Get help now — free helplines

You can call any of these for free. You do not need a diagnosis, an appointment, or a crisis to call — questions and plain exhaustion are reasons enough.

  • Alzheimer's Association 24/7 Helpline 800-272-3900 24 hours a day, 365 days a year Free, confidential support and information for people with dementia, caregivers, families and the public. Master's-level clinicians. Also Spanish.
  • 988 Suicide & Crisis Lifeline 988 24/7 Call or text 988, or chat at 988lifeline.org. For anyone in emotional distress or a mental-health crisis, including caregivers.
  • Alzheimer's Foundation of America (AFA) Helpline 866-232-8484 9:00 am - 9:00 pm ET, seven days a week Licensed social workers providing support, info and referrals. Also text message and web chat. Text: 646-586-5283

In a medical emergency, call 911. More numbers, and what each line does, on the help page.

Newest in this topic

  1. Synaptic loss in alcohol use disorder: clinical and mechanistic insights from a PET imaging study 2026-03-31
  2. Neighborhood environmental deprivation predicts the generalized neurocognitive deficit in schizophrenia 2025-12-19
  3. Bridging the Gap: Can Hippocampal Sclerosis Serve as a Surrogate Biomarker for LATE‐NC? 2025-12-01

Studies

492 studies carry this tag.

Date range

1986 to 2026

Top journals

  • Neurology 38
  • Biological psychiatry 36
  • NeuroImage 32
  • The American journal of psychiatry 22
  • Proceedings of the National Academy of Sciences of the United States of America 20

148 journals in all.

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. Sexual dimorphism of the developing human brain

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Progress in neuro-psychopharmacology & biological psychiatry 1997-11-01 Hippocampus size on brain scans

    1. Sexual dimorphism of human brain anatomy has not been well-studied between 4 and 18 years of age, a time of emerging sex differences in behavior and the sexually specific hormonal changes of adrenarche (the predominantly androgenic augmentation of adrenal cortex function occurring at approximately age 8) and puberty. 2.

  2. Detection and mapping of abnormal brain structure with a probabilistic atlas of cortical surfaces

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Journal of computer assisted tomography 1997-07-01 Brain scans and imaging

    Applications of the random fluid-based probabilistic atlas include the transfer of multisubject 3D functional, vascular, and histologic maps onto a single anatomic template, the mapping of 3D atlases onto the scans of new subjects, and the rapid detection, quantification, and mapping of local shape changes in 3D medical images in disease and during normal or abnormal growth and development.

  3. Hippocampal volume in women victimized by childhood sexual abuse

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Psychological medicine 1997-07-01 Hippocampus size on brain scans

    These findings, which are generally consistent with prior reports of reduced hippocampal volume in combat veterans with PTSD, suggest that diminished hippocampal size may be either a consequence of trauma exposure or a risk factor for the development of psychiatric complications following trauma exposure.

  4. Stress effects on morphology and function of the hippocampus

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Annals of the New York Academy of Sciences 1997-06-01 Clinical safety

    The hippocampal formation, which contains high levels of adrenal steroid receptors, is vulnerable to insults such as stroke, seizures, and head trauma, and it is also sensitive and vulnerable to the effects of stress.

  5. Cortical and hippocampal volume deficits in temporal lobe epilepsy

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Epilepsia 1997-05-01 Hippocampus size on brain scans

    Extrahippocampal volume abnormalities were bilateral and occurred in both temporal and extra-temporal cortical regions in TLE, whereas hippocampal deficits were related to the side of the epileptogenic focus.

  6. Apolipoprotein E epsilon 4 allele and hippocampal volume in twins with normal cognition

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Neurology 1997-04-01 Hippocampus size on brain scans

    We examined the relation of APOE-epsilon 4, hippocampal volume, and cognitive performance in ten pairs of cognitively normal twins who had a mean age of 62.5 years (SD = 7.8).

  7. Specific hippocampal volume reductions in individuals at risk for Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. Neurobiology of aging 1997-03-01 Getting a diagnosis

    Our goal was to ascertain the involvement of the temporal lobe in the preclinical (not yet diagnosable) stages of dementia of the Alzheimer's type (DAT) by using MRI-derived volumes.

