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disorder
492 studies tagged disorder, dated 1986-01-01 to 2026-03-31. Bibliography: BibTeX (.bib) · RIS (.ris)
Newest in this topic
- Synaptic loss in alcohol use disorder: clinical and mechanistic insights from a PET imaging study 2026-03-31
- Neighborhood environmental deprivation predicts the generalized neurocognitive deficit in schizophrenia 2025-12-19
- Bridging the Gap: Can Hippocampal Sclerosis Serve as a Surrogate Biomarker for LATE‐NC? 2025-12-01
Studies
492 studies carry this tag.
Date range
1986 to 2026
Top journals
- Neurology 38
- Biological psychiatry 36
- NeuroImage 32
- The American journal of psychiatry 22
- Proceedings of the National Academy of Sciences of the United States of America 20
148 journals in all.
Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.
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Stress-induced structural remodeling in the adult hippocampus, involving debranching and shortening of dendrites and suppression of neurogenesis, provides a cellular basis for understanding the impairment of neural plasticity in the human hippocampus in depressive illness.
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36/100
With high resolution, quantitative magnetic resonance imaging (MRI) techniques, it is now possible to examine alterations in brain anatomy in vivo and to identify regions affected in the earliest stages of Alzheimer's disease (AD).
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Smaller hippocampal volume is not a necessary risk factor for developing PTSD and does not occur within 6 months of expressing the disorder.
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The data support that HPA axis activation is common in depressed patients.
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Normal volunteers, aged 30 to 99 years, were studied with MRI.
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We used MRI volume sampling with coregistered and atrophy corrected FDG-PET scans to test three hypotheses: 1) hippocampal formation measures are superior to temporal neocortical measures in the discrimination of normal (NL) and mild cognitive impairment (MCI); 2) neocortical measures are most useful in the separation of Alzheimer disease (AD) from NL or MCI; 3) measures of PET glucose metabolism (MRglu) have greater diagnostic sensitivity than MRI volume.
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The sensitivity of MRI volumetric measures to detect cognitive dysfunction is examined in 39 participants of an epidemiological field study (age 75-85, MMSE 19-30).
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Although numerous studies of the longitudinal course of schizophrenia have demonstrated the clinical deterioration that occurs predominantly in the early stages of the illness, the pathophysiology of this clinical phenomenon has not been established.
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Mechanisms by which astrocytes are irreversibly injured from ischemic brain injury remain incompletely defined.
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Three neuroimaging techniques, morphometric neuroimaging, magnetic resonance spectroscopy, and functional neuroimaging, have provided evidence for abnormal hippocampal structure and function in schizophrenia.
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Assessments of hippocampal volume and shape derived from HDBM may be useful in distinguishing early DAT from healthy aging.
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This study compared a fornix cross-sectional-area measurement and hippocampal volume in 86 traumatic brain injury (TBI) subjects with 46 normal controls.
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An extensive literature stretching back decades has shown that prolonged stress or prolonged exposure to glucocorticoids-the adrenal steroids secreted during stress-can have adverse effects on the rodent hippocampus.
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36/100
A number of studies indicate that prolonged, major depression is associated with a selective loss of hippocampal volume that persists long after the depression has resolved.
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Rates of hippocampal atrophy match both baseline cognitive status and the change in cognitive status over time in elderly persons who lie along the cognitive continuum from normal to MCI to AD.
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There is a growing literature on the importance of hippocampal volume in geriatric depression.
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The epsilon4 allele of the apolipoprotein E (APOE) gene confers an increased risk for the development of AD.
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Children born preterm and of very low birth weight have an increased incidence of learning difficulties, but little is known about the specific nature of their cognitive deficits and the underlying neuropathology.
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The results of our study indicate no reduction in the volume of the hippocampus in patients with major depression.
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In the mature brain, chronic alcohol use disorders are associated with graded global brain dysmorphology.
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Despite the theoretical rationale for the superiority of entorhinal measurements in early AD, the authors found MRI measurements of the hippocampus and entorhinal cortex were approximately equivalent at intergroup discrimination.
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Structural MRIs of the brains of humans with extensive navigation experience, licensed London taxi drivers, were analyzed and compared with those of control subjects who did not drive taxis.
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Within the medial temporal lobe, both the hippocampus and amygdala are frequently targeted by researchers and clinicians for volumetric analysis based on magnetic resonance imaging (MRI).
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Atrophy of the hippocampal formation, a region important for the acquisition of new declarative knowledge, has been well-documented in Alzheimer's disease (AD), although the relation of such atrophy to the extent of memory dysfunction in these patients has been less clear.
