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Preclinical Alzheimer's disease biomarkers accurately predict cognitive and neuropathological outcomes
Long JM, Coble DW, Xiong C, Schindler SE, Perrin RJ, Gordon BA, Benzinger TLS, Grant E et al.. Brain : a journal of neurology, 2022-12-01
Topic: Amyloid, tau and blood-test diagnosis
Among cognitively normal participants with positive biomarkers, 34.4% developed cognitive impairment (Clinical Dementia Rating > 0) as compared to 8.4% of those with negative biomarkers. Cox proportional hazards modelling indicated that preclinical Alzheimer's disease biomarker status, APOE ɛ4 carrier status, polygenic risk score and centred age influenced risk of developing cognitive impairment.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Long, J. M., Coble, D. W., Xiong, C., Schindler, S. E., Perrin, R. J., Gordon, B. A., et al. (2022). Preclinical Alzheimer's disease biomarkers accurately predict cognitive and neuropathological outcomes. Brain : a journal of neurology. https://doi.org/10.1093/brain/awac250
Vancouver
Long JM, Coble DW, Xiong C, Schindler SE, Perrin RJ, Gordon BA, et al. Preclinical Alzheimer's disease biomarkers accurately predict cognitive and neuropathological outcomes. Brain : a journal of neurology. 2022. doi:10.1093/brain/awac250. PMID: 35867858.
BibTeX
@article{long2022-35867858,
author = {Long, J. M. and Coble, D. W. and Xiong, C. and Schindler, S. E. and Perrin, R. J. and Gordon, B. A. and Benzinger, T. L. S. and Grant, E. and others},
title = {{Preclinical Alzheimer's disease biomarkers accurately predict cognitive and neuropathological outcomes}},
journal = {Brain : a journal of neurology},
year = {2022},
doi = {10.1093/brain/awac250},
pmid = {35867858},
url = {https://doi.org/10.1093/brain/awac250}
}
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Key findings
- Among cognitively normal participants with positive biomarkers, 34.4% developed cognitive impairment (Clinical Dementia Rating > 0) as compared to 8.4% of those with negative biomarkers.
- Cox proportional hazards modelling indicated that preclinical Alzheimer's disease biomarker status, APOE ɛ4 carrier status, polygenic risk score and centred age influenced risk of developing cognitive impairment.
Why it matters
Among cognitively normal people, those with positive preclinical Alzheimer's biomarkers were more likely to develop cognitive impairment than those with negative biomarkers, and biomarker status, APOE ɛ4 carrier status, polygenic risk score and age influenced that risk. This supports the idea that biomarkers can predict who will develop cognitive problems, but it does not show that any treatment, cure or prevention works.
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Study details
- Study designlongitudinal study
- Participants720
- Effect size34.4%; 8.4%; 90.9%
- Evidence strengthModerate
How this study scored 64/100
Published in a leading specialty journal, and it is a longitudinal study following the same people over time. Scored zero for randomized / blinded because the record does not state it. We have no data on senior author's track record, so that was left out: it earned 61 of the 96 points we could judge it on, which is 64 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Brain : a journal of neurology) |
| Journal's citation record | 4 / 4 | Brain: journal h-index 503 (OpenAlex, 2026-10-29) |
| Study design | 7 / 12 | A longitudinal study following the same people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2022 — within 6 year(s) of the newest study here |
| Sample size | 2 / 4 | 720 participants |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 4 / 7 | Cited 48 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 8.0 citations a year over 6 year(s) since 2022 |
| Impact for its field and year | 3 / 6 | Cited 5.5× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 5 other studies in this library |
| Still being cited | 2 / 4 | Cited 33 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | 2 / 3 | Washington University in St. Louis: institution h-index 1,962 (OpenAlex) |
| Multicenter collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 35867858) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 61 / 96 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 61 of the 96 points we could judge it on is 64 out of 100. |
| Total | 64 / 100 | — |
What each of these 20 components measures, and what this score is not →
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