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Home › Research › Topics › down

down

534 studies tagged down, dated 1975-09-01 to 2026-10-30. Bibliography: BibTeX (.bib) · RIS (.ris)

Newest in this topic

  1. Differential endothelial cell remodeling in Down syndrome and APP duplication drives distinct blood brain barrier dysfunction 2026-10-30
  2. Memory and Plasma pTau217 Refine Prognosis in Down Syndrome 2026-10-02
  3. Tau extent is associated with lower cognition in Down syndrome-related Alzheimer's disease 2026-10-01

Studies

534 studies carry this tag.

Date range

1975 to 2026

Top journals

  • Proceedings of the National Academy of Sciences of the United States of America 21
  • Alzheimer s & Dementia 20
  • Alzheimer's & dementia : the journal of the Alzheimer's Association 15
  • Neurology 14
  • Neuroscience letters 14

239 journals in all.

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. High expression on Kunitz-type protease inhibitor-containing substances in the cerebral vessels of patients with Down syndrome

    ✓ Peer-reviewed alzhub usefulness score 28 out of 100. The Tohoku journal of experimental medicine 1994-11-01 Down syndrome and Alzheimer's

    Down syndrome (DS) brains, from 19 gestational weeks to 50 years of age were studied by immunohistochemical methods with a polyclonal antibody against synthetic peptide comprising part of the Kunitz-type protease inhibitor (KPI) domain of Alzheimer disease amyloid precursor protein (APP), residues 301 to 323 of APP 770.

  2. Age, adaptive behavior, and Alzheimer disease in Down syndrome: cross-sectional and longitudinal analyses

    ✓ Peer-reviewed alzhub usefulness score 37 out of 100. American journal of mental retardation : AJMR 1994-09-01 Down syndrome and Alzheimer's

    Cross-sectional and longitudinal analyses were used to compare age-related changes in adaptive functioning in institutionalized adults with and without Down syndrome.

  3. Neuropeptide Y immunoreactive neurons in murine trisomy 16 cortical cultures. Plasticity of expression and differentiation

    ✓ Peer-reviewed alzhub usefulness score 30 out of 100. Molecular and chemical neuropathology 1994-08-01 Down syndrome and Alzheimer's

    Neuropeptide Y (NPY)-containing neurons are depleted in the cortices of individuals with Alzheimer disease (AD), yet spared in the striatum of patients with Huntington chorea.

  4. Astrocytosis and axonal proliferation in the hippocampus of S100b transgenic mice

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Proceedings of the National Academy of Sciences of the United States of America 1994-06-01 Down syndrome and Alzheimer's

    S100 beta is a calcium-binding protein that is expressed at high levels in brain primarily by astrocytes.

  5. Down syndrome phenotypes: the consequences of chromosomal imbalance

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. Proceedings of the National Academy of Sciences of the United States of America 1994-05-01 Down syndrome and Alzheimer's

    Down syndrome (DS) is a major cause of mental retardation and congenital heart disease.

  6. The evolution of ovarian oocyte decline with aging and possible relationships to Down syndrome and Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 35 out of 100. Experimental gerontology 1994-05-01 Down syndrome and Alzheimer's

    Evolutionary aspects of menopause are considered from several perspectives.

  7. Olfactory deficits in Down subjects: a link with Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 33 out of 100. Perceptual and motor skills 1994-04-01 Down syndrome and Alzheimer's

    Two groups of subjects, 14 young (ages 20 to 31 years) and 14 adults (ages 32 to 54 years), both groups with Down Syndrome, were examined on a matching and naming olfactory task.

  8. Detection of an Alzheimer disease pattern of cerebral metabolism in Down syndrome

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. Dementia (Basel, Switzerland) 1994-03-01 Down syndrome and Alzheimer's

    Correlational analysis of cerebral metabolic (rCMRglc) data obtained with positron emission tomography (PET) assesses group differences and has demonstrated reduced frontal-parietal rCMRglc interdependencies in Alzheimer's disease (AD).

