alzhub.org
Get help now — free helplines

You can call any of these for free. You do not need a diagnosis, an appointment, or a crisis to call — questions and plain exhaustion are reasons enough.

  • Alzheimer's Association 24/7 Helpline 800-272-3900 24 hours a day, 365 days a year Free, confidential support and information for people with dementia, caregivers, families and the public. Master's-level clinicians. Also Spanish.
  • 988 Suicide & Crisis Lifeline 988 24/7 Call or text 988, or chat at 988lifeline.org. For anyone in emotional distress or a mental-health crisis, including caregivers.
  • Alzheimer's Foundation of America (AFA) Helpline 866-232-8484 9:00 am - 9:00 pm ET, seven days a week Licensed social workers providing support, info and referrals. Also text message and web chat. Text: 646-586-5283

In a medical emergency, call 911. More numbers, and what each line does, on the help page.

Home › Research › Topics › down

down

534 studies tagged down, dated 1975-09-01 to 2026-10-30. Bibliography: BibTeX (.bib) · RIS (.ris)

Newest in this topic

  1. Differential endothelial cell remodeling in Down syndrome and APP duplication drives distinct blood brain barrier dysfunction 2026-10-30
  2. Memory and Plasma pTau217 Refine Prognosis in Down Syndrome 2026-10-02
  3. Tau extent is associated with lower cognition in Down syndrome-related Alzheimer's disease 2026-10-01

Studies

534 studies carry this tag.

Date range

1975 to 2026

Top journals

  • Proceedings of the National Academy of Sciences of the United States of America 21
  • Alzheimer s & Dementia 20
  • Alzheimer's & dementia : the journal of the Alzheimer's Association 15
  • Neurology 14
  • Neuroscience letters 14

239 journals in all.

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. A prospective study of Alzheimer disease in Down syndrome

    ✓ Peer-reviewed alzhub usefulness score 49 out of 100. Archives of neurology 1989-08-01 How common it is

    Ninety-six individuals with Down syndrome over age 35 years were evaluated and followed up for evidence of nontreatable dementia.

  2. Absence of familial association between dementia of Alzheimer type and Down syndrome

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. American journal of medical genetics 1989-08-01 Down syndrome and Alzheimer's

    The aim of this study was to test whether there is an excess of dementia of Alzheimer type (DAT) cases in Down syndrome (DS) relatives.

  3. The Alzheimer amyloid precursor protein maps to human chromosome 21 bands q21.105-q21.05

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Genomics 1989-07-01 Down syndrome and Alzheimer's

    The Alzheimer amyloid protein precursor (APP) has previously been localized to human chromosome 21q11.2-q21.

  4. Radioresistant DNA synthesis and human genetic diseases

    ✓ Peer-reviewed alzhub usefulness score 35 out of 100. Human genetics 1989-05-01 Down syndrome and Alzheimer's

    Sixty-eight human fibroblast cell strains were assayed for radioresistant DNA synthesis (RDS), which is defined here as the absence of a steep component of inhibition of DNA synthesis in a dose-response curve when rate of DNA synthesis is plotted against radiation doses from 0 to 20 Gy or more.

  5. Alzheimer-type neuropathology and clinical symptoms of dementia in mentally retarded people without Down syndrome

    ✓ Peer-reviewed alzhub usefulness score 35 out of 100. American journal of mental retardation : AJMR 1989-03-01 Down syndrome and Alzheimer's

    Postmortem morphometric analyses of Bielschowsky stained sections from brains of 70 mentally retarded people without Down syndrome, age 65 and over when they died, indicated Alzheimer-type neuropathology in 22 cases (31%) and a majority with at least presence of some Alzheimer-type lesions.

  6. Beta-amyloid protein probe hybridized to chromosome 9 in 3 Alzheimer disease individuals

    ✓ Peer-reviewed alzhub usefulness score 25 out of 100. Progress in clinical and biological research 1989-01-01 Down syndrome and Alzheimer's

    We have reported recently the sublocalization of an Alzheimer Disease-associated gene that encodes for cerebrovascular beta-amyloid protein (BAP).

  7. Cerebral extracellular preamyloid deposits in Alzheimer's disease, Down syndrome and nondemented elderly individuals

    ✓ Peer-reviewed alzhub usefulness score 27 out of 100. Progress in clinical and biological research 1989-01-01 Down syndrome and Alzheimer's

    Using anti-SP28 (a polyclonal antibody to a 28 residue synthetic peptide homologous to the NH2-terminal region of Alzheimer amyloid beta-protein) to investigate the cerebral cortex of 8 Alzheimer and 6 Down patients and 13 nondemented individuals, we found that, besides senile plaques and congophilic vessels, extracellular deposits unrelated to degenerating neurites, tangle-bearing neurons or congophilic vessels were labelled.

  8. Dendrites, dementia and the Down syndrome

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Brain & development 1989-01-01 Down syndrome and Alzheimer's

    The dendritic atrophy seen in childhood continued into adulthood, with a marked decrease in dendritic branching, dendritic length, and spine frequency in elderly adults with the Down syndrome.

