Get help now — free helplines

You can call any of these for free. You do not need a diagnosis, an appointment, or a crisis to call — questions and plain exhaustion are reasons enough.

  • Alzheimer's Association 24/7 Helpline 800-272-3900 24 hours a day, 365 days a year Free, confidential support and information for people with dementia, caregivers, families and the public. Master's-level clinicians. Also Spanish.
  • 988 Suicide & Crisis Lifeline 988 24/7 Call or text 988, or chat at 988lifeline.org. For anyone in emotional distress or a mental-health crisis, including caregivers.
  • Alzheimer's Foundation of America (AFA) Helpline 866-232-8484 9:00 am - 9:00 pm ET, seven days a week Licensed social workers providing support, info and referrals. Also text message and web chat. Text: 646-586-5283

In a medical emergency, call 911. More numbers, and what each line does, on the help page.

Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.

Highest usefulness score first. Studies without a score come last.

  1. Sleep and Cognition in Older Adults

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Sleep medicine clinics 2017-12-08 Risk factors

    Increased age is associated with normative declines in both sleep and cognitive functioning.

  2. Neurologic Changes and Depression

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. The Psychiatric clinics of North America 2017-12-06 Risk factors

    This article covers current research on the relationship between depression and cognitive impairment in older adults.

  3. Functional connectivity in dementia with Lewy bodies: A within- and between-network analysis

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Human brain mapping 2017-11-29 Brain scans and imaging

    Dementia with Lewy bodies (DLB) is a common form of dementia and is characterized by cognitive fluctuations, visual hallucinations, and Parkinsonism.

  4. Arterial stiffness, cognitive impairment and dementia: confounding factor or real risk?

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Journal of neurochemistry 2017-11-27 Risk factors

    Large artery stiffness is a frequent condition that arises with ageing, and is accelerated by the presence of co-morbidities like hypertension, obesity and diabetes.

  5. Applications of Resting-State Functional Connectivity to Neurodegenerative Disease

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Neuroimaging clinics of North America 2017-11 Brain scans and imaging

    Neurodegenerative diseases target specific large-scale neuronal networks, leading to distinct behavioral and cognitive dysfunctions.

  6. Doctor, Should I Use Computer Games to Prevent Dementia?

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Clinical gerontologist 2017-10-11 Cognitive tests and assessment

    Commercial advertising of computerized "brain games" may result in clinicians being asked whether brain games prevent dementia.

  7. Cerebral amyloid angiopathy-related cognitive impairment: The search for a specific neuropsychological pattern

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Revue neurologique 2017-10-06 Vascular contributions

    Cerebral amyloid angiopathy is diagnosed in stroke units after lobar intracerebral hemorrhage.

  8. Frequency-Dependent Altered Functional Connections of Default Mode Network in Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Frontiers in aging neuroscience 2017-08-03 Brain scans and imaging

    Alzheimer's disease (AD) is a neurodegenerative disorder associated with the progressive dysfunction of cognitive ability.

  9. Circadian Rhythm Sleep-Wake Disorders

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Continuum (Minneapolis, Minn.) 2017-08 Risk factors

    The endogenous circadian rhythms are one of the cardinal processes that control sleep.

  10. Sleep and Alzheimer's disease: A pivotal role for the suprachiasmatic nucleus

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Sleep medicine reviews 2017-07-28 Risk factors

    Alzheimer's disease (AD), which accounts for most of the dementia cases, is, aside from cognitive deterioration, often characterized by the presence of non-cognitive symptoms.

  11. Cognitive reserve is not associated with improved performance in all cognitive domains

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Applied neuropsychology. Adult 2017-06-08 Risk factors

    Cognitive reserve beneficially affects cognitive performance, even into advanced age.

  12. [Clocks, Behavior, and Cognition]

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Brain and nerve = Shinkei kenkyu no shinpo 2017-06 Risk factors

    The nerve center responsible for controlling our circadian rhythm is located in a cluster of cells known as the suprachiasmatic nucleus in the hypothalamus.

  13. Role of Sleep Disturbance in the Trajectory of Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology 2017-05-31 Risk factors

    Sleep disturbances such as insomnia, hypersomnia, and circadian rhythm disturbance are common in normal elderly and Alzheimer's disease (AD) patients.

  14. Altered Functional Connectivity of Cognitive-Related Cerebellar Subregions in Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Frontiers in aging neuroscience 2017-05-16 Brain scans and imaging

    Alzheimer's disease (AD) is the most common cause of dementia.

  15. Alzheimer's disease disrupts alpha and beta-band resting-state oscillatory network connectivity

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 2017-05-08 Brain scans and imaging

    In bilateral parietotemporal areas, oscillatory envelope amplitude increased with healthy ageing, whereas both local amplitude and node-to-global connectivity decreased with AD.

  16. Age-related white matter integrity differences in oldest-old without dementia

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Neurobiology of aging 2017-04-26 Brain scans and imaging

    Aging is known to have deleterious effects on cerebral white matter, yet little is known about these white matter alterations in advanced age.

  17. Overlay of Late-Life Depression and Cognitive Impairment

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Focus (American Psychiatric Publishing) 2017-01-11 Risk factors

    This article appraises several facets of the linkage between depression and cognitive impairment, including dementia, mild cognitive impairment, and vascular dementia.

  18. Functional Disintegration of the Default Mode Network in Prodromal Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Journal of Alzheimer's disease : JAD 2017 Brain scans and imaging

    Neurodegenerative brain changes can affect the functional connectivity strength between nodes of the default-mode network (DMN), which may underlie changes in cognitive performance.

  19. Exercise Training and Functional Connectivity Changes in Mild Cognitive Impairment and Healthy Elders

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Journal of Alzheimer's disease : JAD 2017 Brain scans and imaging

    A linear mixed effects model revealed a significant interaction in the right parietal lobe: the MCI group showed increased connectivity while the healthy elders showed decreased connectivity.

  20. Apathy and intrinsic functional connectivity networks in amnestic mild cognitive impairment

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Neuropsychiatric disease and treatment 2016-12-23 Brain scans and imaging

    We observed that the FCs of the DMN were less and those of CEN were more in the aMCI group than the CON group.

  21. Personalising exercise recommendations for brain health: considerations and future directions

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. British journal of sports medicine 2016-11-17 Prevention trials

    The societal value of strategies that delay the onset and progression of dementia cannot be overstated.

  22. Functional connectivity and microstructural white matter changes in phenocopy frontotemporal dementia

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. European radiology 2016-07-19 Brain scans and imaging

    PhFTD showed subtly increased DMN connectivity and subtle microstructural changes in frontal WM tracts.

  23. Metabolic connectomics targeting brain pathology in dementia with Lewy bodies

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2016-01-01 Brain tissue and pathology

    Dementia with Lewy bodies is characterized by α-synuclein accumulation and degeneration of dopaminergic and cholinergic pathways.

  24. Analysis of entropies based on empirical mode decomposition in amnesic mild cognitive impairment of diabetes mellitus

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Journal of Innovative Optical Health Sciences 2015-08-21 Risk factors

    EEG characteristics that correlate with the cognitive functions are important in detecting mild cognitive impairment (MCI) in T2DM.

  25. Gallery Game: Smartphone-based assessment of long-term memory in adults at risk of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Journal of clinical and experimental neuropsychology 2020-01-24 Cognitive tests and assessment

    Retention intervals of at least three days were needed to evidence significant forgetting at both recognition and paired-associate recall test.

From across this topic

10 of the 1,533 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.

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