  9. [Effect of the chronic treatment with L-acetylcarnitine in Down's syndrome]

    ✓ Peer-reviewed alzhub usefulness score 30 out of 100. La Clinica terapeutica 1994-02-01 Down syndrome and Alzheimer's

    Neuropsychologic tests were performed in subjects with Down syndrome in order to assess the effect of a 90-day treatment with L-acetyl-carnitine (LAC).

  10. The rate of the Down syndrome among offspring of women with Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 26 out of 100. Psychiatric genetics 1994-01-01 Down syndrome and Alzheimer's

    It has been reported that the Down syndrome occurs more often than expected among relatives of individuals with Alzheimer disease.

  11. Expression of APP in brains of transgenic mice containing the entire human APP gene

    ✓ Peer-reviewed alzhub usefulness score 37 out of 100. Biochemical and biophysical research communications 1993-12-01 Down syndrome and Alzheimer's

    A major component of amyloid deposits found in Alzheimer disease and Down syndrome is the beta/A4 peptide, which is derived from the Alzheimer amyloid protein precursor (APP).

  12. Platelet of Alzheimer patients: increased counts and subnormal uptake and accumulation of [14C]5-hydroxytryptamine

    ✓ Peer-reviewed alzhub usefulness score 33 out of 100. Neuroscience letters 1993-11-01 Down syndrome and Alzheimer's

    Platelets are the main source of 5-hydroxytryptamine (5-HT) and amyloid precursor protein (APP) found in plasma.

  13. X-ray-induced chromatid damage in cells from Down syndrome and Alzheimer disease patients in relation to DNA repair and cancer proneness

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Cancer genetics and cytogenetics 1993-10-01 Down syndrome and Alzheimer's

    Frequencies of chromatid aberrations in response to G2-phase x-irradiation were compared in PHA-stimulated blood lymphocytes from healthy control subjects, Down syndrome (DS) patients, and Alzheimer disease (AD) patients.

  14. Immunoglobulin G subclasses in older persons with Down syndrome

    ✓ Peer-reviewed alzhub usefulness score 35 out of 100. Journal of the neurological sciences 1993-07-01 Down syndrome and Alzheimer's

    IgG subclasses were measured in sera from 33 persons with Down syndrome (DS) (mean age 55 +/- 7 years) and 33 age- and sex-matched control individuals using a mouse monoclonal antibody based sandwich enzyme linked immunosorbent assay.

  15. Down syndrome

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Pediatric clinics of North America 1993-06-01 Down syndrome and Alzheimer's

    Down syndrome remains one of the most common causes of mental retardation.

  16. Neuronal and glial gene expression in neocortex of Down's syndrome and Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 37 out of 100. Journal of neuropathology and experimental neurology 1993-05-01 Biomarkers

    The association cortex of Down's syndrome (DS) predictably and prematurely undergoes neurofibrillary degeneration of Alzheimer type.

  17. Age-associated chromosome 21 loss in Down syndrome: possible relevance to mosaicism and Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 34 out of 100. American journal of medical genetics 1993-03-01 Down syndrome and Alzheimer's

    We previously observed low level mosaicism (2-4% normal cells) in phytohemagglutinin-stimulated peripheral blood lymphocytes (PBL) in 29% of a small group of elderly persons with Down syndrome (DS).

  18. Human carbonyl reductase (CBR) localized to band 21q22.1 by high-resolution fluorescence in situ hybridization displays gene dosage effects in trisomy 21 cells

    ✓ Peer-reviewed alzhub usefulness score 34 out of 100. Genomics 1993-01-01 Down syndrome and Alzheimer's

    Human carbonyl reductase (CBR) belongs to a group of NADPH-dependent enzymes called aldo-keto reductases.

  19. Lack of detectable radiation hypersensitivity in lymphoblastoid cells from multiple pedigrees of familial Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 30 out of 100. Alzheimer disease and associated disorders 1993-01-01 Down syndrome and Alzheimer's

    Recent reports suggest that cultivated nonneuronal cells from individuals with Alzheimer disease (AD) and other specific hereditary neurodegenerative disorders show hypersensitivity to DNA-damaging agents such as x-rays and radiomimetic chemicals.

  20. Segmental trisomy as a mouse model for Down syndrome

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Progress in clinical and biological research 1993-01-01 Down syndrome and Alzheimer's

    Mice trisomic for Chromosome (Chr) 16 have been used extensively as an animal model for human Down Syndrome (Trisomy 21).

