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Altered spatiotemporal brain dynamics of interoception in behavioural-variant frontotemporal dementia
Jessica L. Hazelton, Gabriel A. Della Bella, Pablo Barttfeld, Martín Dottori, Raúl González-Gómez, Joaquín Migeot, Sebastián Moguilner, Agustina Legaz et al.. EBioMedicine, 2025-02-22
Topic: Brain proteins, microglia and lab models
In bvFTD patients, longer interoceptive-ACWs than controls were observed in the bilateral fronto-temporal and parietal regions. In AD patients, longer interoceptive-ACWs than controls were observed in central and occipitoparietal brain regions. No differences were observed during exteroception. In bvFTD patients only, longer interoceptive-ACW was linked to worse sociocognitive performance. Structural neural correlates of interoceptive-ACW in bvFTD involved the anterior cingulate, insula, orbitofrontal cortex, hippocampus, and angular gyrus. Our findings suggest a core allostatic-interoceptive deficit occurs in people with bvFTD. Further, altered interoceptive intrinsic neural timescales may provide a neurobiological mechanism underpinning the complex behaviours observed in bvFTD patients. Our findings support synergistic models of brain disease and can inform clinical practice. FUNDING: All funding sources are reported in the Acknowledgements.
Key findings
- In bvFTD patients, longer interoceptive-ACWs than controls were observed in the bilateral fronto-temporal and parietal regions.
- In AD patients, longer interoceptive-ACWs than controls were observed in central and occipitoparietal brain regions.
- No differences were observed during exteroception.
- In bvFTD patients only, longer interoceptive-ACW was linked to worse sociocognitive performance.
- Structural neural correlates of interoceptive-ACW in bvFTD involved the anterior cingulate, insula, orbitofrontal cortex, hippocampus, and angular gyrus.
Why it matters
Findings suggest a core allostatic-interoceptive deficit occurs in people with behavioral-variant frontotemporal dementia, with altered interoceptive intrinsic neural timescales potentially underpinning complex behaviors. Structural neural correlates involved the anterior cingulate, insula, orbitofrontal cortex, hippocampus, and angular gyrus.
Study details
- Evidence strengthLow
How this study scored 47/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (EBioMedicine) |
| Journal's citation record | 2 / 4 | EBioMedicine: journal h-index 181 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 2 / 7 | Cited 13 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 4.3 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 4 / 6 | Cited 8.2× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 3 other studies in this library |
| Still being cited | 1 / 4 | Cited 13 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Agustín M. Ibáñez: h-index 81 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University of California, San Francisco: institution h-index 1,915 (OpenAlex) |
| Multi-centre collaboration | 3 / 3 | OpenAlex lists 18 institution(s) in 8 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 39987747) |
| Free to read | 2 / 2 | Free to read |
| Total | 47 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
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APA 7th
Hazelton, J. L., Della Bella, G. A., Barttfeld, P., Dottori, M., González-Gómez, R., Migeot, J., et al. (2025). Altered spatiotemporal brain dynamics of interoception in behavioural-variant frontotemporal dementia. EBioMedicine. https://doi.org/10.1016/j.ebiom.2025.105614
Vancouver
Hazelton JL, Della Bella GA, Barttfeld P, Dottori M, González-Gómez R, Migeot J, et al. Altered spatiotemporal brain dynamics of interoception in behavioural-variant frontotemporal dementia. EBioMedicine. 2025. doi:10.1016/j.ebiom.2025.105614. PMID: 39987747.
BibTeX
@article{hazelton2025-39987747,
author = {Hazelton, Jessica L. and Della Bella, Gabriel A. and Barttfeld, Pablo and Dottori, Martín and González-Gómez, Raúl and Migeot, Joaquín and Moguilner, Sebastián and Legaz, Agustina and others},
title = {{Altered spatiotemporal brain dynamics of interoception in behavioural-variant frontotemporal dementia}},
journal = {EBioMedicine},
year = {2025},
doi = {10.1016/j.ebiom.2025.105614},
pmid = {39987747},
url = {https://doi.org/10.1016/j.ebiom.2025.105614}
}
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