  year    = {1993},
  doi     = {10.1006/geno.1993.1024},
  pmid    = {8432528},
  url     = {https://doi.org/10.1006/geno.1993.1024}
}

@article{bryant1993-8347332,
  author  = {Bryant, E. M. and Bird, T. D. and Ogburn, C. E. and Traylor, G. H. and Lampe, T. H. and Martin, G. M.},
  title   = {{Lack of detectable radiation hypersensitivity in lymphoblastoid cells from multiple pedigrees of familial Alzheimer disease}},
  journal = {Alzheimer disease and associated disorders},
  year    = {1993},
  doi     = {10.1097/00002093-199307020-00004},
  pmid    = {8347332},
  url     = {https://doi.org/10.1097/00002093-199307020-00004}
}

@article{davisson1993-8115398,
  author  = {Davisson, M. T. and Schmidt, C. and Reeves, R. H. and Irving, N. G. and Akeson, E. C. and Harris, B. S. and Bronson, R. T.},
  title   = {{Segmental trisomy as a mouse model for Down syndrome}},
  journal = {Progress in clinical and biological research},
  year    = {1993},
  pmid    = {8115398}
}

@article{ceballospicot1993-8019910,
  author  = {Ceballos-Picot, I.},
  title   = {{[Transgenic mice overexpressing copper-zinc superoxide dismutase: a model for the study of radical mechanisms and aging]}},
  journal = {Comptes rendus des seances de la Societe de biologie et de ses filiales},
  year    = {1993},
  pmid    = {8019910}
}

@article{yu1992-1642227,
  author  = {Yu, J. and Hartz, J. and Xu, Y. and Gemmill, R. M. and Korenberg, JR. and Patterson, D. and Kao, F. T.},
  title   = {{Isolation, characterization, and regional mapping of microclones from a human chromosome 21 microdissection library}},
  journal = {American journal of human genetics},
  year    = {1992},
  pmid    = {1642227}
}

@article{nitsch1992-1311847,
  author  = {Nitsch, R. M. and Blusztajn, J. K. and Pittas, A. G. and Slack, B. E. and Growdon, J. H. and Wurtman, R. J.},
  title   = {{Evidence for a membrane defect in Alzheimer disease brain}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1992},
  doi     = {10.1073/pnas.89.5.1671},
  pmid    = {1311847},
  url     = {https://doi.org/10.1073/pnas.89.5.1671}
}

@article{korenberg1992-1531166,
  author  = {Korenberg, JR. and Bradley, C. and Disteche, C. M.},
  title   = {{Down syndrome: molecular mapping of the congenital heart disease and duodenal stenosis}},
  journal = {American journal of human genetics},
  year    = {1992},
  pmid    = {1531166}
}

@article{holtzman1992-1741393,
  author  = {Holtzman, D. M. and Li, Y. W. and DeArmond, S. J. and McKinley, M. P. and Gage, F. H. and Epstein, C. J. and Mobley, W. C.},
  title   = {{Mouse model of neurodegeneration: atrophy of basal forebrain cholinergic neurons in trisomy 16 transplants}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1992},
  doi     = {10.1073/pnas.89.4.1383},
  pmid    = {1741393},
  url     = {https://doi.org/10.1073/pnas.89.4.1383}
}

@article{hyman1992-1409740,
  author  = {Hyman, B. T.},
  title   = {{Down syndrome and Alzheimer disease}},
  journal = {Progress in clinical and biological research},
  year    = {1992},
  pmid    = {1409740}
}

@article{young1991-1830635,
  author  = {Young, E. C. and Kramer, B. M.},
  title   = {{Characteristics of age-related language decline in adults with Down syndrome}},
  journal = {Mental retardation},
  year    = {1991},
  pmid    = {1830635}
}

@article{fisher1991-1900367,
  author  = {Fisher, S. and Gearhart, J. D. and Oster-Granite, M. L.},
  title   = {{Expression of the amyloid precursor protein gene in mouse oocytes and embryos}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1991},
  doi     = {10.1073/pnas.88.5.1779},
  pmid    = {1900367},
  url     = {https://doi.org/10.1073/pnas.88.5.1779}
}