  21. [Transgenic mice overexpressing copper-zinc superoxide dismutase: a model for the study of radical mechanisms and aging]

    ✓ Peer-reviewed alzhub usefulness score 32 out of 100. Comptes rendus des seances de la Societe de biologie et de ses filiales 1993-01-01 Down syndrome and Alzheimer's

    It has been suggested that this increment, by accelerating hydrogen peroxide formation, might promote oxidative damage within DS cells and might be involved in the various neurobiological abnormalities found in DS such as premature aging and Alzheimer-type neurological lesions.

  22. Isolation, characterization, and regional mapping of microclones from a human chromosome 21 microdissection library

    ✓ Peer-reviewed alzhub usefulness score 29 out of 100. American journal of human genetics 1992-08-01 Down syndrome and Alzheimer's

    Thirty-four unique-sequence microclones were isolated from a previously described microdissection library of human chromosome 21 and were regionally mapped using a cell hybrid mapping panel which consists of six cell hybrids and divides chromosome 21 into eight regions.

  23. Evidence for a membrane defect in Alzheimer disease brain

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. Proceedings of the National Academy of Sciences of the United States of America 1992-03-01 Down syndrome and Alzheimer's

    To determine whether neurodegeneration in Alzheimer disease brain is associated with degradation of structural cell membrane molecules, we measured tissue levels of the major membrane phospholipids and their metabolites in three cortical areas from postmortem brains of Alzheimer disease patients and matched controls.

  24. Down syndrome: molecular mapping of the congenital heart disease and duodenal stenosis

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. American journal of human genetics 1992-02-01 Down syndrome and Alzheimer's

    Down syndrome (DS) is a major cause of congenital heart and gut disease and mental retardation.

  25. Mouse model of neurodegeneration: atrophy of basal forebrain cholinergic neurons in trisomy 16 transplants

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Proceedings of the National Academy of Sciences of the United States of America 1992-02-01 Down syndrome and Alzheimer's

    Vulnerability of specific brain regions and neuronal populations is a characteristic feature of Alzheimer disease and Down syndrome.

  26. Down syndrome and Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 33 out of 100. Progress in clinical and biological research 1992-01-01 Down syndrome and Alzheimer's

    The brains of individuals with Down's syndrome in their 40's and 50's begin to develop changes that are otherwise seen only in patients with Alzheimer disease.

  27. Characteristics of age-related language decline in adults with Down syndrome

    ✓ Peer-reviewed alzhub usefulness score 34 out of 100. Mental retardation 1991-04-01 Down syndrome and Alzheimer's

    Age-related declines in language and other neuropsychological variables were examined in 60 adults with Down syndrome.

  28. Expression of the amyloid precursor protein gene in mouse oocytes and embryos

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Proceedings of the National Academy of Sciences of the United States of America 1991-03-01 Down syndrome and Alzheimer's

    The amyloid precursor protein (APP) is thought to be processed aberrantly to yield the major constituent of the amyloid plaques observed in the brains of patients with Alzheimer disease and Down syndrome.

  29. Expression of human Cu-Zn superoxide dismutase gene in transgenic mice: model for gene dosage effect in Down syndrome

    ✓ Peer-reviewed alzhub usefulness score 37 out of 100. Free radical research communications 1991-01-01 Down syndrome and Alzheimer's

    It was suggested that increased Cu-Zn superoxide dismutase (SOD-1) might be involved in the various biological abnormalities found in Down's syndrome (DS) such as premature aging and Alzheimer-type neurological lesions.

  30. Familial Alzheimer disease: a large, multigeneration German kindred

    ✓ Peer-reviewed alzhub usefulness score 32 out of 100. Alzheimer disease and associated disorders 1991-01-01 Down syndrome and Alzheimer's

    A German family with 21 members affected by Alzheimer disease (AD) was studied clinically and genetically.

  31. Alzheimer patients and Down patients: abnormal presynaptic terminals are related to cerebral preamyloid deposits

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Neuroscience letters 1990-10-01 Down syndrome and Alzheimer's

    In Alzheimer's disease, in Down syndrome and in normal aging, scattered deposits of amyloid fibril precursors occur in both cerebral cortex and subcortical grey structures.

