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Cerebral Small Vessel Disease, Hypertension, and Vascular Contributions to Cognitive Impairment and Dementia
Hainsworth AH, Markus HS, Schneider JA.. Hypertension (Dallas, Tex. : 1979), 2023-11-29
Topic: Risk, prevention and care in population studies
Hypertension-associated cerebral small vessel disease is a common finding in older people. Strongly associated with age and hypertension, small vessel disease is found at autopsy in over 50% of people aged ≥65 years, with a spectrum of clinical manifestations. It is the main cause of lacunar stroke and a major source of vascular contributions to cognitive impairment and dementia.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Hainsworth, A. H., Markus, H. S., & Schneider, J. A. (2024). Cerebral Small Vessel Disease, Hypertension, and Vascular Contributions to Cognitive Impairment and Dementia. Hypertension (Dallas, Tex. : 1979). https://doi.org/10.1161/hypertensionaha.123.19943
Vancouver
Hainsworth AH, Markus HS, Schneider JA. Cerebral Small Vessel Disease, Hypertension, and Vascular Contributions to Cognitive Impairment and Dementia. Hypertension (Dallas, Tex. : 1979). 2024. doi:10.1161/hypertensionaha.123.19943. PMID: 38044814.
BibTeX
@article{hainsworth2024-38044814,
author = {Hainsworth, A. H. and Markus, H. S. and Schneider, J. A.},
title = {{Cerebral Small Vessel Disease, Hypertension, and Vascular Contributions to Cognitive Impairment and Dementia}},
journal = {Hypertension (Dallas, Tex. : 1979)},
year = {2024},
doi = {10.1161/hypertensionaha.123.19943},
pmid = {38044814},
url = {https://doi.org/10.1161/hypertensionaha.123.19943}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- Strongly associated with age and hypertension, small vessel disease is found at autopsy in over 50% of people aged ≥65 years, with a spectrum of clinical manifestations.
- It is the main cause of lacunar stroke and a major source of vascular contributions to cognitive impairment and dementia.
- The brain areas affected are subcortical and periventricular white matter and deep gray nuclei.
- Neuropathological sequelae are diffuse white matter lesions (seen as white matter hyperintensities on T2-weighted magnetic resonance imaging), small ischemic foci (lacunes or microinfarcts), and less commonly, subcortical microhemorrhages.
Why it matters
This review describes hypertension-associated cerebral small vessel disease, found at autopsy in over 50% of people aged 65 years and older, as a major source of vascular contributions to cognitive impairment and dementia. It addresses a vascular contributor to dementia and does not test a treatment, cure, or prevention for Alzheimer's disease.
Study details
- Evidence strengthLow
How this study scored 59/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Hypertension (Dallas, Tex. : 1979)) |
| Journal's citation record | 3 / 4 | Hypertension: journal h-index 369 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2024 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 248 times (OpenAlex, 2026-10-10) |
| Citations per year | 5 / 5 | 62.0 citations a year over 4 year(s) since 2024 |
| Impact for its field and year | 5 / 6 | Cited 36.5× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 3 / 6 | Cited by 14 other studies in this library |
| Still being cited | 4 / 4 | Cited 248 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Julie A. Schneider: h-index 151 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University of Cambridge: institution h-index 1,973 (OpenAlex) |
| Multicenter collaboration | 2 / 3 | OpenAlex lists 4 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 38044814) |
| Free to read | 2 / 2 | Free to read |
| Total | 59 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1161/hypertensionaha.123.19943
- PubMed: 38044814
- Original source →
- Free full text: Hypertension →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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