@article{ceballos1991-1829430,
  author  = {Ceballos, I. and Nicole, A. and Briand, P. and Grimber, G. and Delacourte, A. and Flament, S. and Blouin, J. L. and Thevenin, M. and others},
  title   = {{Expression of human Cu-Zn superoxide dismutase gene in transgenic mice: model for gene dosage effect in Down syndrome}},
  journal = {Free radical research communications},
  year    = {1991},
  doi     = {10.3109/10715769109145833},
  pmid    = {1829430},
  url     = {https://doi.org/10.3109/10715769109145833}
}

@article{frommelt1991-2025423,
  author  = {Frommelt, P. and Schnabel, R. and Kühne, W. and Nee, L. E. and Polinsky, R. J.},
  title   = {{Familial Alzheimer disease: a large, multigeneration German kindred}},
  journal = {Alzheimer disease and associated disorders},
  year    = {1991},
  doi     = {10.1097/00002093-199100510-00005},
  pmid    = {2025423},
  url     = {https://doi.org/10.1097/00002093-199100510-00005}
}

@article{bugiani1990-1965862,
  author  = {Bugiani, O. and Giaccone, G. and Verga, L. and Pollo, B. and Ghetti, B. and Frangione, B. and Tagliavini, F.},
  title   = {{Alzheimer patients and Down patients: abnormal presynaptic terminals are related to cerebral preamyloid deposits}},
  journal = {Neuroscience letters},
  year    = {1990},
  doi     = {10.1016/0304-3940(90)90754-w},
  pmid    = {1965862},
  url     = {https://doi.org/10.1016/0304-3940(90)90754-w}
}

@article{caltagirone1990-2148315,
  author  = {Caltagirone, C. and Nocentini, U. and Vicari, S.},
  title   = {{Cognitive functions in adult Down's syndrome}},
  journal = {The International journal of neuroscience},
  year    = {1990},
  doi     = {10.3109/00207459008986638},
  pmid    = {2148315},
  url     = {https://doi.org/10.3109/00207459008986638}
}

@article{jorgensen1990-1977892,
  author  = {Jørgensen, O. S. and Brooksbank, B. W. and Balázs, R.},
  title   = {{Neuronal plasticity and astrocytic reaction in Down syndrome and Alzheimer disease}},
  journal = {Journal of the neurological sciences},
  year    = {1990},
  doi     = {10.1016/0022-510x(90)90182-m},
  pmid    = {1977892},
  url     = {https://doi.org/10.1016/0022-510x(90)90182-m}
}

@article{pearlson1990-2142380,
  author  = {Pearlson, G. D. and Warren, A. C. and Starkstein, S. E. and Aylward, E. H. and Kumar, A. J. and Chase, G. A. and Folstein, M. F.},
  title   = {{Brain atrophy in 18 patients with Down syndrome: a CT study}},
  journal = {AJNR. American journal of neuroradiology},
  year    = {1990},
  pmid    = {2142380}
}

@article{percy1990-2142381,
  author  = {Percy, M. E. and Dalton, A. J. and Markovic, V. D. and Crapper McLachlan, D. R. and Gera, E. and Hummel, J. T. and Rusk, A. C. and Somerville, M. J. and others},
  title   = {{Autoimmune thyroiditis associated with mild "subclinical" hypothyroidism in adults with Down syndrome: a comparison of patients with and without manifestations of Alzheimer disease}},
  journal = {American journal of medical genetics},
  year    = {1990},
  doi     = {10.1002/ajmg.1320360205},
  pmid    = {2142381},
  url     = {https://doi.org/10.1002/ajmg.1320360205}
}

@article{sparkman1990-2110208,
  author  = {Sparkman, D. R. and Hammon, K. M. and White, C. L.},
  title   = {{Production and characterization of a monospecific antiserum (A128) to disaggregated Alzheimer paired helical filaments}},
  journal = {The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society},
  year    = {1990},
  doi     = {10.1177/38.5.2110208},
  pmid    = {2110208},
  url     = {https://doi.org/10.1177/38.5.2110208}
}

@article{percy1990-2139757,
  author  = {Percy, M. E. and Dalton, A. J. and Markovic, V. D. and McLachlan, D. R. and Hummel, J. T. and Rusk, A. C. and Andrews, D. F.},
  title   = {{Red cell superoxide dismutase, glutathione peroxidase and catalase in Down syndrome patients with and without manifestations of Alzheimer disease}},
  journal = {American journal of medical genetics},
  year    = {1990},
  doi     = {10.1002/ajmg.1320350403},
  pmid    = {2139757},
  url     = {https://doi.org/10.1002/ajmg.1320350403}
}