  32. Cognitive functions in adult Down's syndrome

    ✓ Peer-reviewed alzhub usefulness score 35 out of 100. The International journal of neuroscience 1990-10-01 Down syndrome and Alzheimer's

    Cognitive profiles of performances were obtained from a selected group of adult Down syndrome (DS) subjects (n = 20; mean age: 34.5 years; s.d.: 7.7) by means of an ad hoc neuropsychological battery.

  33. Neuronal plasticity and astrocytic reaction in Down syndrome and Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Journal of the neurological sciences 1990-08-01 Biomarkers

    Proteins relatively enriched in neurons (neural cell adhesion molecule (NCAM) and D3-protein) or in glia (glutamine synthetase, glial fibrillary acidic protein (GFAP) and S100) were measured by quantitative immunochemical methods in autopsy samples of the cerebral cortex of subjects with Alzheimer disease (AD) and adults with Down syndrome (DS), the latter also presenting manifest signs of Alzheimer type of neuropathology.

  34. Brain atrophy in 18 patients with Down syndrome: a CT study

    ✓ Peer-reviewed alzhub usefulness score 33 out of 100. AJNR. American journal of neuroradiology 1990-07-01 Down syndrome and Alzheimer's

    Individuals with Down syndrome develop neuropathologic and in some cases clinical evidence of Alzheimer disease after age 40.

  35. Autoimmune thyroiditis associated with mild "subclinical" hypothyroidism in adults with Down syndrome: a comparison of patients with and without manifestations of Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 35 out of 100. American journal of medical genetics 1990-06-01 Down syndrome and Alzheimer's

    Serum tests of thyroid function were compared in Down syndrome (DS) patients with and without manifestations of Alzheimer disease (AD).

  36. Production and characterization of a monospecific antiserum (A128) to disaggregated Alzheimer paired helical filaments

    ✓ Peer-reviewed alzhub usefulness score 31 out of 100. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1990-05-01 Down syndrome and Alzheimer's

    Paired helical filaments (PHF), which constitute neurofibrillary tangles (NFT) and neuritic plaque (NP) neurites, serve as a useful marker for Alzheimer disease (AD).

  37. Red cell superoxide dismutase, glutathione peroxidase and catalase in Down syndrome patients with and without manifestations of Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. American journal of medical genetics 1990-04-01 Down syndrome and Alzheimer's

    The activities of red blood cell enzymes that scavenge the superoxide radical and hydrogen peroxide were measured in severely to profoundly retarded adult Down syndrome (DS) patients with and without manifestations of Alzheimer disease (AD), and control individuals matched for sex, age, and time of blood sampling.

  38. Defective gallium-transferrin binding in Alzheimer disease and Down syndrome: possible mechanism for accumulation of aluminium in brain

    ✓ Peer-reviewed alzhub usefulness score 44 out of 100. Lancet (London, England) 1990-03-01 Down syndrome and Alzheimer's

    The plasma distribution of gallium (as an analogue of aluminium) was investigated in patients with Alzheimer disease, Down syndrome, or stroke dementia, in subjects on haemodialysis for chronic renal failure, and in healthy controls.

  39. Growth properties and in vitro life span of Alzheimer disease and Down syndrome fibroblasts. A blind study

    ✓ Peer-reviewed alzhub usefulness score 30 out of 100. Mechanisms of ageing and development 1990-03-01 Down syndrome and Alzheimer's

    A blind study was set up to examine the in vitro growth characteristics of skin fibroblasts from 2 individuals with and 9 at risk for familial Alzheimer disease, 4 individuals with sporadic Alzheimer disease, 18 with Down syndrome as well as 5 younger and 6 older controls.

  40. Regional cerebral glucose metabolism is normal in young adults with Down syndrome

    ✓ Peer-reviewed alzhub usefulness score 42 out of 100. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1990-03-01 Down syndrome and Alzheimer's

    Regional CMRglc (rCMRglc) values were measured with [18F]2-fluoro-2-deoxy-D-glucose (18FDG) and positron emission tomography (PET), using a Scanditronix PC-1024-7B scanner, in 14 healthy, noninstitutionalized subjects with trisomy 21 (Down syndrome; DS) (mean age 30.0 years, range 25-38 years) and in 13 sex-matched, healthy volunteers (mean age 29.5 years, range 22-38 years).

