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Religious Orders Study and Rush Memory and Aging Project
Bennett DA, Buchman AS, Boyle PA, Barnes LL, Wilson RS, Schneider JA.. Journal of Alzheimer's disease : JAD, 2018-01-01
Topic: Risk, prevention and care in population studies
Background The Religious Orders Study and Rush Memory and Aging Project are both ongoing longitudinal clinical-pathologic cohort studies of aging and Alzheimer's disease (AD). Objectives To summarize progress over the past five years and its implications for understanding neurodegenerative diseases. Methods Participants in both studies are older adults who enroll without dementia and agree to detailed longitudinal clinical evaluations and organ donation. The last review summarized findings through the end of 2011. Here we summarize progress and study findings over the past five years and discuss new directions for how these studies can inform on aging and AD in the future. Results We summarize 1) findings on the relation of neurobiology to clinical AD; 2) neurobiologic pathways linking risk factors to clinical AD; 3) non-cognitive AD phenotypes including motor function and decision making; 4) the development of a novel drug discovery platform. Conclusion Complexity at multiple levels needs to be understood and overcome to develop effective treatments and preventions for cognitive decline and AD dementia.
Key findings
- Results We summarize 1) findings on the relation of neurobiology to clinical AD; 2) neurobiologic pathways linking risk factors to clinical AD; 3) non-cognitive AD phenotypes including motor function and decision making; 4) the development of a novel drug discovery platform.
Why it matters
This is a five-year progress review of two "ongoing longitudinal clinical-pathologic cohort studies of aging and Alzheimer's disease", in which older adults "enroll without dementia and agree to detailed longitudinal clinical evaluations and organ donation". It surveys work on how brain changes relate to clinical Alzheimer's, how risk factors may connect to the disease, motor function and decision making, and a drug discovery platform, but the abstract lists these as topics and reports no specific results. The authors conclude that "complexity at multiple levels needs to be understood and overcome to develop effective treatments and preventions", so the paper offers no treatment or prevention.
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Study details
- Study designcohort study
- Evidence strengthModerate
How this study scored 63/100
Published in a peer-reviewed journal, and it is a cohort study following people over time. Scored zero for sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of Alzheimer's disease : JAD) |
| Journal's citation record | 2 / 4 | Journal of Alzheimer s Disease: journal h-index 218 (OpenAlex, 2026-10-29) |
| Study design | 7 / 12 | A cohort study following people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2018 — within 10 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 7 / 7 | Cited 1,273 times (OpenAlex, 2026-10-10) |
| Citations per year | 5 / 5 | 127.3 citations a year over 10 year(s) since 2018 |
| Impact for its field and year | 6 / 6 | Cited 54.6× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 4 / 6 | Cited by 49 other studies in this library |
| Still being cited | 4 / 4 | Cited 604 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Julie A. Schneider: h-index 151 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | Rush University Medical Center: institution h-index 670 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 29865057) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 63 / 100 | — |
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Read the original
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Bennett, D. A., Buchman, A. S., Boyle, P. A., Barnes, L. L., Wilson, R. S., & Schneider, J. A. (2018). Religious Orders Study and Rush Memory and Aging Project. Journal of Alzheimer's disease : JAD. https://doi.org/10.3233/jad-179939
Vancouver
Bennett DA, Buchman AS, Boyle PA, Barnes LL, Wilson RS, Schneider JA. Religious Orders Study and Rush Memory and Aging Project. Journal of Alzheimer's disease : JAD. 2018. doi:10.3233/jad-179939. PMID: 29865057.
BibTeX
@article{bennett2018-29865057,
author = {Bennett, D. A. and Buchman, A. S. and Boyle, P. A. and Barnes, L. L. and Wilson, R. S. and Schneider, J. A.},
title = {{Religious Orders Study and Rush Memory and Aging Project}},
journal = {Journal of Alzheimer's disease : JAD},
year = {2018},
doi = {10.3233/jad-179939},
pmid = {29865057},
url = {https://doi.org/10.3233/jad-179939}
}
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