@article{farrar1990-1969510,
  author  = {Farrar, G. and Altmann, P. and Welch, S. and Wychrij, O. and Ghose, B. and Lejeune, J. and Corbett, J. and Prasher, V. and others},
  title   = {{Defective gallium-transferrin binding in Alzheimer disease and Down syndrome: possible mechanism for accumulation of aluminium in brain}},
  journal = {Lancet (London, England)},
  year    = {1990},
  doi     = {10.1016/0140-6736(90)90868-6},
  pmid    = {1969510},
  url     = {https://doi.org/10.1016/0140-6736(90)90868-6}
}

@article{carmeliet1990-2139155,
  author  = {Carmeliet, G. and Hauman, R. and Dom, R. and David, G. and Fryns, J. P. and Van den Berghe, H. and Cassiman, J. J.},
  title   = {{Growth properties and in vitro life span of Alzheimer disease and Down syndrome fibroblasts. A blind study}},
  journal = {Mechanisms of ageing and development},
  year    = {1990},
  doi     = {10.1016/0047-6374(90)90031-a},
  pmid    = {2139155},
  url     = {https://doi.org/10.1016/0047-6374(90)90031-a}
}

@article{schapiro1990-2137464,
  author  = {Schapiro, M. B. and Grady, C. L. and Kumar, A. and Herscovitch, P. and Haxby, J. V. and Moore, A. M. and White, B. and Friedland, R. P. and others},
  title   = {{Regional cerebral glucose metabolism is normal in young adults with Down syndrome}},
  journal = {Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year    = {1990},
  doi     = {10.1038/jcbfm.1990.35},
  pmid    = {2137464},
  url     = {https://doi.org/10.1038/jcbfm.1990.35}
}

@article{evenhuis1990-2138013,
  author  = {Evenhuis, H. M.},
  title   = {{The natural history of dementia in Down's syndrome}},
  journal = {Archives of neurology},
  year    = {1990},
  doi     = {10.1001/archneur.1990.00530030029011},
  pmid    = {2138013},
  url     = {https://doi.org/10.1001/archneur.1990.00530030029011}
}

@article{pueschel1990-2149974,
  author  = {Pueschel, S. M.},
  title   = {{Clinical aspects of Down syndrome from infancy to adulthood}},
  journal = {American journal of medical genetics. Supplement},
  year    = {1990},
  doi     = {10.1002/ajmg.1320370708},
  pmid    = {2149974},
  url     = {https://doi.org/10.1002/ajmg.1320370708}
}

@article{takashima1990-2146899,
  author  = {Takashima, S. and Kuruta, H. and Mito, T. and Nishizawa, M. and Kunishita, T. and Tabira, T.},
  title   = {{Developmental and aging changes in the expression patterns of beta-amyloid in the brains of normal and Down syndrome cases}},
  journal = {Brain \& development},
  year    = {1990},
  doi     = {10.1016/s0387-7604(12)80066-0},
  pmid    = {2146899},
  url     = {https://doi.org/10.1016/s0387-7604(12)80066-0}
}

@article{cork1990-2149963,
  author  = {Cork, L. C.},
  title   = {{Neuropathology of Down syndrome and Alzheimer disease}},
  journal = {American journal of medical genetics. Supplement},
  year    = {1990},
  doi     = {10.1002/ajmg.1320370756},
  pmid    = {2149963},
  url     = {https://doi.org/10.1002/ajmg.1320370756}
}

@article{krawczun1990-2148262,
  author  = {Krawczun, M. S. and Jenkins, E. C. and Lele, K. P. and Sersen, E. A. and Wisniewski, H. M.},
  title   = {{Study of spindle microtubule reassembly in cells from Alzheimer and Down syndrome patients following exposure to colcemid}},
  journal = {Alzheimer disease and associated disorders},
  year    = {1990},
  doi     = {10.1097/00002093-199040400-00002},
  pmid    = {2148262},
  url     = {https://doi.org/10.1097/00002093-199040400-00002}
}

@article{epstein1990-2149968,
  author  = {Epstein, C. J.},
  title   = {{The consequences of chromosome imbalance}},
  journal = {American journal of medical genetics. Supplement},
  year    = {1990},
  doi     = {10.1002/ajmg.1320370706},
  pmid    = {2149968},
  url     = {https://doi.org/10.1002/ajmg.1320370706}
}