  41. The natural history of dementia in Down's syndrome

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. Archives of neurology 1990-03-01 Digital health tools

    In a prospective longitudinal study with death as the end point in 17 middle-aged patients with Down's syndrome, dementia was clinically diagnosed in 15 patients, by means of careful observations in daily circumstances.

  42. Clinical aspects of Down syndrome from infancy to adulthood

    ✓ Peer-reviewed alzhub usefulness score 34 out of 100. American journal of medical genetics. Supplement 1990-01-01 Down syndrome and Alzheimer's

    In past decades, most individuals with Down syndrome were usually not afforded adequate medical care.

  43. Developmental and aging changes in the expression patterns of beta-amyloid in the brains of normal and Down syndrome cases

    ✓ Peer-reviewed alzhub usefulness score 32 out of 100. Brain & development 1990-01-01 Down syndrome and Alzheimer's

    Immunohistochemical staining with polyclonal antibodies to synthetic amyloid (residues 1-28 of A4) was performed on normal and Down syndrome brains from fetuses to adults.

  44. Neuropathology of Down syndrome and Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. American journal of medical genetics. Supplement 1990-01-01 Down syndrome and Alzheimer's

    Patients with Down syndrome (DS) over 40 years of age, prematurely and consistently develop neurofibrillary tangles (NFT), intracytoplasmic inclusions of highly insoluble straight or paired helical 12-16 nm filaments, and senile plaques (SP) composed of abnormal neurites surrounding a core of beta amyloid.

  45. Study of spindle microtubule reassembly in cells from Alzheimer and Down syndrome patients following exposure to colcemid

    ✓ Peer-reviewed alzhub usefulness score 30 out of 100. Alzheimer disease and associated disorders 1990-01-01 Down syndrome and Alzheimer's

    Numerous intraneuronal neurofibrillary tangles and senile (neuritic) plaques are the two characteristic lesions in Alzheimer disease (AD) and adult Down syndrome (DS).

  46. The consequences of chromosome imbalance

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. American journal of medical genetics. Supplement 1990-01-01 Down syndrome and Alzheimer's

    Review of the clinical cytogenetic literature provides compelling evidence for a specific relationship between imbalance of particular chromosomes or chromosomal regions and the appearance of defined patterns of phenotypic abnormalities.

  47. Construction of human chromosome 21-specific yeast artificial chromosomes

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Proceedings of the National Academy of Sciences of the United States of America 1989-12-01 Down syndrome and Alzheimer's

    Chromosome 21-specific yeast artificial chromosomes (YACs) have been constructed by a method that performs all steps in agarose, allowing size selection by pulsed-field gel electrophoresis and the use of nanogram to microgram quantities of DNA.

  48. Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Proceedings of the National Academy of Sciences of the United States of America 1989-10-01 Down syndrome and Alzheimer's

    Interleukin 1, an immune response-generated cytokine that stimulates astrocyte proliferation and reactivity (astrogliosis), was present in up to 30 times as many glial cells in tissue sections of brain from patients with Down syndrome and Alzheimer disease compared with age-matched control subjects.

  49. [The significance of measurement of contents of serum serine protease inhibitors in senile dementia of the Alzheimer type]

    ✓ Peer-reviewed alzhub usefulness score 31 out of 100. Rinsho shinkeigaku = Clinical neurology 1989-10-01 Down syndrome and Alzheimer's

    We have evaluated serum alpha 1-antichymotrypsin content in dementia of the Alzheimer type (DAT).

  50. Genetic studies support a neuronal origin for the beta amyloid polypeptide

    ✓ Peer-reviewed alzhub usefulness score 32 out of 100. Neurobiology of aging 1989-09-01 Down syndrome and Alzheimer's

    Studies of Alzheimer amyloid protein precursor mRNA expression in the human brain have provided compelling evidence for a neural origin of beta amyloid.

From across this tag

9 of the 527 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 9. The same 9 appear here every time.

All topic tags with their study counts