  9. Molecular genetics of Alzheimer's disease and the amyloid beta peptide precursor gene

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Annals of medicine 1989-01-01 Down syndrome and Alzheimer's

    Alzheimer's disease is a neurodegenerative disorder characterized by global cognitive decline.

  10. Mapping of the gene encoding the beta-amyloid precursor protein and its relationship to the Down syndrome region of chromosome 21

    ✓ Peer-reviewed alzhub usefulness score 44 out of 100. Proceedings of the National Academy of Sciences of the United States of America 1988-11-01 Down syndrome and Alzheimer's

    The gene encoding the beta-amyloid precursor protein has been assigned to human chromosome 21, as has a gene responsible for at least some cases of familial Alzheimer disease.

  11. Human ETS2 gene on chromosome 21 is not rearranged in Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 34 out of 100. Proceedings of the National Academy of Sciences of the United States of America 1988-10-01 Down syndrome and Alzheimer's

    The human ETS2 gene, a member of the ETS gene family, with sequence homology with the retroviral ets sequence of the avian erythroblastosis retrovirus E26 is located on chromosome 21.

  12. Comparative mapping of DNA markers from the familial Alzheimer disease and Down syndrome regions of human chromosome 21 to mouse chromosomes 16 and 17

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. Proceedings of the National Academy of Sciences of the United States of America 1988-08-01 Down syndrome and Alzheimer's

    Mouse trisomy 16 has been proposed as an animal model of Down syndrome (DS), since this chromosome contains homologues of several loci from the q22 band of human chromosome 21.

  13. Reexpression of a developmentally regulated antigen in Down syndrome and Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Proceedings of the National Academy of Sciences of the United States of America 1988-08-01 Down syndrome and Alzheimer's

    ALZ-50 is a monoclonal antibody that recognizes a protein of apparent molecular mass 68 kilodaltons (A68).

  14. Digital and palmar dermatoglyphics in dementia of the Alzheimer type

    ✓ Peer-reviewed alzhub usefulness score 32 out of 100. American journal of medical genetics 1988-07-01 Down syndrome and Alzheimer's

    Digital and palmar dermatoglyphics were examined in 29 men and 27 women with dementia of the Alzheimer type (DAT) and 112 age-, sex-, and racial group-matched controls.

  15. The pathological association between Down syndrome and Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 44 out of 100. Mechanisms of ageing and development 1988-05-01 Down syndrome and Alzheimer's

    The neuropathology of Down syndrome (DS) at middle age is compared with that of Alzheimer disease (AD) at that age, through a review of the published literature and from the author's personal observations on brains from a series of patients of different ages with DS.

  16. Serum IgG brain reactive antibodies in Alzheimer disease and Down syndrome

    ✓ Peer-reviewed alzhub usefulness score 34 out of 100. Alzheimer disease and associated disorders 1988-01-01 Down syndrome and Alzheimer's

    The cause(s) of Alzheimer disease (AD) remain unknown.

  17. Hereditary cerebral hemorrhage with amyloidosis in patients of Dutch origin is related to Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 44 out of 100. Proceedings of the National Academy of Sciences of the United States of America 1987-08-01 Down syndrome and Alzheimer's

    Hereditary cerebral hemorrhage with amyloidosis in Dutch patients is an autosomal dominant form of vascular amyloidosis restricted to the leptomeninges and cerebral cortex.

  18. Molecular cloning and characterization of a cDNA encoding the cerebrovascular and the neuritic plaque amyloid peptides

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Proceedings of the National Academy of Sciences of the United States of America 1987-06-01 Down syndrome and Alzheimer's

    Deposits of amyloid fibers are found in large numbers in the walls of blood vessels and in neuritic plaques in the brains of patients with Alzheimer disease and adults with Down syndrome.

  19. Amyloid of neurofibrillary tangles of Guamanian parkinsonism-dementia and Alzheimer disease share identical amino acid sequence

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Proceedings of the National Academy of Sciences of the United States of America 1987-04-01 Down syndrome and Alzheimer's

    The presence of abundant intraneuronal amyloid in the form of neurofibrillary tangles (NFT) in the brains of Guamanian parkinsonism-dementia patients and the absence of extraneuronal amyloid in the form of vascular amyloid deposits or senile plaques permit the purification of NFT without contamination with extraneuronal amyloid.

  20. The mouse homolog of the human amyloid beta protein (AD-AP) gene is located on the distal end of mouse chromosome 16: further extension of the homology between human chromosome 21 and mouse chromosome 16

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Biochemical and biophysical research communications 1987-04-01 Down syndrome and Alzheimer's

    The human amyloid beta protein is the major constituent of the brain amyloid plaques found in Alzheimer disease.

  21. The mortality of adults with Down syndrome as a function of age

    ✓ Peer-reviewed alzhub usefulness score 27 out of 100. Mechanisms of ageing and development 1986-11-01 Down syndrome and Alzheimer's

    This study sought to test the hypothesis that adults with Down Syndrome may age faster than the general population by comparing the rate of increase in their mortality with age with that of the general population by the method originally described by Gompertz.