@article{mccormick1989-2690083,
  author  = {McCormick, M. K. and Shero, J. H. and Cheung, M. C. and Kan, Y. W. and Hieter, P. A. and Antonarakis, S. E.},
  title   = {{Construction of human chromosome 21-specific yeast artificial chromosomes}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1989},
  doi     = {10.1073/pnas.86.24.9991},
  pmid    = {2690083},
  url     = {https://doi.org/10.1073/pnas.86.24.9991}
}

@article{griffin1989-2529544,
  author  = {Griffin, W. S. and Stanley, L. C. and Ling, C. and White, L. and MacLeod, V. and Perrot, L. J. and White, C. L. and Araoz, C.},
  title   = {{Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1989},
  doi     = {10.1073/pnas.86.19.7611},
  pmid    = {2529544},
  url     = {https://doi.org/10.1073/pnas.86.19.7611}
}

@article{amari1989-2605832,
  author  = {Amari, M. and Matsubara, E. and Ishiguro, K. and Shoji, M. and Hirai, S.},
  title   = {{[The significance of measurement of contents of serum serine protease inhibitors in senile dementia of the Alzheimer type]}},
  journal = {Rinsho shinkeigaku = Clinical neurology},
  year    = {1989},
  pmid    = {2605832}
}

@article{neve1989-2510036,
  author  = {Neve, R. L.},
  title   = {{Genetic studies support a neuronal origin for the beta amyloid polypeptide}},
  journal = {Neurobiology of aging},
  year    = {1989},
  doi     = {10.1016/0197-4580(89)90074-2},
  pmid    = {2510036},
  url     = {https://doi.org/10.1016/0197-4580(89)90074-2}
}

@article{lai1989-2527024,
  author  = {Lai, F. and Williams, R. S.},
  title   = {{A prospective study of Alzheimer disease in Down syndrome}},
  journal = {Archives of neurology},
  year    = {1989},
  doi     = {10.1001/archneur.1989.00520440031017},
  pmid    = {2527024},
  url     = {https://doi.org/10.1001/archneur.1989.00520440031017}
}

@article{berr1989-2531979,
  author  = {Berr, C. and Borghi, E. and Rethoré, M. O. and Lejeune, J. and Alperovitch, A.},
  title   = {{Absence of familial association between dementia of Alzheimer type and Down syndrome}},
  journal = {American journal of medical genetics},
  year    = {1989},
  doi     = {10.1002/ajmg.1320330427},
  pmid    = {2531979},
  url     = {https://doi.org/10.1002/ajmg.1320330427}
}

@article{korenberg1989-2527801,
  author  = {Korenberg, JR. and Pulst, S. M. and Neve, R. L. and West, R.},
  title   = {{The Alzheimer amyloid precursor protein maps to human chromosome 21 bands q21.105-q21.05}},
  journal = {Genomics},
  year    = {1989},
  doi     = {10.1016/0888-7543(89)90095-5},
  pmid    = {2527801},
  url     = {https://doi.org/10.1016/0888-7543(89)90095-5}
}

@article{young1989-2722185,
  author  = {Young, B. R. and Painter, R. B.},
  title   = {{Radioresistant DNA synthesis and human genetic diseases}},
  journal = {Human genetics},
  year    = {1989},
  doi     = {10.1007/bf00284040},
  pmid    = {2722185},
  url     = {https://doi.org/10.1007/bf00284040}
}

@article{barcikowska1989-2706124,
  author  = {Barcikowska, M. and Silverman, W. and Zigman, W. and Kozlowski, P. B. and Kujawa, M. and Rudelli, R. and Wisniewski, H. M.},
  title   = {{Alzheimer-type neuropathology and clinical symptoms of dementia in mentally retarded people without Down syndrome}},
  journal = {American journal of mental retardation : AJMR},
  year    = {1989},
  pmid    = {2706124}
}

@article{jenkins1989-2690102,
  author  = {Jenkins, E. C. and Devine-Gage, E. A. and Yao, X. L. and Houck, G. E. and Brown, W. T. and Robakis, N. K. and Wisniewski, K. E. and Silverman, W. P. and others},
  title   = {{Beta-amyloid protein probe hybridized to chromosome 9 in 3 Alzheimer disease individuals}},
  journal = {Progress in clinical and biological research},
  year    = {1989},
  pmid    = {2690102}
}

