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disorder
492 studies tagged disorder, dated 1986-01-01 to 2026-03-31. Bibliography: BibTeX (.bib) · RIS (.ris)
Newest in this topic
- Synaptic loss in alcohol use disorder: clinical and mechanistic insights from a PET imaging study 2026-03-31
- Neighborhood environmental deprivation predicts the generalized neurocognitive deficit in schizophrenia 2025-12-19
- Bridging the Gap: Can Hippocampal Sclerosis Serve as a Surrogate Biomarker for LATE‐NC? 2025-12-01
Studies
492 studies carry this tag.
Date range
1986 to 2026
Top journals
- Neurology 38
- Biological psychiatry 36
- NeuroImage 32
- The American journal of psychiatry 22
- Proceedings of the National Academy of Sciences of the United States of America 20
148 journals in all.
Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.
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Several neuropsychiatric disorders involving hippocampal structural changes have been studied extensively using volumetric magnetic resonance imaging (MRI).
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Glucocorticoids (GCs) are hormones secreted by the adrenal glands as an endocrine response to stress.
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Expert manual hippocampal volumetry is more sensitive than both automated methods for the detection of hippocampal atrophy associated with mTLE.
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The effects of early life experience on later brain structure and function have been studied extensively in animals, yet the relationship between childhood experience and normal brain development in humans remains largely unknown.
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Elevated glucocorticoid concentrations, decreased hippocampal volume and frontal atrophy with poor cognitive function have been reported in the elderly but not extensively in Alzheimer's disease (AD).
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We examined the effects of voluntary (16 weeks of wheel running) and forced (16 weeks of treadmill running) exercise on memory-related behavior, hippocampal volume, thioflavine-stained plaque number, and soluble Abeta levels in brain tissue in the Tg2576 mouse model of Alzheimer's disease (AD).
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Early identification of patterns of abnormality is of fundamental importance for detecting disease onset and tracking progression.
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Cognitive deficits and hippocampal atrophy, features that are shared with aging and dementia, have been described in type 2 diabetes mellitus (T2DM).
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Due to its crucial role for memory processes and its relevance in neurological and psychiatric disorders, the hippocampus has been the focus of neuroimaging research for several decades.
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The adoption into the UK of children who have been reared in severely deprived conditions provides an opportunity to study possible association between very early negative experiences and subsequent brain development.
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Imaging techniques are a potentially powerful method of identifying phenotypes that are associated with, or are indicative of, a vulnerability to developing major depressive disorder (MDD).
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This study demonstrates that the impact of the BDNF Val66Met polymorphism is not confined to the hippocampus but also extends to the parahippocampal gyrus and the amygdala.
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Chronic stress decreases neurogenesis in the adult brain, while exposure to enriched environment (EE) increases it.
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Adult neurogenesis, particularly in the subgranular zone, is thought to be linked with learning and memory.
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Whole brain atrophy rate discriminates Alzheimer disease (AD) from MCI.
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We present a multivariate alternative to the voxel-based morphometry (VBM) approach called source-based morphometry (SBM), to study gray matter differences between patients and healthy controls.
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Hippocampal volume change over time, measured with MRI, has huge potential as a marker for Alzheimer's disease.
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43/100
The pattern of thinning in TLE-no was different from the pattern in TLE-MTS.
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Chronic exposure to stress results in a reduction of hippocampal neurogenesis and of hippocampal volume.
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Our data shows that early environment has a critical influence on establishing sex differences in neural plasticity and supports the concept that the setpoint for neurogenesis may be determined during perinatal life.
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There is emerging evidence from healthy individuals, as well as direct and indirect evidence from psychiatric and neurological patients with disease-related hippocampal atrophy, linking the cortisol awakening response (CAR) to hippocampal volume.
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Although all studies were cross-sectional, our results suggest that hippocampal volume reductions generally occur after disease onset in patients with MDD.
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Conjugated equine estrogens with or without MPA are associated with greater brain atrophy among women aged 65 years and older; however, the adverse effects are most evident in women experiencing cognitive deficits before initiating hormone therapy.
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The MRI and 1H MRS findings in single-domain aMCI are consistent with a pattern similar to that of Alzheimer disease.
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A state related increase of amygdala volume can be detected early in the course of MDD.
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Using VBM-DARTEL, when corrected for multiple comparisons, significant volume differences were detected between groups in different regions and more specifically in hippocampus with ROI analyses.
