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43/100

✓ Peer-reviewed alzhub usefulness score 43 out of 100. TREM2 and immune genetics

Topic: Brain proteins, microglia and lab models

Background Chronic cerebral hypoperfusion (CCH) is regarded as a high-risk factor for cognitive decline in vascular dementia (VaD). We have previously shown that diabetes mellitus (DM) synergistically promotes CCH-induced cognitive dysfunction via exacerbating neuroinflammation. Furthermore, curcumin has been shown to exhibit anti-inflammatory and neuroprotective activities.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Zheng, Y., Zhang, J., Zhao, Y., Zhang, Y., Zhang, X., Guan, J., et al. (2021). Curcumin protects against cognitive impairments in a rat model of chronic cerebral hypoperfusion combined with diabetes mellitus by suppressing neuroinflammation, apoptosis, and pyroptosis. International immunopharmacology. https://doi.org/10.1016/j.intimp.2021.107422

Vancouver

Zheng Y, Zhang J, Zhao Y, Zhang Y, Zhang X, Guan J, et al. Curcumin protects against cognitive impairments in a rat model of chronic cerebral hypoperfusion combined with diabetes mellitus by suppressing neuroinflammation, apoptosis, and pyroptosis. International immunopharmacology. 2021. doi:10.1016/j.intimp.2021.107422. PMID: 33548579.

BibTeX

@article{zheng2021-33548579,
  author  = {Zheng, Y. and Zhang, J. and Zhao, Y. and Zhang, Y. and Zhang, X. and Guan, J. and Liu, Y. and Fu, J.},
  title   = {{Curcumin protects against cognitive impairments in a rat model of chronic cerebral hypoperfusion combined with diabetes mellitus by suppressing neuroinflammation, apoptosis, and pyroptosis}},
  journal = {International immunopharmacology},
  year    = {2021},
  doi     = {10.1016/j.intimp.2021.107422},
  pmid    = {33548579},
  url     = {https://doi.org/10.1016/j.intimp.2021.107422}
}

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 8 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.

Key findings

We have previously shown that diabetes mellitus (DM) synergistically promotes CCH-induced cognitive dysfunction via exacerbating neuroinflammation.
Furthermore, curcumin has been shown to exhibit anti-inflammatory and neuroprotective activities.
However, the effects of curcumin on CCH-induced cognitive impairments in DM have remained unknown.
Methods Rats were fed with a high-fat diet (HFD) and injected with low-dose streptozotocin (STZ), followed by bilateral common carotid artery occlusion (BCCAO), to model DM and CCH in vivo.

Why it matters

In rats with chronic cerebral hypoperfusion plus diabetes, curcumin protected against cognitive impairment by suppressing neuroinflammation, apoptosis and pyroptosis. This is animal research only and reports no treatment, cure or prevention for people.

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Study details

Evidence strengthLow

How this study scored 43/100

Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported and randomized / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (International immunopharmacology)
Journal's citation record	2 / 4	International Immunopharmacology: journal h-index 165 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	3 / 5	2021 — within 6 year(s) of the newest study here
Sample size	0 / 4	Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	0 / 3	Laboratory or animal study (title names “rat”) — scores zero
Randomized / blinded	0 / 2	No randomization or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	4 / 7	Cited 72 times (OpenAlex, 2026-10-10)
Citations per year	3 / 5	10.3 citations a year over 7 year(s) since 2021
Impact for its field and year	3 / 6	Cited 3.5× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	2 / 6	Cited by 3 other studies in this library
Still being cited	2 / 4	Cited 40 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	2 / 4	Last-listed author Jianliang Fu: h-index 23 (OpenAlex, whole career)
Institution's track record	1 / 3	Shanghai Jiao Tong University: institution h-index 975 (OpenAlex)
Multicenter collaboration	1 / 3	OpenAlex lists 3 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 33548579)
Free to read	0 / 2	Behind a paywall — scores zero
Total	43 / 100	—

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