@article{tagliavini1989-2532368,
  author  = {Tagliavini, F. and Giaccone, G. and Linoli, G. and Frangione, B. and Bugiani, O.},
  title   = {{Cerebral extracellular preamyloid deposits in Alzheimer's disease, Down syndrome and nondemented elderly individuals}},
  journal = {Progress in clinical and biological research},
  year    = {1989},
  pmid    = {2532368}
}

@article{takashima1989-2523670,
  author  = {Takashima, S. and Ieshima, A. and Nakamura, H. and Becker, L. E.},
  title   = {{Dendrites, dementia and the Down syndrome}},
  journal = {Brain \& development},
  year    = {1989},
  doi     = {10.1016/s0387-7604(89)80082-8},
  pmid    = {2523670},
  url     = {https://doi.org/10.1016/s0387-7604(89)80082-8}
}

@article{tanzi1989-2504259,
  author  = {Tanzi, R. E.},
  title   = {{Molecular genetics of Alzheimer's disease and the amyloid beta peptide precursor gene}},
  journal = {Annals of medicine},
  year    = {1989},
  doi     = {10.3109/07853898909149191},
  pmid    = {2504259},
  url     = {https://doi.org/10.3109/07853898909149191}
}

@article{patterson1988-2973063,
  author  = {Patterson, D. and Gardiner, K. and Kao, F. T. and Tanzi, R. and Watkins, P. and Gusella, J. F.},
  title   = {{Mapping of the gene encoding the beta-amyloid precursor protein and its relationship to the Down syndrome region of chromosome 21}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1988},
  doi     = {10.1073/pnas.85.21.8266},
  pmid    = {2973063},
  url     = {https://doi.org/10.1073/pnas.85.21.8266}
}

@article{sacchi1988-2902635,
  author  = {Sacchi, N. and Nalbantoglu, J. and Sergovich, F. R. and Papas, T. S.},
  title   = {{Human ETS2 gene on chromosome 21 is not rearranged in Alzheimer disease}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1988},
  doi     = {10.1073/pnas.85.20.7675},
  pmid    = {2902635},
  url     = {https://doi.org/10.1073/pnas.85.20.7675}
}

@article{cheng1988-2901095,
  author  = {Cheng, S. V. and Nadeau, J. H. and Tanzi, R. E. and Watkins, P. C. and Jagadesh, J. and Taylor, B. A. and Haines, J. L. and Sacchi, N. and others},
  title   = {{Comparative mapping of DNA markers from the familial Alzheimer disease and Down syndrome regions of human chromosome 21 to mouse chromosomes 16 and 17}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1988},
  doi     = {10.1073/pnas.85.16.6032},
  pmid    = {2901095},
  url     = {https://doi.org/10.1073/pnas.85.16.6032}
}

@article{wolozin1988-2970636,
  author  = {Wolozin, B. and Scicutella, A. and Davies, P.},
  title   = {{Reexpression of a developmentally regulated antigen in Down syndrome and Alzheimer disease}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1988},
  doi     = {10.1073/pnas.85.16.6202},
  pmid    = {2970636},
  url     = {https://doi.org/10.1073/pnas.85.16.6202}
}

@article{luxenberg1988-2973233,
  author  = {Luxenberg, J. S. and Plato, C. C. and Fox, K. M. and Friedland, R. P. and Rapoport, S. I.},
  title   = {{Digital and palmar dermatoglyphics in dementia of the Alzheimer type}},
  journal = {American journal of medical genetics},
  year    = {1988},
  doi     = {10.1002/ajmg.1320300306},
  pmid    = {2973233},
  url     = {https://doi.org/10.1002/ajmg.1320300306}
}

@article{mann1988-2969441,
  author  = {Mann, D. M.},
  title   = {{The pathological association between Down syndrome and Alzheimer disease}},
  journal = {Mechanisms of ageing and development},
  year    = {1988},
  doi     = {10.1016/0047-6374(88)90041-3},
  pmid    = {2969441},
  url     = {https://doi.org/10.1016/0047-6374(88)90041-3}
}