  8. Volume and number of neurons of the human hippocampal formation in normal aging and Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 49 out of 100. The Journal of comparative neurology 1997-03-01 Getting a diagnosis

    In order to observe changes owing to aging and Alzheimer's disease (AD) in the volumes of subdivisions of the hippocampus and the number of neurons of the hippocampal formation, 18 normal brains from subjects who died of nonneurological causes and had no history of long-term illness or dementia (ten of these brains comprised the aged control group) and 13 AD brains were analyzed.

  9. Chronic histopathological consequences of fluid-percussion brain injury in rats: effects of post-traumatic hypothermia

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Acta neuropathologica 1997-02-01 Hippocampus size on brain scans

    Early outcome measures of experimental traumatic brain injury (TBI) are useful for characterizing the traumatic severity as well as for clarifying the pathomechanisms underlying patterns of neuronal vulnerability.

  10. Chronic alcohol consumption does not cause hippocampal neuron loss in humans

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Hippocampus 1997-01-01 Hippocampus size on brain scans

    High alcohol consumption for long periods of time causes significant hippocampal neurodegeneration in rodents.

  11. Hippocampal volume in normal aging and traumatic brain injury

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. AJNR. American journal of neuroradiology 1997-01-01 Hippocampus size on brain scans

    Volumetric measures in a group of patients with traumatic brain injury who had received MR imaging 3 months or less after injury were compared with measurements in other patients in the chronic phase of recovery.

  12. Magnetic resonance imaging-based measurement of hippocampal volume in posttraumatic stress disorder related to childhood physical and sexual abuse--a preliminary report

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Biological psychiatry 1997-01-01 Hippocampus size on brain scans

    We have previously reported smaller hippocampal volume and deficits in short-term memory in patients with combat-related posttraumatic stress disorder (PTSD) relative to comparison subjects.

  13. The spectrum of hippocampal sclerosis: a quantitative magnetic resonance imaging study

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Annals of neurology 1997-01-01 Hippocampus size on brain scans

    One hundred patients with intractable temporal lobe epilepsy and 22 control subjects were scanned on a 1.5-T Siemens SP63 Magnetom scanner.

  14. Magnetic resonance imaging study of hippocampal volume in chronic, combat-related posttraumatic stress disorder

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Biological psychiatry 1996-12-01 Hippocampus size on brain scans

    This study used quantitative volumetric magnetic resonance imaging techniques to explore the neuroanatomic correlates of chronic, combat-related posttraumatic stress disorder (PTSD) in seven Vietnam veterans with PTSD compared with seven nonPTSD combat veterans and eight normal nonveterans.

  15. Regionally specific pattern of neurochemical pathology in schizophrenia as assessed by multislice proton magnetic resonance spectroscopic imaging

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The American journal of psychiatry 1996-12-01 Hippocampus size on brain scans

    NAA-relative signal intensity reductions in schizophrenia appear to be remarkably localized, involving primarily the hippocampal region and the dorsolateral prefrontal cortex, two regions implicated prominently in the pathophysiology of this disorder.

  16. Corticobasal degeneration with primary progressive aphasia and accentuated cortical lesion in superior temporal gyrus: case report and review

    ✓ Peer-reviewed alzhub usefulness score 42 out of 100. Acta neuropathologica 1996-11-01 Digital health tools

    A 57-year-old woman showed progressive sensory aphasia as an initial symptom, and then developed total aphasia within 6 years and, finally, severe dementia.

  17. Hippocampal atrophy in recurrent major depression

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Proceedings of the National Academy of Sciences of the United States of America 1996-04-01 Hippocampus size on brain scans

    Hippocampal volumes of subjects with a history of major depressive episodes but currently in remission and with no known medical comorbidity were compared to matched normal controls by using volumetric magnetic resonance images.

  18. 1H-MRS, MRI-based hippocampal volumetry, and 99mTc-HMPAO-SPECT in normal aging, age-associated memory impairment, and probable Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 42 out of 100. Journal of the American Geriatrics Society 1996-02-01 Brain scans and imaging

    1H-MRS showed significantly lower N-acetylasparatate concentration in DAT and AAMI compared with controls.