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Children with prenatal alcohol exposure (PAE) show deficits in verbal learning and spatial memory, as well as abnormal hippocampal development.
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Odor identification deficits occur in Alzheimer's disease (AD) and mild cognitive impairment (MCI), and predict clinical conversion from MCI to AD.
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47/100
The results suggest that structural compromise to multiple fiber tracts is associated with memory and language impairments in patients with temporal lobe epilepsy.
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Epidemiological data suggest that omega-3 polyunsaturated fatty acids (PUFA) consumption may be inversely correlated to the prevalence and severity of depression but little is known about the underlying mechanisms.
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The brain-derived neurotrophic factor gene (BDNF) is one of many genes thought to influence synaptic plasticity in the adult brain and shows a common single nucleotide polymorphism (BDNF Val66Met) in the normal population that is associated with differences in hippocampal volume and episodic memory.
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This study (n=161) related morphometric MR imaging, FDG-PET and APOE genotype to memory scores in normal controls (NC), mild cognitive impairment (MCI) and Alzheimer's disease (AD).
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Subjective cognitive failures (SCF) are associated with lower hippocampal volume, even in subjects without objective cognitive impairment and independent of white matter lesions.
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Overall, our results suggest that a relatively small hippocampal volume may be a vulnerability factor for a bad treatment response in major depression.
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Atrophy of hippocampus and alteration of resting eyes-closed electroencephalographic (EEG) rhythms represent important features of mild cognitive impairment (MCI) and Alzheimer's disease (AD).
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36/100
Since hippocampal volume has been found to be an early biomarker for Alzheimer's disease, there is large interest in automated methods to accurately, robustly, and reproducibly extract the hippocampus from MRI data.
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High level of complex mental activity across the lifespan was correlated with a reduced rate of hippocampal atrophy.
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Childhood trauma is a potent risk factor for developing depression in adulthood, particularly in response to additional stress.
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These results provide new evidence of exposure-related structural abnormalities in the hippocampus and amygdala in long-term heavy cannabis users and corroborate similar findings in the animal literature.
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We investigated in a population-based cohort study the association of global and lobar brain tissue volumes with specific cognitive domains and risk of dementia.
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Temporal lobe epilepsy (TLE) is considered primarily a limbic disorder.
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This is the first study to show aberrant regulation of the protein synthesis machinery in the suicide brain.
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Hippocampal volumes were reduced in PT infants exposed to several perinatal events but were preserved in PT infants without these exposures.
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The automated hippocampal volumetric methods showed good agreement with manual hippocampal volumetry, but the volume measured using FreeSurfer was 35% larger and the agreement was questionable with IBASPM.
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The hippocampus is known to be vulnerable to hypoxia, stress, and undernutrition, all likely to be present in fetal intrauterine growth restriction (IUGR).
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A dysregulated hypothalamic-pituitary-adrenal axis (HPA) has been implicated in major depressive disorder and most commonly used animal models of depression have been shown to elevate circulating levels of plasma corticosterone.
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The hippocampus is the brain structure of highest and earliest structural alteration in Alzheimer's disease (AD).
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Little work has directly examined the course of hippocampal volume in children and adults with childhood maltreatment-related posttraumatic stress disorder (PTSD).
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Volumetric MRI scans from 26 women with repeated episodes of childhood sexual abuse and 17 healthy female comparison subjects (ages 18-22 years) were analyzed for sensitive period effects on hippocampal and amygdala volume, frontal cortex gray matter volume and corpus callosum area.
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Posttraumatic stress disorder (PTSD) is associated with long-term changes in neurobiology.
From across this tag
8 of the 492 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 8. The same 8 appear here every time.
- Decrease in cortisol reverses human hippocampal atrophy following treatment of Cushing's disease
- Higher RBC EPA + DHA corresponds with larger total brain and hippocampal volumes: WHIMS-MRI study
- Hippocampal changes associated with early-life adversity and vulnerability to depression
- Hippocampal hypocellularity in the Ts65Dn mouse originates early in development
- Brain morphology and schizophrenia. A magnetic resonance imaging study of limbic, prefrontal cortex, and caudate structures
- Bridging the Gap: Can Hippocampal Sclerosis Serve as a Surrogate Biomarker for LATE‐NC?
- The possibility of neurotoxicity in the hippocampus in major depression: a primer on neuron death
- Navigation expertise and the human hippocampus: a structural brain imaging analysis