@article{kumar1988-2974704,
  author  = {Kumar, M. and Cohen, D. and Eisdorfer, C.},
  title   = {{Serum IgG brain reactive antibodies in Alzheimer disease and Down syndrome}},
  journal = {Alzheimer disease and associated disorders},
  year    = {1988},
  doi     = {10.1097/00002093-198802010-00006},
  pmid    = {2974704},
  url     = {https://doi.org/10.1097/00002093-198802010-00006}
}

@article{vanduinen1987-3475718,
  author  = {van Duinen, S. G. and Castaño, E. M. and Prelli, F. and Bots, G. T. and Luyendijk, W. and Frangione, B.},
  title   = {{Hereditary cerebral hemorrhage with amyloidosis in patients of Dutch origin is related to Alzheimer disease}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1987},
  doi     = {10.1073/pnas.84.16.5991},
  pmid    = {3475718},
  url     = {https://doi.org/10.1073/pnas.84.16.5991}
}

@article{robakis1987-3035574,
  author  = {Robakis, N. K. and Ramakrishna, N. and Wolfe, G. and Wisniewski, H. M.},
  title   = {{Molecular cloning and characterization of a cDNA encoding the cerebrovascular and the neuritic plaque amyloid peptides}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1987},
  doi     = {10.1073/pnas.84.12.4190},
  pmid    = {3035574},
  url     = {https://doi.org/10.1073/pnas.84.12.4190}
}

@article{guiroy1987-3470778,
  author  = {Guiroy, D. C. and Miyazaki, M. and Multhaup, G. and Fischer, P. and Garruto, R. M. and Beyreuther, K. and Masters, C. L. and Simms, G. and others},
  title   = {{Amyloid of neurofibrillary tangles of Guamanian parkinsonism-dementia and Alzheimer disease share identical amino acid sequence}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1987},
  doi     = {10.1073/pnas.84.7.2073},
  pmid    = {3470778},
  url     = {https://doi.org/10.1073/pnas.84.7.2073}
}

@article{lovett1987-3555492,
  author  = {Lovett, M. and Goldgaber, D. and Ashley, P. and Cox, D. R. and Gajdusek, D. C. and Epstein, C. J.},
  title   = {{The mouse homolog of the human amyloid beta protein (AD-AP) gene is located on the distal end of mouse chromosome 16: further extension of the homology between human chromosome 21 and mouse chromosome 16}},
  journal = {Biochemical and biophysical research communications},
  year    = {1987},
  doi     = {10.1016/s0006-291x(87)80073-6},
  pmid    = {3555492},
  url     = {https://doi.org/10.1016/s0006-291x(87)80073-6}
}

@article{sinex1986-2948082,
  author  = {Sinex, F. M.},
  title   = {{The mortality of adults with Down syndrome as a function of age}},
  journal = {Mechanisms of ageing and development},
  year    = {1986},
  doi     = {10.1016/0047-6374(86)90088-6},
  pmid    = {2948082},
  url     = {https://doi.org/10.1016/0047-6374(86)90088-6}
}

@article{wisniewski1985-3159974,
  author  = {Wisniewski, K. E. and Dalton, A. J. and McLachlan, C. and Wen, G. Y. and Wisniewski, H. M.},
  title   = {{Alzheimer's disease in Down's syndrome: clinicopathologic studies}},
  journal = {Neurology},
  year    = {1985},
  doi     = {10.1212/wnl.35.7.957},
  pmid    = {3159974},
  url     = {https://doi.org/10.1212/wnl.35.7.957}
}

@article{masters1985-3159021,
  author  = {Masters, C. L. and Simms, G. and Weinman, N. A. and Multhaup, G. and McDonald, B. L. and Beyreuther, K.},
  title   = {{Amyloid plaque core protein in Alzheimer disease and Down syndrome}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1985},
  doi     = {10.1073/pnas.82.12.4245},
  pmid    = {3159021},
  url     = {https://doi.org/10.1073/pnas.82.12.4245}
}

@article{otsuka1985-3159854,
  author  = {Otsuka, F. and Tarone, R. E. and Seguin, L. R. and Robbins, J. H.},
  title   = {{Hypersensitivity to ionizing radiation in cultured cells from Down syndrome patients}},
  journal = {Journal of the neurological sciences},
  year    = {1985},
  doi     = {10.1016/0022-510x(85)90011-5},
  pmid    = {3159854},
  url     = {https://doi.org/10.1016/0022-510x(85)90011-5}
}