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These findings are consistent with smaller left hippocampal volume in depression.
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For 11 AD cases and four normal elderly controls, post mortem volumes of the hippocampal subdivisions were calculated by using magnetic resonance imaging and histological sections.
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43/100
Changes in human HFV associated with sustained hypercortisolemia are reversible, at least in part, once cortisol levels decrease.
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40/100
There is a reduction in the volume of amygdala and hippocampus in people with autism, particularly in relation to total brain volume.
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These findings require further work to determine if the abnormalities are an expression of the genetic liability to schizophrenia.
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This study takes advantage of continuing advances in the precision of magnetic resonance imaging (MRI) to quantify hippocampal volumes in a series of human subjects with a history of depression compared with controls.
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These data suggest that the overwhelming stress of maltreatment experiences in childhood is associated with adverse brain development.
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Magnetic resonance imaging (MRI) studies have produced controversial results concerning the correlation of hippocampal volume loss with increasing age.
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Studies in animals showed that stress results in damage to the hippocampus, a brain area involved in learning and memory, with associated memory deficits.
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In chronic alcoholism, the reduction of hippocampal volume is proportional to the reduction of the brain volume.
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43/100
Hippocampal volume, while disproportionately small for brain size in individuals with Down's syndrome, remains fairly constant through the fifth decade of life in those without dementia.
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During the period of longitudinal observation, which averaged 32.6 months, 27 of the 80 MCI patients became demented.
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Functional imaging data indicate that the pathophysiology of schizophrenia reflects aberrant activity in, and integration of, the components of distributed circuits involving the prefrontal cortex, hippocampus and certain subcortical structures.
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Chronic exposure to increased glucocorticoid concentrations appears to lower the threshold for hippocampal neuronal degeneration in the old rat.
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In order to study the neurobiological basis of seasonal changes in hippocampal structure and function, the rate of cell proliferation was examined in male and female wild meadow voles captured during different seasons.
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These data show that smaller hippocampal volumes are present from the onset of illness.
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Measurement of regional abnormalities of HT2 along the length of the hippocampus provides further refinement to the MRI assessment of the hippocampi in patients with temporal lobe epilepsy and is complementary to volumetric and morphological data.
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Theories of the pathophysiology of schizophrenia have implicated the hippocampus, but controversy remains regarding hippocampal abnormalities in patients with schizophrenia.
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Delayed memory impairments and medial temporal-lobe atrophy are considered to be cardinal features of Alzheimer's disease (AD).
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Brain imaging techniques have the potential to characterize neurobiological changes that precede the onset of cognitive impairment in persons at risk for Alzheimer's disease.
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The amygdala is a key structure in the brain's integration of emotional meaning with perception and experience.
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Elevated glucocorticoid levels produce hippocampal dysfunction and correlate with individual deficits in spatial learning in aged rats.
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Schizophrenia is associated with a bilateral volumetric reduction of the hippocampus and probably of the amygdala as well.
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In patients with cryptogenic epilepsy, recurrent seizures may cause damage to the hippocampus throughout the lifetime of the patient.
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Our results provide some support for the lateralised model of material specific memory deficits, but suggest that a number of demographic and epilepsy-related factors may interact with the extent and laterality of hippocampal pathology in shaping the nature of the associated neuropsychological deficit.
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The aims of this study were to examine the relationships of hippocampal T2 (HCT2) relaxation time and magnetic resonance (MR)-based hippocampal volume (HCV) to neuronal (ND) and glial cell densities (GD) of hippocampal neuronal cell layers, and to obtain a better clinicopathological definition of hippocampal sclerosis (HS) and end folium sclerosis (EFS).
From across this tag
9 of the 492 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 9. The same 9 appear here every time.
- Association of DISC1/TRAX haplotypes with schizophrenia, reduced prefrontal gray matter, and impaired short- and long-term memory
- Seizure-associated hippocampal volume loss: a longitudinal magnetic resonance study of temporal lobe epilepsy
- Maternal anxiety and infants' hippocampal development: timing matters
- Central obesity and the aging brain
- Hippocampal sclerosis--origins and imaging
- Hippocampal activation in adults with mild cognitive impairment predicts subsequent cognitive decline
- Amygdala and hippocampus enlargement during adolescence in autism
- How does the brain deal with cumulative stress? A review with focus on developmental stress, HPA axis function and hippocampal structure in humans
- Mapping subcortical brain maturation during adolescence: evidence of hemisphere- and sex-specific longitudinal changes