  19. Spatial learning with a minislab in the dorsal hippocampus

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Proceedings of the National Academy of Sciences of the United States of America 1995-10-01 Hippocampus size on brain scans

    We have determined the volume and location of hippocampal tissue required for normal acquisition of a spatial memory task.

  20. Anterior hippocampal volume reductions predict frontal lobe dysfunction in first episode schizophrenia

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Schizophrenia research 1995-09-01 Hippocampus size on brain scans

    This study examined relations of mesiotemporal lobe tissue volumes with neuropsychological (NP) functions in a sample of patients with first episode schizophrenia.

  21. MRI-based measurement of hippocampal volume in patients with combat-related posttraumatic stress disorder

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The American journal of psychiatry 1995-07-01 Hippocampus size on brain scans

    These findings are consistent with a smaller right hippocampal volume in PTSD that is associated with functional deficits in verbal memory.

  22. Cerebral cortical dysgenesis (CD) is a heterogeneous disorder of cortical development and organization commonly associated with epilepsy, with a variety of subtypes.

  23. Seasonal variation in hippocampal volume in a food-storing bird, the black-capped chickadee

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of neurobiology 1995-05-01 Hippocampus size on brain scans

    Black-capped chickadees (Parus atricapillus) in upstate New York show a peak in food-hoarding intensity in October.

  24. Methods for normalization of hippocampal volumes measured with MR

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. AJNR. American journal of neuroradiology 1995-04-01 Hippocampus size on brain scans

    Correction processes can define absolute hippocampal volumes for correlation studies and may enable identification of unsuspected bilateral hippocampal volume loss.

  25. Anterior hippocampal volume deficits in nonamnesic, aging chronic alcoholics

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Alcoholism, clinical and experimental research 1995-02-01 Hippocampus size on brain scans

    Magnetic resonance imaging was used to quantify the volume of the hippocampus in 47 men with chronic alcoholism and 72 healthy male control subjects.

  26. Volumes of hippocampus, amygdala and frontal lobes in the MRI-based diagnosis of early Alzheimer's disease: correlation with memory functions

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Journal of neural transmission. Parkinson's disease and dementia section 1995-01-01 Cognitive tests and assessment

    We studied the usefulness of measuring volumes of the hippocampus, amygdala and frontal lobes with coronal magnetic resonance imaging (MRI) scans in the diagnosis of early Alzheimer's disease (AD).

  27. Hippocampal sclerosis: a common pathological feature of dementia in very old (> or = 80 years of age) humans

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. Acta neuropathologica 1994-01-01 Brain tissue and pathology

    In a neuropathological study of 81 brains of prospectively studied subjects of 80 years of age or older at the time of death, 13 cases (16%), including 4 men and 9 women, had hippocampal sclerosis (HpScl) affecting the vulnerable region of the hippocampus.

  28. MRI-based hippocampal volume measurements in epilepsy

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Epilepsia 1994-01-01 Hippocampus size on brain scans

    In the study of brain morphometry, it is accepted that a relationship exists between brain structure and function, both normal and abnormal.

  29. The relative contributions of MRI, SPECT, and PET imaging in epilepsy

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Epilepsia 1994-01-01 Hippocampus size on brain scans

    Functional and structural neuroimaging techniques are increasingly indispensable in the evaluation of epileptic patients for localization of the epileptic area as well as for understanding pathophysiology, propagation, and neurochemical correlates of chronic epilepsy.

  30. X-chromosome effects on female brain: a magnetic resonance imaging study of Turner's syndrome

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Lancet (London, England) 1993-11-01 Hippocampus size on brain scans

    Many neuropsychiatric disorders differ between the sexes in incidence, symptoms, and age at onset.

  31. MRI hippocampal volumes and memory function before and after temporal lobectomy

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Neurology 1993-09-01 Hippocampus size on brain scans

    We investigated the relationship between preoperative MRI hippocampal volumes and clinical neuropsychological memory test data obtained before and after temporal lobectomy and amygdalohippocampectomy for intractable epilepsy in 44 left (LTL) and 36 right (RTL) temporal lobectomy patients.