@article{wisniewski1985-3158266,
  author  = {Wisniewski, K. E. and Wı́sniewski, Henryk M. and Wen, G. Y.},
  title   = {{Occurrence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome}},
  journal = {Annals of Neurology},
  year    = {1985},
  doi     = {10.1002/ana.410170310},
  pmid    = {3158266},
  url     = {https://doi.org/10.1002/ana.410170310}
}

@article{glenner1984-6236805,
  author  = {Glenner, George G. and Wong, Caine W.},
  title   = {{Alzheimer's disease and Down's syndrome: Sharing of a unique cerebrovascular amyloid fibril protein}},
  journal = {Biochemical and Biophysical Research Communications},
  year    = {1984},
  doi     = {10.1016/0006-291x(84)91209-9},
  pmid    = {6236805},
  url     = {https://doi.org/10.1016/0006-291x(84)91209-9}
}

@article{sorbi1983-6219611,
  author  = {Sorbi, S. and Bird, E. D. and Blass, J. P.},
  title   = {{Decreased pyruvate dehydrogenase complex activity in Huntington and Alzheimer brain}},
  journal = {Annals of neurology},
  year    = {1983},
  doi     = {10.1002/ana.410130116},
  pmid    = {6219611},
  url     = {https://doi.org/10.1002/ana.410130116}
}

@article{miniszek1983-6219583,
  author  = {Miniszek, N. A.},
  title   = {{Development of Alzheimer disease in Down syndrome individuals}},
  journal = {American journal of mental deficiency},
  year    = {1983},
  pmid    = {6219583}
}

@article{harding1982-7066668,
  author  = {Harding, A. E.},
  title   = {{The clinical features and classification of the late onset autosomal dominant cerebellar ataxias. A study of 11 families, including descendants of the 'the Drew family of Walworth'}},
  journal = {Brain : a journal of neurology},
  year    = {1982},
  doi     = {10.1093/brain/105.1.1},
  pmid    = {7066668},
  url     = {https://doi.org/10.1093/brain/105.1.1}
}

@article{ropper1980-6446047,
  author  = {Ropper, A. H. and Williams, R. S.},
  title   = {{Relationship between plaques, tangles, and dementia in Down syndrome}},
  journal = {Neurology},
  year    = {1980},
  doi     = {10.1212/wnl.30.6.639},
  pmid    = {6446047},
  url     = {https://doi.org/10.1212/wnl.30.6.639}
}

@article{ball1980-6446875,
  author  = {Ball, M. J. and Nuttall, K.},
  title   = {{Neurofibrillary tangles, granulovacuolar degeneration, and neuron loss in Down Syndrome: quantitative comparison with Alzheimer dementia}},
  journal = {Annals of neurology},
  year    = {1980},
  doi     = {10.1002/ana.410070512},
  pmid    = {6446875},
  url     = {https://doi.org/10.1002/ana.410070512}
}

@article{cook1979-384295,
  author  = {Cook, R. H. and Ward, B. E. and Austin, J. H.},
  title   = {{Studies in aging of the brain: IV. Familial Alzheimer disease: Relation to transmissible dementia, aneuploidy, and microtubular defects}},
  journal = {Neurology},
  year    = {1979},
  doi     = {10.1212/wnl.29.10.1402},
  pmid    = {384295},
  url     = {https://doi.org/10.1212/wnl.29.10.1402}
}

@article{wisniewski1979-156000,
  author  = {Wisniewski, K. and Jervis, G. A. and Moretz, R. C. and Wisniewski, H. M.},
  title   = {{Alzheimer neurofibrillary tangles in diseases other than senile and presenile dementia}},
  journal = {Annals of neurology},
  year    = {1979},
  doi     = {10.1002/ana.410050311},
  pmid    = {156000},
  url     = {https://doi.org/10.1002/ana.410050311}
}

@article{crapper1975-126052,
  author  = {Crapper, D. R. and Dalton, A. J. and Skoptiz, M. and Scott, J. W. and Hachinski, V. C.},
  title   = {{Alzheimer degeneration in Down syndrome. Electrophysiologic alterations and histopathologic findings}},
  journal = {Archives of neurology},
  year    = {1975},
  doi     = {10.1001/archneur.1975.00490510074006},
  pmid    = {126052},
  url     = {https://doi.org/10.1001/archneur.1975.00490510074006}
}