  22. Alzheimer's disease in Down's syndrome: clinicopathologic studies

    ✓ Peer-reviewed alzhub usefulness score 61 out of 100. Neurology 1985-07-01 Getting a diagnosis

    Clinical and neuropathologic evidence points to the development of Alzheimer's disease (AD) in seven Down's syndrome patients above age 40.

  23. Amyloid plaque core protein in Alzheimer disease and Down syndrome

    ✓ Peer-reviewed alzhub usefulness score 56 out of 100. Proceedings of the National Academy of Sciences of the United States of America 1985-06-01 Down syndrome and Alzheimer's

    We have purified and characterized the cerebral amyloid protein that forms the plaque core in Alzheimer disease and in aged individuals with Down syndrome.

  24. Hypersensitivity to ionizing radiation in cultured cells from Down syndrome patients

    ✓ Peer-reviewed alzhub usefulness score 35 out of 100. Journal of the neurological sciences 1985-05-01 Down syndrome and Alzheimer's

    Down syndrome is caused by trisomy of chromosome 21 and is comprised of a constellation of abnormalities including neuropathological features that closely resemble those characterizing the neurodegeneration of Alzheimer disease.

  25. Occurrence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome

    ✓ Peer-reviewed alzhub usefulness score 56 out of 100. Annals of Neurology 1985-03-01 Down syndrome and Alzheimer's

    One hundred brains of patients with Down's syndrome (DS) who died in institutions for chronic care were examined for clinicopathological correlation of Alzheimer's disease.

  26. Alzheimer's disease and Down's syndrome: Sharing of a unique cerebrovascular amyloid fibril protein

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Biochemical and Biophysical Research Communications 1984-08-01 Down syndrome and Alzheimer's

  27. Decreased pyruvate dehydrogenase complex activity in Huntington and Alzheimer brain

    ✓ Peer-reviewed alzhub usefulness score 51 out of 100. Annals of neurology 1983-01-01 Down syndrome and Alzheimer's

    The activity of the pyruvate dehydrogenase complex (PDHC) was reduced in affected areas of brain from patients with Huntington disease (caudate, putamen) and Alzheimer disease (frontal cortex) where choline acetyltransferase (CAT) activity was low.

  28. Development of Alzheimer disease in Down syndrome individuals

    ✓ Peer-reviewed alzhub usefulness score 34 out of 100. American journal of mental deficiency 1983-01-01 Down syndrome and Alzheimer's

    Because of their initially low levels of mental functioning, Down syndrome persons' clinical symptoms frequently go undetected until the disease is advanced and deterioration severe.

  29. The clinical features and classification of the late onset autosomal dominant cerebellar ataxias. A study of 11 families, including descendants of the 'the Drew family of Walworth'

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Brain : a journal of neurology 1982-03-01 Brain tissue and pathology

    The clinical features of 11 families containing 73 individuals with dominantly inherited cerebellar ataxia of late onset are described.

  30. Relationship between plaques, tangles, and dementia in Down syndrome

    ✓ Peer-reviewed alzhub usefulness score 51 out of 100. Neurology 1980-06-01 Down syndrome and Alzheimer's

    In patients with Down syndrome, senile plaques and neurofibrillary tangles accumulate in the cortex at an earlier age than in persons of normal karyotype.

  31. Neurofibrillary tangles, granulovacuolar degeneration, and neuron loss in Down Syndrome: quantitative comparison with Alzheimer dementia

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Annals of neurology 1980-05-01 Down syndrome and Alzheimer's

    The degree of neurofibrillary tangle formation, granulovascuolar degeneration, and nerve cell loss was quantified in serial sections of the hippocampal formation from the brains of 5 adults dying with Down syndrome (monogolism).

  32. Studies in aging of the brain: IV. Familial Alzheimer disease: Relation to transmissible dementia, aneuploidy, and microtubular defects

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Neurology 1979-10-01 Down syndrome and Alzheimer's

    Alzheimer disease was transmitted in a pattern consistent with an autosomal dominant trait in three families.

  33. Alzheimer neurofibrillary tangles in diseases other than senile and presenile dementia

    ✓ Peer-reviewed alzhub usefulness score 42 out of 100. Annals of neurology 1979-03-01 Down syndrome and Alzheimer's

    A brief description is given of neurofibrillary changes of the paired helical filament type in a variety of chronic neurological diseases.

  34. Alzheimer degeneration in Down syndrome. Electrophysiologic alterations and histopathologic findings

    ✓ Peer-reviewed alzhub usefulness score 37 out of 100. Archives of neurology 1975-09-01 Down syndrome and Alzheimer's

    Progressive electroencephalographic disorganization and decreased voltage amplitude in the late components of the averaged visual evoked potentials were recorded in the last two years of life of a patient with Down disease and Alzheimer degeneration.

From across this tag

10 of the 527 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.

All topic tags with their study counts