  32. Spatial learning impairment parallels the magnitude of dorsal hippocampal lesions, but is hardly present following ventral lesions

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The Journal of neuroscience : the official journal of the Society for Neuroscience 1993-09-01 Hippocampus size on brain scans

    The hippocampus plays an essential role in spatial learning.

  33. Hypercortisolemia and hippocampal changes in depression

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Psychiatry research 1993-05-01 Hippocampus size on brain scans

    Hypercortisolemia is a frequently observed abnormality in patients with major depression.

  34. Quantitative synaptic alterations in the human neocortex during normal aging

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Neurology 1993-01-01 Disease mechanisms

    We quantified the synaptic population density in the frontal cortex of 25 individuals without dementia 16 to 98 years old, using sections double-immunolabeled for beta/A4 amyloid and for synaptophysin, and found a significant inverse correlation between the presynaptic terminal (PT) counts and age (r = -0.7, p < 0.001).

  35. Brain morphology and schizophrenia. A magnetic resonance imaging study of limbic, prefrontal cortex, and caudate structures

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Archives of general psychiatry 1992-12-01 Hippocampus size on brain scans

    We used magnetic resonance imaging to examine the morphologic characteristics of the amygdala/hippocampus, prefrontal cortex, and caudate nucleus in 29 healthy volunteers matched for age, gender, and head of household socioeconomic status and 44 patients with chronic schizophrenia.

  36. Anatomic basis of amygdaloid and hippocampal volume measurement by magnetic resonance imaging

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Neurology 1992-09-01 Hippocampus size on brain scans

    Both the amygdala and the hippocampus are involved in the pathogenesis of a number of neurologic conditions, including temporal lobe epilepsy, postanoxic amnesia, and Alzheimer's disease.

  37. Hippocampal volumetric and morphometric studies in frontal and temporal lobe epilepsy

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. Brain : a journal of neurology 1992-08-01 Hippocampus size on brain scans

    The most common temporal lobe pathology is Ammons Horn sclerosis (AHS), and several different imaging techniques have been utilized to detect this with varying success.

  38. Evidence of dysfunction of a prefrontal-limbic network in schizophrenia: a magnetic resonance imaging and regional cerebral blood flow study of discordant monozygotic twins

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The American journal of psychiatry 1992-07-01 Hippocampus size on brain scans

    This finding is consistent with the notion that schizophrenia involves pathology of and dysfunction within a widely distributed neocortical-limbic neural network that has been implicated in, among other activities, the performance of cognitive tasks requiring working memory.

  39. Hippocampal neuron number in schizophrenia. A stereological study

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Archives of general psychiatry 1991-11-01 Hippocampus size on brain scans

    Neuropathologic and neuroradiologic studies have reported hippocampal abnormalities in schizophrenics.

  40. Evolution of spatial cognition: sex-specific patterns of spatial behavior predict hippocampal size

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Proceedings of the National Academy of Sciences of the United States of America 1990-08-01 Hippocampus size on brain scans

    In a study of two congeneric rodent species, sex differences in hippocampal size were predicted by sex-specific patterns of spatial cognition.

  41. Hippocampal specialization of food-storing birds

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Proceedings of the National Academy of Sciences of the United States of America 1989-02-01 Hippocampus size on brain scans

    In a study of 52 individuals belonging to 35 species or subspecies of passerine birds it was shown that the volume of the hippocampal complex relative to brain and body size is significantly larger in species that store food than in species that do not.

  42. Postmortem evidence of structural brain changes in schizophrenia. Differences in brain weight, temporal horn area, and parahippocampal gyrus compared with affective disorder

    ✓ Peer-reviewed alzhub usefulness score 49 out of 100. Archives of general psychiatry 1986-01-01 Getting a diagnosis

    The brains of 232 patients with a case-note diagnosis of schizophrenia or affective disorder who died in one mental hospital over a period of 22 years were weighed, and were assessed in a coronal section at the level of the interventricular foramina.

From across this tag

9 of the 492 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 9. The same 9 appear here every time.

All topic tags with their study counts